Free for academic non-profit institutions. Other users need a Commercial license

Aliases for MIR411 Gene

Subcategory (RNA class) for MIR411 Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR411 Gene

  • MicroRNA 411 2 3 5
  • Hsa-Mir-411 3
  • Mir-411 3
  • MIRN411 3

External Ids for MIR411 Gene

ORGUL Members for MIR411 Gene

Previous HGNC Symbols for MIR411 Gene

  • MIRN411

Previous GeneCards Identifiers for MIR411 Gene

  • GC14P100812
  • GC14P100904
  • GC14P101489
  • GC14P101231
  • GC14P101802
  • GC14P102096
  • GC14P102330
  • GC14P102502

Summaries for MIR411 Gene

Entrez Gene Summary for MIR411 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR411 Gene

MIR411 (MicroRNA 411) is an RNA Gene, and is affiliated with the miRNA class.

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR411 Gene

Genomics for MIR411 Gene

Genomic Location for MIR411 Gene

Chromosome:
14
Start:
101,023,325 bp from pter
End:
101,023,420 bp from pter
Size:
96 bases
Orientation:
Plus strand

Genomic View for MIR411 Gene

Genes around MIR411 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR411 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR411 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR411 Gene

No data available for Regulatory Elements for MIR411 Gene

Proteins for MIR411 Gene

Post-translational modifications for MIR411 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR411 Gene

Domains & Families for MIR411 Gene

Gene Families for MIR411 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR411: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR411 Gene

Function for MIR411 Gene

Animal Model Products

miRNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR411 Gene

Localization for MIR411 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR411 Gene

Pathways & Interactions for MIR411 Gene

SuperPathways for MIR411 Gene

No Data Available

Interacting Proteins for MIR411 Gene

Gene Ontology (GO) - Biological Process for MIR411 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for MIR411 Gene

Drugs & Compounds for MIR411 Gene

No Compound Related Data Available

Transcripts for MIR411 Gene

mRNA/cDNA for MIR411 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

miRNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR411 Gene

No ASD Table

Relevant External Links for MIR411 Gene

GeneLoc Exon Structure for
MIR411
ECgene alternative splicing isoforms for
MIR411

Expression for MIR411 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MIR411 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR411 Gene:

MIR411
genes like me logo Genes that share expression patterns with MIR411: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR411 Gene

Orthologs for MIR411 Gene

Evolution for MIR411 Gene

ENSEMBL:
Gene Tree for MIR411 (if available)
TreeFam:
Gene Tree for MIR411 (if available)

No data available for Orthologs for MIR411 Gene

Paralogs for MIR411 Gene

No data available for Paralogs for MIR411 Gene

Variants for MIR411 Gene

Sequence variations from dbSNP and Humsavar for MIR411 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
rs1000602249 -- 101,022,942(+) CTCCC(C/T)ACTCC upstream-variant-2KB
rs1001056043 -- 101,022,619(+) CAGTG(C/G)CAAGT downstream-variant-500B, upstream-variant-2KB
rs1001300191 -- 101,022,800(+) TTTTT(C/T)TTTAA upstream-variant-2KB
rs1003412680 -- 101,021,384(+) GGCCC(C/T)GTCTA upstream-variant-2KB
rs1005786036 -- 101,021,993(+) AGAAA(A/G)CTTTC upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MIR411 Gene

Variant ID Type Subtype PubMed ID
esv3635521 CNV gain 21293372
esv3635523 CNV gain 21293372
nsv1040993 CNV gain 25217958
nsv1426 CNV insertion 18451855
nsv565859 CNV gain 21841781
nsv565860 CNV gain 21841781

Relevant External Links for MIR411 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR411

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR411 Gene

Disorders for MIR411 Gene

Relevant External Links for MIR411

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR411

No disorders were found for MIR411 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR411 Gene

Publications for MIR411 Gene

  1. miRNA-411 acts as a potential tumor suppressor miRNA via the downregulation of specificity protein 1 in breast cancer. (PMID: 27572271) Guo L. … Wang X. (Mol Med Rep 2016) 3 64
  2. miR-411 contributes the cell proliferation of lung cancer by targeting FOXO1. (PMID: 26572153) Zhao Z. … Li S. (Tumour Biol. 2016) 3 64
  3. miR-411 regulated ITCH expression and promoted cell proliferation in human hepatocellular carcinoma cells. (PMID: 25776495) Xia K. … Zhang S. (Biomed. Pharmacother. 2015) 3 64
  4. A MicroRNA cluster at 14q32 drives aggressive lung adenocarcinoma. (PMID: 24833665) Nadal E. … Chen G. (Clin. Cancer Res. 2014) 3 64
  5. miR-379/411 cluster regulates IL-18 and contributes to drug resistance in malignant pleural mesothelioma. (PMID: 25231602) Yamamoto K. … Gemma A. (Oncol. Rep. 2014) 3 64

Products for MIR411 Gene

Sources for MIR411 Gene

Content
Loading form....