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Aliases for MIR409 Gene

Subcategory (RNA class) for MIR409 Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR409 Gene

  • MicroRNA 409 2 3 5
  • Hsa-Mir-409 3
  • Mir-409 3
  • MIRN409 3

External Ids for MIR409 Gene

ORGUL Members for MIR409 Gene

Previous HGNC Symbols for MIR409 Gene

  • MIRN409

Previous GeneCards Identifiers for MIR409 Gene

  • GC14P100840
  • GC14P100930
  • GC14P101531
  • GC14P101273
  • GC14P101889
  • GC14P102205
  • GC14P102373
  • GC14P102552
  • GC14P102725

Summaries for MIR409 Gene

Entrez Gene Summary for MIR409 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR409 Gene

MIR409 (MicroRNA 409) is an RNA Gene, and is affiliated with the miRNA class. Among its related pathways are Parkinsons Disease Pathway.

Additional gene information for MIR409 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR409 Gene

Genomics for MIR409 Gene

Regulatory Elements for MIR409 Gene

Enhancers for MIR409 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH14H101096 0.8 FANTOM5 ENCODE 11.4 +33.0 33048 3 POLR2A JUN MAFK RTL1 LOC105370670 MEG9 MIR369 MIR409 MIR410 MIR412 MIR541 MIR656 MIR154
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MIR409 on UCSC Golden Path with GeneCards custom track

Genomic Location for MIR409 Gene

Chromosome:
14
Start:
101,065,300 bp from pter
End:
101,065,378 bp from pter
Size:
79 bases
Orientation:
Plus strand

Genomic View for MIR409 Gene

Genes around MIR409 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR409 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR409 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR409 Gene

Proteins for MIR409 Gene

Post-translational modifications for MIR409 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR409 Gene

Domains & Families for MIR409 Gene

Gene Families for MIR409 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR409: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR409 Gene

Function for MIR409 Gene

Gene Ontology (GO) - Molecular Function for MIR409 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:1903231 mRNA binding involved in posttranscriptional gene silencing IDA 20570858
genes like me logo Genes that share ontologies with MIR409: view

Animal Model Products

CRISPR Products

miRNA Products

Clone Products

  • Applied Biological Materials Clones for MIR409
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR409 Gene

Localization for MIR409 Gene

Gene Ontology (GO) - Cellular Components for MIR409 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IDA 26646931
genes like me logo Genes that share ontologies with MIR409: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for MIR409 Gene

Pathways & Interactions for MIR409 Gene

SuperPathways for MIR409 Gene

SuperPathway Contained pathways
1 Parkinsons Disease Pathway
genes like me logo Genes that share pathways with MIR409: view

Pathways by source for MIR409 Gene

1 BioSystems pathway for MIR409 Gene

Interacting Proteins for MIR409 Gene

Gene Ontology (GO) - Biological Process for MIR409 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0035195 gene silencing by miRNA IDA 20570858
GO:0061754 negative regulation of circulating fibrinogen levels IDA 20570858
genes like me logo Genes that share ontologies with MIR409: view

No data available for SIGNOR curated interactions for MIR409 Gene

Drugs & Compounds for MIR409 Gene

No Compound Related Data Available

Transcripts for MIR409 Gene

mRNA/cDNA for MIR409 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

CRISPR Products

miRNA Products

Clone Products

  • Applied Biological Materials Clones for MIR409
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for MIR409 Gene

No ASD Table

Relevant External Links for MIR409 Gene

GeneLoc Exon Structure for
MIR409
ECgene alternative splicing isoforms for
MIR409

Expression for MIR409 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MIR409 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR409 Gene:

MIR409
genes like me logo Genes that share expression patterns with MIR409: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR409 Gene

Orthologs for MIR409 Gene

This gene was present in the common ancestor of mammals.

Orthologs for MIR409 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-409 34
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia bta-mir-409b 34
  • 76 (a)
OneToOne
dog
(Canis familiaris)
Mammalia cfa-mir-409 34
  • 76 (a)
OneToOne
Species where no ortholog for MIR409 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MIR409 Gene

ENSEMBL:
Gene Tree for MIR409 (if available)
TreeFam:
Gene Tree for MIR409 (if available)

Paralogs for MIR409 Gene

No data available for Paralogs for MIR409 Gene

Variants for MIR409 Gene

Sequence variations from dbSNP and Humsavar for MIR409 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
rs1001834602 -- 101,063,859(+) GGCCC(A/G)AGATA upstream-variant-2KB
rs1003049499 -- 101,065,113(+) TTCTG(G/T)GAAGA upstream-variant-2KB
rs1003932318 -- 101,064,797(+) ATGGT(C/T)AGCCA downstream-variant-500B, upstream-variant-2KB
rs1004485962 -- 101,063,577(+) TTTAG(A/G)GAGAC upstream-variant-2KB
rs1004625205 -- 101,063,811(+) GTTTA(C/T)CCTGA upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MIR409 Gene

Variant ID Type Subtype PubMed ID
esv3635521 CNV gain 21293372
nsv1040993 CNV gain 25217958
nsv509551 CNV insertion 20534489
nsv565859 CNV gain 21841781
nsv565860 CNV gain 21841781

Relevant External Links for MIR409 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR409

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR409 Gene

Disorders for MIR409 Gene

Relevant External Links for MIR409

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR409

No disorders were found for MIR409 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR409 Gene

Publications for MIR409 Gene

  1. MicroRNA-409-5p is upregulated in breast cancer and its downregulation inhibits cancer development through downstream target of RSU1. (PMID: 28459205) Yu H … Huang Y (Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 2017) 3 60
  2. miR-409-3p sensitizes colon cancer cells to oxaliplatin by inhibiting Beclin-1-mediated autophagy. (PMID: 26935807) Tan S … Zhang X (International journal of molecular medicine 2016) 3 60
  3. Association of MicroRNAs and YRNAs With Platelet Function. (PMID: 26646931) Kaudewitz D … Mayr M (Circulation research 2016) 3 60
  4. MicroRNA-409-3p regulates cell invasion and metastasis by targeting ZEB1 in breast cancer. (PMID: 27079864) Ma Z … Tian X (IUBMB life 2016) 3 60
  5. MicroRNA-409-3p inhibits osteosarcoma cell migration and invasion by targeting catenin-δ1. (PMID: 26992637) Wu S … Zhang T (Gene 2016) 3 60

Products for MIR409 Gene

Sources for MIR409 Gene

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