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Aliases for MIR3974 Gene

Subcategory (RNA class) for MIR3974 Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR3974 Gene

  • MicroRNA 3974 2 3 5
  • Hsa-Mir-3974 3

External Ids for MIR3974 Gene

Previous GeneCards Identifiers for MIR3974 Gene

  • GC12U901597
  • GC12P017828

Summaries for MIR3974 Gene

Entrez Gene Summary for MIR3974 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR3974 Gene

MIR3974 (MicroRNA 3974) is an RNA Gene, and is affiliated with the miRNA class.

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR3974 Gene

Genomics for MIR3974 Gene

Regulatory Elements for MIR3974 Gene

Enhancers for MIR3974 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH12G017671 1.6 VISTA 0.7 -0.6 -638 1.5 ATF2 MIR3974 LINC02378
GH12G017695 1.6 VISTA 0.3 +22.5 22497 1.2 SMARCA4 GC12P017706 MIR3974
GH12G017641 0.6 Ensembl 0.3 -31.3 -31298 0.4 CTCF ZNF654 TRIM22 ZNF143 SMC3 RAD21 MIR3974 LINC02378
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MIR3974 on UCSC Golden Path with GeneCards custom track

Genomic Location for MIR3974 Gene

Chromosome:
12
Start:
17,673,299 bp from pter
End:
17,673,394 bp from pter
Size:
96 bases
Orientation:
Plus strand

Genomic View for MIR3974 Gene

Genes around MIR3974 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR3974 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR3974 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR3974 Gene

Proteins for MIR3974 Gene

Post-translational modifications for MIR3974 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR3974 Gene

Domains & Families for MIR3974 Gene

Gene Families for MIR3974 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR3974: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR3974 Gene

Function for MIR3974 Gene

Animal Model Products

miRNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR3974 Gene

Localization for MIR3974 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR3974 Gene

Pathways & Interactions for MIR3974 Gene

SuperPathways for MIR3974 Gene

No Data Available

Interacting Proteins for MIR3974 Gene

Gene Ontology (GO) - Biological Process for MIR3974 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for MIR3974 Gene

Drugs & Compounds for MIR3974 Gene

No Compound Related Data Available

Transcripts for MIR3974 Gene

mRNA/cDNA for MIR3974 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

miRNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR3974 Gene

No ASD Table

Relevant External Links for MIR3974 Gene

GeneLoc Exon Structure for
MIR3974
ECgene alternative splicing isoforms for
MIR3974

Expression for MIR3974 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR3974 Gene:

MIR3974
No Expression Related Data Available

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR3974 Gene

Orthologs for MIR3974 Gene

Evolution for MIR3974 Gene

ENSEMBL:
Gene Tree for MIR3974 (if available)
TreeFam:
Gene Tree for MIR3974 (if available)

No data available for Orthologs for MIR3974 Gene

Paralogs for MIR3974 Gene

No data available for Paralogs for MIR3974 Gene

Variants for MIR3974 Gene

Sequence variations from dbSNP and Humsavar for MIR3974 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs1001806907 -- 17,672,354(+) ACACA(G/T)AGCCT upstream-variant-2KB
rs1002090029 -- 17,673,525(+) ACTCC(C/T)TGTTT downstream-variant-500B
rs1004553732 -- 17,673,144(+) TTTTT(C/T)TGGAA upstream-variant-2KB
rs1005663179 -- 17,671,660(+) AATAG(C/T)GATGC upstream-variant-2KB
rs1006669597 -- 17,673,186(+) TGATG(A/G)AAGTA upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MIR3974 Gene

Variant ID Type Subtype PubMed ID
esv3892152 CNV gain 25118596
nsv470272 CNV loss 18288195
nsv832342 CNV loss 17160897

Relevant External Links for MIR3974 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR3974

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR3974 Gene

Disorders for MIR3974 Gene

Relevant External Links for MIR3974

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR3974

No disorders were found for MIR3974 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR3974 Gene

Publications for MIR3974 Gene

  1. Complete characterization of the microRNAome in a patient with acute myeloid leukemia. (PMID: 20876853) Ramsingh G. … Link D.C. (Blood 2010) 3 64
  2. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S. … Enright A.J. (Nucleic Acids Res. 2006) 3 64

Products for MIR3974 Gene

Sources for MIR3974 Gene

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