Subcategory (RNA class) for MIR3940 Gene
Quality Score for this RNA gene is
Aliases for MIR3940 Gene
External Ids for MIR3940 Gene
Previous GeneCards Identifiers for MIR3940 Gene
microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
GeneCards Summary for MIR3940 Gene
MIR3940 (MicroRNA 3940) is an RNA Gene, and is affiliated with the miRNA class. Among its related pathways are Metabolism of proteins and Regulation of activated PAK-2p34 by proteasome mediated degradation. An important paralog of this gene is FUBP1.
UniProtKB/Swiss-Prot for MIR3940 Gene
Binds to the dendritic targeting element and may play a role in mRNA trafficking (By similarity). Part of a ternary complex that binds to the downstream control sequence (DCS) of the pre-mRNA. Mediates exon inclusion in transcripts that are subject to tissue-specific alternative splicing. May interact with single-stranded DNA from the far-upstream element (FUSE). May activate gene expression. Also involved in degradation of inherently unstable mRNAs that contain AU-rich elements (AREs) in their 3-UTR, possibly by recruiting degradation machinery to ARE-containing mRNAs.