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Aliases for MIR3917 Gene

Subcategory (RNA class) for MIR3917 Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR3917 Gene

  • MicroRNA 3917 2 3
  • STMN1 4 5
  • Leukemia-Associated Phosphoprotein P18 4
  • Phosphoprotein P19 4
  • Oncoprotein 18 4
  • Hsa-Mir-3917 3
  • Protein Pr22 4
  • Metablastin 4
  • Stathmin 1 5
  • Mir-3917 3
  • C1orf215 4
  • Prosolin 4
  • LAP18 4
  • OP18 4
  • Pp17 4
  • Pp19 4

External Ids for MIR3917 Gene

Previous GeneCards Identifiers for MIR3917 Gene

  • GC01U903123
  • GC01M026237
  • GC01M026243
  • GC01M026246
  • GC01M025906

Summaries for MIR3917 Gene

Entrez Gene Summary for MIR3917 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR3917 Gene

MIR3917 (MicroRNA 3917) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR3917 include Acute Leukemia. An important paralog of this gene is STMN2.

UniProtKB/Swiss-Prot for MIR3917 Gene

  • Involved in the regulation of the microtubule (MT) filament system by destabilizing microtubules. Prevents assembly and promotes disassembly of microtubules. Phosphorylation at Ser-16 may be required for axon formation during neurogenesis. Involved in the control of the learned and innate fear (By similarity).

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR3917 Gene

Genomics for MIR3917 Gene

Regulatory Elements for MIR3917 Gene

Enhancers for MIR3917 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around MIR3917 on UCSC Golden Path with GeneCards custom track

Promoters for MIR3917 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around MIR3917 on UCSC Golden Path with GeneCards custom track

Genomic Location for MIR3917 Gene

Chromosome:
1
Start:
25,884,181 bp from pter
End:
25,906,991 bp from pter
Size:
22,811 bases
Orientation:
Minus strand

Genomic View for MIR3917 Gene

Genes around MIR3917 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR3917 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR3917 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR3917 Gene

Proteins for MIR3917 Gene

  • Protein details for MIR3917 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P16949-STMN1_HUMAN
    Recommended name:
    Stathmin
    Protein Accession:
    P16949
    Secondary Accessions:
    • A2A2D1
    • B2R4E7
    • B7Z8N4
    • D3DPJ5

    Protein attributes for MIR3917 Gene

    Size:
    149 amino acids
    Molecular mass:
    17303 Da
    Quaternary structure:
    • Binds to two alpha/beta-tubulin heterodimers. Interacts with KIST.
    • Binds to two alpha/beta-tubulin heterodimers. Interacts with KIST.

    Alternative splice isoforms for MIR3917 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MIR3917 Gene

Post-translational modifications for MIR3917 Gene

  • Many different phosphorylated forms are observed depending on specific combinations among the sites which can be phosphorylated. MAPK is responsible for the phosphorylation of stathmin in response to NGF. Phosphorylation at Ser-16 seems to be required for neuron polarization (By similarity). Phosphorylation at Ser-63 reduces tubulin binding 10-fold and suppresses the MT polymerization inhibition activity.
  • Ubiquitination at Lys 9, Lys 85, Lys 137, and Lys 140
  • Modification sites at PhosphoSitePlus

Other Protein References for MIR3917 Gene

No data available for DME Specific Peptides for MIR3917 Gene

Domains & Families for MIR3917 Gene

Gene Families for MIR3917 Gene

Protein Domains for MIR3917 Gene

InterPro:
Blocks:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

P16949

UniProtKB/Swiss-Prot:

STMN1_HUMAN :
  • Contains 1 SLD (stathmin-like) domain.
  • Belongs to the stathmin family.
Domain:
  • Contains 1 SLD (stathmin-like) domain.
Family:
  • Belongs to the stathmin family.
genes like me logo Genes that share domains with MIR3917: view

No data available for Suggested Antigen Peptide Sequences for MIR3917 Gene

Function for MIR3917 Gene

Molecular function for MIR3917 Gene

UniProtKB/Swiss-Prot Function:
Involved in the regulation of the microtubule (MT) filament system by destabilizing microtubules. Prevents assembly and promotes disassembly of microtubules. Phosphorylation at Ser-16 may be required for axon formation during neurogenesis. Involved in the control of the learned and innate fear (By similarity).
UniProtKB/Swiss-Prot Induction:
Down-regulated in response to enterovirus 71 (EV71) infection (at protein level).

Gene Ontology (GO) - Molecular Function for MIR3917 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004871 signal transducer activity TAS --
GO:0005515 protein binding IPI --
GO:0015631 tubulin binding IDA --
genes like me logo Genes that share ontologies with MIR3917: view

Animal Model Products

miRNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR3917 Gene

Localization for MIR3917 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MIR3917 Gene

Cytoplasm, cytoskeleton.

Gene Ontology (GO) - Cellular Components for MIR3917 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IDA --
GO:0005737 cytoplasm IBA --
GO:0005829 cytosol IEA --
GO:0005874 microtubule IEA --
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with MIR3917: view

No data available for Subcellular locations from COMPARTMENTS for MIR3917 Gene

Pathways & Interactions for MIR3917 Gene

SuperPathways for MIR3917 Gene

No Data Available

Gene Ontology (GO) - Biological Process for MIR3917 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007019 microtubule depolymerization IDA --
GO:0007052 mitotic spindle organization IDA --
GO:0007165 signal transduction NAS --
GO:0007409 axonogenesis IEA --
GO:0007420 brain development IEA --
genes like me logo Genes that share ontologies with MIR3917: view

No data available for Pathways by source and SIGNOR curated interactions for MIR3917 Gene

Drugs & Compounds for MIR3917 Gene

No Compound Related Data Available

Transcripts for MIR3917 Gene

mRNA/cDNA for MIR3917 Gene

(10) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR3917 Gene

No ASD Table

Relevant External Links for MIR3917 Gene

GeneLoc Exon Structure for
MIR3917
ECgene alternative splicing isoforms for
MIR3917

Expression for MIR3917 Gene

mRNA expression in normal human tissues for MIR3917 Gene

mRNA differential expression in normal tissues according to GTEx for MIR3917 Gene

This gene is overexpressed in Brain - Spinal cord (cervical c-1) (x5.8), Brain - Frontal Cortex (BA9) (x5.3), Brain - Anterior cingulate cortex (BA24) (x5.0), and Brain - Cortex (x4.4).

NURSA nuclear receptor signaling pathways regulating expression of MIR3917 Gene:

MIR3917

mRNA Expression by UniProt/SwissProt for MIR3917 Gene:

P16949-STMN1_HUMAN
Tissue specificity: Ubiquitous. Expression is strongest in fetal and adult brain, spinal cord, and cerebellum, followed by thymus, bone marrow, testis, and fetal liver. Expression is intermediate in colon, ovary, placenta, uterus, and trachea, and is readily detected at substantially lower levels in all other tissues examined. Lowest expression is found in adult liver. Present in much greater abundance in cells from patients with acute leukemia of different subtypes than in normal peripheral blood lymphocytes, non-leukemic proliferating lymphoid cells, bone marrow cells, or cells from patients with chronic lymphoid or myeloid leukemia.
genes like me logo Genes that share expression patterns with MIR3917: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for MIR3917 Gene

Orthologs for MIR3917 Gene

This gene was present in the common ancestor of animals.

Orthologs for MIR3917 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia -- 35
  • 79 (a)
OneToMany
STMN1 35
  • 87 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia STMN1 35
  • 85 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia STMN1 35
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia STMN1 35
  • 87 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia STMN1 35
  • 83 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Stmn1 35
  • 86 (a)
OneToOne
chicken
(Gallus gallus)
Aves STMN1 35
  • 86 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia STMN1 35
  • 82 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii stmn1a 35
  • 68 (a)
OneToMany
stmn1b 35
  • 68 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta stai 35
  • 13 (a)
OneToMany
Species where no ortholog for MIR3917 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MIR3917 Gene

ENSEMBL:
Gene Tree for MIR3917 (if available)
TreeFam:
Gene Tree for MIR3917 (if available)

Paralogs for MIR3917 Gene

Paralogs for MIR3917 Gene

Pseudogenes.org Pseudogenes for MIR3917 Gene

genes like me logo Genes that share paralogs with MIR3917: view

Variants for MIR3917 Gene

Structural Variations from Database of Genomic Variants (DGV) for MIR3917 Gene

Variant ID Type Subtype PubMed ID
nsv834491 CNV loss 17160897
nsv834502 CNV gain 17160897

Relevant External Links for MIR3917 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR3917

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations from dbSNP and Humsavar and Variation tolerance for MIR3917 Gene

Disorders for MIR3917 Gene

MalaCards: The human disease database

(1) MalaCards diseases for MIR3917 Gene - From: GeneCards

Disorder Aliases PubMed IDs
acute leukemia
  • stem cell leukaemia
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for MIR3917

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR3917
genes like me logo Genes that share disorders with MIR3917: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MIR3917 Gene

Publications for MIR3917 Gene

  1. N-terminome analysis of the human mitochondrial proteome. (PMID: 25944712) Vaca Jacome A.S. … Carapito C. (Proteomics 2015) 4 65
  2. An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. (PMID: 24275569) Bian Y. … Zou H. (J. Proteomics 2014) 4 65
  3. Toward a comprehensive characterization of a human cancer cell phosphoproteome. (PMID: 23186163) Zhou H. … Mohammed S. (J. Proteome Res. 2013) 4 65
  4. Comparative large scale characterization of plant versus mammal proteins reveals similar and idiosyncratic N-I+-acetylation features. (PMID: 22223895) Bienvenut W.V. … Giglione C. (Mol. Cell Proteomics 2012) 4 65
  5. N-terminal acetylome analyses and functional insights of the N- terminal acetyltransferase NatB. (PMID: 22814378) Van Damme P. … Aldabe R. (Proc. Natl. Acad. Sci. U.S.A. 2012) 4 65

Products for MIR3917 Gene

Sources for MIR3917 Gene

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