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Aliases for MIR383 Gene

Subcategory (RNA class) for MIR383 Gene

miRNA

Quality Score for this RNA gene is

8

Aliases for MIR383 Gene

  • MicroRNA 383 2 3 5
  • Hsa-Mir-383 3
  • Mir-383 3
  • MIRN383 3

External Ids for MIR383 Gene

Previous HGNC Symbols for MIR383 Gene

  • MIRN383

Previous GeneCards Identifiers for MIR383 Gene

  • GC08M014757
  • GC08M014710

Summaries for MIR383 Gene

Entrez Gene Summary for MIR383 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR383 Gene

MIR383 (MicroRNA 383) is an RNA Gene, and is affiliated with the miRNA class.

fRNAdb sequence ontologies for MIR383 Gene

  • pre_miRNA: The 60-70 nucleotide region remain after Drosha processing of the primary transcript, that folds back upon itself to form a hairpin sructure.

View fRNAdb secondary structures for MIR383

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR383 Gene

Genomics for MIR383 Gene

Genomic Location for MIR383 Gene

Chromosome:
8
Start:
14,853,438 bp from pter
End:
14,853,510 bp from pter
Size:
73 bases
Orientation:
Minus strand

Genomic View for MIR383 Gene

Genes around MIR383 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR383 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR383 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR383 Gene

ORGUL Member Location for MIR383 Gene

ORGUL Member Location for MIR383 gene

No data available for Regulatory Elements for MIR383 Gene

Proteins for MIR383 Gene

Post-translational modifications for MIR383 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR383 Gene

Domains & Families for MIR383 Gene

Gene Families for MIR383 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR383: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR383 Gene

Function for MIR383 Gene

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR383 Gene

Localization for MIR383 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR383 Gene

Pathways & Interactions for MIR383 Gene

SuperPathways for MIR383 Gene

No Data Available

Interacting Proteins for MIR383 Gene

Gene Ontology (GO) - Biological Process for MIR383 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for MIR383 Gene

Drugs & Compounds for MIR383 Gene

No Compound Related Data Available

Transcripts for MIR383 Gene

fRNAdb Secondary structures for MIR383 Gene

  • hsa-miR-383-5p_MIMAT0000738_Homo_sapiens_miR-383-5p_mature

mRNA/cDNA for MIR383 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR383 Gene

No ASD Table

Relevant External Links for MIR383 Gene

GeneLoc Exon Structure for
MIR383
ECgene alternative splicing isoforms for
MIR383

Expression for MIR383 Gene

No Expression Related Data Available

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for MIR383 Gene

Orthologs for MIR383 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIR383 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia bta-mir-383 36
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia cfa-mir-383 36
  • 100 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia mdo-mir-383 36
  • 89 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mir383 36
  • 96 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia oan-mir-383 36
  • 57 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-383 36
  • 100 (a)
OneToOne
chicken
(Gallus gallus)
Aves gga-mir-383 36
  • 95 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia aca-mir-383 36
  • 60 (a)
OneToOne
Species with no ortholog for MIR383:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MIR383 Gene

ENSEMBL:
Gene Tree for MIR383 (if available)
TreeFam:
Gene Tree for MIR383 (if available)

Paralogs for MIR383 Gene

No data available for Paralogs for MIR383 Gene

Variants for MIR383 Gene

Structural Variations from Database of Genomic Variants (DGV) for MIR383 Gene

Variant ID Type Subtype PubMed ID
nsv890441 CNV Loss 21882294
dgv2222e1 CNV Complex 17122850
nsv8298 CNV Gain+Loss 18304495
nsv818605 CNV Loss 17921354
dgv248e55 CNV Loss 17911159
nsv438041 CNV Loss 16468122
nsv890444 CNV Loss 21882294
nsv469745 CNV Loss 16826518
nsv437049 CNV Loss 16327808
nsv465541 CNV Gain 19166990
nsv890445 CNV Gain 21882294
nsv890446 CNV Gain 21882294

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations from dbSNP and Humsavar , Variation tolerance and Relevant External Links for MIR383 Gene

Disorders for MIR383 Gene

Relevant External Links for MIR383

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR383

No disorders were found for MIR383 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR383 Gene

Publications for MIR383 Gene

  1. MicroRNA-383 expression regulates proliferation, migration, invasion, and apoptosis in human glioma cells. (PMID: 25936342) Xu D. … Jin B. (Tumour Biol. 2015) 3 67
  2. A pancreatic islet-specific microRNA regulates insulin secretion. (PMID: 15538371) Poy M.N. … Stoffel M. (Nature 2004) 1 3
  3. microRNA-383 impairs phosphorylation of H2AX by targeting PNUTS and inducing cell cycle arrest in testicular embryonal carcinoma cells. (PMID: 24462707) Huang H. … Sun F. (Cell. Signal. 2014) 3
  4. MicroRNA-383 regulates the apoptosis of tumor cells through targeting Gadd45g. (PMID: 25415264) Zhao L. … Qian B. (PLoS ONE 2014) 3
  5. MicroRNA-383 inhibits anchorage-independent growth and induces cell cycle arrest of glioma cells by targeting CCND1. (PMID: 25450356) Xu Z. … Chen Q. (Biochem. Biophys. Res. Commun. 2014) 3

Products for MIR383 Gene

Sources for MIR383 Gene

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