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Aliases for MIR381 Gene

Subcategory (RNA class) for MIR381 Gene

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Quality Score for this RNA gene is

3

Aliases for MIR381 Gene

  • MicroRNA 381 2 3
  • Hsa-Mir-381 3
  • MIRN381 3

External Ids for MIR381 Gene

ORGUL Members for MIR381 Gene

Previous HGNC Symbols for MIR381 Gene

  • MIRN381

Previous GeneCards Identifiers for MIR381 Gene

  • GC14P100824
  • GC14P100914
  • GC14P101515
  • GC14P101544
  • GC14P101577
  • GC14P101618
  • GC14P101646
  • GC14P101679
  • GC14P101717
  • GC14P101759
  • GC14P101817
  • GC14P101957
  • GC14P102153

Summaries for MIR381 Gene

Entrez Gene Summary for MIR381 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR381 Gene

MIR381 (MicroRNA 381) is an RNA Gene, and is affiliated with the undefined RNA class.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR381 Gene

Genomics for MIR381 Gene

Genomic Location for MIR381 Gene

Start:
101,045,898 bp from pter
End:
101,046,005 bp from pter
Size:
108 bases
Orientation:
Plus strand

Genomic View for MIR381 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MIR381 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR381 Gene

No data available for Regulatory Elements for MIR381 Gene

Proteins for MIR381 Gene

Post-translational modifications for MIR381 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR381 Gene

Domains for MIR381 Gene

Gene Families for MIR381 Gene

HGNC:
  • MIR :ncRNAs / Micro RNAs

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR381: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR381 Gene

Function for MIR381 Gene

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for MIR381 Gene

Localization for MIR381 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR381 Gene

Pathways for MIR381 Gene

SuperPathways for MIR381 Gene

No Data Available

Interacting Proteins for MIR381 Gene

Gene Ontology (GO) - Biological Process for MIR381 Gene

None

No data available for Pathways by source for MIR381 Gene

Transcripts for MIR381 Gene

mRNA/cDNA for MIR381 Gene

(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR381 Gene

No ASD Table

Relevant External Links for MIR381 Gene

GeneLoc Exon Structure for
MIR381
ECgene alternative splicing isoforms for
MIR381

Expression for MIR381 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

genes like me logo Genes that share expressions with MIR381: view

In Situ Assay Products

No data available for mRNA expression in normal human tissues , mRNA differential expression in normal tissues , Protein expression and mRNA Expression by UniProt/SwissProt for MIR381 Gene

Orthologs for MIR381 Gene

This gene was present in the common ancestor of mammals.

Orthologs for MIR381 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-381 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia bta-mir-381 36
  • 92 (a)
OneToOne
dog
(Canis familiaris)
Mammalia cfa-mir-381 36
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia mmu-mir-381 36
  • 83 (a)
OneToOne
Species with no ortholog for MIR381:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MIR381 Gene

ENSEMBL:
Gene Tree for MIR381 (if available)
TreeFam:
Gene Tree for MIR381 (if available)

Paralogs for MIR381 Gene

No data available for Paralogs for MIR381 Gene

Variants for MIR381 Gene

Relevant External Links for MIR381 Gene

HapMap Linkage Disequilibrium report
MIR381

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations from dbSNP and Humsavar and Structural Variations from Database of Genomic Variants (DGV) for MIR381 Gene

Disorders for MIR381 Gene

Relevant External Links for MIR381

Genetic Association Database (GAD)
MIR381
Human Genome Epidemiology (HuGE) Navigator
MIR381
genes like me logo Genes that share disorders with MIR381: view

No data available for UniProtKB/Swiss-Prot for MIR381 Gene

Publications for MIR381 Gene

  1. Novel genetic variants in miR-191 gene and familial ovarian cancer. (PMID: 20167074) Shen J. … Zhao H. (BMC Cancer 2010) 3 48
  2. Genetic polymorphisms in the precursor MicroRNA flanking region and non-small cell lung cancer survival. (PMID: 20889907) Hu Z. … Shen H. (Am. J. Respir. Crit. Care Med. 2011) 3
  3. Interaction of hsa-miR-381 and glioma suppressor LRRC4 is involved in glioma growth. (PMID: 21435336) Tang H. … Li G. (Brain Res. 2011) 3
  4. Deep-sequencing of endothelial cells exposed to hypoxia reveals the complexity of known and novel microRNAs. (PMID: 22282338) Voellenkle C. … Martelli F. (RNA 2012) 3
  5. MicroRNA-381 represses ID1 and is deregulated in lung adenocarcinoma. (PMID: 22592211) Rothschild S.I. … Gautschi O. (J Thorac Oncol 2012) 3

Products for MIR381 Gene

Sources for MIR381 Gene

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