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Aliases for MIR381 Gene

Subcategory (RNA class) for MIR381 Gene

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Quality Score for this RNA gene is

3

Aliases for MIR381 Gene

  • MicroRNA 381 2 3 5
  • Hsa-Mir-381 3
  • Mir-381 3
  • MIRN381 3

External Ids for MIR381 Gene

ORGUL Members for MIR381 Gene

Previous HGNC Symbols for MIR381 Gene

  • MIRN381

Previous GeneCards Identifiers for MIR381 Gene

  • GC14P100824
  • GC14P100914
  • GC14P101515
  • GC14P101544
  • GC14P101577
  • GC14P101618
  • GC14P101646
  • GC14P101679
  • GC14P101717
  • GC14P101759
  • GC14P101817
  • GC14P101957
  • GC14P102153
  • GC14P101256
  • GC14P101866

Summaries for MIR381 Gene

Entrez Gene Summary for MIR381 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR381 Gene

MIR381 (MicroRNA 381) is an RNA Gene, and is affiliated with the undefined RNA class.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR381 Gene

Genomics for MIR381 Gene

Genomic Location for MIR381 Gene

Chromosome:
14
Start:
101,045,898 bp from pter
End:
101,046,005 bp from pter
Size:
108 bases
Orientation:
Plus strand

Genomic View for MIR381 Gene

Genes around MIR381 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR381 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR381 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR381 Gene

No data available for Regulatory Elements for MIR381 Gene

Proteins for MIR381 Gene

Post-translational modifications for MIR381 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR381 Gene

Domains & Families for MIR381 Gene

Gene Families for MIR381 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR381: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR381 Gene

Function for MIR381 Gene

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR381 Gene

Localization for MIR381 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR381 Gene

Pathways & Interactions for MIR381 Gene

SuperPathways for MIR381 Gene

No Data Available

Interacting Proteins for MIR381 Gene

Gene Ontology (GO) - Biological Process for MIR381 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for MIR381 Gene

Drugs & Compounds for MIR381 Gene

No Compound Related Data Available

Transcripts for MIR381 Gene

mRNA/cDNA for MIR381 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR381 Gene

No ASD Table

Relevant External Links for MIR381 Gene

GeneLoc Exon Structure for
MIR381
ECgene alternative splicing isoforms for
MIR381

Expression for MIR381 Gene

No Expression Related Data Available

In Situ Assay Products

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for MIR381 Gene

Orthologs for MIR381 Gene

This gene was present in the common ancestor of mammals.

Orthologs for MIR381 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia bta-mir-381 36
  • 92 (a)
OneToOne
dog
(Canis familiaris)
Mammalia cfa-mir-381 36
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia mmu-mir-381 36
  • 83 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-381 36
  • 100 (a)
OneToOne
Species with no ortholog for MIR381:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MIR381 Gene

ENSEMBL:
Gene Tree for MIR381 (if available)
TreeFam:
Gene Tree for MIR381 (if available)

Paralogs for MIR381 Gene

No data available for Paralogs for MIR381 Gene

Variants for MIR381 Gene

Relevant External Links for MIR381 Gene

HapMap Linkage Disequilibrium report
MIR381

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations from dbSNP and Humsavar , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for MIR381 Gene

Disorders for MIR381 Gene

Relevant External Links for MIR381

Genetic Association Database (GAD)
MIR381
Human Genome Epidemiology (HuGE) Navigator
MIR381
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR381

No disorders were found for MIR381 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR381 Gene

Publications for MIR381 Gene

  1. Novel genetic variants in miR-191 gene and familial ovarian cancer. (PMID: 20167074) Shen J. … Zhao H. (BMC Cancer 2010) 3 48 67
  2. MicroRNAs, miR-154, miR-299-5p, miR-376a, miR-376c, miR-377, miR-381, miR-487b, miR-485-3p, miR-495 and miR-654-3p, mapped to the 14q32.31 locus, regulate proliferation, apoptosis, migration and invasion in metastatic prostate cancer cells. (PMID: 24166498) Formosa A. … Candi E. (Oncogene 2014) 3
  3. Disturbing miR-182 and -381 inhibits BRD7 transcription and glioma growth by directly targeting LRRC4. (PMID: 24404152) Tang H. … Li G. (PLoS ONE 2014) 3
  4. miR-381, a novel intrinsic WEE1 inhibitor, sensitizes renal cancer cells to 5-FU by up-regulation of Cdc2 activities in 786-O. (PMID: 23816136) Chen B. … Jiang X. (J Chemother 2013) 3
  5. Changes in the expression of miR-381 and miR-495 are inversely associated with the expression of the MDR1 gene and development of multi-drug resistance. (PMID: 24303078) Xu Y. … Fan J.Y. (PLoS ONE 2013) 3

Products for MIR381 Gene

Sources for MIR381 Gene

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