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MIR379 Gene(RNA Gene)

MicroRNA 379

GCID:
GC14P103023
GIFtS:
14
Genes Participants
UDN Logo

Aliases for MIR379 Gene

Subcategory (RNA class) for MIR379 Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR379 Gene

  • MicroRNA 379 2 3 5
  • Hsa-Mir-379 3
  • Mir-379 3
  • MIRN379 3

External Ids for MIR379 Gene

ORGUL Members for MIR379 Gene

Previous HGNC Symbols for MIR379 Gene

  • MIRN379

Previous GeneCards Identifiers for MIR379 Gene

  • GC14P100811
  • GC14P100903
  • GC14P101488
  • GC14P101230
  • GC14P101801
  • GC14P102095
  • GC14P102329
  • GC14P102499
  • GC14P102676
  • GC14P102848

Summaries for MIR379 Gene

Entrez Gene Summary for MIR379 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR379 Gene

MIR379 (MicroRNA 379) is an RNA Gene, and is affiliated with the miRNA class.

Additional gene information for MIR379 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR379 Gene

Genomics for MIR379 Gene

Products:

  1. Regulatory Element

GeneHancer (GH) Regulatory Elements for MIR379 Gene

Promoters and enhancers for MIR379 Gene
GeneHancer (GH) Identifier GH Type GH
Score		 GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites		 Gene Targets
GH14I101020 Enhancer 0.5 ENCODE 550.8 -1.1 -1081 1 KLF1 ZNF488 KLF8 ZNF248 ZBTB1 MIR379 GC14P103195 MEG9 ENSG00000222185 MEG8
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around MIR379 on UCSC Golden Path with GeneCards custom track

Genomic Locations for MIR379 Gene

Genomic Locations for MIR379 Gene
chr14:101,022,066-101,022,132
(GRCh38/hg38)
Size:
67 bases
Orientation:
Plus strand
chr14:101,488,366-101,488,491
(GRCh37/hg19)

Genomic View for MIR379 Gene

Genes around MIR379 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR379 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR379 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for MIR379 Gene

Proteins for MIR379 Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

Post-translational modifications for MIR379 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR379 Gene

Domains & Families for MIR379 Gene

Gene Families for MIR379 Gene

HGNC:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR379: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR379 Gene

Function for MIR379 Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line

Phenotypes From GWAS Catalog for MIR379 Gene

Animal Model Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR379 Gene

Localization for MIR379 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR379 Gene

Pathways & Interactions for MIR379 Gene

SuperPathways for MIR379 Gene

PathCards logo More details on SuperPathways for MIR379
No Data Available

Interacting Proteins for MIR379 Gene

Gene Ontology (GO) - Biological Process for MIR379 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for MIR379 Gene

Drugs & Compounds for MIR379 Gene

Products:

  1. Drug
No Compound Related Data Available

Transcripts for MIR379 Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone

mRNA/cDNA for MIR379 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR379 Gene

No ASD Table

Relevant External Links for MIR379 Gene

GeneLoc Exon Structure for
MIR379
ECgene alternative splicing isoforms for
MIR379

Expression for MIR379 Gene

Products:

  1. Primer

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MIR379 Gene

mRNA expression in normal human tissues for MIR379 Gene
mRNA expression by GTEx for MIR379 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR379 Gene:

MIR379
genes like me logo Genes that share expression patterns with MIR379: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR379 Gene

Orthologs for MIR379 Gene

Evolution for MIR379 Gene

ENSEMBL:
Gene Tree for MIR379 (if available)
TreeFam:
Gene Tree for MIR379 (if available)

No data available for Orthologs for MIR379 Gene

Paralogs for MIR379 Gene

No data available for Paralogs for MIR379 Gene

Variants for MIR379 Gene

Sequence variations from dbSNP and Humsavar for MIR379 Gene

SNP ID Clin Chr 14 pos Variation AA Info Type
rs1001056043 -- 101,022,619(+) C/G downstream_transcript_variant
rs1001734264 -- 101,020,376(+) C/G upstream_transcript_variant
rs1003412680 -- 101,021,384(+) C/T upstream_transcript_variant
rs1003500241 -- 101,021,122(+) G/A/C upstream_transcript_variant
rs1003855846 -- 101,021,267(+) G/A upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for MIR379 Gene

Variant ID Type Subtype PubMed ID
esv3635521 CNV gain 21293372
nsv1040993 CNV gain 25217958
nsv1426 CNV insertion 18451855
nsv565859 CNV gain 21841781
nsv565860 CNV gain 21841781

Additional Variant Information for MIR379 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR379

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR379 Gene

Disorders for MIR379 Gene

Additional Disease Information for MIR379

ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for MIR379 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR379 Gene

Publications for MIR379 Gene

  1. Suppression of EIF4G2 by miR-379 potentiates the cisplatin chemosensitivity in nonsmall cell lung cancer cells. (PMID: 28117895) Hao GJ … Zhang BB (FEBS letters 2017) 3 58
  2. MicroRNA-379 suppresses osteosarcoma progression by targeting PDK1. (PMID: 27781416) Li Z … Wu WK (Journal of cellular and molecular medicine 2017) 3 58
  3. MicroRNA-379-5p inhibits tumor invasion and metastasis by targeting FAK/AKT signaling in hepatocellular carcinoma. (PMID: 26944318) Chen JS … Huang XH (Cancer letters 2016) 3 58
  4. microRNA-379 couples glucocorticoid hormones to dysfunctional lipid homeostasis. (PMID: 25510864) de Guia RM … Herzig S (The EMBO journal 2015) 3 58
  5. miR-154* and miR-379 in the DLK1-DIO3 microRNA mega-cluster regulate epithelial to mesenchymal transition and bone metastasis of prostate cancer. (PMID: 25324143) Gururajan M … Chung LW (Clinical cancer research : an official journal of the American Association for Cancer Research 2014) 3 58

Products for MIR379 Gene

Sources for MIR379 Gene

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