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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

MIR379 Gene

RNA gene GIFtS: 19
GCID: GC14P101488

MicroRNA 379

(Previous symbol: MIRN379)

See related disease
at

MalaCards

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
About This Section

Subcategory (RNA class): miRNA

Quality score for this RNA gene is 3

Aliases
MicroRNA 379¹ ²
MIRN379¹ ²
hsa-mir-379²
mir-379⁹

External Ids:	HGNC: 31872¹	Entrez Gene: 494328²	Ensembl: ENSG00000199088⁷

Export aliases for MIR379 gene to outside databases

Previous GC identifers: GC14P100811 GC14P100903

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for MIR379 Gene:

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of

gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are

transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can

be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme

to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the

cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The

mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through

imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of

the target mRNA. The RefSeq represents the predicted microRNA stem-loop. (provided by RefSeq, Sep 2009)

GeneCards Summary for MIR379 Gene:

MIR379 (microRNA 379) is an RNA gene, and is affiliated with the miRNA class. Diseases associated with MIR379 include pancreatitis.

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

Regulatory elements:

Search SABiosciences Regulatory transcription factor binding sites for MIR379
Other transcription factors

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Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MIR379

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q32.31 Ensembl cytogenetic band: 14q32.31 HGNC cytogenetic band: 14q32.31

MIR379 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MIR379 gene location

GeneLoc information about chromosome 14 GeneLoc Exon Structure

GeneLoc location for GC14P101488: view genomic region (via miRBase) (about GC identifiers)

Start:	101,488,366 bp from pter	End:	101,488,491 bp from pter
Size:	126 bases	Orientation:	plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB: --

(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

HGNC Gene Families:

MIR: ncRNAs / Micro RNAs

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

Animal Models:

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(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for MIR379

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for MIR379

Search CenterWatch for drugs/clinical trials and news about MIR379

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

1 Ensembl transcript including schematic representation, and UCSC links where relevant:

ENST00000362218(miRNA)

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GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

Expression evidence for MIR379:none

MIR379 expression in normal human tissues (normalized intensities) MIR379 embryonic expression: see
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: --

About this image

MIR379 expression in embryonic tissues and stem cells About this table

Data from LifeMap, the Embryonic Development and Stem Cells Database

5/2 selected tissues (see all 2) fully expand


Umbilical Cord (Extraembryonic Tissues)
Umbilical cord blood-derived endothelial progenitor cells

Endothelium (Cardiovascular System)
Umbilical cord blood-derived endothelial progenitor cells

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In Situ
Assay Products:

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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

--

ENSEMBL Gene Tree for MIR379 (if available)
TreeFam Gene Tree for MIR379 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 14 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs61991130^1,2	C,F	--	101486453(+)	`CACCCC/AGTCCA`	1	--	us2k¹		1		NA	120
rs12895125^1,2	C,F,H	--	101486541(+)	`CCAGTC/ACACAC`	1	--	us2k¹		12		EA NS NA WA CSA	628
rs74183829^1,2	C	--	101486596(+)	`ACGTTA/GCATCC`	1	--	us2k¹		1		WA	2
rs61991154^1,2	C,F	--	101486924(+)	`TCCATC/GCAGTT`	1	--	us2k¹		2		NA	122
rs181688995^1,2		--	101486931(+)	`AGTTCA/TTGCCC`	1	--	us2k¹		0	--	--	--	--
rs7142412^1,2	C,F,H	--	101487001(+)	`ATACTC/GCATCC`	1	--	us2k¹		15		NS EA WA NA CSA	673
rs147736635^1,2	C	--	101487159(+)	`TTATCA/TTCTAA`	1	--	us2k¹		0	--	--	--	--
rs76333971^1,2	C,F	--	101487170(+)	`TCTAAA/GCTTCT`	1	--	us2k¹		1		EA	120
rs142354496^1,2		--	101487249(+)	`CCTCAC/TATTTT`	1	--	us2k¹		0	--	--	--	--
rs187333019^1,2		--	101487251(+)	`TCACAC/TTTTGA`	1	--	us2k¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for MIR379 (101488366 - 101488491 bp)

Structural Variations
Database of Genomic Variants (DGV) 1 variation for MIR379: About this table

Variant ID	Type	Subtype	PubMed ID
nsv1426	CNV	Insertion	18451855

SABiosciences Cancer Mutation PCR Assays

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

2 diseases for MIR379: About MalaCards

pancreatitis

MIR379 for disorders About GeneDecksing

Export disorders for MIR379 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for MIR379 gene integrated from 9 sources:
(articles sorted by number of sources associating them with MIR379)

Utopia: connect your pdf to the dynamic
world of online information

A mammalian microRNA expression atlas based on small RNA library sequencing. (PubMed id 17604727)¹ Landgraf P....Tuschl T. (2007)
miRBase: microRNA sequences, targets and gene nomencl ature. (PubMed id 16381832)¹ Griffiths-Jones S....Enright A.J. (2006)
Clustering and conservation patterns of human microRNAs. (PubMed id 15891114)¹ Altuvia Y....Margalit H. (2005)
Identification of clustered microRNAs using an ab ini tio prediction method. (PubMed id 16274478)¹ Sewer A....Zavolan M. (2005)
A pancreatic islet-specific microRNA regulates insulin secretion. (PubMed id 15538371)¹ Poy M.N....Stoffel M. (2004)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 494328	HGNC: 31872	Ensembl:ENSG00000199088	miRBase: hsa-mir-379	euGenes: HUgn494328
ECgene: MIR379	H-InvDB: MIR379

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for MIR379	Pharmacogenomics, SNPs, Pathways

Intellectual Property for MIR379 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for MIR379 gene:
Search GeneIP for patents involving MIR379

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
About This Section


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