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Aliases for MIR378I Gene

Subcategory (RNA class) for MIR378I Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR378I Gene

  • MicroRNA 378i 2 3
  • TNFRSF13C 4 5
  • Tumor Necrosis Factor Receptor Superfamily Member 13C 5
  • B-Cell-Activating Factor Receptor 4
  • BLyS Receptor 3 4
  • BAFF Receptor 4
  • CD268 Antigen 4
  • Hsa-Mir-378i 3
  • BAFF-R 4
  • BAFFR 4
  • BR3 4

External Ids for MIR378I Gene

Previous GeneCards Identifiers for MIR378I Gene

  • GC22U900799
  • GC22M042322
  • GC22M041926

Summaries for MIR378I Gene

Entrez Gene Summary for MIR378I Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR378I Gene

MIR378I (MicroRNA 378i) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR378I include Immunodeficiency, Common Variable, 4.

UniProtKB/Swiss-Prot for MIR378I Gene

  • B-cell receptor specific for TNFSF13B/TALL1/BAFF/BLyS. Promotes the survival of mature B-cells and the B-cell response.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR378I Gene

Genomics for MIR378I Gene

Regulatory Elements for MIR378I Gene

Enhancers for MIR378I Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around MIR378I on UCSC Golden Path with GeneCards custom track

Promoters for MIR378I Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around MIR378I on UCSC Golden Path with GeneCards custom track

Genomic Location for MIR378I Gene

Chromosome:
22
Start:
41,922,023 bp from pter
End:
41,926,818 bp from pter
Size:
4,796 bases
Orientation:
Minus strand

Genomic View for MIR378I Gene

Genes around MIR378I on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR378I Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR378I Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR378I Gene

ORGUL Member Location for MIR378I Gene

ORGUL Member Location for MIR378I gene

Proteins for MIR378I Gene

  • Protein details for MIR378I Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96RJ3-TR13C_HUMAN
    Recommended name:
    Tumor necrosis factor receptor superfamily member 13C
    Protein Accession:
    Q96RJ3

    Protein attributes for MIR378I Gene

    Size:
    184 amino acids
    Molecular mass:
    18864 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for MIR378I Gene

    Alternative splice isoforms for MIR378I Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MIR378I Gene

Post-translational modifications for MIR378I Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MIR378I Gene

ENSEMBL proteins:

No data available for DME Specific Peptides for MIR378I Gene

Domains & Families for MIR378I Gene

Gene Families for MIR378I Gene

Protein Domains for MIR378I Gene

Graphical View of Domain Structure for InterPro Entry

Q96RJ3

UniProtKB/Swiss-Prot:

TR13C_HUMAN :
  • Contains 1 TNFR-Cys repeat.
Similarity:
  • Contains 1 TNFR-Cys repeat.
genes like me logo Genes that share domains with MIR378I: view

No data available for Suggested Antigen Peptide Sequences for MIR378I Gene

Function for MIR378I Gene

Molecular function for MIR378I Gene

UniProtKB/Swiss-Prot Function:
B-cell receptor specific for TNFSF13B/TALL1/BAFF/BLyS. Promotes the survival of mature B-cells and the B-cell response.

Animal Model Products

miRNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR378I Gene

Localization for MIR378I Gene

Subcellular locations from UniProtKB/Swiss-Prot for MIR378I Gene

Membrane; Single-pass type III membrane protein.

Gene Ontology (GO) - Cellular Components for MIR378I Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0009897 external side of plasma membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with MIR378I: view

No data available for Subcellular locations from COMPARTMENTS for MIR378I Gene

Pathways & Interactions for MIR378I Gene

SuperPathways for MIR378I Gene

No Data Available

Gene Ontology (GO) - Biological Process for MIR378I Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002250 adaptive immune response IEA --
GO:0002636 positive regulation of germinal center formation IEA --
GO:0030890 positive regulation of B cell proliferation IEA --
GO:0031295 T cell costimulation IEA --
GO:0031296 B cell costimulation IEA --
genes like me logo Genes that share ontologies with MIR378I: view

No data available for Pathways by source and SIGNOR curated interactions for MIR378I Gene

Drugs & Compounds for MIR378I Gene

No Compound Related Data Available

Transcripts for MIR378I Gene

mRNA/cDNA for MIR378I Gene

(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR378I Gene

No ASD Table

Relevant External Links for MIR378I Gene

GeneLoc Exon Structure for
MIR378I
ECgene alternative splicing isoforms for
MIR378I

Expression for MIR378I Gene

mRNA expression in normal human tissues for MIR378I Gene

mRNA differential expression in normal tissues according to GTEx for MIR378I Gene

This gene is overexpressed in Spleen (x16.6), Small Intestine - Terminal Ileum (x9.4), and Whole Blood (x9.3).

NURSA nuclear receptor signaling pathways regulating expression of MIR378I Gene:

MIR378I

mRNA Expression by UniProt/SwissProt for MIR378I Gene:

Q96RJ3-TR13C_HUMAN
Tissue specificity: Highly expressed in spleen and lymph node, and in resting B-cells. Detected at lower levels in activated B-cells, resting CD4+ T-cells, in thymus and peripheral blood leukocytes.
genes like me logo Genes that share expression patterns with MIR378I: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for MIR378I Gene

Orthologs for MIR378I Gene

This gene was present in the common ancestor of mammals.

Orthologs for MIR378I Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia TNFRSF13C 35
  • 59 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TNFRSF13C 35
  • 67 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tnfrsf13c 35
  • 54 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia TNFRSF13C 35
  • 98 (a)
OneToOne
Species where no ortholog for MIR378I was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MIR378I Gene

ENSEMBL:
Gene Tree for MIR378I (if available)
TreeFam:
Gene Tree for MIR378I (if available)

Paralogs for MIR378I Gene

No data available for Paralogs for MIR378I Gene

Variants for MIR378I Gene

Sequence variations from dbSNP and Humsavar for MIR378I Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type
rs5996086 -- 41,924,257(+) tgagg(C/T)gggcg upstream-variant-2KB
rs35868120 -- 41,924,487(+) GTCTC(-/A)AAAAA upstream-variant-2KB
rs77665467 -- 41,923,712(+) CTGTG(C/T)CTTGG upstream-variant-2KB
rs9607855 -- 41,923,272(+) TCCAC(C/T)TTCTG nc-transcript-variant
rs9607856 -- 41,924,375(+) cccag(C/T)tactc upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MIR378I Gene

Variant ID Type Subtype PubMed ID
nsv1057208 CNV gain 25217958
nsv508736 CNV insertion 20534489
nsv589053 CNV loss 21841781
nsv955162 CNV deletion 24416366

Relevant External Links for MIR378I Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR378I

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR378I Gene

Disorders for MIR378I Gene

MalaCards: The human disease database

(1) MalaCards diseases for MIR378I Gene - From: OMIM and GeneCards

Disorder Aliases PubMed IDs
immunodeficiency, common variable, 4
  • cvid4
- elite association - COSMIC cancer census association via MalaCards

UniProtKB/Swiss-Prot

TR13C_HUMAN
  • Immunodeficiency, common variable, 4 (CVID4) [MIM:613494]: A primary immunodeficiency characterized by antibody deficiency, hypogammaglobulinemia, recurrent bacterial infections and an inability to mount an antibody response to antigen. The defect results from a failure of B-cell differentiation and impaired secretion of immunoglobulins; the numbers of circulating B-cells is usually in the normal range, but can be low. {ECO:0000269 PubMed:19666484}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for MIR378I

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR378I
genes like me logo Genes that share disorders with MIR378I: view

No data available for Genatlas for MIR378I Gene

Publications for MIR378I Gene

  1. Deep sequencing of the small RNA transcriptome of normal and malignant human B cells identifies hundreds of novel microRNAs. (PMID: 20733160) Jima D.D. … Dave S.S. (Blood 2010) 3 65
  2. B-cell activating factor receptor deficiency is associated with an adult-onset antibody deficiency syndrome in humans. (PMID: 19666484) Warnatz K. … Eibel H. (Proc. Natl. Acad. Sci. U.S.A. 2009) 4 65
  3. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S. … Enright A.J. (Nucleic Acids Res. 2006) 3 65
  4. Synthetic anti-BR3 antibodies that mimic BAFF binding and target both human and murine B cells. (PMID: 16840730) Lee C.V. … Fuh G. (Blood 2006) 4 65
  5. Mutational analysis of human BAFF receptor TNFRSF13C (BAFF-R) in patients with common variable immunodeficiency. (PMID: 16160919) Losi C.G. … Plebani A. (J. Clin. Immunol. 2005) 4 65

Products for MIR378I Gene

Sources for MIR378I Gene

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