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MIR378E Gene(RNA Gene)

MicroRNA 378e

GCID:
GC05P170028
GIFtS:
13
Genes Participants
UDN Logo

Aliases for MIR378E Gene

Subcategory (RNA class) for MIR378E Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR378E Gene

  • MicroRNA 378e 2 3 5
  • Hsa-Mir-378e 3
  • Mir-378e 3

External Ids for MIR378E Gene

Previous GeneCards Identifiers for MIR378E Gene

  • GC05U901578
  • GC05P169457

Summaries for MIR378E Gene

Entrez Gene Summary for MIR378E Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR378E Gene

MIR378E (MicroRNA 378e) is an RNA Gene, and is affiliated with the miRNA class.

Additional gene information for MIR378E Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR378E Gene

Genomics for MIR378E Gene

Products:

  1. Regulatory Element

GeneHancer (GH) Regulatory Elements for MIR378E Gene

Promoters and enhancers for MIR378E Gene
GeneHancer (GH) Identifier GH Type GH
Score		 GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites		 Gene Targets
GH05I170100 Enhancer 1 Ensembl ENCODE dbSUPER 0.2 +72.1 72148 0.9 CTCF ZNF654 REST ELF1 RAD21 CC2D1A ATF3 ARID2 SMC3 ZNF143 FOXI1 MIR378E
GH05I169987 Enhancer 0.5 dbSUPER 0.3 -39.6 -39567 3.1 SP1 JUN NFE2 FOSL2 FOS ENSG00000253269 FAM196B MIR378E DOCK2
GH05I170105 Promoter 0.7 EPDnew 0.2 +77.4 77390 0.1 KLF1 ZNF512 FOXI1 MIR378E
GH05I170098 Enhancer 0.5 Ensembl 0.2 +69.7 69713 0.4 ZNF148 IKZF1 MAX ETV6 NR2F2 SPI1 FOXI1 MIR378E
GH05I170103 Enhancer 0.4 dbSUPER 0.2 +75.6 75555 0.9 MZF1 CEBPG FOXI1 MIR378E
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around MIR378E on UCSC Golden Path with GeneCards custom track

Genomic Locations for MIR378E Gene

Genomic Locations for MIR378E Gene
chr5:170,028,488-170,028,566
(GRCh38/hg38)
Size:
79 bases
Orientation:
Plus strand
chr5:169,455,492-169,455,570
(GRCh37/hg19)

Genomic View for MIR378E Gene

Genes around MIR378E on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR378E Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR378E Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for MIR378E Gene

Proteins for MIR378E Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

Post-translational modifications for MIR378E Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR378E Gene

Domains & Families for MIR378E Gene

Gene Families for MIR378E Gene

HGNC:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR378E: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR378E Gene

Function for MIR378E Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line

Animal Model Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR378E Gene

Localization for MIR378E Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR378E Gene

Pathways & Interactions for MIR378E Gene

SuperPathways for MIR378E Gene

PathCards logo More details on SuperPathways for MIR378E
No Data Available

Interacting Proteins for MIR378E Gene

Gene Ontology (GO) - Biological Process for MIR378E Gene

None

No data available for Pathways by source and SIGNOR curated interactions for MIR378E Gene

Drugs & Compounds for MIR378E Gene

Products:

  1. Drug
No Compound Related Data Available

Transcripts for MIR378E Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone

mRNA/cDNA for MIR378E Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR378E Gene

No ASD Table

Relevant External Links for MIR378E Gene

GeneLoc Exon Structure for
MIR378E
ECgene alternative splicing isoforms for
MIR378E

Expression for MIR378E Gene

Products:

  1. Primer

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MIR378E Gene

mRNA expression in normal human tissues for MIR378E Gene
mRNA expression by GTEx for MIR378E Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR378E Gene:

MIR378E
genes like me logo Genes that share expression patterns with MIR378E: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR378E Gene

Orthologs for MIR378E Gene

This gene was present in the common ancestor of mammals.

Orthologs for MIR378E Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
 Mammalia ptr-mir-378e 34
  • 99 (a)
 OneToOne
platypus
(Ornithorhynchus anatinus)
 Mammalia -- 34
  • 50 (a)
 OneToMany
Species where no ortholog for MIR378E was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MIR378E Gene

ENSEMBL:
Gene Tree for MIR378E (if available)
TreeFam:
Gene Tree for MIR378E (if available)

Paralogs for MIR378E Gene

No data available for Paralogs for MIR378E Gene

Variants for MIR378E Gene

Sequence variations from dbSNP and Humsavar for MIR378E Gene

SNP ID Clin Chr 05 pos Variation AA Info Type
rs1000521773 -- 170,028,765(+) A/G downstream_transcript_variant
rs1003388078 -- 170,028,830(+) G/T downstream_transcript_variant
rs1004687873 -- 170,026,677(+) C/G upstream_transcript_variant
rs1006105557 -- 170,028,005(+) G/A upstream_transcript_variant
rs1006794275 -- 170,027,243(+) G/A upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for MIR378E Gene

Variant ID Type Subtype PubMed ID
nsv600259 CNV loss 21841781

Additional Variant Information for MIR378E Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR378E

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR378E Gene

Disorders for MIR378E Gene

Additional Disease Information for MIR378E

ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for MIR378E Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR378E Gene

Publications for MIR378E Gene

  1. Genome-wide association study identifies three novel susceptibility loci for severe Acne vulgaris. (PMID: 24927181) Navarini AA … Barker JN (Nature communications 2014) 3 58
  2. miRBase: integrating microRNA annotation and deep-sequencing data. (PMID: 21037258) Kozomara A … Griffiths-Jones S (Nucleic acids research 2011) 3 58
  3. Deep sequencing of the small RNA transcriptome of normal and malignant human B cells identifies hundreds of novel microRNAs. (PMID: 20733160) Jima DD … Hematologic Malignancies Research Consortium (Blood 2010) 3 58
  4. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S … Enright AJ (Nucleic acids research 2006) 3 58

Products for MIR378E Gene

Sources for MIR378E Gene

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