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Aliases for MIR378C Gene

Subcategory (RNA class) for MIR378C Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR378C Gene

  • MicroRNA 378c 2 3 5
  • Hsa-Mir-378c 3
  • Mir-378c 3

External Ids for MIR378C Gene

Previous GeneCards Identifiers for MIR378C Gene

  • GC10U901430
  • GC10M132760

Summaries for MIR378C Gene

Entrez Gene Summary for MIR378C Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR378C Gene

MIR378C (MicroRNA 378c) is an RNA Gene, and is affiliated with the miRNA class.

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR378C Gene

Genomics for MIR378C Gene

Regulatory Elements for MIR378C Gene

Enhancers for MIR378C Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH10G130933 0.7 ENCODE 0.3 +26.9 26895 4.1 CTCF MXI1 TAF1 JUN TEAD4 MAX RFX5 SMC3 RCOR1 FOS MIR378C LOC105378562
GH10G131048 0.7 ENCODE 0.2 -86.5 -86475 1.3 ZNF263 TEAD4 REST ZIC2 ETS1 JUND HDAC2 POLR2A BCL11A POU5F1 PIR59984 MIR378C
GH10G131001 0.4 ENCODE 0.3 -39.8 -39802 1.0 MAX KDM1A MIR378C PIR59984
GH10G131088 0.9 FANTOM5 0.1 -126.1 -126063 0.1 CTCF CBX3 ATF1 ETV1 ZBTB40 DIDO1 ZNF366 ELK1 ZNF600 CREM PIR59984 MIR378C
GH10G131086 0.7 ENCODE 0.1 -123.6 -123625 0.2 SOX5 SOX13 GATAD2A TFAP4 ESRRA FOXA2 FOXA3 NR2F1 EP300 RARA PIR59984 MIR378C
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MIR378C on UCSC Golden Path with GeneCards custom track

Genomic Location for MIR378C Gene

Chromosome:
10
Start:
130,962,588 bp from pter
End:
130,962,668 bp from pter
Size:
81 bases
Orientation:
Minus strand

Genomic View for MIR378C Gene

Genes around MIR378C on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR378C Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR378C Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR378C Gene

Proteins for MIR378C Gene

Post-translational modifications for MIR378C Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR378C Gene

Domains & Families for MIR378C Gene

Gene Families for MIR378C Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR378C: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR378C Gene

Function for MIR378C Gene

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR378C Gene

Localization for MIR378C Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR378C Gene

Pathways & Interactions for MIR378C Gene

SuperPathways for MIR378C Gene

No Data Available

Interacting Proteins for MIR378C Gene

Gene Ontology (GO) - Biological Process for MIR378C Gene

None

No data available for Pathways by source and SIGNOR curated interactions for MIR378C Gene

Drugs & Compounds for MIR378C Gene

No Compound Related Data Available

Transcripts for MIR378C Gene

mRNA/cDNA for MIR378C Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR378C Gene

No ASD Table

Relevant External Links for MIR378C Gene

GeneLoc Exon Structure for
MIR378C
ECgene alternative splicing isoforms for
MIR378C

Expression for MIR378C Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MIR378C Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR378C Gene:

MIR378C
genes like me logo Genes that share expression patterns with MIR378C: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR378C Gene

Orthologs for MIR378C Gene

Evolution for MIR378C Gene

ENSEMBL:
Gene Tree for MIR378C (if available)
TreeFam:
Gene Tree for MIR378C (if available)

No data available for Orthologs for MIR378C Gene

Paralogs for MIR378C Gene

No data available for Paralogs for MIR378C Gene

Variants for MIR378C Gene

Sequence variations from dbSNP and Humsavar for MIR378C Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
rs1001460526 -- 130,964,512(+) GGAGA(C/T)GTCTG upstream-variant-2KB
rs1003474645 -- 130,962,319(+) CATGG(A/G)CCTGG downstream-variant-500B
rs1004033674 -- 130,963,361(+) AGGTT(A/G)GAAGA upstream-variant-2KB
rs1004853359 -- 130,963,662(+) CGAGA(C/T)TCTGT upstream-variant-2KB
rs1005407594 -- 130,962,775(+) TGAGA(C/T)GGGAG upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MIR378C Gene

Variant ID Type Subtype PubMed ID
nsv1048253 CNV gain 25217958
nsv1054934 CNV gain 25217958
nsv428242 CNV gain 18775914
nsv552322 CNV gain 21841781

Relevant External Links for MIR378C Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR378C

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR378C Gene

Disorders for MIR378C Gene

Relevant External Links for MIR378C

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR378C

No disorders were found for MIR378C Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR378C Gene

Publications for MIR378C Gene

  1. Decreased expression of miR-378 correlates with tumor invasiveness and poor prognosis of patients with glioma. (PMID: 26261592) Li B. … Tao B. (Int J Clin Exp Pathol 2015) 3 64
  2. miRBase: integrating microRNA annotation and deep-sequencing data. (PMID: 21037258) Kozomara A. … Griffiths-Jones S. (Nucleic Acids Res. 2011) 3 64
  3. Ago2 immunoprecipitation identifies predicted microRNAs in human embryonic stem cells and neural precursors. (PMID: 19784364) Goff L.A. … Hart R.P. (PLoS ONE 2009) 3 64
  4. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S. … Enright A.J. (Nucleic Acids Res. 2006) 3 64

Products for MIR378C Gene

Sources for MIR378C Gene

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