Free for academic non-profit institutions. Other users need a Commercial license

Aliases for MIR378A Gene

Subcategory (RNA class) for MIR378A Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR378A Gene

  • MicroRNA 378a 2 3 5
  • MicroRNA 378 2 3
  • Hsa-Mir-378a 3
  • Hsa-Mir-378 3
  • MiRNA378 3
  • MIRN378 3
  • MIR378 3

External Ids for MIR378A Gene

ORGUL Members for MIR378A Gene

Previous HGNC Symbols for MIR378A Gene

  • MIRN378
  • MIR378

Previous GeneCards Identifiers for MIR378A Gene

  • GC05P149113

Summaries for MIR378A Gene

Entrez Gene Summary for MIR378A Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR378A Gene

MIR378A (MicroRNA 378a) is an RNA Gene, and is affiliated with the miRNA class.

Additional gene information for MIR378A Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR378A Gene

Genomics for MIR378A Gene

GeneHancer (GH) Regulatory Elements for MIR378A Gene

Promoters and enhancers for MIR378A Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH05I149729 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 550.8 -1.0 -1010 4 HDGF FOXA2 CLOCK ARNT ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 PPARGC1B GC05P149733 GC05P149734 MIR378A IL17B HMGXB3 CAMK2A AFAP1L1 ARHGEF37 CDX1
GH05I149756 Enhancer 0.7 ENCODE dbSUPER 11.7 +24.7 24658 1.5 CTBP1 ZNF687 NFIB CREB1 HNF4A FOXA1 PPARGC1B MIR378A ENSG00000221043 RNU6-588P GC05P149733 GC05P149853
GH05I149821 Enhancer 0.6 ENCODE dbSUPER 12.1 +88.5 88468 0.2 ZNF664 NFE2 NFE2L2 MIR378A PPARGC1B RNU6-588P HMGXB3 TIGD6 GC05P149853 GC05P149733
GH05I149820 Enhancer 0.5 dbSUPER 12.1 +87.6 87571 0.7 ZFHX2 ATF4 ZFP3 ZBTB40 EGR2 MIR378A PPARGC1B RNU6-588P HMGXB3 TIGD6 GC05P149853 GC05P149733
GH05I149817 Enhancer 0.5 dbSUPER 12.1 +85.4 85433 1 ZFHX2 ZSCAN5C EBF1 ZNF592 ZNF7 EGR2 MIR378A PPARGC1B RNU6-588P HMGXB3 TIGD6 GC05P149853 GC05P149733
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around MIR378A on UCSC Golden Path with GeneCards custom track

Genomic Locations for MIR378A Gene

Genomic Locations for MIR378A Gene
chr5:149,732,825-149,732,890
(GRCh38/hg38)
Size:
66 bases
Orientation:
Plus strand
chr5:149,112,388-149,112,453
(GRCh37/hg19)

Genomic View for MIR378A Gene

Genes around MIR378A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR378A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR378A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR378A Gene

Proteins for MIR378A Gene

Post-translational modifications for MIR378A Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR378A Gene

Domains & Families for MIR378A Gene

Gene Families for MIR378A Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR378A: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR378A Gene

Function for MIR378A Gene

Phenotypes From GWAS Catalog for MIR378A Gene

Gene Ontology (GO) - Molecular Function for MIR378A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000993 RNA polymerase II core binding IDA 25336585
genes like me logo Genes that share ontologies with MIR378A: view

Animal Model Products

miRNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR378A Gene

Localization for MIR378A Gene

Gene Ontology (GO) - Cellular Components for MIR378A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IDA 26646931
genes like me logo Genes that share ontologies with MIR378A: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for MIR378A Gene

Pathways & Interactions for MIR378A Gene

SuperPathways for MIR378A Gene

No Data Available

Interacting Proteins for MIR378A Gene

Gene Ontology (GO) - Biological Process for MIR378A Gene

None

No data available for Pathways by source and SIGNOR curated interactions for MIR378A Gene

Drugs & Compounds for MIR378A Gene

No Compound Related Data Available

Transcripts for MIR378A Gene

mRNA/cDNA for MIR378A Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

miRNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR378A Gene

No ASD Table

Relevant External Links for MIR378A Gene

GeneLoc Exon Structure for
MIR378A
ECgene alternative splicing isoforms for
MIR378A

Expression for MIR378A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MIR378A Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR378A Gene:

MIR378A
genes like me logo Genes that share expression patterns with MIR378A: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR378A Gene

Orthologs for MIR378A Gene

This gene was present in the common ancestor of mammals.

Orthologs for MIR378A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-378a 34
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia bta-mir-378-1 34
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia cfa-mir-378 34
  • 98 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 77 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Gm25301 34
  • 43 (a)
OneToOne
Species where no ortholog for MIR378A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MIR378A Gene

ENSEMBL:
Gene Tree for MIR378A (if available)
TreeFam:
Gene Tree for MIR378A (if available)

Paralogs for MIR378A Gene

No data available for Paralogs for MIR378A Gene

Variants for MIR378A Gene

Sequence variations from dbSNP and Humsavar for MIR378A Gene

SNP ID Clin Chr 05 pos Variation AA Info Type
rs1000425484 -- 149,732,747(+) T/C upstream_transcript_variant
rs1001704444 -- 149,732,410(+) T/C upstream_transcript_variant
rs1001709230 -- 149,733,373(+) G/A downstream_transcript_variant
rs1002314782 -- 149,731,968(+) A/G upstream_transcript_variant
rs1002648510 -- 149,730,944(+) T/G upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for MIR378A Gene

Variant ID Type Subtype PubMed ID
nsv1019813 CNV gain 25217958
nsv1027896 CNV gain 25217958
nsv5060 CNV deletion 18451855

Additional Variant Information for MIR378A Gene

Human Gene Mutation Database (HGMD)
MIR378A
SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR378A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR378A Gene

Disorders for MIR378A Gene

Additional Disease Information for MIR378A

No disorders were found for MIR378A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR378A Gene

Publications for MIR378A Gene

  1. miR-125b-1 and miR-378a are predictive biomarkers for the efficacy of vaccine treatment against colorectal cancer. (PMID: 28859241) Tanaka H … Nagano H (Cancer science 2017) 3 58
  2. miR-378 suppresses the proliferation, migration and invasion of colon cancer cells by inhibiting SDAD1. (PMID: 28725241) Zeng M … Kang C (Cellular & molecular biology letters 2017) 3 58
  3. Deregulation of MicroRNAs mediated control of carnitine cycle in prostate cancer: molecular basis and pathophysiological consequences. (PMID: 28671672) Valentino A … Peluso G (Oncogene 2017) 3 58
  4. Cancer-associated fibroblasts release exosomal microRNAs that dictate an aggressive phenotype in breast cancer. (PMID: 28121625) Donnarumma E … Condorelli G (Oncotarget 2017) 3 58
  5. Increased Proangiogenic Activity of Mobilized CD34+ Progenitor Cells of Patients With Acute ST-Segment-Elevation Myocardial Infarction: Role of Differential MicroRNA-378 Expression. (PMID: 28062497) Templin C … Landmesser U (Arteriosclerosis, thrombosis, and vascular biology 2017) 3 58

Products for MIR378A Gene

Sources for MIR378A Gene

Content
Loading form....