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Aliases for MIR378A Gene

Subcategory (RNA class) for MIR378A Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR378A Gene

  • MicroRNA 378a 2 3 5
  • MicroRNA 378 2 3
  • Hsa-Mir-378a 3
  • Hsa-Mir-378 3
  • MiRNA378 3
  • MIRN378 3
  • MIR378 3

External Ids for MIR378A Gene

ORGUL Members for MIR378A Gene

Previous HGNC Symbols for MIR378A Gene

  • MIRN378
  • MIR378

Previous GeneCards Identifiers for MIR378A Gene

  • GC05P149113

Summaries for MIR378A Gene

Entrez Gene Summary for MIR378A Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR378A Gene

MIR378A (MicroRNA 378a) is an RNA Gene, and is affiliated with the miRNA class.

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR378A Gene

Genomics for MIR378A Gene

Regulatory Elements for MIR378A Gene

Enhancers for MIR378A Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH05G149756 0.8 ENCODE dbSUPER 11.7 +24.7 24659 1.5 CTBP1 ZNF687 NFIB CREB1 HNF4A FOXA1 PPARGC1B MIR378A ENSG00000221043 RNU6-588P GC05P149733 GC05P149853
GH05G149821 0.7 ENCODE dbSUPER 12.1 +88.5 88468 0.2 ZNF664 NFE2 NFE2L2 MIR378A PPARGC1B RNU6-588P HMGXB3 TIGD6 GC05P149853 GC05P149733
GH05G149755 0.7 dbSUPER 11.7 +23.2 23181 0.3 TAF1 MAX RAD21 YY1 GATA2 HNF4G FOS CEBPB NR3C1 ATF2 MIR378A PPARGC1B RNU6-588P GC05P149733 GC05P149853
GH05G149753 0.7 dbSUPER 11.7 +21.3 21342 1.1 ZNF639 ZBTB11 E2F5 YY1 ZNF589 ZFHX2 EGR1 ZKSCAN8 ZNF584 CUX1 PPARGC1B MIR378A RNU6-588P GC05P149733 GC05P149853
GH05G149817 0.6 dbSUPER 12.1 +85.4 85434 1.0 ZFHX2 ZSCAN5C ZFP64 EBF1 ZNF7 EGR2 MIR378A PPARGC1B RNU6-588P TIGD6 HMGXB3 GC05P149853 GC05P149733
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MIR378A on UCSC Golden Path with GeneCards custom track

Genomic Location for MIR378A Gene

Chromosome:
5
Start:
149,732,825 bp from pter
End:
149,732,890 bp from pter
Size:
66 bases
Orientation:
Plus strand

Genomic View for MIR378A Gene

Genes around MIR378A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR378A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR378A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR378A Gene

Proteins for MIR378A Gene

Post-translational modifications for MIR378A Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR378A Gene

Domains & Families for MIR378A Gene

Gene Families for MIR378A Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR378A: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR378A Gene

Function for MIR378A Gene

Animal Model Products

miRNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR378A Gene

Localization for MIR378A Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR378A Gene

Pathways & Interactions for MIR378A Gene

SuperPathways for MIR378A Gene

No Data Available

Interacting Proteins for MIR378A Gene

Gene Ontology (GO) - Biological Process for MIR378A Gene

None

No data available for Pathways by source and SIGNOR curated interactions for MIR378A Gene

Drugs & Compounds for MIR378A Gene

No Compound Related Data Available

Transcripts for MIR378A Gene

mRNA/cDNA for MIR378A Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

miRNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR378A Gene

No ASD Table

Relevant External Links for MIR378A Gene

GeneLoc Exon Structure for
MIR378A
ECgene alternative splicing isoforms for
MIR378A

Expression for MIR378A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MIR378A Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR378A Gene:

MIR378A
genes like me logo Genes that share expression patterns with MIR378A: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR378A Gene

Orthologs for MIR378A Gene

This gene was present in the common ancestor of mammals.

Orthologs for MIR378A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-378a 35
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia bta-mir-378-1 35
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia cfa-mir-378 35
  • 98 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 77 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Gm25301 35
  • 43 (a)
OneToOne
Species where no ortholog for MIR378A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MIR378A Gene

ENSEMBL:
Gene Tree for MIR378A (if available)
TreeFam:
Gene Tree for MIR378A (if available)

Paralogs for MIR378A Gene

No data available for Paralogs for MIR378A Gene

Variants for MIR378A Gene

Sequence variations from dbSNP and Humsavar for MIR378A Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs1000425484 -- 149,732,747(+) CTTAT(C/T)TTACA intron-variant, upstream-variant-2KB
rs1001704444 -- 149,732,410(+) TGGAC(C/T)GTACC intron-variant, upstream-variant-2KB
rs1001709230 -- 149,733,373(+) CCCTG(A/G)CCCAG intron-variant, downstream-variant-500B
rs1002314782 -- 149,731,968(+) GGCAG(A/G)GGCCG intron-variant, upstream-variant-2KB
rs1002648510 -- 149,730,944(+) GAGTT(G/T)CCTGC intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MIR378A Gene

Variant ID Type Subtype PubMed ID
nsv1019813 CNV gain 25217958
nsv1027896 CNV gain 25217958
nsv5060 CNV deletion 18451855

Relevant External Links for MIR378A Gene

Human Gene Mutation Database (HGMD)
MIR378A
SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR378A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR378A Gene

Disorders for MIR378A Gene

Relevant External Links for MIR378A

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR378A

No disorders were found for MIR378A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR378A Gene

Publications for MIR378A Gene

  1. miRNA-378 reverses chemoresistance to cisplatin in lung adenocarcinoma cells by targeting secreted clusterin. (PMID: 26781643) Chen X. … Cai L. (Sci Rep 2016) 3 64
  2. RNA Editing Modulates Human Hepatic Aryl Hydrocarbon Receptor Expression by Creating MicroRNA Recognition Sequence. (PMID: 26601943) Nakano M. … Nakajima M. (J. Biol. Chem. 2016) 3 64
  3. MiR-378 suppresses prostate cancer cell growth through downregulation of MAPK1 in vitro and in vivo. (PMID: 26346167) Chen Q.G. … Kong C.Z. (Tumour Biol. 2016) 3 64
  4. The Epigenetically-Regulated microRNA-378a Targets TGF-I^2 in TGF-I^1-Treated Hepatic Stellate Cells. (PMID: 27855367) Yu F. … Zheng J. (Cell. Physiol. Biochem. 2016) 3 64
  5. Activation of Hepatic Stellate Cells is Inhibited by microRNA-378a-3p via Wnt10a. (PMID: 27832641) Yu F. … Zheng J. (Cell. Physiol. Biochem. 2016) 3 64

Products for MIR378A Gene

Sources for MIR378A Gene

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