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Aliases for MIR377 Gene

Subcategory (RNA class) for MIR377 Gene

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Quality Score for this RNA gene is

3

Aliases for MIR377 Gene

  • MicroRNA 377 2 3
  • Hsa-Mir-377 3
  • MIRN377 3

External Ids for MIR377 Gene

ORGUL Members for MIR377 Gene

Previous HGNC Symbols for MIR377 Gene

  • MIRN377

Previous GeneCards Identifiers for MIR377 Gene

  • GC14P100838
  • GC14P100928
  • GC14P101529
  • GC14P101559
  • GC14P101592
  • GC14P101631
  • GC14P101659
  • GC14P101693
  • GC14P101731
  • GC14P101771
  • GC14P101829
  • GC14P101969
  • GC14P102166

Summaries for MIR377 Gene

Entrez Gene Summary for MIR377 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR377 Gene

MIR377 (MicroRNA 377) is an RNA Gene, and is affiliated with the undefined RNA class.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR377 Gene

Genomics for MIR377 Gene

Genomic Location for MIR377 Gene

Start:
101,062,024 bp from pter
End:
101,062,132 bp from pter
Size:
109 bases
Orientation:
Plus strand

Genomic View for MIR377 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MIR377 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR377 Gene

No data available for Regulatory Elements for MIR377 Gene

Proteins for MIR377 Gene

Post-translational modifications for MIR377 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR377 Gene

Domains for MIR377 Gene

Gene Families for MIR377 Gene

HGNC:
  • MIR :ncRNAs / Micro RNAs

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR377: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR377 Gene

Function for MIR377 Gene

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for MIR377 Gene

Localization for MIR377 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR377 Gene

Pathways for MIR377 Gene

SuperPathways for MIR377 Gene

No Data Available

Interacting Proteins for MIR377 Gene

Gene Ontology (GO) - Biological Process for MIR377 Gene

None

No data available for Pathways by source for MIR377 Gene

Transcripts for MIR377 Gene

mRNA/cDNA for MIR377 Gene

(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR377 Gene

No ASD Table

Relevant External Links for MIR377 Gene

GeneLoc Exon Structure for
MIR377
ECgene alternative splicing isoforms for
MIR377

Expression for MIR377 Gene

mRNA expression in normal human tissues for MIR377 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

genes like me logo Genes that share expressions with MIR377: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues , Protein expression and mRNA Expression by UniProt/SwissProt for MIR377 Gene

Orthologs for MIR377 Gene

This gene was present in the common ancestor of mammals.

Orthologs for MIR377 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-377 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia bta-mir-377 36
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia cfa-mir-377 36
  • 86 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mir377 36
  • 99 (a)
OneToOne
Species with no ortholog for MIR377:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MIR377 Gene

ENSEMBL:
Gene Tree for MIR377 (if available)
TreeFam:
Gene Tree for MIR377 (if available)

Paralogs for MIR377 Gene

No data available for Paralogs for MIR377 Gene

Variants for MIR377 Gene

Sequence variations from dbSNP and Humsavar for MIR377 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type MAF
rs6575812 -- 101,061,773(+) CAGGG(G/T)CTGAC upstream-variant-2KB
rs7150660 -- 101,061,413(+) GTGTC(A/G)CCAGA upstream-variant-2KB
rs8013103 -- 101,061,376(+) CCTGA(C/G)GGCAG upstream-variant-2KB
rs10714577 -- 101,062,420(+) CACCA(-/T)TTTTT downstream-variant-500B
rs36027842 -- 101,062,358(+) CTGGA(-/C)CCCTG downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for MIR377 Gene

Variant ID Type Subtype PubMed ID
nsv509551 CNV Insertion 20534489

Relevant External Links for MIR377 Gene

HapMap Linkage Disequilibrium report
MIR377

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MIR377 Gene

Disorders for MIR377 Gene

No disorders were found for MIR377 Gene.

No data available for UniProtKB/Swiss-Prot for MIR377 Gene

Publications for MIR377 Gene

  1. Clustering and conservation patterns of human microRNAs. (PMID: 15891114) Altuvia Y. … Margalit H. (Nucleic Acids Res. 2005) 3
  2. Identification of clustered microRNAs using an ab initio prediction method. (PMID: 16274478) Sewer A. … Zavolan M. (BMC Bioinformatics 2005) 3
  3. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S. … Enright A.J. (Nucleic Acids Res. 2006) 3
  4. A mammalian microRNA expression atlas based on small RNA library sequencing. (PMID: 17604727) Landgraf P. … Tuschl T. (Cell 2007) 3
  5. MicroRNA-377 is up-regulated and can lead to increased fibronectin production in diabetic nephropathy. (PMID: 18716028) Wang Q. … Quigg R.J. (FASEB J. 2008) 3

Products for MIR377 Gene

Sources for MIR377 Gene

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