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Aliases for MIR377 Gene

Subcategory (RNA class) for MIR377 Gene


Quality Score for this RNA gene is


Aliases for MIR377 Gene

  • MicroRNA 377 2 3 5
  • Hsa-Mir-377 3
  • Mir-377 3
  • MIRN377 3

External Ids for MIR377 Gene

ORGUL Members for MIR377 Gene

Previous HGNC Symbols for MIR377 Gene

  • MIRN377

Previous GeneCards Identifiers for MIR377 Gene

  • GC14P100838
  • GC14P100928
  • GC14P101529
  • GC14P101559
  • GC14P101592
  • GC14P101631
  • GC14P101659
  • GC14P101693
  • GC14P101731
  • GC14P101771
  • GC14P101829
  • GC14P101969
  • GC14P102166
  • GC14P101271
  • GC14P101887

Summaries for MIR377 Gene

Entrez Gene Summary for MIR377 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR377 Gene

MIR377 (MicroRNA 377) is an RNA Gene, and is affiliated with the undefined RNA class.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR377 Gene

Genomics for MIR377 Gene

Regulatory Elements for MIR377 Gene

Enhancers for MIR377 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around MIR377 on UCSC Golden Path with GeneCards custom track

Genomic Location for MIR377 Gene

101,062,024 bp from pter
101,062,132 bp from pter
109 bases
Plus strand

Genomic View for MIR377 Gene

Genes around MIR377 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR377 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR377 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR377 Gene

Proteins for MIR377 Gene

Post-translational modifications for MIR377 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR377 Gene

Domains & Families for MIR377 Gene

Gene Families for MIR377 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR377: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR377 Gene

Function for MIR377 Gene

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR377 Gene

Localization for MIR377 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR377 Gene

Pathways & Interactions for MIR377 Gene

SuperPathways for MIR377 Gene

No Data Available

Interacting Proteins for MIR377 Gene

Gene Ontology (GO) - Biological Process for MIR377 Gene


No data available for Pathways by source and SIGNOR curated interactions for MIR377 Gene

Drugs & Compounds for MIR377 Gene

No Compound Related Data Available

Transcripts for MIR377 Gene

mRNA/cDNA for MIR377 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR377 Gene

No ASD Table

Relevant External Links for MIR377 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MIR377 Gene

mRNA expression in normal human tissues for MIR377 Gene

genes like me logo Genes that share expression patterns with MIR377: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for MIR377 Gene

Orthologs for MIR377 Gene

This gene was present in the common ancestor of mammals.

Orthologs for MIR377 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia bta-mir-377 36
  • 99 (a)
(Canis familiaris)
Mammalia cfa-mir-377 36
  • 86 (a)
(Mus musculus)
Mammalia Mir377 36
  • 99 (a)
(Pan troglodytes)
Mammalia ptr-mir-377 36
  • 99 (a)
Species with no ortholog for MIR377:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MIR377 Gene

Gene Tree for MIR377 (if available)
Gene Tree for MIR377 (if available)

Paralogs for MIR377 Gene

No data available for Paralogs for MIR377 Gene

Variants for MIR377 Gene

Sequence variations from dbSNP and Humsavar for MIR377 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
rs7150660 -- 101,061,413(+) GTGTC(A/G)CCAGA upstream-variant-2KB
rs8013103 -- 101,061,376(+) CCTGA(C/G)GGCAG upstream-variant-2KB
rs10714577 -- 101,062,420(+) CACCA(-/T)TTTTT downstream-variant-500B
rs36027842 -- 101,062,358(+) CTGGA(-/C)CCCTG downstream-variant-500B
rs75771437 -- 101,061,542(+) GCTGT(C/T)CCTGT upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MIR377 Gene

Variant ID Type Subtype PubMed ID
nsv509551 CNV Insertion 20534489

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Variation tolerance and Relevant External Links for MIR377 Gene

Disorders for MIR377 Gene

Relevant External Links for MIR377

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for MIR377 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR377 Gene

Publications for MIR377 Gene

  1. MicroRNA-377 predicts poor clinical outcome of gastric cancer and induces tumorigenesis by targeting multiple tumor-suppressor genes. (PMID: 25998046) Wen X. … Tang J.H. (Oncol. Rep. 2015) 3 67
  2. microRNA-377 suppresses the proliferation of human osteosarcoma MG-63 cells by targeting CDK6. (PMID: 25577249) Wang L. … Zhao J. (Tumour Biol. 2015) 3
  3. MicroRNA-377 suppresses cell proliferation and invasion by inhibiting TIAM1 expression in hepatocellular carcinoma. (PMID: 25739101) Chen G. … Yuan D. (PLoS ONE 2015) 3
  4. miR-377 functions as a tumor suppressor in human clear cell renal cell carcinoma by targeting ETS1. (PMID: 25776481) Wang R. … Ma P. (Biomed. Pharmacother. 2015) 3
  5. MiR-377 targets E2F3 and alters the NF-kB signaling pathway through MAP3K7 in malignant melanoma. (PMID: 25889255) Zehavi L. … Avni D. (Mol. Cancer 2015) 3

Products for MIR377 Gene

Sources for MIR377 Gene