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Aliases for MIR376C Gene

Subcategory (RNA class) for MIR376C Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR376C Gene

  • MicroRNA 376c 2 3 5
  • MicroRNA 368 2 3
  • Hsa-Mir-376c 3
  • Hsa-Mir-368 3
  • MiRNA368 3
  • Mir-376c 3
  • MIRN376C 3
  • MIRN368 3
  • MIR368 3

External Ids for MIR376C Gene

ORGUL Members for MIR376C Gene

Previous HGNC Symbols for MIR376C Gene

  • MIRN368
  • MIRN376C

Previous GeneCards Identifiers for MIR376C Gene

  • GC14P100802
  • GC14P100897
  • GC14P101507
  • GC14P101538
  • GC14P101571
  • GC14P101613
  • GC14P101641
  • GC14P101673
  • GC14P101706
  • GC14P101747
  • GC14P101812
  • GC14P101952
  • GC14P102143
  • GC14P101248
  • GC14P101854
  • GC14P102106
  • GC14P102343
  • GC14P102513
  • GC14P102692

Summaries for MIR376C Gene

Entrez Gene Summary for MIR376C Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR376C Gene

MIR376C (MicroRNA 376c) is an RNA Gene, and is affiliated with the miRNA class.

Additional gene information for MIR376C Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR376C Gene

Genomics for MIR376C Gene

Regulatory Elements for MIR376C Gene

Enhancers for MIR376C Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH14H101287 1 ENCODE 9.4 +249.2 249231 2 FOXA2 ATF1 MLX ZFP64 ARID4B YY1 SP5 ZHX2 NFYC REST MEG3 MIR1185-2 MIR381 MIR487B MIR539 MIR544A MIR889 MIR655 MIR1185-1 MIR300
GH14H101004 0.8 Ensembl ENCODE 10.9 -34.6 -34606 1 GATA3 MNT MYC TCF7L2 MIR134 MIR487A MIR154 MIR323B MIR485 MIR377 MIR496 MIR376C MIR1185-1 MIR1185-2
GH14H101096 0.8 FANTOM5 ENCODE 10.7 +58.7 58658 3 POLR2A JUN MAFK RTL1 LOC105370670 MEG9 MIR369 MIR409 MIR410 MIR412 MIR541 MIR656 MIR154
GH14H101330 0.9 ENCODE 8.9 +291.2 291165 0 ELF3 FOXA2 MLX ARID4B RAD21 THRB ZSCAN9 RARA CREM MIXL1 MIR1185-1 MIR1185-2 MIR300 MIR381 MIR487B MIR539 MIR544A MIR655 MIR889 MIR376C
GH14H101333 0.9 ENCODE 8.9 +295.4 295367 2 ELF3 FOXA2 ARID4B ZSCAN9 RAD21 RARA YY1 CREM MIXL1 THAP11 MIR381 MIR487B MIR539 MIR544A MIR655 MIR889 MIR376C MIR1185-1 MIR1185-2 MIR300
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MIR376C on UCSC Golden Path with GeneCards custom track

Genomic Location for MIR376C Gene

Chromosome:
14
Start:
101,039,690 bp from pter
End:
101,039,755 bp from pter
Size:
66 bases
Orientation:
Plus strand

Genomic View for MIR376C Gene

Genes around MIR376C on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR376C Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR376C Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR376C Gene

Proteins for MIR376C Gene

Post-translational modifications for MIR376C Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR376C Gene

Domains & Families for MIR376C Gene

Gene Families for MIR376C Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR376C: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR376C Gene

Function for MIR376C Gene

Animal Model Products

CRISPR Products

Clone Products

  • Applied Biological Materials Clones for MIR376C
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR376C Gene

Localization for MIR376C Gene

Gene Ontology (GO) - Cellular Components for MIR376C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IDA 26646931
genes like me logo Genes that share ontologies with MIR376C: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for MIR376C Gene

Pathways & Interactions for MIR376C Gene

SuperPathways for MIR376C Gene

No Data Available

Interacting Proteins for MIR376C Gene

Gene Ontology (GO) - Biological Process for MIR376C Gene

None

No data available for Pathways by source and SIGNOR curated interactions for MIR376C Gene

Drugs & Compounds for MIR376C Gene

No Compound Related Data Available

Transcripts for MIR376C Gene

mRNA/cDNA for MIR376C Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

CRISPR Products

Clone Products

  • Applied Biological Materials Clones for MIR376C
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for MIR376C Gene

No ASD Table

Relevant External Links for MIR376C Gene

GeneLoc Exon Structure for
MIR376C
ECgene alternative splicing isoforms for
MIR376C

Expression for MIR376C Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MIR376C Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR376C Gene:

MIR376C
genes like me logo Genes that share expression patterns with MIR376C: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR376C Gene

Orthologs for MIR376C Gene

Evolution for MIR376C Gene

ENSEMBL:
Gene Tree for MIR376C (if available)
TreeFam:
Gene Tree for MIR376C (if available)

No data available for Orthologs for MIR376C Gene

Paralogs for MIR376C Gene

No data available for Paralogs for MIR376C Gene

Variants for MIR376C Gene

Sequence variations from dbSNP and Humsavar for MIR376C Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
rs1000084197 -- 101,037,952(+) ACATG(A/G)AGCAT upstream-variant-2KB
rs1000454623 -- 101,038,656(+) TGGTG(G/T)TGGTG upstream-variant-2KB
rs1001865358 -- 101,038,056(+) TTGAG(A/T)CTGGG upstream-variant-2KB
rs1003009472 -- 101,039,870(+) GAACA(C/T)GTGCT downstream-variant-500B, upstream-variant-2KB
rs1008717797 -- 101,038,899(+) ACATT(G/T)GTCAT upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MIR376C Gene

Variant ID Type Subtype PubMed ID
esv3635521 CNV gain 21293372
nsv1040993 CNV gain 25217958
nsv565859 CNV gain 21841781
nsv565860 CNV gain 21841781

Relevant External Links for MIR376C Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR376C

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR376C Gene

Disorders for MIR376C Gene

Relevant External Links for MIR376C

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR376C

No disorders were found for MIR376C Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR376C Gene

Publications for MIR376C Gene

  1. Association of MicroRNAs and YRNAs With Platelet Function. (PMID: 26646931) Kaudewitz D … Mayr M (Circulation research 2016) 3 60
  2. Epigenetic regulation of steroid inactivating UDP-glucuronosyltransferases by microRNAs in prostate cancer. (PMID: 26385605) Margaillan G … Guillemette C (The Journal of steroid biochemistry and molecular biology 2016) 3 60
  3. Dysregulation of RUNX2/Activin-A Axis upon miR-376c Downregulation Promotes Lymph Node Metastasis in Head and Neck Squamous Cell Carcinoma. (PMID: 27760788) Chang WM … Shiah SG (Cancer research 2016) 3 60
  4. MicroRNA-376c suppresses non-small-cell lung cancer cell growth and invasion by targeting LRH-1-mediated Wnt signaling pathway. (PMID: 27049310) Jiang W … Tian D (Biochemical and biophysical research communications 2016) 3 60
  5. miR-376c inhibits cervical cancer cell proliferation and invasion by targeting BMI1. (PMID: 27345009) Deng Y … Liu Y (International journal of experimental pathology 2016) 3 60

Products for MIR376C Gene

Sources for MIR376C Gene

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