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Aliases for MIR376C Gene

Subcategory (RNA class) for MIR376C Gene


Quality Score for this RNA gene is


Aliases for MIR376C Gene

  • MicroRNA 376c 2 3 5
  • MicroRNA 368 2 3
  • Hsa-Mir-376c 3
  • Hsa-Mir-368 3
  • MiRNA368 3
  • Mir-376c 3
  • MIRN376C 3
  • MIRN368 3
  • MIR368 3

External Ids for MIR376C Gene

ORGUL Members for MIR376C Gene

Previous HGNC Symbols for MIR376C Gene

  • MIRN368
  • MIRN376C

Previous GeneCards Identifiers for MIR376C Gene

  • GC14P100802
  • GC14P100897
  • GC14P101507
  • GC14P101538
  • GC14P101571
  • GC14P101613
  • GC14P101641
  • GC14P101673
  • GC14P101706
  • GC14P101747
  • GC14P101812
  • GC14P101952
  • GC14P102143
  • GC14P101248
  • GC14P101854
  • GC14P102106
  • GC14P102343

Summaries for MIR376C Gene

Entrez Gene Summary for MIR376C Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR376C Gene

MIR376C (MicroRNA 376c) is an RNA Gene, and is affiliated with the miRNA class.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR376C Gene

Genomics for MIR376C Gene

Regulatory Elements for MIR376C Gene

Enhancers for MIR376C Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH14F101096 1.1 FANTOM5 ENCODE 10.7 +58.7 58658 3.2 CTCF SUZ12 JUN ZIC2 ZNF335 GLIS2 ZNF366 POLR2A SCRT2 PATZ1 RTL1 LOC105370670 MEG9 MIR369 MIR409 MIR410 MIR412 MIR541 MIR656 MIR154
GH14F101215 1 ENCODE 9.9 +177.0 177035 2.8 HDGF ARID4B ZNF48 GATA2 SSRP1 ZNF658 ETV4 HNF4A KDM1A ZNF785 MIR6764 SNORD113-4 SNORD113-3 SNORD113-6 SNORD113-7 SNORD113-8 SNORD113-9 MIR543 ENSG00000222185 ENSG00000222095
GH14F101287 1 ENCODE 9.4 +249.2 249231 2.5 ATF1 MLX ZFP64 ARID4B ZNF48 YY1 SP5 NFYC MIER2 PPARG MEG3 MIR655 MIR1185-1 MIR300 MIR376C MIR654 MIR1185-2 MIR381 MIR487B MIR539
GH14F101004 0.8 Ensembl ENCODE 10.9 -34.4 -34415 2.3 GATA3 MAX MNT ZIC2 MYC TCF7L2 MIR134 MIR487A MIR154 MIR323B MIR485 MIR377 MIR496 MIR376C MIR654 MIR1185-1
GH14F101330 0.9 ENCODE 8.9 +291.2 291165 0.3 ELF3 MLX ARID4B THRB ZNF48 ZSCAN9 RAD21 RARA CREM MIXL1 MIR381 MIR487B MIR539 MIR544A MIR655 MIR889 MIR1185-1 MIR1185-2 MIR300 MIR376C
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MIR376C on UCSC Golden Path with GeneCards custom track

Genomic Location for MIR376C Gene

101,039,690 bp from pter
101,039,755 bp from pter
66 bases
Plus strand

Genomic View for MIR376C Gene

Genes around MIR376C on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR376C Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR376C Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR376C Gene

Proteins for MIR376C Gene

Post-translational modifications for MIR376C Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR376C Gene

Domains & Families for MIR376C Gene

Gene Families for MIR376C Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR376C: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR376C Gene

Function for MIR376C Gene

Animal Model Products

miRNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR376C Gene

Localization for MIR376C Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR376C Gene

Pathways & Interactions for MIR376C Gene

SuperPathways for MIR376C Gene

No Data Available

Interacting Proteins for MIR376C Gene

Gene Ontology (GO) - Biological Process for MIR376C Gene


No data available for Pathways by source and SIGNOR curated interactions for MIR376C Gene

Transcripts for MIR376C Gene

mRNA/cDNA for MIR376C Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

miRNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR376C Gene

No ASD Table

Relevant External Links for MIR376C Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MIR376C Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MIR376C Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR376C Gene:

genes like me logo Genes that share expression patterns with MIR376C: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for MIR376C Gene

Orthologs for MIR376C Gene

Evolution for MIR376C Gene

Gene Tree for MIR376C (if available)
Gene Tree for MIR376C (if available)

No data available for Orthologs for MIR376C Gene

Paralogs for MIR376C Gene

No data available for Paralogs for MIR376C Gene

Variants for MIR376C Gene

Sequence variations from dbSNP and Humsavar for MIR376C Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
rs111217198 -- 101,038,436(+) GTGGT(A/G)TTGGT upstream-variant-2KB
rs111736947 -- 101,038,542(+) TGGTG(A/G)TGTTG upstream-variant-2KB
rs112142802 -- 101,038,879(+) CTCCA(G/T)CCCAC upstream-variant-2KB
rs112758791 -- 101,038,299(+) TGGTG(A/C/G)TGGTG upstream-variant-2KB
rs114035552 -- 101,039,996(+) GCTCT(C/T)CTCTG downstream-variant-500B, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MIR376C Gene

Variant ID Type Subtype PubMed ID
nsv565860 CNV gain 21841781
nsv565859 CNV gain 21841781
nsv1040993 CNV gain 25217958
esv3635521 CNV gain 21293372

Relevant External Links for MIR376C Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR376C Gene

Disorders for MIR376C Gene

Relevant External Links for MIR376C

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for MIR376C Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR376C Gene

Publications for MIR376C Gene

  1. Epigenetic regulation of steroid inactivating UDP-glucuronosyltransferases by microRNAs in prostate cancer. (PMID: 26385605) Margaillan G. … Guillemette C. (J. Steroid Biochem. Mol. Biol. 2016) 3 64
  2. Regulation of Human UGT2B15 and UGT2B17 by miR-376c in Prostate Cancer Cell Lines. (PMID: 26163549) Wijayakumara D.D. … Mackenzie P.I. (J. Pharmacol. Exp. Ther. 2015) 3 64
  3. MicroRNAs, miR-154, miR-299-5p, miR-376a, miR-376c, miR-377, miR-381, miR-487b, miR-485-3p, miR-495 and miR-654-3p, mapped to the 14q32.31 locus, regulate proliferation, apoptosis, migration and invasion in metastatic prostate cancer cells. (PMID: 24166498) Formosa A. … Candi E. (Oncogene 2014) 3 64
  4. A reciprocal antagonism between miR-376c and TGF-I^ signaling regulates neural differentiation of human pluripotent stem cells. (PMID: 25114173) Liu J. … Pan G. (FASEB J. 2014) 3 64
  5. miR-638 mediated regulation of BRCA1 affects DNA repair and sensitivity to UV and cisplatin in triple-negative breast cancer. (PMID: 25228385) Tan X. … Fu S.W. (Breast Cancer Res. 2014) 3 64

Products for MIR376C Gene

Sources for MIR376C Gene

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