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Aliases for MIR376B Gene

Subcategory (RNA class) for MIR376B Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR376B Gene

  • MicroRNA 376b 2 3 5
  • Hsa-Mir-376b 3
  • Mir-376b 3
  • MIRN376B 3

External Ids for MIR376B Gene

ORGUL Members for MIR376B Gene

Previous HGNC Symbols for MIR376B Gene

  • MIRN376B

Previous GeneCards Identifiers for MIR376B Gene

  • GC14P100805
  • GC14P100899
  • GC14P101509
  • GC14P101565
  • GC14P101598
  • GC14P081690
  • GC14P101664
  • GC14P101699
  • GC14P101736
  • GC14P101776
  • GC14P101834
  • GC14P101974
  • GC14P102171
  • GC14P101250
  • GC14P101857
  • GC14P102109
  • GC14P102346
  • GC14P102516

Summaries for MIR376B Gene

Entrez Gene Summary for MIR376B Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR376B Gene

MIR376B (MicroRNA 376b) is an RNA Gene, and is affiliated with the miRNA class.

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR376B Gene

Genomics for MIR376B Gene

Genomic Location for MIR376B Gene

Chromosome:
14
Start:
101,040,436 bp from pter
End:
101,040,535 bp from pter
Size:
100 bases
Orientation:
Plus strand

Genomic View for MIR376B Gene

Genes around MIR376B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR376B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR376B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR376B Gene

No data available for Regulatory Elements for MIR376B Gene

Proteins for MIR376B Gene

Post-translational modifications for MIR376B Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR376B Gene

Domains & Families for MIR376B Gene

Gene Families for MIR376B Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR376B: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR376B Gene

Function for MIR376B Gene

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR376B Gene

Localization for MIR376B Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR376B Gene

Pathways & Interactions for MIR376B Gene

SuperPathways for MIR376B Gene

No Data Available

Interacting Proteins for MIR376B Gene

Gene Ontology (GO) - Biological Process for MIR376B Gene

None

No data available for Pathways by source and SIGNOR curated interactions for MIR376B Gene

Drugs & Compounds for MIR376B Gene

No Compound Related Data Available

Transcripts for MIR376B Gene

mRNA/cDNA for MIR376B Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR376B Gene

No ASD Table

Relevant External Links for MIR376B Gene

GeneLoc Exon Structure for
MIR376B
ECgene alternative splicing isoforms for
MIR376B

Expression for MIR376B Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR376B Gene:

MIR376B
No Expression Related Data Available

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR376B Gene

Orthologs for MIR376B Gene

Evolution for MIR376B Gene

ENSEMBL:
Gene Tree for MIR376B (if available)
TreeFam:
Gene Tree for MIR376B (if available)

No data available for Orthologs for MIR376B Gene

Paralogs for MIR376B Gene

No data available for Paralogs for MIR376B Gene

Variants for MIR376B Gene

Sequence variations from dbSNP and Humsavar for MIR376B Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
rs1000454623 -- 101,038,656(+) TGGTG(G/T)TGGTG upstream-variant-2KB
rs1002993194 -- 101,040,828(+) TAATC(A/G)TAGAG nc-transcript-variant, downstream-variant-500B, upstream-variant-2KB
rs1003009472 -- 101,039,870(+) GAACA(C/T)GTGCT downstream-variant-500B, upstream-variant-2KB
rs1005972957 -- 101,040,739(+) CTCAA(A/G)CACAG downstream-variant-500B, upstream-variant-2KB
rs1006274237 -- 101,040,361(+) CTACG(A/G)GACTG downstream-variant-500B, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MIR376B Gene

Variant ID Type Subtype PubMed ID
esv3635521 CNV gain 21293372
nsv1040993 CNV gain 25217958
nsv565859 CNV gain 21841781
nsv565860 CNV gain 21841781

Relevant External Links for MIR376B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR376B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR376B Gene

Disorders for MIR376B Gene

Relevant External Links for MIR376B

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR376B

No disorders were found for MIR376B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR376B Gene

Publications for MIR376B Gene

  1. miR-376b-5p regulates angiogenesis in cerebral ischemia. (PMID: 24789343) Li L.J. … Liu Y.H. (Mol Med Rep 2014) 3 64
  2. miR-376b controls starvation and mTOR inhibition-related autophagy by targeting ATG4C and BECN1. (PMID: 22248718) Korkmaz G. … Gozuacik D. (Autophagy 2012) 3 64
  3. Deep-sequencing of endothelial cells exposed to hypoxia reveals the complexity of known and novel microRNAs. (PMID: 22282338) Voellenkle C. … Martelli F. (RNA 2012) 3 64
  4. Differential microRNA expression in peripheral blood mononuclear cells from Graves' disease patients. (PMID: 22456620) Liu R. … Wang S. (J. Clin. Endocrinol. Metab. 2012) 3 64
  5. miRBase: integrating microRNA annotation and deep-sequencing data. (PMID: 21037258) Kozomara A. … Griffiths-Jones S. (Nucleic Acids Res. 2011) 3 64

Products for MIR376B Gene

Sources for MIR376B Gene

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