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Aliases for MIR375 Gene

Subcategory (RNA class) for MIR375 Gene


Quality Score for this RNA gene is


Aliases for MIR375 Gene

  • MicroRNA 375 2 3
  • MIRN375 3 6
  • Hsa-Mir-375 3
  • MiRNA375 3

External Ids for MIR375 Gene

Previous HGNC Symbols for MIR375 Gene

  • MIRN375

Previous GeneCards Identifiers for MIR375 Gene

  • GC02M219576
  • GC02M219866

Summaries for MIR375 Gene

Entrez Gene Summary for MIR375 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR375 Gene

MIR375 (MicroRNA 375) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR375 include lobular neoplasia and esophageal cancer. Among its related pathways are MicroRNAs in cancer.

fRNAdb sequence ontologies for MIR375 Gene

  • pre_miRNA: The 60-70 nucleotide region remain after Drosha processing of the primary transcript, that folds back upon itself to form a hairpin sructure.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR375 Gene

Genomics for MIR375 Gene

Genomic Location for MIR375 Gene

219,001,628 bp from pter
219,001,739 bp from pter
112 bases
Minus strand

Genomic View for MIR375 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MIR375 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR375 Gene

No data available for Regulatory Elements for MIR375 Gene

Proteins for MIR375 Gene

Post-translational modifications for MIR375 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR375 Gene

Domains for MIR375 Gene

Gene Families for MIR375 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR375: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR375 Gene

Function for MIR375 Gene

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for MIR375 Gene

Localization for MIR375 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR375 Gene

Pathways for MIR375 Gene

SuperPathways for MIR375 Gene

Superpath Contained pathways
1 MicroRNAs in cancer
genes like me logo Genes that share pathways with MIR375: view

Pathways by source for MIR375 Gene

1 KEGG pathway for MIR375 Gene

Interacting Proteins for MIR375 Gene

Gene Ontology (GO) - Biological Process for MIR375 Gene


Transcripts for MIR375 Gene

mRNA/cDNA for MIR375 Gene

(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR375 Gene

No ASD Table

Relevant External Links for MIR375 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MIR375 Gene

No Expression Related Data Available

Primer Products

In Situ Assay Products

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Expression partners for MIR375 Gene

Orthologs for MIR375 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIR375 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia bta-mir-375 36
  • 100 (a)
(Canis familiaris)
Mammalia cfa-mir-375 36
  • 100 (a)
(Monodelphis domestica)
Mammalia mdo-mir-375 36
  • 98 (a)
(Mus musculus)
Mammalia Mir375 36
  • 93 (a)
(Pan troglodytes)
Mammalia ptr-mir-375 36
  • 100 (a)
(Gallus gallus)
Aves gga-mir-375 36
  • 85 (a)
(Anolis carolinensis)
Reptilia aca-mir-375 36
  • 82 (a)
(Danio rerio)
Actinopterygii dre-mir-375-1 36
  • 60 (a)
dre-mir-375-2 36
  • 61 (a)
Species with no ortholog for MIR375:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MIR375 Gene

Gene Tree for MIR375 (if available)
Gene Tree for MIR375 (if available)

Paralogs for MIR375 Gene

No data available for Paralogs for MIR375 Gene

Variants for MIR375 Gene

Structural Variations from Database of Genomic Variants (DGV) for MIR375 Gene

Variant ID Type Subtype PubMed ID
nsv834542 CNV Gain 17160897

Relevant External Links for MIR375 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations from dbSNP and Humsavar for MIR375 Gene

Disorders for MIR375 Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for MIR375 Gene in MalaCards »

(2) Diseases for MIR375 Gene

genes like me logo Genes that share disorders with MIR375: view

No data available for OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for MIR375 Gene

Publications for MIR375 Gene

  1. A pancreatic islet-specific microRNA regulates insulin secretion. (PMID: 15538371) Poy M.N. … Stoffel M. (Nature 2004) 3
  2. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S. … Enright A.J. (Nucleic Acids Res. 2006) 3
  3. A mammalian microRNA expression atlas based on small RNA library sequencing. (PMID: 17604727) Landgraf P. … Tuschl T. (Cell 2007) 3
  4. MicroRNA-375 targets Hippo-signaling effector YAP in liver cancer and inhibits tumor properties. (PMID: 20226166) Liu A.M. … Luk J.M. (Biochem. Biophys. Res. Commun. 2010) 3
  5. Up-regulated pancreatic tissue microRNA-375 associates with human type 2 diabetes through beta-cell deficit and islet amyloid deposition. (PMID: 20467341) Zhao H. … Chan J.C. (Pancreas 2010) 3

Products for MIR375 Gene

Sources for MIR375 Gene

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