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Aliases for MIR375 Gene

Subcategory (RNA class) for MIR375 Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR375 Gene

  • MicroRNA 375 2 3 5
  • Hsa-Mir-375 3
  • MiRNA375 3
  • Mir-375 3
  • MIRN375 3

External Ids for MIR375 Gene

Previous HGNC Symbols for MIR375 Gene

  • MIRN375

Previous GeneCards Identifiers for MIR375 Gene

  • GC02M219576
  • GC02M219866

Summaries for MIR375 Gene

Entrez Gene Summary for MIR375 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR375 Gene

MIR375 (MicroRNA 375) is an RNA Gene, and is affiliated with the miRNA class. Among its related pathways are MicroRNAs in cancer.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR375 Gene

Genomics for MIR375 Gene

Genomic Location for MIR375 Gene

Chromosome:
2
Start:
219,001,628 bp from pter
End:
219,001,739 bp from pter
Size:
112 bases
Orientation:
Minus strand

Genomic View for MIR375 Gene

Genes around MIR375 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR375 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR375 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR375 Gene

No data available for Regulatory Elements for MIR375 Gene

Proteins for MIR375 Gene

Post-translational modifications for MIR375 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR375 Gene

Domains & Families for MIR375 Gene

Gene Families for MIR375 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR375: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR375 Gene

Function for MIR375 Gene

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR375 Gene

Localization for MIR375 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR375 Gene

Pathways & Interactions for MIR375 Gene

SuperPathways for MIR375 Gene

Superpath Contained pathways
1 MicroRNAs in cancer
genes like me logo Genes that share pathways with MIR375: view

Pathways by source for MIR375 Gene

1 KEGG pathway for MIR375 Gene

Interacting Proteins for MIR375 Gene

Gene Ontology (GO) - Biological Process for MIR375 Gene

None

No data available for SIGNOR curated interactions for MIR375 Gene

Drugs & Compounds for MIR375 Gene

No Compound Related Data Available

Transcripts for MIR375 Gene

mRNA/cDNA for MIR375 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR375 Gene

No ASD Table

Relevant External Links for MIR375 Gene

GeneLoc Exon Structure for
MIR375
ECgene alternative splicing isoforms for
MIR375

Expression for MIR375 Gene

No Expression Related Data Available

In Situ Assay Products

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for MIR375 Gene

Orthologs for MIR375 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIR375 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-375 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia bta-mir-375 36
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia cfa-mir-375 36
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mir375 36
  • 93 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia mdo-mir-375 36
  • 98 (a)
OneToOne
chicken
(Gallus gallus)
Aves gga-mir-375 36
  • 85 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia aca-mir-375 36
  • 82 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii dre-mir-375-1 36
  • 60 (a)
OneToMany
dre-mir-375-2 36
  • 61 (a)
OneToMany
Species with no ortholog for MIR375:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MIR375 Gene

ENSEMBL:
Gene Tree for MIR375 (if available)
TreeFam:
Gene Tree for MIR375 (if available)

Paralogs for MIR375 Gene

No data available for Paralogs for MIR375 Gene

Variants for MIR375 Gene

Structural Variations from Database of Genomic Variants (DGV) for MIR375 Gene

Variant ID Type Subtype PubMed ID
nsv834542 CNV Gain 17160897

Relevant External Links for MIR375 Gene

HapMap Linkage Disequilibrium report
MIR375

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations from dbSNP and Humsavar and Variation tolerance for MIR375 Gene

Disorders for MIR375 Gene

Relevant External Links for MIR375

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR375

No disorders were found for MIR375 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR375 Gene

Publications for MIR375 Gene

  1. The combined serum levels of miR-375 and urokinase plasminogen activator receptor are suggested as diagnostic and prognostic biomarkers in prostate cancer. (PMID: 25754273) Wach S. … Taubert H. (Int. J. Cancer 2015) 3
  2. Identification of circulating miR-101, miR-375 and miR-802 as biomarkers for type 2 diabetes. (PMID: 25726255) Higuchi C. … Wada J. (Metab. Clin. Exp. 2015) 3
  3. Epigenetic deregulated miR-375 contributes to the constitutive activation of JAK2/STAT signaling in myeloproliferative neoplasm. (PMID: 25666256) Yin L.H. … Gao S.M. (Leuk. Res. 2015) 3
  4. Combinations of serum prostate-specific antigen and plasma expression levels of let-7c, miR-30c, miR-141, and miR-375 as potential better diagnostic biomarkers for prostate cancer. (PMID: 25521481) Kachakova D. … Kaneva R. (DNA Cell Biol. 2015) 3
  5. Usefulness of microRNAa89375 as a prognostic and therapeutic tool in esophageal squamous cell carcinoma. (PMID: 25501018) Isozaki Y. … Matsubara H. (Int. J. Oncol. 2015) 3

Products for MIR375 Gene

Sources for MIR375 Gene

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