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Aliases for MIR375 Gene

Subcategory (RNA class) for MIR375 Gene

miRNA

Quality Score for this RNA gene is

8

Aliases for MIR375 Gene

  • MicroRNA 375 2 3 5
  • Hsa-Mir-375 3
  • MiRNA375 3
  • Mir-375 3
  • MIRN375 3

External Ids for MIR375 Gene

Previous HGNC Symbols for MIR375 Gene

  • MIRN375

Previous GeneCards Identifiers for MIR375 Gene

  • GC02M219576
  • GC02M219866

Summaries for MIR375 Gene

Entrez Gene Summary for MIR375 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR375 Gene

MIR375 (MicroRNA 375) is an RNA Gene, and is affiliated with the miRNA class. Among its related pathways are Mesodermal Commitment Pathway and Parkinsons Disease Pathway.

fRNAdb sequence ontologies for MIR375 Gene

  • pre_miRNA: The 60-70 nucleotide region remain after Drosha processing of the primary transcript, that folds back upon itself to form a hairpin sructure.

View fRNAdb secondary structures for MIR375

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR375 Gene

Genomics for MIR375 Gene

Regulatory Elements for MIR375 Gene

Enhancers for MIR375 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH02G219121 1.5 Ensembl ENCODE dbSUPER 10.8 -123.4 -123361 7.2 FOXA2 ATF1 ARID4B YBX1 TCF12 FOS SP5 KAT8 SREBF1 MIER3 SLC23A3 NHEJ1 IHH LOC100129175 MIR375 CRYBA2 FEV LINC00608 CNPPD1 RETREG2
GH02G218819 1.6 FANTOM5 ENCODE dbSUPER 9.9 +180.3 180298 4.7 PKNOX1 ATF1 ZFP64 SIN3A KLF13 PAF1 ZNF263 SP3 CAVIN1 NFYC WNT6 PLCD4 RNF25 LOC100129175 MIR375 ZNF142 BCS1L SLC11A1 PNKD GC02P218820
GH02G218829 1.5 FANTOM5 Ensembl ENCODE dbSUPER 9.6 +169.5 169453 5.2 BCOR PKNOX1 FOXA2 JUN ZMYM3 ZNF384 ZIC2 ZFHX2 GATA3 RCOR1 WNT6 PLCD4 RNF25 STK36 LOC100129175 MIR375 PRKAG3 SLC11A1 RPL23AP31
GH02G219110 1.2 ENCODE dbSUPER 11.3 -110.6 -110574 3.0 ELF3 FOXA2 ATF1 MLX ARID4B THRB ZNF48 ZSCAN9 RAD21 RARA IHH LOC100129175 MIR375 CRYBA2 FEV LINC00608 PTPRN NHEJ1 SLC23A3 CDK5R2
GH02G219070 1.2 ENCODE dbSUPER 10.8 -70.7 -70682 4.0 ELF3 FOXA2 MLX ZSCAN9 RAD21 RARA GATA4 ZNF143 CREM MIXL1 NHEJ1 SLC23A3 MIR375 LOC100129175 PTPRN ZFAND2B ENSG00000272644 RN7SL764P
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MIR375 on UCSC Golden Path with GeneCards custom track

Genomic Location for MIR375 Gene

Chromosome:
2
Start:
219,001,645 bp from pter
End:
219,001,708 bp from pter
Size:
64 bases
Orientation:
Minus strand

Genomic View for MIR375 Gene

Genes around MIR375 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR375 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR375 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR375 Gene

ORGUL Member Location for MIR375 Gene

ORGUL Member Location for MIR375 gene

Proteins for MIR375 Gene

Post-translational modifications for MIR375 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR375 Gene

Domains & Families for MIR375 Gene

Gene Families for MIR375 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR375: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR375 Gene

Function for MIR375 Gene

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR375 Gene

Localization for MIR375 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR375 Gene

Pathways & Interactions for MIR375 Gene

genes like me logo Genes that share pathways with MIR375: view

Pathways by source for MIR375 Gene

Interacting Proteins for MIR375 Gene

Gene Ontology (GO) - Biological Process for MIR375 Gene

None

No data available for SIGNOR curated interactions for MIR375 Gene

Drugs & Compounds for MIR375 Gene

No Compound Related Data Available

Transcripts for MIR375 Gene

fRNAdb Secondary structures for MIR375 Gene

  • hsa-miR-375_MIMAT0000728_Homo_sapiens_miR-375_mature

mRNA/cDNA for MIR375 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR375 Gene

No ASD Table

Relevant External Links for MIR375 Gene

GeneLoc Exon Structure for
MIR375
ECgene alternative splicing isoforms for
MIR375

Expression for MIR375 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR375 Gene:

MIR375
No Expression Related Data Available

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR375 Gene

Orthologs for MIR375 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIR375 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia bta-mir-375 35
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia cfa-mir-375 35
  • 100 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-375 35
  • 100 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia mdo-mir-375 35
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mir375 35
  • 93 (a)
OneToOne
chicken
(Gallus gallus)
Aves gga-mir-375 35
  • 85 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia aca-mir-375 35
  • 82 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii dre-mir-375-2 35
  • 61 (a)
OneToMany
dre-mir-375-1 35
  • 60 (a)
OneToMany
Species where no ortholog for MIR375 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MIR375 Gene

ENSEMBL:
Gene Tree for MIR375 (if available)
TreeFam:
Gene Tree for MIR375 (if available)

Paralogs for MIR375 Gene

No data available for Paralogs for MIR375 Gene

Variants for MIR375 Gene

Sequence variations from dbSNP and Humsavar for MIR375 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs1001341512 -- 219,003,577(+) GGGAC(A/T)GGGTG intron-variant, upstream-variant-2KB
rs1003080648 -- 219,001,901(+) ACCCT(C/G)CGCCC upstream-variant-2KB
rs1003403621 -- 219,001,834(+) GCTGA(A/C/T)ACGTC upstream-variant-2KB
rs1003868351 -- 219,003,403(+) TACAC(C/T)ATGGG intron-variant, upstream-variant-2KB
rs1005317333 -- 219,001,874(+) ACCTG(A/G)CCCGC upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MIR375 Gene

Variant ID Type Subtype PubMed ID
nsv584491 CNV loss 21841781
nsv834542 CNV gain 17160897
nsv954839 CNV deletion 24416366

Relevant External Links for MIR375 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR375

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR375 Gene

Disorders for MIR375 Gene

Relevant External Links for MIR375

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR375

No disorders were found for MIR375 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR375 Gene

Publications for MIR375 Gene

  1. A pancreatic islet-specific microRNA regulates insulin secretion. (PMID: 15538371) Poy M.N. … Stoffel M. (Nature 2004) 1 3 64
  2. miR-375 ameliorates sepsis by downregulating miR-21 level via inhibiting JAK2-STAT3 signaling. (PMID: 28006751) Sheng B. … Chen W. (Biomed. Pharmacother. 2017) 3 64
  3. Insulin producing cells generation by overexpression of miR-375 in adipose-derived mesenchymal stem cells from diabetic patients. (PMID: 28017506) Piran M. … Ardeshirylajimi A. (Biologicals 2017) 3 64
  4. miR-375 inhibits cancer stem cell phenotype and tamoxifen resistance by degrading HOXB3 in human ER-positive breast cancer. (PMID: 28075453) Fu H. … Yu J.M. (Oncol. Rep. 2017) 3 64
  5. Evaluation of miR-21 and miR-375 as prognostic biomarkers in oesophageal cancer in high-risk areas in China. (PMID: 27885434) He Y. … Shan B. (Clin. Exp. Metastasis 2017) 3 64

Products for MIR375 Gene

Sources for MIR375 Gene

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