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Aliases for MIR374B Gene

Subcategory (RNA class) for MIR374B Gene


Quality Score for this RNA gene is


Aliases for MIR374B Gene

  • MicroRNA 374b 2 3 5
  • Hsa-Mir-374b 3
  • Mir-374b 3
  • MIRN374B 3

External Ids for MIR374B Gene

Previous HGNC Symbols for MIR374B Gene

  • MIRN374B

Previous GeneCards Identifiers for MIR374B Gene

  • GC0XM073359
  • GC0XM073439
  • GC0XM073440
  • GC0XM073443
  • GC0XM073446
  • GC0XM074219
  • GC0XM074221
  • GC0XM074222
  • GC0XM074223
  • GC0XM074224
  • GC0XM074225

Summaries for MIR374B Gene

Entrez Gene Summary for MIR374B Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR374B Gene

MIR374B (MicroRNA 374b) is an RNA Gene, and is affiliated with the miRNA class. Among its related pathways are miRNAs involved in DNA damage response.

Additional gene information for MIR374B Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR374B Gene

Genomics for MIR374B Gene

Regulatory Elements for MIR374B Gene

Enhancers for MIR374B Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH0XH074240 1.1 Ensembl ENCODE 13.2 -23.8 -23809 3 ELF3 FOXA2 THRB RARA CREM MIXL1 PPARG NFIL3 CEBPA ETV4 MIR374B MIR421 FTX ZCCHC13 MIR374A MIR545 JPX RN7SL648P GC0XP074233
GH0XH074248 1.1 Ensembl ENCODE 13.2 -32.0 -31985 5 HDAC1 ELF3 FOXA2 FEZF1 ZBTB40 TCF12 ZNF121 ZSCAN5C FOS ZEB2 MIR374B MIR421 MIR374A MIR545 FTX JPX GC0XP074249 ENSG00000278421
GH0XH074246 0.6 ENCODE 13.2 -28.6 -28601 1.2 FOSL1 JUND JUN CEBPB FOS CEBPG EP300 MIR374B MIR421 GC0XP074243 GC0XP074249
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MIR374B on UCSC Golden Path with GeneCards custom track

Genomic Locations for MIR374B Gene

Genomic Locations for MIR374B Gene
72 bases
Minus strand

Genomic View for MIR374B Gene

Genes around MIR374B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR374B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR374B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR374B Gene

Proteins for MIR374B Gene

Post-translational modifications for MIR374B Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR374B Gene

Domains & Families for MIR374B Gene

Gene Families for MIR374B Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR374B: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR374B Gene

Function for MIR374B Gene

Animal Model Products

miRNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR374B Gene

Localization for MIR374B Gene

Gene Ontology (GO) - Cellular Components for MIR374B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IDA 26646931
genes like me logo Genes that share ontologies with MIR374B: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for MIR374B Gene

Pathways & Interactions for MIR374B Gene

genes like me logo Genes that share pathways with MIR374B: view

Pathways by source for MIR374B Gene

1 BioSystems pathway for MIR374B Gene

Interacting Proteins for MIR374B Gene

Gene Ontology (GO) - Biological Process for MIR374B Gene


No data available for SIGNOR curated interactions for MIR374B Gene

Drugs & Compounds for MIR374B Gene

No Compound Related Data Available

Transcripts for MIR374B Gene

mRNA/cDNA for MIR374B Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

miRNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR374B Gene

No ASD Table

Relevant External Links for MIR374B Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MIR374B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MIR374B Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR374B Gene:

genes like me logo Genes that share expression patterns with MIR374B: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR374B Gene

Orthologs for MIR374B Gene

This gene was present in the common ancestor of mammals.

Orthologs for MIR374B Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ptr-mir-374b 34
  • 100 (a)
(Canis familiaris)
Mammalia cfa-mir-374b 34
  • 98 (a)
(Bos Taurus)
Mammalia bta-mir-374b 34
  • 73 (a)
(Mus musculus)
Mammalia Mir374 34
  • 71 (a)
Species where no ortholog for MIR374B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MIR374B Gene

Gene Tree for MIR374B (if available)
Gene Tree for MIR374B (if available)

Paralogs for MIR374B Gene

No data available for Paralogs for MIR374B Gene

Variants for MIR374B Gene

Sequence variations from dbSNP and Humsavar for MIR374B Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type
rs1000002777 -- 74,219,524(+) GCCCC(C/T)TGAAA intron-variant, upstream-variant-2KB
rs1000033517 -- 74,218,756(+) TATAG(A/G)GTGCC intron-variant, downstream-variant-500B, upstream-variant-2KB
rs1004138518 -- 74,218,503(+) GCACT(A/G)TCCTT intron-variant, downstream-variant-500B, upstream-variant-2KB
rs1008055857 -- 74,219,346(+) CATAA(G/T)AGAAA intron-variant, upstream-variant-2KB
rs1013069137 -- 74,218,345(+) CGTTG(C/T)TGGCA intron-variant, downstream-variant-500B, upstream-variant-2KB

Relevant External Links for MIR374B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for MIR374B Gene

Disorders for MIR374B Gene

Relevant External Links for MIR374B

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for MIR374B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR374B Gene

Publications for MIR374B Gene

  1. p53/microRNA-374b/AKT1 regulates colorectal cancer cell apoptosis in response to DNA damage. (PMID: 28339062) Gong H … Pan Y (International journal of oncology 2017) 3 60
  2. Association of MicroRNAs and YRNAs With Platelet Function. (PMID: 26646931) Kaudewitz D … Mayr M (Circulation research 2016) 3 60
  3. The potential value of miR-1 and miR-374b as biomarkers for colorectal cancer. (PMID: 26045793) Wu X … Xu Y (International journal of clinical and experimental pathology 2015) 3 60
  4. MicroRNA-374b Suppresses Proliferation and Promotes Apoptosis in T-cell Lymphoblastic Lymphoma by Repressing AKT1 and Wnt-16. (PMID: 26100275) Qian D … Cai Q (Clinical cancer research : an official journal of the American Association for Cancer Research 2015) 3 60
  5. MiR-374b-5p suppresses RECK expression and promotes gastric cancer cell invasion and metastasis. (PMID: 25516656) Xie J … Li GQ (World journal of gastroenterology 2014) 3 60

Products for MIR374B Gene

Sources for MIR374B Gene

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