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Aliases for MIR374A Gene

Subcategory (RNA class) for MIR374A Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR374A Gene

  • MicroRNA 374a 2 3 5
  • MicroRNA 374 2 3
  • Hsa-Mir-374a 3
  • Hsa-Mir-374 3
  • Mir-374a 3
  • MIRN374A 3
  • MIRN374 3

External Ids for MIR374A Gene

Previous HGNC Symbols for MIR374A Gene

  • MIRN374
  • MIRN374A

Previous GeneCards Identifiers for MIR374A Gene

  • GC0XM073427
  • GC0XM073507
  • GC0XM074288
  • GC0XM074290
  • GC0XM074291
  • GC0XM074292

Summaries for MIR374A Gene

Entrez Gene Summary for MIR374A Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR374A Gene

MIR374A (MicroRNA 374a) is an RNA Gene, and is affiliated with the miRNA class.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR374A Gene

Genomics for MIR374A Gene

Regulatory Elements for MIR374A Gene

Enhancers for MIR374A Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH0XF074248 1.1 Ensembl ENCODE 12.9 +36.7 36694 5.1 ELF3 FEZF1 ZBTB40 ZNF121 ZEB2 ZNF843 SMARCA4 CEBPA GLIS1 KDM1A MIR374B MIR421 MIR374A MIR545 FTX JPX ENSG00000271430 GC0XP074249 ENSG00000278421
GH0XF074240 1.1 Ensembl ENCODE 12.1 +44.9 44931 3.0 ELF3 THRB RARA CREM MIXL1 ZNF263 PPARG CEBPA ETV4 SOX13 MIR421 MIR374B FTX ZCCHC13 MIR545 MIR374A JPX RN7SL648P ENSG00000271430
GH0XF074550 0.9 ENCODE 11.7 -263.1 -263104 0.2 INSM2 ZNF76 KLF17 ZNF2 RAD21 GTF3C2 ZNF121 ZNF143 ZNF391 CREM RAB11FIP1P1 ENSG00000271430 RN7SL648P FTX MIR374A MIR545 PIR45746 PIR50185
GH0XF074262 0.5 ENCODE 13.7 +24.5 24452 1.5 JUND GLIS1 POU5F1 ZBTB40 MIR374A MIR545 FTX ENSG00000278421 GC0XP074249
GH0XF074259 0.4 ENCODE 13.7 +27.1 27112 1.4 MAX POU5F1 MIR374A MIR545 FTX JPX ENSG00000271430 ENSG00000278421 GC0XP074249
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MIR374A on UCSC Golden Path with GeneCards custom track

Genomic Location for MIR374A Gene

Chromosome:
X
Start:
74,287,286 bp from pter
End:
74,287,357 bp from pter
Size:
72 bases
Orientation:
Minus strand

Genomic View for MIR374A Gene

Genes around MIR374A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR374A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR374A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR374A Gene

Proteins for MIR374A Gene

Post-translational modifications for MIR374A Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR374A Gene

Domains & Families for MIR374A Gene

Gene Families for MIR374A Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR374A: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR374A Gene

Function for MIR374A Gene

Animal Model Products

miRNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR374A Gene

Localization for MIR374A Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR374A Gene

Pathways & Interactions for MIR374A Gene

SuperPathways for MIR374A Gene

No Data Available

Interacting Proteins for MIR374A Gene

Gene Ontology (GO) - Biological Process for MIR374A Gene

None

No data available for Pathways by source and SIGNOR curated interactions for MIR374A Gene

Transcripts for MIR374A Gene

mRNA/cDNA for MIR374A Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

miRNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR374A Gene

No ASD Table

Relevant External Links for MIR374A Gene

GeneLoc Exon Structure for
MIR374A
ECgene alternative splicing isoforms for
MIR374A

Expression for MIR374A Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR374A Gene:

MIR374A
No Expression Related Data Available

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for MIR374A Gene

Orthologs for MIR374A Gene

This gene was present in the common ancestor of mammals.

Orthologs for MIR374A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-374a 35
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia bta-mir-374a 35
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia cfa-mir-374a 35
  • 94 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mir374 35
  • 58 (a)
OneToMany
Species where no ortholog for MIR374A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MIR374A Gene

ENSEMBL:
Gene Tree for MIR374A (if available)
TreeFam:
Gene Tree for MIR374A (if available)

Paralogs for MIR374A Gene

No data available for Paralogs for MIR374A Gene

Variants for MIR374A Gene

Sequence variations from dbSNP and Humsavar for MIR374A Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type
rs112129167 -- 74,289,021(+) TGAAT(A/G)ATTCA intron-variant, upstream-variant-2KB
rs139107933 -- 74,289,001(+) AATAA(C/T)ATTCA intron-variant, upstream-variant-2KB
rs141329807 -- 74,286,870(+) TACTA(A/T)TTGGA intron-variant, downstream-variant-500B
rs174145 -- 74,288,955(+) ATATT(A/G)CTGGG intron-variant, upstream-variant-2KB
rs180707472 -- 74,288,830(+) AAAAA(C/T)AAAAA intron-variant, upstream-variant-2KB

Relevant External Links for MIR374A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR374A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for MIR374A Gene

Disorders for MIR374A Gene

Relevant External Links for MIR374A

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR374A

No disorders were found for MIR374A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR374A Gene

Publications for MIR374A Gene

  1. MiR-130a and MiR-374a Function as Novel Regulators of Cisplatin Resistance in Human Ovarian Cancer A2780 Cells. (PMID: 26043084) Li N. … Xu P. (PLoS ONE 2015) 3 64
  2. MicroRNA-374a promotes esophageal cancer cell proliferation via Axin2 suppression. (PMID: 26252180) Wang Y. … Yu H. (Oncol. Rep. 2015) 3 64
  3. Increased miR-374b promotes cell proliferation and the production of aberrant glycosylated IgA1 in B cells of IgA nephropathy. (PMID: 26545495) Hu S. … Liu Z. (FEBS Lett. 2015) 3 64
  4. MiR-374a promotes the proliferation of osteosarcoma cell proliferation by targeting Axin2. (PMID: 26617789) Lu T. … Jia J.L. (Int J Clin Exp Pathol 2015) 3 64
  5. Downregulation of Umbilical Cord Blood Levels of miR-374a in Neonatal Hypoxic Ischemic Encephalopathy. (PMID: 26001314) Looney A.M. … Murray D.M. (J. Pediatr. 2015) 3 64

Products for MIR374A Gene

Sources for MIR374A Gene

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