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Aliases for MIR374A Gene

Subcategory (RNA class) for MIR374A Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR374A Gene

  • MicroRNA 374a 2 3
  • MicroRNA 374 2 3
  • Hsa-Mir-374a 3
  • Hsa-Mir-374 3
  • Mir-374a 3
  • MIRN374A 3
  • MIRN374 3

External Ids for MIR374A Gene

Previous HGNC Symbols for MIR374A Gene

  • MIRN374
  • MIRN374A

Previous GeneCards Identifiers for MIR374A Gene

  • GC0XM073427
  • GC0XM073507
  • GC0XM074288

Summaries for MIR374A Gene

Entrez Gene Summary for MIR374A Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR374A Gene

MIR374A (MicroRNA 374a) is an RNA Gene, and is affiliated with the miRNA class.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR374A Gene

Genomics for MIR374A Gene

Genomic Location for MIR374A Gene

Chromosome:
X
Start:
74,287,276 bp from pter
End:
74,287,386 bp from pter
Size:
111 bases
Orientation:
Minus strand

Genomic View for MIR374A Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MIR374A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR374A Gene

No data available for Regulatory Elements for MIR374A Gene

Proteins for MIR374A Gene

Post-translational modifications for MIR374A Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR374A Gene

Domains & Families for MIR374A Gene

Gene Families for MIR374A Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR374A: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR374A Gene

Function for MIR374A Gene

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR374A Gene

Localization for MIR374A Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR374A Gene

Pathways & Interactions for MIR374A Gene

SuperPathways for MIR374A Gene

No Data Available

Interacting Proteins for MIR374A Gene

Gene Ontology (GO) - Biological Process for MIR374A Gene

None

No data available for Pathways by source and SIGNOR curated interactions for MIR374A Gene

Drugs & Compounds for MIR374A Gene

No Compound Related Data Available

Transcripts for MIR374A Gene

mRNA/cDNA for MIR374A Gene

(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR374A Gene

No ASD Table

Relevant External Links for MIR374A Gene

GeneLoc Exon Structure for
MIR374A
ECgene alternative splicing isoforms for
MIR374A

Expression for MIR374A Gene

No Expression Related Data Available

Primer Products

In Situ Assay Products

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for MIR374A Gene

Orthologs for MIR374A Gene

This gene was present in the common ancestor of mammals.

Orthologs for MIR374A Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia bta-mir-374a 36
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia cfa-mir-374a 36
  • 94 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mir374 36
  • 58 (a)
OneToMany
chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-374a 36
  • 100 (a)
OneToOne
Species with no ortholog for MIR374A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MIR374A Gene

ENSEMBL:
Gene Tree for MIR374A (if available)
TreeFam:
Gene Tree for MIR374A (if available)

Paralogs for MIR374A Gene

No data available for Paralogs for MIR374A Gene

Variants for MIR374A Gene

Relevant External Links for MIR374A Gene

HapMap Linkage Disequilibrium report
MIR374A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations from dbSNP and Humsavar , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for MIR374A Gene

Disorders for MIR374A Gene

Relevant External Links for MIR374A

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR374A
genes like me logo Genes that share disorders with MIR374A: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR374A Gene

Publications for MIR374A Gene

  1. miR-374a promotes cell proliferation, migration and invasion by targeting SRCIN1 in gastric cancer. (PMID: 25554419) Xu X. … Sun Y. (FEBS Lett. 2015) 67
  2. Axl-altered microRNAs regulate tumorigenicity and gefitinib resistance in lung cancer. (PMID: 24832599) Wang Y. … Cai H. (Cell Death Dis 2014) 67
  3. Mechanical stress induces pre-B-cell colony-enhancing factor/NAMPT expression via epigenetic regulation by miR-374a and miR-568 in human lung endothelium. (PMID: 24053186) Adyshev D.M. … Garcia J.G. (Am. J. Respir. Cell Mol. Biol. 2014) 67
  4. Effects of differential distribution of microvessel density, possibly regulated by miR-374a, on breast cancer prognosis. (PMID: 23679262) Li J.Y. … Tian R. (Asian Pac. J. Cancer Prev. 2013) 67
  5. Integrated microRNA and mRNA signatures associated with survival in triple negative breast cancer. (PMID: 23405235) Cascione L. … Huebner K. (PLoS ONE 2013) 67

Products for MIR374A Gene

Sources for MIR374A Gene

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