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microRNA 373
(Previous symbol: MIRN373)
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Aliases
for MIR373 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
Subcategory (RNA class): miRNA
Quality score for this RNA gene is 13
| Aliases |
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| MicroRNA 3731 2 | | MIRN3731 2 5 | | Hsa-Mir-3731 | | MiRNA3731 | | Mir-3731 |
| External Ids: | HGNC: 317871 | Entrez Gene: 4429182 | Ensembl: ENSG000001991437 | OMIM: 6119545 |
Export aliases for MIR373 gene to outside databasesPrevious GC identifers: GC19P058993 GC19P059032 GC19P054294 GC19P054306 GC19P054331
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Summaries
for MIR373 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
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Entrez Gene summary for MIR373:
microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of geneexpression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribedby RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be eitherprotein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce anapproximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicerribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporatedinto a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with themiRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeqrepresents the predicted microRNA stem-loop. (provided by RefSeq, Sep 2009)
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Genomic Views
for MIR373 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| Regulatory elements:
 Search SABiosciences Regulatory transcription factor binding sites for MIR373
Other transcription factors
Search SABiosciences Chromatin IP Primers for MIR373
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MIR373 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 19q13.42 Ensembl cytogenetic band: 19q13.42 HGNC cytogenetic band: 19q13.42MIR373 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 19 GeneLoc Exon Structure GeneLoc location for GC19P054353: view genomic region (via miRBase)
(about GC identifiers)
Start:
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54,291,959 bp from pter |
End:
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54,292,027 bp from pter |
Size:
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69 bases |
Orientation:
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plus strand |
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Proteins
for MIR373 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
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UniProtKB: --
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Protein
Domains /
Families
for MIR373 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| -- |
Function
for MIR373 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
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miRNA
Products: | | miRTarBase genes targeted by MIR373:
XPA(MIRT003918), C2orf18(MIRT002498), KIF23(MIRT002495), TXNIP(MIRT005561), CENPF(MIRT002525), C13orf27(MIRT003943), CSDC2(MIRT001931), PDIK1L(MIRT003816), RELA(MIRT002531), GLTP(MIRT002530), PHC2(MIRT002500), CD44(MIRT002428), GBAS(MIRT002496), TMEM14A(MIRT002540), ZHX1(MIRT002558), TFAP4(MIRT002538), FAM13B(MIRT004468), UBXN1(MIRT003817), ADAM9(MIRT002555), TMEM9B(MIRT003846), FYCO1(MIRT002515), RPIA(MIRT002559), RAD23B(MIRT000056), TBC1D2(MIRT002537), USP12(MIRT002534), KLHL12(MIRT002506), MICA(MIRT002551), RNF149(MIRT002520), VEGFA(MIRT000721), CDK19(MIRT003832), MRE11A(MIRT003919), MKRN1(MIRT002511), TNFAIP1(MIRT002521), MARCH4(MIRT004073), LUC7L2(MIRT002509), RECK(MIRT000606), ARHGEF3(MIRT002512), CFL2(MIRT002526), BAZ1A(MIRT002533), ANKRD13B(MIRT003948), RABEP1(MIRT005562), LMNB1(MIRT002510), C9orf78(MIRT002548), CMTM4(MIRT003843), STK4(MIRT002541), LATS2(MIRT001754), TTC8(MIRT002556), CD24(MIRT002501), HERPUD1(MIRT002508), TUSC2(MIRT002528), RAD52(MIRT003914), PRC1(MIRT002532), CYB5R4(MIRT004438), PBK(MIRT004449), PACRGL(MIRT003942), GPSM2(MIRT002524), C12orf23(MIRT003944), SEPT2(MIRT004515), CNOT6(MIRT004074), PCGF5(MIRT003815), VPS26A(MIRT004448), CD83(MIRT002516), NUPL1(MIRT002504) |
| |  | Browse 3'-UTR reporter clones for miRNA target validation
Browse MicroRNA Expression Plasmids
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MIR373 | | | Search QIAGEN for miScript miRNA Assays for microRNAs that regulate MIR373 | |  | Browse SwitchGear 3'UTR luciferase reporter plasmids |
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Pathways & Interactions
for MIR373 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
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Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for MIR373
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Drugs & Compounds
for MIR373 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
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 Browse Tocris compounds for MIR373
Search CenterWatch for drugs/clinical trials and news about MIR373 
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Transcripts
for MIR373 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
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1 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000362273(miRNA)
GeneLoc Exon Structure
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Expression
for MIR373 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| Expression evidence for MIR373:none
MIR373 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image SABiosciences Custom PCR Arrays for MIR373
Primer
Products: | | Browse OriGene genome-wide validated SYBR primer pairs
Browse OriGene validated miRNA SYBR primer pairs
| | | Search SABiosciences RT2 qPCR
Primer Assays in human, mouse, rat MIR373 | | | Search QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MIR373 | | | Search QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MIR373 |
Orthologs
for MIR373 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
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ENSEMBL Gene Tree for MIR373 (if available)
TreeFam Gene Tree for MIR373 (if available) |
Paralogs
for MIR373 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for MIR373 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
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| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 19 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
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HapMap Linkage Disequilibrium report for MIR373 (54291959 - 54292027 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for MIR373: -- | SABiosciences Cancer Mutation PCR Assays |
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Disorders
/ Diseases
for MIR373 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
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MIR373 for disorders About GeneDecksing
OMIM gene information: 611954
OMIM disorders: --
9  diseases for MIR373: About MalaCardstesticular germ cell tumor germ cell tumor renal cell carcinoma hepatitis b
esophageal cancer esophagitis cholangiocarcinoma hepatitis
carcinoma
Human Genome Epidemiology (HuGE) Navigator: MIR373 (3 documents)
Export disorders for MIR373 gene to outside databases
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Publications
for MIR373 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for MIR373 gene, integrated from 9 sources (see all 16):
(articles sorted by number of sources associating them with MIR373) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Mutual regulation between microRNA-373 and methyl-CpG- binding domain protein 2 in hilar cholangiocarcinoma. (PubMed id 22876037)1 Chen Y.J....Zou S.Q. (2012)
- Epigenetic repression of E-cadherin expression by hepa titis B virus x antigen in liver cancer. (PubMed id 21706058)1 Arzumanyan A....Feitelson M.A. (2012)
- MicroRNA-520/373 family functions as a tumor suppresso r in estrogen receptor negative breast cancer by targeting NF-kB and TGF-b signa ling pathways. (PubMed id 22158050)1 Keklikoglou I....Tschulena U. (2012)
- miR-373 negatively regulates methyl-CpG-binding domai n protein 2 (MBD2) in hilar cholangiocarcinoma. (PubMed id 21086164)1 Chen Y....Zou S. (2011)
- MicroRNAs-372/373 promote the expression of hepatitis B virus through the targeting of nuclear factor I/B. (PubMed id 21608007)1 Guo H....Cheng J. (2011)
- Methyl-CpG binding protein MBD2 is implicated in meth ylation-mediated suppression of miR-373 in hilar cholangiocarcinoma. (PubMed id 21165562)1 Chen Y....Zou S. (2011)
- MicroRNA-373, a new regulator of protein phosphatase 6 , functions as an oncogene in hepatocellular carcinoma. (PubMed id 21481188)1 Wu N....Tang H. (2011)
- Genetic variation in MicroRNA genes and risk of oral premalignant lesions. (PubMed id 19851984)1 Clague J....Wu X. (2010)
- Genetic variations in microRNA-related genes are asso ciated with survival and recurrence in patients with renal cell carcinoma. (PubMed id 20732906)1 Lin J....Wu X. (2010)
- MicroRNA-373 (miR-373) post-transcriptionally regulat es large tumor suppressor, homolog 2 (LATS2) and stimulates proliferation in hu man esophageal cancer. (PubMed id 19501585)1 Lee K.H....Lu P.J. (2009)
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External Searches for MIR373 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
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Genome Databases showing MIR373 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
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Other Databases showing MIR373 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing MIR373 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for MIR373 | Pharmacogenomics, SNPs, Pathways |
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About This Section
| Patent Information for MIR373 gene:
Search GeneIP for patents involving MIR373
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Products
for MIR373 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
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|  | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat MIR373 | | | Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MIR373 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MIR373 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MIR373 | | | Search QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MIR373 | | | Search QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MIR373 |
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| | | | Search Tocris compounds for MIR373 |
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 | | | | |  |  |  | | | | Search ThermoFisher Antibodies for MIR373 |
| | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat MIR373 |
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GeneCards Homepage -
Last full update: 19 Mar 2013 -
Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013
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