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Aliases for MIR373 Gene

Subcategory (RNA class) for MIR373 Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR373 Gene

  • MicroRNA 373 2 3
  • MIRN373 3 6
  • Hsa-Mir-373 3
  • MiRNA373 3

External Ids for MIR373 Gene

ORGUL Members for MIR373 Gene

Previous HGNC Symbols for MIR373 Gene

  • MIRN373

Previous GeneCards Identifiers for MIR373 Gene

  • GC19P058993
  • GC19P059032
  • GC19P054294
  • GC19P054306
  • GC19P054331
  • GC19P054353
  • GC19P054430
  • GC19P054508

Summaries for MIR373 Gene

Entrez Gene Summary for MIR373 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR373 Gene

MIR373 (MicroRNA 373) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR373 include testicular germ cell tumor and esophageal cancer. Among its related pathways are MicroRNAs in cancer and miRNAs involved in DDR.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR373 Gene

Genomics for MIR373 Gene

Genomic Location for MIR373 Gene

Start:
53,788,705 bp from pter
End:
53,788,773 bp from pter
Size:
69 bases
Orientation:
Plus strand

Genomic View for MIR373 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MIR373 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR373 Gene

No data available for Regulatory Elements for MIR373 Gene

Proteins for MIR373 Gene

Post-translational modifications for MIR373 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR373 Gene

Domains for MIR373 Gene

Gene Families for MIR373 Gene

HGNC:
  • MIR :ncRNAs / Micro RNAs

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR373: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR373 Gene

Function for MIR373 Gene

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for MIR373 Gene

Localization for MIR373 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR373 Gene

Pathways for MIR373 Gene

genes like me logo Genes that share pathways with MIR373: view

Pathways by source for MIR373 Gene

1 BioSystems pathway for MIR373 Gene
1 KEGG pathway for MIR373 Gene

Interacting Proteins for MIR373 Gene

Gene Ontology (GO) - Biological Process for MIR373 Gene

None

Transcripts for MIR373 Gene

mRNA/cDNA for MIR373 Gene

(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR373 Gene

No ASD Table

Relevant External Links for MIR373 Gene

GeneLoc Exon Structure for
MIR373
ECgene alternative splicing isoforms for
MIR373

Expression for MIR373 Gene

mRNA expression in normal human tissues for MIR373 Gene

genes like me logo Genes that share expressions with MIR373: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Expression partners for MIR373 Gene

Orthologs for MIR373 Gene

Evolution for MIR373 Gene

ENSEMBL:
Gene Tree for MIR373 (if available)
TreeFam:
Gene Tree for MIR373 (if available)

No data available for Orthologs for MIR373 Gene

Paralogs for MIR373 Gene

No data available for Paralogs for MIR373 Gene

Variants for MIR373 Gene

Structural Variations from Database of Genomic Variants (DGV) for MIR373 Gene

Variant ID Type Subtype PubMed ID
esv2718812 CNV Deletion 23290073
dgv3999n71 CNV Gain 21882294
nsv458781 CNV Gain 19166990

Relevant External Links for MIR373 Gene

HapMap Linkage Disequilibrium report
MIR373

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations from dbSNP and Humsavar for MIR373 Gene

Disorders for MIR373 Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for MIR373 Gene in MalaCards »

(2) Diseases for MIR373 Gene including...

Relevant External Links for MIR373

Genetic Association Database (GAD)
MIR373
Human Genome Epidemiology (HuGE) Navigator
MIR373
genes like me logo Genes that share disorders with MIR373: view

No data available for OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for MIR373 Gene

Publications for MIR373 Gene

  1. Genetic variation in MicroRNA genes and risk of oral premalignant lesions. (PMID: 19851984) Clague J. … Wu X. (Mol. Carcinog. 2010) 3 48
  2. Genetic variations in microRNA-related genes are associated with survival and recurrence in patients with renal cell carcinoma. (PMID: 20732906) Lin J. … Wu X. (Carcinogenesis 2010) 3 48
  3. Genetic variations in microRNA-related genes are novel susceptibility loci for esophageal cancer risk. (PMID: 19138993) Ye Y. … Wu X. (Cancer Prev Res (Phila) 2008) 3 48
  4. MicroRNA-373 (miR-373) post-transcriptionally regulates large tumor suppressor, homolog 2 (LATS2) and stimulates proliferation in human esophageal cancer. (PMID: 19501585) Lee K.H. … Lu P.J. (Exp. Cell Res. 2009) 3
  5. Human embryonic stem cells express a unique set of microRNAs. (PMID: 15183728) Suh M.R. … Kim K.S. (Dev. Biol. 2004) 3

Products for MIR373 Gene

Sources for MIR373 Gene

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