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Aliases for MIR372 Gene

Subcategory (RNA class) for MIR372 Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR372 Gene

  • MicroRNA 372 2 3 5
  • Hsa-Mir-372 3
  • MIRN372 3

External Ids for MIR372 Gene

ORGUL Members for MIR372 Gene

Previous HGNC Symbols for MIR372 Gene

  • MIRN372

Previous GeneCards Identifiers for MIR372 Gene

  • GC19P058992
  • GC19P059031
  • GC19P054291
  • GC19P053789
  • GC19P053810
  • GC19P053841
  • GC19P053862

Summaries for MIR372 Gene

Entrez Gene Summary for MIR372 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR372 Gene

MIR372 (MicroRNA 372) is an RNA Gene, and is affiliated with the miRNA class. Among its related pathways are miRNAs involved in DDR.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR372 Gene

Genomics for MIR372 Gene

Genomic Location for MIR372 Gene

Chromosome:
19
Start:
53,787,890 bp from pter
End:
53,787,956 bp from pter
Size:
67 bases
Orientation:
Plus strand

Genomic View for MIR372 Gene

Genes around MIR372 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR372 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR372 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR372 Gene

No data available for Regulatory Elements for MIR372 Gene

Proteins for MIR372 Gene

Post-translational modifications for MIR372 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR372 Gene

Domains & Families for MIR372 Gene

Gene Families for MIR372 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR372: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR372 Gene

Function for MIR372 Gene

Animal Model Products

miRNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR372 Gene

Localization for MIR372 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR372 Gene

Pathways & Interactions for MIR372 Gene

SuperPathways for MIR372 Gene

SuperPathway Contained pathways
1 miRNAs involved in DDR
genes like me logo Genes that share pathways with MIR372: view

Pathways by source for MIR372 Gene

1 BioSystems pathway for MIR372 Gene

Interacting Proteins for MIR372 Gene

Gene Ontology (GO) - Biological Process for MIR372 Gene

None

No data available for SIGNOR curated interactions for MIR372 Gene

Transcripts for MIR372 Gene

mRNA/cDNA for MIR372 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR372 Gene

No ASD Table

Relevant External Links for MIR372 Gene

GeneLoc Exon Structure for
MIR372
ECgene alternative splicing isoforms for
MIR372

Expression for MIR372 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR372 Gene:

MIR372
No Expression Related Data Available

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for MIR372 Gene

Orthologs for MIR372 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIR372 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-372 35
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mir291a 35
  • 54 (a)
ManyToMany
chicken
(Gallus gallus)
Aves gga-mir-219b 35
  • 31 (a)
OneToMany
Species where no ortholog for MIR372 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MIR372 Gene

ENSEMBL:
Gene Tree for MIR372 (if available)
TreeFam:
Gene Tree for MIR372 (if available)

Paralogs for MIR372 Gene

No data available for Paralogs for MIR372 Gene

Variants for MIR372 Gene

Sequence variations from dbSNP and Humsavar for MIR372 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs11084295 -- 53,786,224(+) accac(A/G)ccgag upstream-variant-2KB
rs11084296 -- 53,787,231(+) TTTTT(A/G)GGAGA downstream-variant-500B, upstream-variant-2KB
rs11084297 -- 53,787,405(+) CGAAG(G/T)CCCCA downstream-variant-500B, upstream-variant-2KB
rs111707564 -- 53,787,614(+) AAAAG(C/T)CTCTT downstream-variant-500B, upstream-variant-2KB
rs112811521 -- 53,786,062(+) TTTTT(A/T)AAAAT upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MIR372 Gene

Variant ID Type Subtype PubMed ID
esv2718812 CNV deletion 23290073
nsv1058969 CNV gain 25217958
nsv1064558 CNV gain 25217958
nsv458781 CNV gain 19166990
nsv580108 CNV gain 21841781

Relevant External Links for MIR372 Gene

Human Gene Mutation Database (HGMD)
MIR372
SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR372

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR372 Gene

Disorders for MIR372 Gene

Relevant External Links for MIR372

Human Genome Epidemiology (HuGE) Navigator
MIR372
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR372

No disorders were found for MIR372 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR372 Gene

Publications for MIR372 Gene

  1. Serum miR-372 is a Diagnostic and Prognostic Biomarker in Patients with Early Colorectal Cancer. (PMID: 26179262) Yu J. … Zhu X. (Anticancer Agents Med Chem 2016) 3 64
  2. A pipeline to quantify serum and cerebrospinal fluid microRNAs for diagnosis and detection of relapse in paediatric malignant germ-cell tumours. (PMID: 26671749) Murray M.J. … Coleman N. (Br. J. Cancer 2016) 3 64
  3. miR-372 regulates glioma cell proliferation and invasion by directly targeting PHLPP2. (PMID: 25160587) Chen X. … Liu J. (J. Cell. Biochem. 2015) 3 64
  4. Low mir-372 expression correlates with poor prognosis and tumor metastasis in hepatocellular carcinoma. (PMID: 25880458) Wu G. … Liu B. (BMC Cancer 2015) 3 64
  5. miR-372 suppresses tumour proliferation and invasion by targeting IGF2BP1 in renal cell carcinoma. (PMID: 26332146) Huang X. … Li Y. (Cell Prolif. 2015) 3 64

Products for MIR372 Gene

Sources for MIR372 Gene

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