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Aliases for MIR3714 Gene

Subcategory (RNA class) for MIR3714 Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR3714 Gene

  • MicroRNA 3714 2 3
  • PLCL2 4 5
  • Phospholipase C-Epsilon-2 4
  • Phospholipase C Like 2 5
  • Phospholipase C-L2 4
  • PLC-Epsilon-2 4
  • Hsa-Mir-3714 3
  • EC 3.1.4.11 61
  • KIAA1092 4
  • PLC-L(2) 4
  • PLC-L2 4
  • PLCE2 4

External Ids for MIR3714 Gene

Previous GeneCards Identifiers for MIR3714 Gene

  • GC03U901705
  • GC03P016976

Summaries for MIR3714 Gene

Entrez Gene Summary for MIR3714 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR3714 Gene

MIR3714 (MicroRNA 3714) is an RNA Gene, and is affiliated with the miRNA class. An important paralog of this gene is PLCL1.

UniProtKB/Swiss-Prot for MIR3714 Gene

  • May play an role in the regulation of Ins(1,4,5)P3 around the endoplasmic reticulum.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR3714 Gene

Genomics for MIR3714 Gene

Regulatory Elements for MIR3714 Gene

Enhancers for MIR3714 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH03F016823 0.8 Ensembl ENCODE 12.4 +21.7 21732 1.2 IKZF1 PLCL2 MIR3714 LOC105376972
GH03F016828 1 Ensembl ENCODE 11.5 +26.4 26350 0.4 CTCF ZNF654 ESRRA SMC3 TRIM22 ZNF384 RAD21 PLCL2 MIR3714 LOC105376972
GH03F016769 0.2 ENCODE 11.1 -32.8 -32807 0.6 MIR3714 PLCL2 GC03M016771 LOC105377641
GH03F016770 1.1 ENCODE 11.1 -33.5 -33503 0.2 SCRT1 SCRT2 TEAD4 MIR3714 PLCL2 GC03M016771 LOC105377641
GH03F016768 0.4 Ensembl 11.1 -34.2 -34151 0.6 CEBPB CEBPG SPI1 MIR3714 PLCL2 GC03M016771 LOC105377641
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around MIR3714 on UCSC Golden Path with GeneCards custom track

Genomic Location for MIR3714 Gene

Chromosome:
3
Start:
16,802,651 bp from pter
End:
17,090,594 bp from pter
Size:
287,944 bases
Orientation:
Plus strand

Genomic View for MIR3714 Gene

Genes around MIR3714 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR3714 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR3714 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR3714 Gene

Proteins for MIR3714 Gene

  • Protein details for MIR3714 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UPR0-PLCL2_HUMAN
    Recommended name:
    Inactive phospholipase C-like protein 2
    Protein Accession:
    Q9UPR0
    Secondary Accessions:
    • A8K5V4
    • Q8N498
    • Q9H8L0
    • Q9UFP9

    Protein attributes for MIR3714 Gene

    Size:
    1127 amino acids
    Molecular mass:
    125866 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAA83044.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAB14606.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for MIR3714 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MIR3714 Gene

Selected DME Specific Peptides for MIR3714 Gene

Post-translational modifications for MIR3714 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MIR3714 Gene

Domains & Families for MIR3714 Gene

Gene Families for MIR3714 Gene

Graphical View of Domain Structure for InterPro Entry

Q9UPR0

UniProtKB/Swiss-Prot:

PLCL2_HUMAN :
  • Contains 1 C2 domain.
Domain:
  • Contains 1 C2 domain.
  • Contains 1 PH domain.
  • Contains 1 PI-PLC X-box domain.
  • Contains 1 PI-PLC Y-box domain.
genes like me logo Genes that share domains with MIR3714: view

No data available for Suggested Antigen Peptide Sequences for MIR3714 Gene

Function for MIR3714 Gene

Molecular function for MIR3714 Gene

UniProtKB/Swiss-Prot Function:
May play an role in the regulation of Ins(1,4,5)P3 around the endoplasmic reticulum.

Enzyme Numbers (IUBMB) for MIR3714 Gene

Gene Ontology (GO) - Molecular Function for MIR3714 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004435 phosphatidylinositol phospholipase C activity IEA --
GO:0004871 signal transducer activity IEA --
GO:0008081 phosphoric diester hydrolase activity IEA --
GO:0016787 hydrolase activity IEA --
GO:0050811 GABA receptor binding IDA --
genes like me logo Genes that share ontologies with MIR3714: view

Animal Model Products

miRNA Products

Clone Products

Flow Cytometry Products

No data available for Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR3714 Gene

Localization for MIR3714 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MIR3714 Gene

Cytoplasm. Note=Predominantly localized to perinuclear areas in both myoblast and myotube C2C12 cells. {ECO:0000250}.

Gene Ontology (GO) - Cellular Components for MIR3714 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with MIR3714: view

No data available for Subcellular locations from COMPARTMENTS for MIR3714 Gene

Pathways & Interactions for MIR3714 Gene

SuperPathways for MIR3714 Gene

No Data Available

Interacting Proteins for MIR3714 Gene

Gene Ontology (GO) - Biological Process for MIR3714 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002337 B-1a B cell differentiation IEA --
GO:0006629 lipid metabolic process IEA --
GO:0007165 signal transduction IEA --
GO:0007214 gamma-aminobutyric acid signaling pathway IEA --
GO:0016042 lipid catabolic process IEA --
genes like me logo Genes that share ontologies with MIR3714: view

No data available for Pathways by source and SIGNOR curated interactions for MIR3714 Gene

Transcripts for MIR3714 Gene

mRNA/cDNA for MIR3714 Gene

(5) Ensembl transcripts including schematic representations, and UCSC links where relevant :

miRNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR3714 Gene

No ASD Table

Relevant External Links for MIR3714 Gene

GeneLoc Exon Structure for
MIR3714
ECgene alternative splicing isoforms for
MIR3714

Expression for MIR3714 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR3714 Gene:

MIR3714
No Expression Related Data Available

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for MIR3714 Gene

Orthologs for MIR3714 Gene

This gene was present in the common ancestor of animals.

Orthologs for MIR3714 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PLCL2 35
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PLCL2 35
  • 99 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PLCL2 35
  • 93 (a)
OneToOne
cow
(Bos Taurus)
Mammalia PLCL2 35
  • 88 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Plcl2 35
  • 87 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia PLCL2 35
  • 84 (a)
OneToOne
chicken
(Gallus gallus)
Aves PLCL2 35
  • 82 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PLCL2 35
  • 81 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii PLCL2 35
  • 73 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea pll-1 35
  • 38 (a)
ManyToMany
plc-4 35
  • 32 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 43 (a)
OneToMany
Species where no ortholog for MIR3714 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for MIR3714 Gene

ENSEMBL:
Gene Tree for MIR3714 (if available)
TreeFam:
Gene Tree for MIR3714 (if available)

Paralogs for MIR3714 Gene

Paralogs for MIR3714 Gene

genes like me logo Genes that share paralogs with MIR3714: view

Variants for MIR3714 Gene

Sequence variations from dbSNP and Humsavar for MIR3714 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs114296282 -- 16,931,788(+) TGAAA(C/G)CATCT intron-variant, upstream-variant-2KB
rs114744207 -- 16,932,371(+) TTTTC(C/T)TAAGA intron-variant, upstream-variant-2KB
rs114765352 -- 16,931,599(+) AAATA(C/T)TATTT intron-variant, upstream-variant-2KB
rs114831313 -- 16,931,613(+) GAGAA(A/C)ATGCA intron-variant, upstream-variant-2KB
rs114970586 -- 16,932,144(+) AATTC(A/G)TTATG intron-variant, upstream-variant-2KB

Relevant External Links for MIR3714 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR3714

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for MIR3714 Gene

Disorders for MIR3714 Gene

Relevant External Links for MIR3714

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR3714

No disorders were found for MIR3714 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR3714 Gene

Publications for MIR3714 Gene

  1. An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. (PMID: 24275569) Bian Y. … Zou H. (J. Proteomics 2014) 4 64
  2. Toward a comprehensive characterization of a human cancer cell phosphoproteome. (PMID: 23186163) Zhou H. … Mohammed S. (J. Proteome Res. 2013) 4 64
  3. Deep sequencing reveals differential expression of microRNAs in favorable versus unfavorable neuroblastoma. (PMID: 20466808) Schulte J.H. … Schramm A. (Nucleic Acids Res. 2010) 3 64
  4. Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. (PMID: 20068231) Olsen J.V. … Mann M. (Sci. Signal. 2010) 4 64
  5. Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. (PMID: 19413330) Gauci S. … Mohammed S. (Anal. Chem. 2009) 4 64

Products for MIR3714 Gene

Sources for MIR3714 Gene

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