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Aliases for MIR370 Gene

Subcategory (RNA class) for MIR370 Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR370 Gene

  • MicroRNA 370 2 3
  • Hsa-Mir-370 3
  • Mir-370 3
  • MIRN370 3

External Ids for MIR370 Gene

ORGUL Members for MIR370 Gene

Previous HGNC Symbols for MIR370 Gene

  • MIRN370

Previous GeneCards Identifiers for MIR370 Gene

  • GC14P100468
  • GC14P100850
  • GC14P101377
  • GC14P101061

Summaries for MIR370 Gene

Entrez Gene Summary for MIR370 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR370 Gene

MIR370 (MicroRNA 370) is an RNA Gene, and is affiliated with the miRNA class.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR370 Gene

Genomics for MIR370 Gene

Genomic Location for MIR370 Gene

Chromosome:
14
Start:
100,911,139 bp from pter
End:
100,911,275 bp from pter
Size:
137 bases
Orientation:
Plus strand

Genomic View for MIR370 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MIR370 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR370 Gene

No data available for Regulatory Elements for MIR370 Gene

Proteins for MIR370 Gene

Post-translational modifications for MIR370 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR370 Gene

Domains & Families for MIR370 Gene

Gene Families for MIR370 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR370: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR370 Gene

Function for MIR370 Gene

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR370 Gene

Localization for MIR370 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR370 Gene

Pathways & Interactions for MIR370 Gene

SuperPathways for MIR370 Gene

No Data Available

Interacting Proteins for MIR370 Gene

Gene Ontology (GO) - Biological Process for MIR370 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for MIR370 Gene

Drugs & Compounds for MIR370 Gene

No Compound Related Data Available

Transcripts for MIR370 Gene

mRNA/cDNA for MIR370 Gene

(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR370 Gene

No ASD Table

Relevant External Links for MIR370 Gene

GeneLoc Exon Structure for
MIR370
ECgene alternative splicing isoforms for
MIR370

Expression for MIR370 Gene

mRNA expression in normal human tissues for MIR370 Gene

genes like me logo Genes that share expression patterns with MIR370: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for MIR370 Gene

Orthologs for MIR370 Gene

This gene was present in the common ancestor of mammals.

Orthologs for MIR370 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia bta-mir-370 36
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia cfa-mir-370 36
  • 92 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mir370 36
  • 90 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-370 36
  • 100 (a)
OneToOne
Species with no ortholog for MIR370:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MIR370 Gene

ENSEMBL:
Gene Tree for MIR370 (if available)
TreeFam:
Gene Tree for MIR370 (if available)

Paralogs for MIR370 Gene

No data available for Paralogs for MIR370 Gene

Variants for MIR370 Gene

Sequence variations from dbSNP and Humsavar for MIR370 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type MAF
rs7140696 -- 100,910,405(+) TGGGA(C/T)GATCG upstream-variant-2KB
rs9324026 -- 100,911,399(+) GGGAA(A/G)CAGGC downstream-variant-500B
rs11844247 -- 100,910,611(+) GAGTT(C/G)CTCTG upstream-variant-2KB
rs11845236 -- 100,911,320(+) TTTAA(A/C)CTGGT downstream-variant-500B
rs58024286 -- 100,910,971(+) CTGGG(-/GA)CTGTT upstream-variant-2KB

Relevant External Links for MIR370 Gene

HapMap Linkage Disequilibrium report
MIR370

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for MIR370 Gene

Disorders for MIR370 Gene

Relevant External Links for MIR370

Genetic Association Database (GAD)
MIR370
Human Genome Epidemiology (HuGE) Navigator
MIR370
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR370
genes like me logo Genes that share disorders with MIR370: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR370 Gene

Publications for MIR370 Gene

  1. A MicroRNA cluster at 14q32 drives aggressive lung adenocarcinoma. (PMID: 24833665) Nadal E. … Chen G. (Clin. Cancer Res. 2014) 67
  2. MicroRNA-370 suppresses proliferation and promotes endometrioid ovarian cancer chemosensitivity to cDDP by negatively regulating ENG. (PMID: 25063739) Chen X.P. … Shen Z.J. (Cancer Lett. 2014) 67
  3. Birth and expression evolution of mammalian microRNA genes. (PMID: 23034410) Meunier J. … Kaessmann H. (Genome Res. 2013) 67
  4. FoxM1 is overexpressed in Helicobacter pylori-induced gastric carcinogenesis and is negatively regulated by miR-370. (PMID: 23576572) Feng Y. … Jia J. (Mol. Cancer Res. 2013) 67
  5. Perturbation of MicroRNA-370/Lin-28 homolog A/nuclear factor kappa B regulatory circuit contributes to the development of hepatocellular carcinoma. (PMID: 23728999) Xu W.P. … Xie W.F. (Hepatology 2013) 67

Products for MIR370 Gene

Sources for MIR370 Gene

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