Aliases for MIR3686 Gene
Subcategory (RNA class) for MIR3686 Gene
miRNA
Quality Score for this RNA gene is
8
External Ids for MIR3686 Gene
- HGNC: 38887
- Entrez Gene: 100500839
- Ensembl: ENSG00000263763
- miRBase: hsa-mir-3686
ORGUL Members for MIR3686 Gene
Previous GeneCards Identifiers for MIR3686 Gene
- GC08U901497
- GC08M130498
Summaries for MIR3686 Gene
-
microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
GeneCards Summary for MIR3686 Gene
MIR3686 (MicroRNA 3686) is an RNA Gene, and is affiliated with the miRNA class.
No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR3686 Gene
Genomics for MIR3686 Gene
Regulatory Elements for MIR3686 Gene
Enhancers for MIR3686 Gene
| GeneHancer Identifier | Enhancer Score | Enhancer Sources | Gene-Enhancer Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites within enhancer | Gene Targets for Enhancer |
|---|---|---|---|---|---|---|---|---|
| GH08G129479 | 1 | Ensembl ENCODE | 0.7 | +3.8 | 3845 | 1.6 | BCOR CTCF PKNOX1 ATF1 BACH1 ZNF175 ZMYM3 ZNF316 NFE2 PRDM10 | MIR3686 ENSG00000253926 |
| GH08G129490 | 1.2 | FANTOM5 ENCODE | 0.4 | -7.2 | -7175 | 1.7 | ATF1 ARNT SIN3A FEZF1 GLIS2 ZNF766 GATA2 FOS SP3 NCOA1 | MIR3686 GC08P129559 |
| GH08G129513 | 1.5 | Ensembl ENCODE dbSUPER | 0.3 | -31.4 | -31437 | 3.4 | PKNOX1 SIN3A TCF12 GATA2 FOS DEK JUNB REST ZNF592 MBD2 | MIR3686 GC08P129559 |
| GH08G129489 | 0.9 | FANTOM5 Ensembl | 0.4 | -5.4 | -5350 | 0.6 | SREBF1 CEBPB MAX SPI1 | MIR3686 GC08P129559 |
| GH08G129546 | 1.8 | FANTOM5 Ensembl ENCODE dbSUPER | 0.2 | -63.6 | -63640 | 3.4 | TBP PKNOX1 TBL1XR1 WRNIP1 ZNF766 RELB ETV6 IKZF2 CREM CAVIN1 | FAM49B GC08P129559 MIR3686 |
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around MIR3686 on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Location for MIR3686 Gene
- Chromosome:
- 8
- Start:
- 129,484,057 bp from pter
- End:
- 129,484,142 bp from pter
- Size:
- 86 bases
- Orientation:
- Minus strand
Genomic View for MIR3686 Gene
Genes around MIR3686 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 8q24.21 by Ensembl
- 8q24.21 by Entrez Gene
- 8q24.21 by HGNC
MIR3686 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for MIR3686 Gene
ORGUL Member Location for MIR3686 Gene
Proteins for MIR3686 Gene
Post-translational modifications for MIR3686 Gene
No Post-translational modifications
Antibody Products
- Search GeneTex for Antibodies for MIR3686
Protein Products
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for MIR3686
- Origene Custom Protein Services for MIR3686
- Search GeneTex for Proteins for MIR3686
No data available for DME Specific Peptides for MIR3686 Gene
Domains & Families for MIR3686 Gene
Gene Families for MIR3686 Gene
- HGNC:
Graphical View of Domain Structure for InterPro Entry
No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR3686 Gene
Function for MIR3686 Gene
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for MIR3686
-
- Search ViGene Biosciences for MIR3686
CRISPR Products
- Browse CRISPR knockouts for MIR3686
Inhibitory RNA Products
- Search ViGene Biosciences for MIR3686
Clone Products
- GenScript: Custom all cDNA clones Services for MIR3686
- VectorBuilder custom plasmid, inducible vectors for MIR3686
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for MIR3686
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR3686 Gene
Localization for MIR3686 Gene
No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR3686 Gene
Transcripts for MIR3686 Gene
mRNA/cDNA for MIR3686 Gene
- (1) Ensembl transcripts including schematic representations, and UCSC links where relevant :
CRISPR Products
- Browse CRISPR knockouts for MIR3686
Inhibitory RNA Products
- Search ViGene Biosciences for MIR3686
Clone Products
- GenScript: Custom all cDNA clones Services for MIR3686
- VectorBuilder custom plasmid, inducible vectors for MIR3686
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for MIR3686
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Expression for MIR3686 Gene
NURSA nuclear receptor signaling pathways regulating expression of MIR3686 Gene:
MIR3686
No Expression Related Data Available
Primer Products
No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR3686 Gene
Orthologs for MIR3686 Gene
No data available for Orthologs for MIR3686 Gene
Paralogs for MIR3686 Gene
No data available for Paralogs for MIR3686 Gene
Variants for MIR3686 Gene
| SNP ID | Clin | Chr 08 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs1001327690 | -- | 129,485,371(+) | TATTT(-/TA)TATAT | intron-variant, upstream-variant-2KB | |
| rs1001675899 | -- | 129,485,530(+) | CACAC(-/AT)ATGTA | intron-variant, upstream-variant-2KB | |
| rs1002649052 | -- | 129,485,197(+) | TGGAA(C/T)AAATG | intron-variant, upstream-variant-2KB | |
| rs1004133615 | -- | 129,484,285(+) | TGAAG(A/G)ACAGA | intron-variant, upstream-variant-2KB | |
| rs1004295777 | -- | 129,484,586(+) | TCTTG(A/C)CTTTA | intron-variant, upstream-variant-2KB |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| nsv1015611 | CNV | gain | 25217958 |
Relevant External Links for MIR3686 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- MIR3686
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR3686 Gene
Disorders for MIR3686 Gene
Relevant External Links for MIR3686
- Atlas of Genetics and Cytogenetics in Oncology and Haematology:
- MIR3686
No disorders were found for MIR3686 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR3686 Gene
Publications for MIR3686 Gene
- The MicroRNA3686 Inhibits the Proliferation of Pancreas Carcinoma Cell Line by Targeting the Polo-Like Kinase 1. (PMID: 26090465) Jin H.Y. … Yang B. (Biomed Res Int 2015) 3 64
- Analysis of microRNA transcriptome by deep sequencing of small RNA libraries of peripheral blood. (PMID: 20459673) Vaz C. … Bhattacharya A. (BMC Genomics 2010) 3 64
- miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S. … Enright A.J. (Nucleic Acids Res. 2006) 3 64
Products for MIR3686 Gene
- Browse R&D Systems for Antibodies
- Browse R&D Systems for Human Recombinant Proteins
- Browse R&D Systems for biochemical assays
- Browse Primary Antibodies
- Browse Proteins and Enzymes
- Browse ELISAs
- Browse Activity Assays
- Browse cDNA Clones
- Browse Cell Culture Products
- Browse Cell Selection and Detection Kits
- Browse DNA Damage and Repair Kits
- Browse ELISpot/FluoroSpot Kits and Development Modules
- Browse Flow Cytometry Kits
- Browse Immunoprecipitation Assays
- Browse Luminex Assays
- Browse Peptides
- Browse Proteome Profiler Antibody Arrays
- Browse Small Molecules
- Browse OriGene Antibodies
- Custom Antibody Services
- Browse OriGene ELISA Kits
- Custom Assay Services
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for MIR3686
- Origene Custom Protein Services for MIR3686
- Browse OriGene Inhibitory RNA Products For MIR3686
- Browse OriGene qPCR primer pairs and template standards
- Browse CRISPR knockouts for MIR3686
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For MIR3686
- GenScript: Custom all cDNA clones Services for MIR3686
- GenScript Custom Purified and Recombinant Proteins Services for MIR3686
- GenScript Custom Assay Services for MIR3686
- GenScript Custom overexpressing Cell Line Services for MIR3686
- Browse GenScript CRISPR for MIR3686
- Design optimal peptide antigens
- CloneReady with Over 120,000 Genes
- Gene Synthesis: Any Gene in Any Vector
- Vector-based siRNA and miRNA, Ready for Transfection
- Gene Mutant Library, Variants up to 10^11
- Plasmid Preparation
- GenScript Custom Peptide Services for MIR3686
- Browse Sino Biological cDNA Clones
- Browse Sino Biological Cell Lysates
- Browse Sino Biological Proteins
- Sino Biological Antibodies
- Sino Biological ELISA Kits and Pair Sets
- Sino Biological Cell Lysates
- Sino Biological qPCR Primers
- Sino Biological CRO Services for Proteins, Antibodies and Genes
- Sino Biological Transfection Reagents
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- Search GeneTex for Antibodies for MIR3686
- Search GeneTex for Proteins for MIR3686
- Search ViGene Biosciences for MIR3686
- Cyagen custom Knockout/knockin (KOKI) mouse models for MIR3686
- VectorBuilder custom plasmid, inducible vectors for MIR3686
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for MIR3686
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for MIR3686 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
- (61) DME
- (62) NCBI
- (63) OriGene
- (64) PubMed
- (65) R&D Systems
- (66) TGDB
- (67) Tocris
- (68) Abcam
- (69) Novus
- (70) ProSpec
- (71) Sino Biological
- (72) GenScript
- (73) Qiagen
- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
- (78) MOPED
- (79) SPIRE
- (80) neXtProt
- (81) Reactome
- (82) GeneGo (Thomson Reuters)
- (83) fRNAdb
- (84) DISEASES
- (85) SIMAP
- (86) GenomeRNAi
- (87) LifeMap
- (88) miRTarBase
- (89) MalaCards
- (90) Invitrogen
- (91) BitterDB
- (92) Vector BioLabs
- (93) ESI-BIO
- (94) RefSeq
- (95) BioSystems
- (96) MaxQB
- (97) IUPHAR
- (98) BioGPS
- (99) Illumina
- (100) COMPARTMENTS
- (101) HOMER
- (102) PaxDb
- (103) ApexBio
- (104) Addgene
- (105) antibodies-online
- (106) CYP
- (107) NONCODE
- (108) SwitchGear Genomics
- (109) TreeFam
- (110) PathCards
- (111) GeneReviews
- (112) GeneTex
- (113) Taconic Biosciences
- (114) GTEx
- (115) ProteomicsDB
- (116) SCBT
- (117) DGIdb
- (118) ClinicalTrials
- (119) FDA Approved Drugs
- (120) RVIS
- (121) SIGNOR
- (122) diseasecard
- (123) NIH Rare Diseases
- (124) Orphanet
- (125) UMLS
- (126) GTR
- (127) Disease Ontology
- (128) Genetics Home Reference
- (129) MeSH
- (130) MedlinePlus
- (131) CDC
- (132) NINDS
- (133) NCBI Bookshelf
- (134) ClinVar
- (135) Gene Damage Index
- (136) ViGene Biosciences
- (137) HPO
- (138) UDN
- (139) VISTA
- (140) FANTOM5
- (141) ENCODE
- (142) ProSci
- (143) Horizon
- (144) NURSA
- (145) IID
- (146) Cyagen
- (147) VectorBuilder
- (148) SNPedia
- (149) BRCA Exchange
- (150) St John's Lab
- (151) CIViC
- (152) ProteoGenix
- (153) dbSUPER
- (154) TISSUES
- (155) Gene ORGANizer