Free for academic non-profit institutions. Other users need a Commercial license

Aliases for MIR3686 Gene

Subcategory (RNA class) for MIR3686 Gene

miRNA

Quality Score for this RNA gene is

8

Aliases for MIR3686 Gene

  • MicroRNA 3686 2 3 5
  • Hsa-Mir-3686 3

External Ids for MIR3686 Gene

Previous GeneCards Identifiers for MIR3686 Gene

  • GC08U901497
  • GC08M130498

Summaries for MIR3686 Gene

Entrez Gene Summary for MIR3686 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR3686 Gene

MIR3686 (MicroRNA 3686) is an RNA Gene, and is affiliated with the miRNA class.

Additional gene information for MIR3686 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR3686 Gene

Genomics for MIR3686 Gene

Regulatory Elements for MIR3686 Gene

Enhancers for MIR3686 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH08H129479 1 Ensembl ENCODE 0.7 +3.8 3845 1.6 BCOR PKNOX1 ATF1 BACH1 ZNF175 ZMYM3 ZNF316 NFE2 ATF7 MAFK MIR3686 ENSG00000253926
GH08H129546 1.8 FANTOM5 Ensembl ENCODE dbSUPER 0.2 -63.6 -63640 3.4 TBL1XR1 BATF ZNF766 ATF7 ETV6 RUNX3 CREM IKZF2 CAVIN1 SMAD5 FAM49B GC08P129559 MIR3686
GH08H129420 1.7 FANTOM5 Ensembl ENCODE dbSUPER 0.2 +63.2 63209 1.1 HDAC1 PKNOX1 TBL1XR1 RAD21 CHAMP1 ETV6 CEBPB ELF1 NR2F2 ZNF592 ENSG00000253926 MIR3686
GH08H129551 1.7 FANTOM5 Ensembl ENCODE dbSUPER 0.2 -68.3 -68255 1.6 ZNF766 GATA2 ELK1 ATF7 RUNX3 CAVIN1 JUNB ZNF592 MEF2D NBN GC08P129559 MIR3686
GH08H129513 1.1 Ensembl ENCODE dbSUPER 0.3 -31.4 -31437 3.4 CEBPB MAX CEBPG TEAD3 JUND GATA3 POLR2A IKZF1 POU5F1 ATF7 MIR3686 GC08P129559
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MIR3686 on UCSC Golden Path with GeneCards custom track

Genomic Locations for MIR3686 Gene

Genomic Locations for MIR3686 Gene
chr8:129,484,057-129,484,142
(GRCh38/hg38)
Size:
86 bases
Orientation:
Minus strand
chr8:130,496,303-130,496,388
(GRCh37/hg19)

Genomic View for MIR3686 Gene

Genes around MIR3686 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR3686 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR3686 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR3686 Gene

ORGUL Member Location for MIR3686 Gene

ORGUL Member Location for MIR3686 gene

Proteins for MIR3686 Gene

Post-translational modifications for MIR3686 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR3686 Gene

Domains & Families for MIR3686 Gene

Gene Families for MIR3686 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR3686: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR3686 Gene

Function for MIR3686 Gene

Animal Model Products

miRNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR3686 Gene

Localization for MIR3686 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR3686 Gene

Pathways & Interactions for MIR3686 Gene

SuperPathways for MIR3686 Gene

No Data Available

Interacting Proteins for MIR3686 Gene

Gene Ontology (GO) - Biological Process for MIR3686 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for MIR3686 Gene

Drugs & Compounds for MIR3686 Gene

No Compound Related Data Available

Transcripts for MIR3686 Gene

mRNA/cDNA for MIR3686 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

miRNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR3686 Gene

No ASD Table

Relevant External Links for MIR3686 Gene

GeneLoc Exon Structure for
MIR3686
ECgene alternative splicing isoforms for
MIR3686

Expression for MIR3686 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR3686 Gene:

MIR3686
No Expression Related Data Available

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR3686 Gene

Orthologs for MIR3686 Gene

Evolution for MIR3686 Gene

ENSEMBL:
Gene Tree for MIR3686 (if available)
TreeFam:
Gene Tree for MIR3686 (if available)

No data available for Orthologs for MIR3686 Gene

Paralogs for MIR3686 Gene

No data available for Paralogs for MIR3686 Gene

Variants for MIR3686 Gene

Sequence variations from dbSNP and Humsavar for MIR3686 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
rs1001327690 -- 129,485,371(+) TATTT(-/TA)TATAT intron-variant, upstream-variant-2KB
rs1001675899 -- 129,485,530(+) CACAC(-/AT)ATGTA intron-variant, upstream-variant-2KB
rs1002649052 -- 129,485,197(+) TGGAA(C/T)AAATG intron-variant, upstream-variant-2KB
rs1004133615 -- 129,484,285(+) TGAAG(A/G)ACAGA intron-variant, upstream-variant-2KB
rs1004295777 -- 129,484,586(+) TCTTG(A/C)CTTTA intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MIR3686 Gene

Variant ID Type Subtype PubMed ID
nsv1015611 CNV gain 25217958

Relevant External Links for MIR3686 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR3686

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR3686 Gene

Disorders for MIR3686 Gene

Relevant External Links for MIR3686

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR3686

No disorders were found for MIR3686 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR3686 Gene

Publications for MIR3686 Gene

  1. The MicroRNA3686 Inhibits the Proliferation of Pancreas Carcinoma Cell Line by Targeting the Polo-Like Kinase 1. (PMID: 26090465) Jin HY … Yang B (BioMed research international 2015) 3 60
  2. Analysis of microRNA transcriptome by deep sequencing of small RNA libraries of peripheral blood. (PMID: 20459673) Vaz C … Bhattacharya A (BMC genomics 2010) 3 60
  3. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S … Enright AJ (Nucleic acids research 2006) 3 60

Products for MIR3686 Gene

Sources for MIR3686 Gene

Content
Loading form....