Free for academic non-profit institutions. Other users need a Commercial license

Aliases for MIR3674 Gene

Subcategory (RNA class) for MIR3674 Gene


Quality Score for this RNA gene is


Aliases for MIR3674 Gene

  • MicroRNA 3674 2 3
  • CLN8 4 5
  • Ceroid-Lipofuscinosis, Neuronal 8 5
  • Hsa-Mir-3674 3
  • C8orf61 4

External Ids for MIR3674 Gene

Previous GeneCards Identifiers for MIR3674 Gene

  • GC08U901489
  • GC08P001751

Summaries for MIR3674 Gene

Entrez Gene Summary for MIR3674 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR3674 Gene

MIR3674 (MicroRNA 3674) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR3674 include Ceroid Lipofuscinosis, Neuronal, 8 and Ceroid Lipofuscinosis, Neuronal, 8, Northern Epilepsy Variant. Among its related pathways are Synaptic vesicle cycle. An important paralog of this gene is ENSG00000283239.

UniProtKB/Swiss-Prot for MIR3674 Gene

  • Could play a role in cell proliferation during neuronal differentiation and in protection against cell death.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR3674 Gene

Genomics for MIR3674 Gene

Regulatory Elements for MIR3674 Gene

Enhancers for MIR3674 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH08F001754 1.4 FANTOM5 ENCODE 0.8 +0.3 257 2.9 HDGF PKNOX1 ATF1 ARNT ARID4B SIN3A FOS ZMIZ1 KDM4B GTF2B ENSG00000253982 CLN8 ENSG00000282021 MIR3674
GH08F001758 1.3 Ensembl ENCODE 0.8 +3.9 3895 2.8 PKNOX1 ATF1 ARNT FEZF1 ZNF2 ZNF121 GLIS2 GATA2 NCOA1 TSHZ1 ENSG00000253982 CLN8 ENSG00000282021 MIR3674
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MIR3674 on UCSC Golden Path with GeneCards custom track

Promoters for MIR3674 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Location for MIR3674 Gene

1,755,778 bp from pter
1,801,711 bp from pter
45,934 bases
Plus strand

Genomic View for MIR3674 Gene

Genes around MIR3674 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR3674 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR3674 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR3674 Gene

Proteins for MIR3674 Gene

  • Protein details for MIR3674 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein CLN8
    Protein Accession:
    Secondary Accessions:
    • Q86U71
    • Q96I95

    Protein attributes for MIR3674 Gene

    286 amino acids
    Molecular mass:
    32787 Da
    Quaternary structure:
    • Interacts with CLN5.
    • Interacts with CLN5.

neXtProt entry for MIR3674 Gene

Post-translational modifications for MIR3674 Gene

No data available for DME Specific Peptides for MIR3674 Gene

Domains & Families for MIR3674 Gene

Gene Families for MIR3674 Gene

Protein Domains for MIR3674 Gene


Graphical View of Domain Structure for InterPro Entry



  • Contains 1 TLC (TRAM/LAG1/CLN8) domain.
  • Contains 1 TLC (TRAM/LAG1/CLN8) domain.
genes like me logo Genes that share domains with MIR3674: view

No data available for Suggested Antigen Peptide Sequences for MIR3674 Gene

Function for MIR3674 Gene

Molecular function for MIR3674 Gene

UniProtKB/Swiss-Prot Function:
Could play a role in cell proliferation during neuronal differentiation and in protection against cell death.

Animal Model Products

miRNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR3674 Gene

Localization for MIR3674 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MIR3674 Gene

Endoplasmic reticulum membrane; Multi-pass membrane protein. Endoplasmic reticulum-Golgi intermediate compartment membrane; Multi-pass membrane protein. Endoplasmic reticulum.

Gene Ontology (GO) - Cellular Components for MIR3674 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005789 endoplasmic reticulum membrane IEA --
GO:0005793 endoplasmic reticulum-Golgi intermediate compartment IDA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0033116 endoplasmic reticulum-Golgi intermediate compartment membrane IEA --
genes like me logo Genes that share ontologies with MIR3674: view

No data available for Subcellular locations from COMPARTMENTS for MIR3674 Gene

Pathways & Interactions for MIR3674 Gene

SuperPathways for MIR3674 Gene

SuperPathway Contained pathways
1 Synaptic vesicle cycle
genes like me logo Genes that share pathways with MIR3674: view

Pathways by source for MIR3674 Gene

1 BioSystems pathway for MIR3674 Gene

Gene Ontology (GO) - Biological Process for MIR3674 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006644 phospholipid metabolic process IMP --
GO:0006672 ceramide metabolic process IMP --
GO:0006869 lipid transport NAS --
GO:0007399 nervous system development IMP --
GO:0008203 cholesterol metabolic process IMP --
genes like me logo Genes that share ontologies with MIR3674: view

No data available for SIGNOR curated interactions for MIR3674 Gene

Transcripts for MIR3674 Gene

mRNA/cDNA for MIR3674 Gene

(15) Ensembl transcripts including schematic representations, and UCSC links where relevant :

miRNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR3674 Gene

No ASD Table

Relevant External Links for MIR3674 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MIR3674 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR3674 Gene:

No Expression Related Data Available

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for MIR3674 Gene

Orthologs for MIR3674 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIR3674 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia CLN8 35
  • 99 (a)
(Canis familiaris)
Mammalia CLN8 35
  • 89 (a)
(Mus musculus)
Mammalia Cln8 35
  • 85 (a)
(Monodelphis domestica)
Mammalia CLN8 35
  • 78 (a)
(Bos Taurus)
Mammalia CLN8 35
  • 75 (a)
(Gallus gallus)
Aves CLN8 35
  • 58 (a)
(Anolis carolinensis)
Reptilia CLN8 35
  • 57 (a)
(Danio rerio)
Actinopterygii cln8 35
  • 56 (a)
Species where no ortholog for MIR3674 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MIR3674 Gene

Gene Tree for MIR3674 (if available)
Gene Tree for MIR3674 (if available)

Paralogs for MIR3674 Gene

Paralogs for MIR3674 Gene

genes like me logo Genes that share paralogs with MIR3674: view

Variants for MIR3674 Gene

Sequence variations from dbSNP and Humsavar for MIR3674 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
rs10105496 -- 1,801,692(+) TAAAC(A/G)GCCAT downstream-variant-500B
rs10108340 -- 1,801,538(+) gagca(C/T)cttgc downstream-variant-500B
rs112044149 -- 1,800,241(+) ACTTT(C/T)TTTTA upstream-variant-2KB
rs112081393 -- 1,801,327(+) GCCAT(C/T)GCATC downstream-variant-500B
rs112366959 -- 1,799,346(+) TTCTT(C/G)TTCTT upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MIR3674 Gene

Variant ID Type Subtype PubMed ID
nsv824454 CNV gain 20364138
nsv609533 CNV gain 21841781
nsv609531 CNV gain 21841781
nsv609527 CNV loss 21841781
nsv509244 CNV insertion 20534489
nsv470167 CNV gain 18288195
nsv465277 CNV gain 19166990
nsv1025591 CNV gain 25217958
nsv1024325 CNV gain 25217958
nsv1017597 CNV loss 25217958
esv3891267 CNV gain 25118596
esv3615846 CNV loss 21293372
esv3615842 CNV gain 21293372
esv3615841 CNV loss 21293372
esv3576504 CNV gain 25503493
dgv850n27 CNV loss 19166990
dgv11822n54 CNV loss 21841781

Relevant External Links for MIR3674 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR3674 Gene

Disorders for MIR3674 Gene

MalaCards: The human disease database

(4) MalaCards diseases for MIR3674 Gene - From: GeneCards

Disorder Aliases PubMed IDs
ceroid lipofuscinosis, neuronal, 8
  • cln8 disease
ceroid lipofuscinosis, neuronal, 8, northern epilepsy variant
  • ceroid lipofuscinosis, neuronal, 8
neuronal ceroid-lipofuscinoses
  • ceroid lipofuscinosis, neuronal, 1
late-infantile neuronal ceroid lipofuscinosis
  • jansky-bielschowsky disease
- elite association - COSMIC cancer census association via MalaCards


  • Ceroid lipofuscinosis, neuronal, 8 (CLN8) [MIM:600143]: A form of neuronal ceroid lipofuscinosis with onset in childhood. Neuronal ceroid lipofuscinoses are progressive neurodegenerative, lysosomal storage diseases characterized by intracellular accumulation of autofluorescent liposomal material, and clinically by seizures, dementia, visual loss, and/or cerebral atrophy. The lipopigment patterns observed most often in neuronal ceroid lipofuscinosis type 8 comprise mixed combinations of granular, curvilinear, and fingerprint profiles. {ECO:0000269 PubMed:15024724, ECO:0000269 PubMed:16570191, ECO:0000269 PubMed:19201763, ECO:0000269 PubMed:19431184, ECO:0000269 PubMed:19807737, ECO:0000269 PubMed:21990111, ECO:0000269 PubMed:26443629}. Note=The disease is caused by mutations affecting the gene represented in this entry.
  • Ceroid lipofuscinosis, neuronal, 8, Northern epilepsy variant (CLN8NE) [MIM:610003]: A form of neuronal ceroid lipofuscinosis clinically characterized by epilepsy that presents between 5 and 10 years of age with frequent tonic-clonic seizures followed by progressive mental retardation. Visual loss is not a prominent feature. Intracellular accumulation of autofluorescent material results in curvilinear and granular profiles on ultrastructural analysis. {ECO:0000269 PubMed:10508524, ECO:0000269 PubMed:21990111}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for MIR3674

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with MIR3674: view

No data available for Genatlas for MIR3674 Gene

Publications for MIR3674 Gene

  1. Novel missense mutation in CLN8 in late infantile neuronal ceroid lipofuscinosis: The first report of a CLN8 mutation in Japan. (PMID: 26443629) Katata Y. … Kure S. (Brain Dev. 2015) 4 64
  2. Update of the mutation spectrum and clinical correlations of over 360 mutations in eight genes that underlie the neuronal ceroid lipofuscinoses. (PMID: 21990111) Kousi M. … Mole S.E. (Hum. Mutat. 2012) 4 64
  3. Analysis of microRNA transcriptome by deep sequencing of small RNA libraries of peripheral blood. (PMID: 20459673) Vaz C. … Bhattacharya A. (BMC Genomics 2010) 3 64
  4. Novel CLN8 mutations confirm the clinical and ethnic diversity of late infantile neuronal ceroid lipofuscinosis. (PMID: 19807737) Reinhardt K. … Steinfeld R. (Clin. Genet. 2010) 4 64
  5. A novel CLN8 mutation in late-infantile-onset neuronal ceroid lipofuscinosis (LINCL) reveals aspects of CLN8 neurobiological function. (PMID: 19431184) Vantaggiato C. … Bassi M.T. (Hum. Mutat. 2009) 4 64

Products for MIR3674 Gene

Sources for MIR3674 Gene

Loading form....