Free for academic non-profit institutions. Other users need a Commercial license

Aliases for MIR3658 Gene

Subcategory (RNA class) for MIR3658 Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR3658 Gene

  • MicroRNA 3658 2 3
  • EC 2.7.1.48 4 61
  • UCK2 4 5
  • Testis-Specific Protein TSA903 4
  • Cytidine Monophosphokinase 2 4
  • Uridine Monophosphokinase 2 4
  • Uridine-Cytidine Kinase 2 5
  • Hsa-Mir-3658 3
  • UCK 2 4
  • UMPK 4

External Ids for MIR3658 Gene

Previous GeneCards Identifiers for MIR3658 Gene

  • GC01U903155
  • GC01P165882

Summaries for MIR3658 Gene

Entrez Gene Summary for MIR3658 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR3658 Gene

MIR3658 (MicroRNA 3658) is an RNA Gene, and is affiliated with the miRNA class. Among its related pathways are Metabolism and Purine metabolism (REACTOME). An important paralog of this gene is UCK1.

UniProtKB/Swiss-Prot for MIR3658 Gene

  • Phosphorylates uridine and cytidine to uridine monophosphate and cytidine monophosphate. Does not phosphorylate deoxyribonucleosides or purine ribonucleosides. Can use ATP or GTP as a phosphate donor. Can also phosphorylate cytidine and uridine nucleoside analogs such as 6-azauridine, 5-fluorouridine, 4-thiouridine, 5-bromouridine, N(4)-acetylcytidine, N(4)-benzoylcytidine, 5-fluorocytidine, 2-thiocytidine, 5-methylcytidine, and N(4)-anisoylcytidine.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR3658 Gene

Genomics for MIR3658 Gene

Regulatory Elements for MIR3658 Gene

Enhancers for MIR3658 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01F165852 1.3 FANTOM5 Ensembl ENCODE 19.5 +28.9 28877 8.0 HDGF PKNOX1 ARNT CREB3L1 WRNIP1 ZFP64 ARID4B SIN3A DMAP1 YY1 LOC284685 MIR3658 TMCO1 LOC100147773 ENSG00000236364 UCK2 LOC105371586
GH01F165883 1 Ensembl ENCODE 19.4 +57.0 56970 3.0 PKNOX1 ATF1 ZNF493 ZFP64 SIN3A ZNF121 KLF7 FOS ZNF202 REST LOC284685 DUTP6 MIR3658 UCK2 TMCO1 LOC100147773 ENSG00000236364 LOC105371586
GH01F165695 0.2 ENCODE 12.1 -130.1 -130117 3.7 HDGF PKNOX1 ARNT CREB3L1 ZFP64 ARID4B SIN3A FEZF1 DMAP1 ZNF2 ALDH9A1 LOC284685 MIR3658 MGST3 ENSG00000236364 LOC440700 GC01M165672
GH01F165877 0.2 ENCODE 12 +50.7 50665 1.3 PKNOX1 CBX3 TBL1XR1 FEZF1 BMI1 RFX5 GATA2 CBX5 ETV6 CREM ENSG00000236364 UCK2 MIR3658 TMCO1 LOC100147773 LOC105371586
GH01F165874 0.9 Ensembl ENCODE 11.9 +48.3 48288 2.2 PKNOX1 RFX1 MTA2 MAFG BMI1 TBX21 RELA ZNF316 ZFP3 SCRT2 MIR3658 UCK2 TMCO1 LOC100147773 LOC105371586 ENSG00000236364
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around MIR3658 on UCSC Golden Path with GeneCards custom track

Promoters for MIR3658 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000286783 969 3001 HDGF ARNT CREB3L1 ZFP64 ARID4B SIN3A DMAP1 YY1 KLF13 ZNF263

Genomic Location for MIR3658 Gene

Chromosome:
1
Start:
165,827,531 bp from pter
End:
165,911,618 bp from pter
Size:
84,088 bases
Orientation:
Plus strand

Genomic View for MIR3658 Gene

Genes around MIR3658 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR3658 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR3658 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR3658 Gene

Proteins for MIR3658 Gene

  • Protein details for MIR3658 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BZX2-UCK2_HUMAN
    Recommended name:
    Uridine-cytidine kinase 2
    Protein Accession:
    Q9BZX2
    Secondary Accessions:
    • Q5VV91
    • Q7KZV3
    • Q92528
    • Q96KG5
    • Q9BU42

    Protein attributes for MIR3658 Gene

    Size:
    261 amino acids
    Molecular mass:
    29299 Da
    Quaternary structure:
    • Homotetramer.
    • Homotetramer.

    Three dimensional structures from OCA and Proteopedia for MIR3658 Gene

    Alternative splice isoforms for MIR3658 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MIR3658 Gene

Selected DME Specific Peptides for MIR3658 Gene

Q9BZX2:
  • ADVIIPRG
  • SQDSFYR
  • DHPDAFD
  • VAINLIVQHIQD
  • LFEGILAFY
  • RGRDLEQ
  • HSRKEET
  • EQKAKALKGQ
  • YPADVVLFEGIL
  • LLGQNEV
  • RLSRRVLRD

Post-translational modifications for MIR3658 Gene

  • Ubiquitination at Lys 33, Lys 54, and Lys 78
  • Modification sites at PhosphoSitePlus

Other Protein References for MIR3658 Gene

Domains & Families for MIR3658 Gene

Gene Families for MIR3658 Gene

Protein Domains for MIR3658 Gene

Graphical View of Domain Structure for InterPro Entry

Q9BZX2

UniProtKB/Swiss-Prot:

UCK2_HUMAN :
  • Belongs to the uridine kinase family.
Family:
  • Belongs to the uridine kinase family.
genes like me logo Genes that share domains with MIR3658: view

No data available for Suggested Antigen Peptide Sequences for MIR3658 Gene

Function for MIR3658 Gene

Molecular function for MIR3658 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + uridine = ADP + UMP.
UniProtKB/Swiss-Prot CatalyticActivity:
ATP + cytidine = ADP + CMP.
UniProtKB/Swiss-Prot Function:
Phosphorylates uridine and cytidine to uridine monophosphate and cytidine monophosphate. Does not phosphorylate deoxyribonucleosides or purine ribonucleosides. Can use ATP or GTP as a phosphate donor. Can also phosphorylate cytidine and uridine nucleoside analogs such as 6-azauridine, 5-fluorouridine, 4-thiouridine, 5-bromouridine, N(4)-acetylcytidine, N(4)-benzoylcytidine, 5-fluorocytidine, 2-thiocytidine, 5-methylcytidine, and N(4)-anisoylcytidine.

Enzyme Numbers (IUBMB) for MIR3658 Gene

Gene Ontology (GO) - Molecular Function for MIR3658 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004849 uridine kinase activity IBA --
GO:0005524 ATP binding IEA --
GO:0016301 kinase activity IEA --
GO:0016740 transferase activity IEA --
GO:0019206 nucleoside kinase activity EXP --
genes like me logo Genes that share ontologies with MIR3658: view

Animal Model Products

No data available for Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR3658 Gene

Localization for MIR3658 Gene

Gene Ontology (GO) - Cellular Components for MIR3658 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with MIR3658: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from COMPARTMENTS for MIR3658 Gene

Pathways & Interactions for MIR3658 Gene

genes like me logo Genes that share pathways with MIR3658: view

Pathways by source for MIR3658 Gene

1 BioSystems pathway for MIR3658 Gene

UniProtKB/Swiss-Prot Q9BZX2-UCK2_HUMAN

  • Pathway: Pyrimidine metabolism; CTP biosynthesis via salvage pathway; CTP from cytidine: step 1/3.
  • Pathway: Pyrimidine metabolism; UMP biosynthesis via salvage pathway; UMP from uridine: step 1/1.

Gene Ontology (GO) - Biological Process for MIR3658 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006206 pyrimidine nucleobase metabolic process IBA --
GO:0006238 CMP salvage IEA --
GO:0008152 metabolic process IEA --
GO:0016310 phosphorylation IEA --
GO:0043097 pyrimidine nucleoside salvage TAS --
genes like me logo Genes that share ontologies with MIR3658: view

No data available for SIGNOR curated interactions for MIR3658 Gene

Transcripts for MIR3658 Gene

mRNA/cDNA for MIR3658 Gene

(9) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR3658 Gene

No ASD Table

Relevant External Links for MIR3658 Gene

GeneLoc Exon Structure for
MIR3658
ECgene alternative splicing isoforms for
MIR3658

Expression for MIR3658 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MIR3658 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR3658 Gene:

MIR3658

mRNA Expression by UniProt/SwissProt for MIR3658 Gene:

Q9BZX2-UCK2_HUMAN
Tissue specificity: According to PubMed:8812458; testis-specific. According to PubMed:11306702, placenta-specific.
genes like me logo Genes that share expression patterns with MIR3658: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for MIR3658 Gene

Orthologs for MIR3658 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for MIR3658 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia UCK2 35
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia UCK2 35
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Uck2 35
  • 98 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia UCK2 35
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia UCK2 35
  • 91 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia UCK2 35
  • 90 (a)
OneToOne
chicken
(Gallus gallus)
Aves UCK2 35
  • 93 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia UCK2 35
  • 93 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii uck2a 35
  • 84 (a)
OneToMany
uck2b 35
  • 79 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG6364 35
  • 50 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea B0001.4 35
  • 44 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes URK1 35
  • 19 (a)
OneToMany
DAS2 37
sea squirt
(Ciona savignyi)
Ascidiacea CSA.6934 35
  • 55 (a)
OneToMany
Species where no ortholog for MIR3658 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for MIR3658 Gene

ENSEMBL:
Gene Tree for MIR3658 (if available)
TreeFam:
Gene Tree for MIR3658 (if available)

Paralogs for MIR3658 Gene

Paralogs for MIR3658 Gene

genes like me logo Genes that share paralogs with MIR3658: view

Variants for MIR3658 Gene

Sequence variations from dbSNP and Humsavar for MIR3658 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs113225450 -- 165,907,766(+) CTCAA(C/T)GGCTA upstream-variant-2KB, reference, synonymous-codon
rs115293728 -- 165,907,091(+) TGAAG(A/G)AATTA intron-variant, upstream-variant-2KB
rs116363232 -- 165,906,272(+) GAGGC(C/T)ACCTT intron-variant, upstream-variant-2KB
rs117075497 -- 165,906,473(+) CTCCA(A/G)TTCCT intron-variant, upstream-variant-2KB
rs117648963 -- 165,906,439(+) AAGTG(C/T)AGTAG intron-variant, upstream-variant-2KB

Relevant External Links for MIR3658 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR3658

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for MIR3658 Gene

Disorders for MIR3658 Gene

Relevant External Links for MIR3658

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR3658

No disorders were found for MIR3658 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR3658 Gene

Publications for MIR3658 Gene

  1. Initial characterization of the human central proteome. (PMID: 21269460) Burkard T.R. … Colinge J. (BMC Syst. Biol. 2011) 4 64
  2. System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PMID: 21406692) Rigbolt K.T. … Blagoev B. (Sci. Signal. 2011) 4 64
  3. Discovery of microRNAs and other small RNAs in solid tumors. (PMID: 20483914) Meiri E. … Sitbon E. (Nucleic Acids Res. 2010) 3 64
  4. Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. (PMID: 19413330) Gauci S. … Mohammed S. (Anal. Chem. 2009) 4 64
  5. Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle. (PMID: 18691976) Daub H. … Mann M. (Mol. Cell 2008) 4 64

Products for MIR3658 Gene

Sources for MIR3658 Gene

Content
Loading form....