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Aliases for MIR3652 Gene

Subcategory (RNA class) for MIR3652 Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR3652 Gene

  • MicroRNA 3652 2 3
  • HSP90B1 4 5
  • Heat Shock Protein 90 Beta Family Member 1 5
  • Heat Shock Protein 90 KDa Beta Member 1 4
  • 94 KDa Glucose-Regulated Protein 4
  • Tumor Rejection Antigen 1 4
  • Gp96 Homolog 4
  • Hsa-Mir-3652 3
  • GRP-94 4
  • GRP94 4
  • TRA1 4

External Ids for MIR3652 Gene

Previous GeneCards Identifiers for MIR3652 Gene

  • GC12U901512
  • GC12P104330
  • GC12P104335
  • GC12P103931

Summaries for MIR3652 Gene

Entrez Gene Summary for MIR3652 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR3652 Gene

MIR3652 (MicroRNA 3652) is an RNA Gene, and is affiliated with the miRNA class. Among its related pathways are Immune System and Vesicle-mediated transport. An important paralog of this gene is HSP90AA1.

UniProtKB/Swiss-Prot for MIR3652 Gene

  • Molecular chaperone that functions in the processing and transport of secreted proteins. When associated with CNPY3, required for proper folding of Toll-like receptors (By similarity). Functions in endoplasmic reticulum associated degradation (ERAD). Has ATPase activity.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR3652 Gene

Genomics for MIR3652 Gene

Regulatory Elements for MIR3652 Gene

Enhancers for MIR3652 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH12F103955 1.2 ENCODE 12.3 +26.8 26840 2.6 HDGF ARNT CREB3L1 MLX WRNIP1 ZFP64 ARID4B SIN3A FEZF1 DMAP1 GLT8D2 C12orf73 MIR3652 HSP90B1 TTC41P HCFC2 TDG GC12P103942
GH12F103960 0.6 ENCODE 12.3 +31.0 30981 1.7 HDAC1 ATF1 PKNOX1 SCRT2 CREM SMARCA5 ZNF623 SSRP1 SMARCA4 IKZF1 TTC41P C12orf73 MIR3652 HSP90B1 NT5DC3 GC12P103942
GH12F103879 1.2 Ensembl ENCODE 11.9 -49.2 -49153 2.1 ELF3 BCOR PKNOX1 TBL1XR1 ZMYM3 BMI1 ZIC2 RELA ZBTB48 PATZ1 TTC41P HSP90B1 MIR3652 NT5DC3 TDG C12orf73 ENSG00000257327
GH12F103883 0.5 ENCODE 11.9 -47.0 -47010 0.2 HDGF IKZF1 CEBPA FEZF1 RELA HSP90B1 MIR3652 TTC41P TDG ENSG00000257327
GH12F103905 0.8 Ensembl ENCODE 11.7 -23.8 -23799 0.9 HDGF CHD7 ZKSCAN1 ZFHX2 POLR2A EGR1 ZNF366 EED ZNF207 ETV6 TTC41P HSP90B1 MIR3652 TDG C12orf73 ENSG00000257327
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around MIR3652 on UCSC Golden Path with GeneCards custom track

Promoters for MIR3652 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001614577 593 4201 HDGF PKNOX1 MLX WRNIP1 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9

Genomic Location for MIR3652 Gene

Chromosome:
12
Start:
103,930,107 bp from pter
End:
103,953,645 bp from pter
Size:
23,539 bases
Orientation:
Plus strand

Genomic View for MIR3652 Gene

Genes around MIR3652 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR3652 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR3652 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR3652 Gene

Proteins for MIR3652 Gene

  • Protein details for MIR3652 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P14625-ENPL_HUMAN
    Recommended name:
    Endoplasmin
    Protein Accession:
    P14625
    Secondary Accessions:
    • Q96A97

    Protein attributes for MIR3652 Gene

    Size:
    803 amino acids
    Molecular mass:
    92469 Da
    Quaternary structure:
    • Homodimer; disulfide-linked. Component of an EIF2 complex at least composed of CELF1/CUGBP1, CALR, CALR3, EIF2S1, EIF2S2, HSP90B1 and HSPA5 (By similarity). Part of a large chaperone multiprotein complex comprising DNAJB11, HSP90B1, HSPA5, HYOU, PDIA2, PDIA4, PDIA6, PPIB, SDF2L1, UGT1A1 and very small amounts of ERP29, but not, or at very low levels, CALR nor CANX. Interacts with AIMP1; regulates its retention in the endoplasmic reticulum. Interacts with OS9. Interacts with CNPY3. This interaction is disrupted in the presence of ATP (By similarity). Interacts with TLR4 and TLR9, but not with TLR3. Interacts with MZB1 in a calcium-dependent manner (By similarity). Interacts with METTL23.
    • Homodimer; disulfide-linked. Component of an EIF2 complex at least composed of CELF1/CUGBP1, CALR, CALR3, EIF2S1, EIF2S2, HSP90B1 and HSPA5 (By similarity). Part of a large chaperone multiprotein complex comprising DNAJB11, HSP90B1, HSPA5, HYOU, PDIA2, PDIA4, PDIA6, PPIB, SDF2L1, UGT1A1 and very small amounts of ERP29, but not, or at very low levels, CALR nor CANX. Interacts with AIMP1; regulates its retention in the endoplasmic reticulum. Interacts with OS9. Interacts with CNPY3. This interaction is disrupted in the presence of ATP (By similarity). Interacts with TLR4 and TLR9, but not with TLR3. Interacts with MZB1 in a calcium-dependent manner (By similarity). Interacts with METTL23.

    Three dimensional structures from OCA and Proteopedia for MIR3652 Gene

neXtProt entry for MIR3652 Gene

Post-translational modifications for MIR3652 Gene

  • Ubiquitination at Lys 75, Lys 142, Lys 168, Lys 270, Lys 434, and Lys 671
  • Glycosylation at Asn 62, Asn 107, Asn 217, Asn 445, Asn 481, and Asn 502
  • Modification sites at PhosphoSitePlus

Other Protein References for MIR3652 Gene

No data available for DME Specific Peptides for MIR3652 Gene

Domains & Families for MIR3652 Gene

Gene Families for MIR3652 Gene

Graphical View of Domain Structure for InterPro Entry

P14625

UniProtKB/Swiss-Prot:

ENPL_HUMAN :
  • Belongs to the heat shock protein 90 family.
Family:
  • Belongs to the heat shock protein 90 family.
genes like me logo Genes that share domains with MIR3652: view

No data available for Suggested Antigen Peptide Sequences for MIR3652 Gene

Function for MIR3652 Gene

Molecular function for MIR3652 Gene

UniProtKB/Swiss-Prot Function:
Molecular chaperone that functions in the processing and transport of secreted proteins. When associated with CNPY3, required for proper folding of Toll-like receptors (By similarity). Functions in endoplasmic reticulum associated degradation (ERAD). Has ATPase activity.

Gene Ontology (GO) - Molecular Function for MIR3652 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding IDA --
GO:0005509 calcium ion binding TAS --
GO:0005515 protein binding IPI --
GO:0005524 ATP binding IEA --
GO:0019903 protein phosphatase binding IDA --
genes like me logo Genes that share ontologies with MIR3652: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR3652 Gene

Localization for MIR3652 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MIR3652 Gene

Endoplasmic reticulum lumen. Melanosome. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV.

Gene Ontology (GO) - Cellular Components for MIR3652 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005634 nucleus IDA --
GO:0005783 endoplasmic reticulum TAS --
GO:0005788 endoplasmic reticulum lumen IEA --
GO:0005789 endoplasmic reticulum membrane IDA --
genes like me logo Genes that share ontologies with MIR3652: view

No data available for Subcellular locations from COMPARTMENTS for MIR3652 Gene

Pathways & Interactions for MIR3652 Gene

genes like me logo Genes that share pathways with MIR3652: view

Gene Ontology (GO) - Biological Process for MIR3652 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001666 response to hypoxia IDA --
GO:0002224 toll-like receptor signaling pathway TAS --
GO:0006457 protein folding IEA --
GO:0006898 receptor-mediated endocytosis TAS --
GO:0006950 response to stress IEA --
genes like me logo Genes that share ontologies with MIR3652: view

No data available for SIGNOR curated interactions for MIR3652 Gene

Transcripts for MIR3652 Gene

mRNA/cDNA for MIR3652 Gene

(11) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR3652 Gene

No ASD Table

Relevant External Links for MIR3652 Gene

GeneLoc Exon Structure for
MIR3652
ECgene alternative splicing isoforms for
MIR3652

Expression for MIR3652 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MIR3652 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR3652 Gene:

MIR3652
genes like me logo Genes that share expression patterns with MIR3652: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for MIR3652 Gene

Orthologs for MIR3652 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for MIR3652 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia HSP90B1 35
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia HSP90B1 35
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia HSP90B1 35
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Hsp90b1 35
  • 97 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia HSP90B1 35
  • 92 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia HSP90B1 35
  • 92 (a)
OneToOne
chicken
(Gallus gallus)
Aves HSP90B1 35
  • 91 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia HSP90B1 35
  • 88 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii hsp90b1 35
  • 83 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Gp93 35
  • 60 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea enpl-1 35
  • 63 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes HSC82 35
  • 46 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.4613 35
  • 67 (a)
OneToOne
Species where no ortholog for MIR3652 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for MIR3652 Gene

ENSEMBL:
Gene Tree for MIR3652 (if available)
TreeFam:
Gene Tree for MIR3652 (if available)

Paralogs for MIR3652 Gene

Paralogs for MIR3652 Gene

Pseudogenes.org Pseudogenes for MIR3652 Gene

genes like me logo Genes that share paralogs with MIR3652: view

Variants for MIR3652 Gene

Sequence variations from dbSNP and Humsavar for MIR3652 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs1007652 -- 103,930,862(+) GCGAG(C/T)CCCTC intron-variant, downstream-variant-500B, upstream-variant-2KB
rs11111851 -- 103,929,600(+) TAAAA(G/T)CTGTG intron-variant, nc-transcript-variant, upstream-variant-2KB
rs111892261 -- 103,929,506(+) GCTCT(G/T)GAGCC intron-variant, nc-transcript-variant, upstream-variant-2KB
rs112832728 -- 103,929,145(+) CCGTT(C/T)TCATG intron-variant, upstream-variant-2KB
rs114365355 -- 103,930,859(+) TGTGC(A/G)AGTCC intron-variant, downstream-variant-500B, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MIR3652 Gene

Variant ID Type Subtype PubMed ID
nsv560039 CNV gain 21841781

Relevant External Links for MIR3652 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR3652

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR3652 Gene

Disorders for MIR3652 Gene

Relevant External Links for MIR3652

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR3652

No disorders were found for MIR3652 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR3652 Gene

Publications for MIR3652 Gene

  1. N-terminome analysis of the human mitochondrial proteome. (PMID: 25944712) Vaca Jacome A.S. … Carapito C. (Proteomics 2015) 4 64
  2. A single kinase generates the majority of the secreted phosphoproteome. (PMID: 26091039) Tagliabracci V.S. … Dixon J.E. (Cell 2015) 4 64
  3. An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. (PMID: 24275569) Bian Y. … Zou H. (J. Proteomics 2014) 4 64
  4. Toward a comprehensive characterization of a human cancer cell phosphoproteome. (PMID: 23186163) Zhou H. … Mohammed S. (J. Proteome Res. 2013) 4 64
  5. A newly uncovered group of distantly related lysine methyltransferases preferentially interact with molecular chaperones to regulate their activity. (PMID: 23349634) Cloutier P. … Coulombe B. (PLoS Genet. 2013) 4 64

Products for MIR3652 Gene

Sources for MIR3652 Gene

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