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Aliases for MIR3649 Gene

Subcategory (RNA class) for MIR3649 Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR3649 Gene

  • MicroRNA 3649 2 3 5
  • Hsa-Mir-3649 3

External Ids for MIR3649 Gene

Previous GeneCards Identifiers for MIR3649 Gene

  • GC12U901533
  • GC12M001774

Summaries for MIR3649 Gene

Entrez Gene Summary for MIR3649 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR3649 Gene

MIR3649 (MicroRNA 3649) is an RNA Gene, and is affiliated with the miRNA class.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR3649 Gene

Genomics for MIR3649 Gene

Regulatory Elements for MIR3649 Gene

Enhancers for MIR3649 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH12F001658 1.5 FANTOM5 ENCODE 0.8 -0.9 -906 5.3 PKNOX1 MLX ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 ZNF416 FOS ADIPOR2 CACNA1C-AS3 CACNA1C-IT3 CACNA2D4 ENSG00000256706 DCP1B LRTM2 MIR3649
GH12F001665 1.6 FANTOM5 Ensembl ENCODE 0.4 -8.1 -8128 7.0 HDGF PKNOX1 ATF1 ARID4B SIN3A ZNF48 YY1 KLF7 FOS SP5 CACNA2D4 ADIPOR2 ENSG00000256706 MIR3649
GH12F001649 1.5 FANTOM5 Ensembl ENCODE 0.4 +9.9 9859 2.4 ATF1 MLX FEZF1 DMAP1 YY1 GATA2 ZNF263 MIER2 PPARG KAT8 ADIPOR2 ENSG00000256706 CACNA2D4 MIR3649 FBXL14
GH12F001634 1.5 FANTOM5 Ensembl ENCODE 0.3 +25.0 25017 1.7 NFXL1 RAD21 YY1 RARA ZNF143 CREM ZNF263 ZNF280D ZNF654 REST ENSG00000256706 CACNA2D4 MIR3649 FBXL14
GH12F001652 1 Ensembl ENCODE 0.4 +7.4 7380 0.4 CTCF ZNF362 ZNF654 TRIM22 ZNF384 REST RAD21 RFX5 ZGPAT ZNF143 ADIPOR2 CACNA2D4 ENSG00000256706 MIR3649 FBXL14
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MIR3649 on UCSC Golden Path with GeneCards custom track

Promoters for MIR3649 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001774160 -1820 2401 PKNOX1 MLX ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF416 FOS SP3

Genomic Location for MIR3649 Gene

Chromosome:
12
Start:
1,660,315 bp from pter
End:
1,660,380 bp from pter
Size:
66 bases
Orientation:
Minus strand

Genomic View for MIR3649 Gene

Genes around MIR3649 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR3649 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR3649 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR3649 Gene

Proteins for MIR3649 Gene

Post-translational modifications for MIR3649 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR3649 Gene

Domains & Families for MIR3649 Gene

Gene Families for MIR3649 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR3649: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR3649 Gene

Function for MIR3649 Gene

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR3649 Gene

Localization for MIR3649 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR3649 Gene

Pathways & Interactions for MIR3649 Gene

SuperPathways for MIR3649 Gene

No Data Available

Interacting Proteins for MIR3649 Gene

Gene Ontology (GO) - Biological Process for MIR3649 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for MIR3649 Gene

Transcripts for MIR3649 Gene

mRNA/cDNA for MIR3649 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR3649 Gene

No ASD Table

Relevant External Links for MIR3649 Gene

GeneLoc Exon Structure for
MIR3649
ECgene alternative splicing isoforms for
MIR3649

Expression for MIR3649 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR3649 Gene:

MIR3649
No Expression Related Data Available

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for MIR3649 Gene

Orthologs for MIR3649 Gene

Evolution for MIR3649 Gene

ENSEMBL:
Gene Tree for MIR3649 (if available)
TreeFam:
Gene Tree for MIR3649 (if available)

No data available for Orthologs for MIR3649 Gene

Paralogs for MIR3649 Gene

No data available for Paralogs for MIR3649 Gene

Variants for MIR3649 Gene

Sequence variations from dbSNP and Humsavar for MIR3649 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs10848543 -- 1,660,764(+) CAGGG(C/T)CTTAG upstream-variant-2KB
rs10848544 -- 1,660,999(+) TGGCA(C/G)CCCCA upstream-variant-2KB
rs112531557 -- 1,661,066(+) CCCAC(C/G)CGTCT upstream-variant-2KB
rs112725338 -- 1,662,062(+) CACAC(G/T)TGCAT upstream-variant-2KB
rs113774559 -- 1,661,121(+) CCCAC(C/G)CGTCT upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MIR3649 Gene

Variant ID Type Subtype PubMed ID
nsv556995 CNV loss 21841781
nsv832304 CNV gain 17160897

Relevant External Links for MIR3649 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR3649

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR3649 Gene

Disorders for MIR3649 Gene

Relevant External Links for MIR3649

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR3649

No disorders were found for MIR3649 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR3649 Gene

Publications for MIR3649 Gene

  1. Discovery of microRNAs and other small RNAs in solid tumors. (PMID: 20483914) Meiri E. … Sitbon E. (Nucleic Acids Res. 2010) 3 64
  2. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S. … Enright A.J. (Nucleic Acids Res. 2006) 3 64

Products for MIR3649 Gene

Sources for MIR3649 Gene

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