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Aliases for MIR3646 Gene

Subcategory (RNA class) for MIR3646 Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR3646 Gene

  • MicroRNA 3646 2 3 5
  • Hsa-Mir-3646 3

External Ids for MIR3646 Gene

Previous GeneCards Identifiers for MIR3646 Gene

  • GC20U900618
  • GC20P043038

Summaries for MIR3646 Gene

Entrez Gene Summary for MIR3646 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR3646 Gene

MIR3646 (MicroRNA 3646) is an RNA Gene, and is affiliated with the miRNA class.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR3646 Gene

Genomics for MIR3646 Gene

Regulatory Elements for MIR3646 Gene

Enhancers for MIR3646 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH20F044397 0.5 ENCODE 0.8 +1.1 1135 22.8 HDGF PKNOX1 CREB3L1 MLX ZFP64 ARID4B YBX1 DMAP1 YY1 SLC30A9 IFT52 FITM2 LINC01430 LINC01620 HNF4A OSER1-AS1 MIR3646
GH20F044421 1 Ensembl ENCODE 0.3 +21.4 21405 15.2 PKNOX1 ATF1 MLX ARID4B DMAP1 YBX1 YY1 SLC30A9 ZNF143 PAF1 HNF4A LOC105372629 FITM2 LINC01430 LINC01620 PKIG MIR3646
GH20F044438 1.2 Ensembl ENCODE 0.3 +35.5 35469 10.0 ELF3 RAD21 ZBTB40 YY1 ZNF121 RCOR1 SMARCC1 CEBPB ZNF623 NR2F2 LINC01430 LINC01620 MIR3646
GH20F044450 1.1 ENCODE 0.2 +43.1 43103 0.5 GATAD2A TBP ZNF511 ARID4B THRB ZNF48 SMARCA4 RXRB LINC01430 LINC01620 MIR3646
GH20F044460 0.2 ENCODE 0.2 +53.4 53366 1.3 ELF3 ATF1 ARID4B ZSCAN9 DNMT3B RAD21 RARA RFX5 KAT2B YY1 FITM2 LINC01430 LINC01620 MIR3646
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around MIR3646 on UCSC Golden Path with GeneCards custom track

Genomic Location for MIR3646 Gene

Chromosome:
20
Start:
44,408,120 bp from pter
End:
44,408,203 bp from pter
Size:
84 bases
Orientation:
Plus strand

Genomic View for MIR3646 Gene

Genes around MIR3646 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR3646 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR3646 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR3646 Gene

Proteins for MIR3646 Gene

Post-translational modifications for MIR3646 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR3646 Gene

Domains & Families for MIR3646 Gene

Gene Families for MIR3646 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR3646: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR3646 Gene

Function for MIR3646 Gene

Animal Model Products

miRNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR3646 Gene

Localization for MIR3646 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR3646 Gene

Pathways & Interactions for MIR3646 Gene

SuperPathways for MIR3646 Gene

No Data Available

Interacting Proteins for MIR3646 Gene

Gene Ontology (GO) - Biological Process for MIR3646 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for MIR3646 Gene

Transcripts for MIR3646 Gene

mRNA/cDNA for MIR3646 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

miRNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR3646 Gene

No ASD Table

Relevant External Links for MIR3646 Gene

GeneLoc Exon Structure for
MIR3646
ECgene alternative splicing isoforms for
MIR3646

Expression for MIR3646 Gene

mRNA expression in normal human tissues for MIR3646 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR3646 Gene:

MIR3646
genes like me logo Genes that share expression patterns with MIR3646: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for MIR3646 Gene

Orthologs for MIR3646 Gene

Evolution for MIR3646 Gene

ENSEMBL:
Gene Tree for MIR3646 (if available)
TreeFam:
Gene Tree for MIR3646 (if available)

No data available for Orthologs for MIR3646 Gene

Paralogs for MIR3646 Gene

No data available for Paralogs for MIR3646 Gene

Variants for MIR3646 Gene

Sequence variations from dbSNP and Humsavar for MIR3646 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type
rs587777732 Pathogenic 44,406,195(+) TCTTC(C/T)GGAGG upstream-variant-2KB, reference, missense
rs193922471 Likely pathogenic 44,407,437(+) CTGCA(C/GG)CTCAA upstream-variant-2KB, reference, frameshift-variant
rs112386711 Benign 44,407,494(+) CTCCC(C/G/T)GCCCC intron-variant, upstream-variant-2KB
rs736823 Benign 44,406,143(-) CCCGT(A/G)GCCCG upstream-variant-2KB, reference, synonymous-codon
rs111565814 -- 44,407,200(+) ACAGG(A/T)CTGGG intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MIR3646 Gene

Variant ID Type Subtype PubMed ID
nsv1057847 CNV loss 25217958
nsv586065 CNV gain 21841781

Relevant External Links for MIR3646 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR3646

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR3646 Gene

Disorders for MIR3646 Gene

Relevant External Links for MIR3646

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR3646

No disorders were found for MIR3646 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR3646 Gene

Publications for MIR3646 Gene

  1. Identification of microRNAs in Nipple Discharge as Potential Diagnostic Biomarkers for Breast Cancer. (PMID: 25976861) Zhang K. … Ma R. (Ann. Surg. Oncol. 2015) 3 64
  2. Discovery of microRNAs and other small RNAs in solid tumors. (PMID: 20483914) Meiri E. … Sitbon E. (Nucleic Acids Res. 2010) 3 64
  3. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S. … Enright A.J. (Nucleic Acids Res. 2006) 3 64

Products for MIR3646 Gene

Sources for MIR3646 Gene

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