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Aliases for MIR3620 Gene

Subcategory (RNA class) for MIR3620 Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR3620 Gene

  • MicroRNA 3620 2 3
  • ARF1 4 5
  • ADP Ribosylation Factor 1 5
  • Hsa-Mir-3620 3
  • Mir-3620 3

External Ids for MIR3620 Gene

Previous GeneCards Identifiers for MIR3620 Gene

  • GC01U903105
  • GC01P228288

Summaries for MIR3620 Gene

Entrez Gene Summary for MIR3620 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR3620 Gene

MIR3620 (MicroRNA 3620) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR3620 include Cholera. Among its related pathways are Integrated Pancreatic Cancer Pathway and Insulin Signaling. An important paralog of this gene is ARF3.

UniProtKB/Swiss-Prot for MIR3620 Gene

  • GTP-binding protein that functions as an allosteric activator of the cholera toxin catalytic subunit, an ADP-ribosyltransferase. Involved in protein trafficking among different compartments. Modulates vesicle budding and uncoating within the Golgi complex. Deactivation induces the redistribution of the entire Golgi complex to the endoplasmic reticulum, suggesting a crucial role in protein trafficking. In its GTP-bound form, its triggers the association with coat proteins with the Golgi membrane. The hydrolysis of ARF1-bound GTP, which is mediated by ARFGAPs proteins, is required for dissociation of coat proteins from Golgi membranes and vesicles. The GTP-bound form interacts with PICK1 to limit PICK1-mediated inhibition of Arp2/3 complex activity; the function is linked to AMPA receptor (AMPAR) trafficking, regulation of synaptic plasicity of excitatory synapses and spine shrinkage during long-term depression (LTD).

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR3620 Gene

Genomics for MIR3620 Gene

Regulatory Elements for MIR3620 Gene

Enhancers for MIR3620 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around MIR3620 on UCSC Golden Path with GeneCards custom track

Promoters for MIR3620 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Location for MIR3620 Gene

Chromosome:
1
Start:
228,082,660 bp from pter
End:
228,099,212 bp from pter
Size:
16,553 bases
Orientation:
Plus strand

Genomic View for MIR3620 Gene

Genes around MIR3620 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR3620 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR3620 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR3620 Gene

Proteins for MIR3620 Gene

  • Protein details for MIR3620 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P84077-ARF1_HUMAN
    Recommended name:
    ADP-ribosylation factor 1
    Protein Accession:
    P84077
    Secondary Accessions:
    • P10947
    • P32889

    Protein attributes for MIR3620 Gene

    Size:
    181 amino acids
    Molecular mass:
    20697 Da
    Quaternary structure:
    • Interacts with ARHGAP21, ASAP2, GGA1, HERC1, PRKCABP, PIP5K1B, TMED2, PSCD2, TMED10 and GRIA2. Interacts with ARFGAP1, which hydrolyzes GTP and thus, regulates its function. Interacts with PI4KB in the Golgi complex. Interacts with NCS1/FREQ in the Golgi and at the plasma membrane. Interacts with PLEKHA3. Interacts with PLEKHA8; the interaction, together with phosphatidylinositol 4-phosphate binding, is required for FAPP2-mediated glucosylceramide transfer activity. Interacts (activated) with PICK1 (via PDZ domain); the interaction blocks Arp2/3 complex inhibition. Interacts with IQSEC1 (PubMed:24058294).
    • Interacts with ARHGAP21, ASAP2, GGA1, HERC1, PRKCABP, PIP5K1B, TMED2, PSCD2, TMED10 and GRIA2. Interacts with ARFGAP1, which hydrolyzes GTP and thus, regulates its function. Interacts with PI4KB in the Golgi complex. Interacts with NCS1/FREQ in the Golgi and at the plasma membrane. Interacts with PLEKHA3. Interacts with PLEKHA8; the interaction, together with phosphatidylinositol 4-phosphate binding, is required for FAPP2-mediated glucosylceramide transfer activity. Interacts (activated) with PICK1 (via PDZ domain); the interaction blocks Arp2/3 complex inhibition. Interacts with IQSEC1 (PubMed:24058294).

    Three dimensional structures from OCA and Proteopedia for MIR3620 Gene

neXtProt entry for MIR3620 Gene

Post-translational modifications for MIR3620 Gene

  • Demyristoylated by S.flexneri cysteine protease IpaJ which cleaves the peptide bond between N-myristoylated Gly-2 and Asn-3.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MIR3620 Gene

No data available for DME Specific Peptides for MIR3620 Gene

Domains & Families for MIR3620 Gene

Gene Families for MIR3620 Gene

Protein Domains for MIR3620 Gene

Graphical View of Domain Structure for InterPro Entry

P84077

UniProtKB/Swiss-Prot:

ARF1_HUMAN :
  • Belongs to the small GTPase superfamily. Arf family.
Family:
  • Belongs to the small GTPase superfamily. Arf family.
genes like me logo Genes that share domains with MIR3620: view

No data available for Suggested Antigen Peptide Sequences for MIR3620 Gene

Function for MIR3620 Gene

Molecular function for MIR3620 Gene

UniProtKB/Swiss-Prot Function:
GTP-binding protein that functions as an allosteric activator of the cholera toxin catalytic subunit, an ADP-ribosyltransferase. Involved in protein trafficking among different compartments. Modulates vesicle budding and uncoating within the Golgi complex. Deactivation induces the redistribution of the entire Golgi complex to the endoplasmic reticulum, suggesting a crucial role in protein trafficking. In its GTP-bound form, its triggers the association with coat proteins with the Golgi membrane. The hydrolysis of ARF1-bound GTP, which is mediated by ARFGAPs proteins, is required for dissociation of coat proteins from Golgi membranes and vesicles. The GTP-bound form interacts with PICK1 to limit PICK1-mediated inhibition of Arp2/3 complex activity; the function is linked to AMPA receptor (AMPAR) trafficking, regulation of synaptic plasicity of excitatory synapses and spine shrinkage during long-term depression (LTD).

Gene Ontology (GO) - Molecular Function for MIR3620 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000287 magnesium ion binding IEA --
GO:0003924 GTPase activity TAS --
GO:0005057 receptor signaling protein activity TAS --
GO:0005515 protein binding IEA --
GO:0005525 GTP binding IEA --
genes like me logo Genes that share ontologies with MIR3620: view

Animal Model Products

miRNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR3620 Gene

Localization for MIR3620 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MIR3620 Gene

Golgi apparatus. Cytoplasm, perinuclear region. Cell junction, synapse, synaptosome. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density. Membrane; Lipid-anchor.

Gene Ontology (GO) - Cellular Components for MIR3620 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005770 late endosome IEA --
GO:0005778 peroxisomal membrane IEA --
GO:0005794 Golgi apparatus IEA --
GO:0005802 trans-Golgi network IEA --
GO:0005829 cytosol IEA --
genes like me logo Genes that share ontologies with MIR3620: view

No data available for Subcellular locations from COMPARTMENTS for MIR3620 Gene

Pathways & Interactions for MIR3620 Gene

genes like me logo Genes that share pathways with MIR3620: view

Pathways by source for MIR3620 Gene

3 BioSystems pathways for MIR3620 Gene

Gene Ontology (GO) - Biological Process for MIR3620 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002090 regulation of receptor internalization IEA --
GO:0006661 phosphatidylinositol biosynthetic process TAS --
GO:0006878 cellular copper ion homeostasis IMP --
GO:0006892 post-Golgi vesicle-mediated transport TAS --
GO:0007015 actin filament organization IEA --
genes like me logo Genes that share ontologies with MIR3620: view

No data available for SIGNOR curated interactions for MIR3620 Gene

Drugs & Compounds for MIR3620 Gene

No Compound Related Data Available

Transcripts for MIR3620 Gene

mRNA/cDNA for MIR3620 Gene

(15) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR3620 Gene

No ASD Table

Relevant External Links for MIR3620 Gene

GeneLoc Exon Structure for
MIR3620
ECgene alternative splicing isoforms for
MIR3620

Expression for MIR3620 Gene

mRNA expression in normal human tissues for MIR3620 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR3620 Gene:

MIR3620
genes like me logo Genes that share expression patterns with MIR3620: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for MIR3620 Gene

Orthologs for MIR3620 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for MIR3620 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ARF1 35
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ARF1 35
  • 95 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ARF1 35
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Arf1 35
  • 100 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 67 (a)
ManyToMany
chimpanzee
(Pan troglodytes)
Mammalia ARF1 35
  • 100 (a)
OneToOne
chicken
(Gallus gallus)
Aves ARF1 35
  • 100 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ARF1 35
  • 100 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii arf2 35
  • 97 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta Arf79F 35
  • 95 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea arf-1.2 35
  • 93 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ARF1 35
  • 77 (a)
ManyToMany
ARF2 35
  • 77 (a)
ManyToMany
ARF2 37
sea squirt
(Ciona savignyi)
Ascidiacea CSA.11304 35
  • 82 (a)
ManyToMany
Species where no ortholog for MIR3620 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for MIR3620 Gene

ENSEMBL:
Gene Tree for MIR3620 (if available)
TreeFam:
Gene Tree for MIR3620 (if available)

Paralogs for MIR3620 Gene

Pseudogenes.org Pseudogenes for MIR3620 Gene

genes like me logo Genes that share paralogs with MIR3620: view

Variants for MIR3620 Gene

Structural Variations from Database of Genomic Variants (DGV) for MIR3620 Gene

Variant ID Type Subtype PubMed ID
esv32853 CNV gain 17666407
nsv1160102 CNV deletion 26073780
nsv516409 CNV loss 19592680
nsv523935 CNV loss 19592680
nsv826908 CNV gain 20364138
nsv832803 CNV loss 17160897
nsv952136 CNV deletion 24416366

Relevant External Links for MIR3620 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR3620

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations from dbSNP and Humsavar and Variation tolerance for MIR3620 Gene

Disorders for MIR3620 Gene

MalaCards: The human disease database

(1) MalaCards diseases for MIR3620 Gene - From: GeneCards

Disorder Aliases PubMed IDs
cholera
  • cholera - vibrio cholerae
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for MIR3620

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR3620
genes like me logo Genes that share disorders with MIR3620: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MIR3620 Gene

Publications for MIR3620 Gene

  1. Multifunctional reagents for quantitative proteome-wide analysis of protein modification in human cells and dynamic profiling of protein lipidation during vertebrate development. (PMID: 25807930) Broncel M. … Tate E.W. (Angew. Chem. Int. Ed. 2015) 4 65
  2. N-terminome analysis of the human mitochondrial proteome. (PMID: 25944712) Vaca Jacome A.S. … Carapito C. (Proteomics 2015) 4 65
  3. An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. (PMID: 24275569) Bian Y. … Zou H. (J. Proteomics 2014) 4 65
  4. Global profiling of co- and post-translationally N-myristoylated proteomes in human cells. (PMID: 25255805) Thinon E. … Tate E.W. (Nat. Commun. 2014) 4 65
  5. Proteolytic elimination of N-myristoyl modifications by the Shigella virulence factor IpaJ. (PMID: 23535599) Burnaevskiy N. … Alto N.M. (Nature 2013) 4 65

Products for MIR3620 Gene

Sources for MIR3620 Gene

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