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Aliases for MIR3618 Gene

Subcategory (RNA class) for MIR3618 Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR3618 Gene

  • MicroRNA 3618 2 3
  • DGCR8 4 5
  • DGCR8, Microprocessor Complex Subunit 5
  • DiGeorge Syndrome Critical Region 8 4
  • Hsa-Mir-3618 3
  • C22orf12 4
  • DGCRK6 4

External Ids for MIR3618 Gene

Previous GeneCards Identifiers for MIR3618 Gene

  • GC22U900749
  • GC22P020078

Summaries for MIR3618 Gene

Entrez Gene Summary for MIR3618 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR3618 Gene

MIR3618 (MicroRNA 3618) is an RNA Gene, and is affiliated with the miRNA class. Among its related pathways are Mitotic Prophase and mRNA Capping.

UniProtKB/Swiss-Prot for MIR3618 Gene

  • Component of the microprocessor complex that acts as a RNA- and heme-binding protein that is involved in the initial step of microRNA (miRNA) biogenesis. Component of the microprocessor complex that is required to process primary miRNA transcripts (pri-miRNAs) to release precursor miRNA (pre-miRNA) in the nucleus. Within the microprocessor complex, DGCR8 function as a molecular anchor necessary for the recognition of pri-miRNA at dsRNA-ssRNA junction and directs DROSHA to cleave 11 bp away form the junction to release hairpin-shaped pre-miRNAs that are subsequently cut by the cytoplasmic DICER to generate mature miRNAs (PubMed:26027739, PubMed:26748718). The heme-bound DGCR8 dimer binds pri-miRNAs as a cooperative trimer (of dimers) and is active in triggering pri-miRNA cleavage, whereas the heme-free DGCR8 monomer binds pri-miRNAs as a dimer and is much less active. Both double-stranded and single-stranded regions of a pri-miRNA are required for its binding (PubMed:15531877, PubMed:15574589, PubMed:15589161, PubMed:16751099, PubMed:16906129, PubMed:16963499, PubMed:17159994). Specifically recognizes and binds N6-methyladenosine (m6A)-containing pri-miRNAs, a modification required for pri-miRNAs processing (PubMed:25799998). Involved in the silencing of embryonic stem cell self-renewal (By similarity).

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR3618 Gene

Genomics for MIR3618 Gene

Regulatory Elements for MIR3618 Gene

Enhancers for MIR3618 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH22F020084 1 Ensembl ENCODE 0.8 +4.7 4691 1.5 HDGF ATF1 PKNOX1 ARNT CREB3L1 MLX SIN3A ARID4B ZNF2 GATA2 LINC01311 SCARF2 THAP7-AS1 THAP7 RPL7AP70 DGCR8 ZDHHC8 CCDC188 MIR1306 MIR3618
GH22F020078 1.1 FANTOM5 ENCODE 0.8 +1.3 1290 5.2 HDGF PKNOX1 ARNT CREB3L1 MLX ZFP64 ARID4B SIN3A DMAP1 ZNF2 DGCR8 RPL8P5 TRMT2A THAP7-AS1 THAP7 RPL7AP70 SCARF2 LINC01311 ENSG00000243762 RANBP1
GH22F020076 0.6 ENCODE 0.8 -3.3 -3324 1.1 HDGF PKNOX1 ARNT TBL1XR1 YBX1 GATA2 SMARCA5 ZBTB2 CEBPB ZEB2 ENSG00000243762 RANBP1 TRMT2A MIR185 ZDHHC8 CCDC188 DGCR8 MIR1306 MIR3618 ENSG00000277950
GH22F020093 0.4 ENCODE 0.4 +13.3 13331 0.1 ATF1 TBL1XR1 SIN3A ARID4B RAD21 YY1 ZNF335 SCRT2 ZNF391 ZNF263 ABHD17AP4 DGCR8 MIR1306 MIR3618 ENSG00000243762
GH22F020105 0.7 ENCODE 0.3 +26.2 26181 2.2 TBL1XR1 ZNF740 NR4A1 TSC22D4 MNT ZIC2 RAD21 YY1 POLR2A ATF3 ABHD17AP4 ZDHHC8 MIR185 CCDC188 ENSG00000243762 DGCR8 MIR1306 MIR3618
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around MIR3618 on UCSC Golden Path with GeneCards custom track

Promoters for MIR3618 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000615475 68 2201 HDGF PKNOX1 ARNT CREB3L1 MLX ZFP64 ARID4B SIN3A DMAP1 ZNF2

Genomic Location for MIR3618 Gene

Chromosome:
22
Start:
20,080,232 bp from pter
End:
20,111,877 bp from pter
Size:
31,646 bases
Orientation:
Plus strand

Genomic View for MIR3618 Gene

Genes around MIR3618 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR3618 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR3618 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR3618 Gene

Proteins for MIR3618 Gene

  • Protein details for MIR3618 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8WYQ5-DGCR8_HUMAN
    Recommended name:
    Microprocessor complex subunit DGCR8
    Protein Accession:
    Q8WYQ5
    Secondary Accessions:
    • B2R8G1
    • Q6DCB2
    • Q6MZE9
    • Q6Y2L0
    • Q96G39
    • Q96GP8
    • Q9H6L8
    • Q9H6T7
    • Q9NRW2

    Protein attributes for MIR3618 Gene

    Size:
    773 amino acids
    Molecular mass:
    86045 Da
    Cofactor:
    Name=heme; Xref=ChEBI:CHEBI:30413;
    Quaternary structure:
    • Monomer; in absence of heme. Homodimer; the association with heme promotes its dimerization (PubMed:17159994). Component of the microprocessor complex, or pri-miRNA processing protein complex, which is composed of DROSHA and DGCR8 (PubMed:15589161, PubMed:15574589, PubMed:15531877, PubMed:16751099, PubMed:19135890, PubMed:26027739, PubMed:26748718). The microprocessor complex is a heterotrimer; each of the two DROSHA RNase III domains binds one DGCR8 (via C-terminal region) (PubMed:26027739, PubMed:26748718). Interacts with ILF3, NCL and DROSHA (PubMed:17765891).
    • Monomer; in absence of heme. Homodimer; the association with heme promotes its dimerization (PubMed:17159994). Component of the microprocessor complex, or pri-miRNA processing protein complex, which is composed of DROSHA and DGCR8 (PubMed:15589161, PubMed:15574589, PubMed:15531877, PubMed:16751099, PubMed:19135890, PubMed:26027739, PubMed:26748718). The microprocessor complex is a heterotrimer; each of the two DROSHA RNase III domains binds one DGCR8 (via C-terminal region) (PubMed:26027739, PubMed:26748718). Interacts with ILF3, NCL and DROSHA (PubMed:17765891).
    • Monomer; in absence of heme. Homodimer; the association with heme promotes its dimerization (PubMed:17159994). Component of the microprocessor complex, or pri-miRNA processing protein complex, which is composed of DROSHA and DGCR8 (PubMed:15589161, PubMed:15574589, PubMed:15531877, PubMed:16751099, PubMed:19135890, PubMed:26027739, PubMed:26748718). The microprocessor complex is a heterotrimer; each of the two DROSHA RNase III domains binds one DGCR8 (via C-terminal region) (PubMed:26027739, PubMed:26748718). Interacts with ILF3, NCL and DROSHA (PubMed:17765891).
    SequenceCaution:
    • Sequence=AAO86726.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAB15165.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAB15238.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for MIR3618 Gene

    Alternative splice isoforms for MIR3618 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MIR3618 Gene

Post-translational modifications for MIR3618 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MIR3618 Gene

No data available for DME Specific Peptides for MIR3618 Gene

Domains & Families for MIR3618 Gene

Gene Families for MIR3618 Gene

Protein Domains for MIR3618 Gene

Graphical View of Domain Structure for InterPro Entry

Q8WYQ5

UniProtKB/Swiss-Prot:

DGCR8_HUMAN :
  • Both DRBM domains are required for efficient binding to pri-miRNA. The region between residues 276 and 498 has an autoinhibitory function on pri-miRNA processing activity.
Domain:
  • Both DRBM domains are required for efficient binding to pri-miRNA. The region between residues 276 and 498 has an autoinhibitory function on pri-miRNA processing activity.
  • Contains 2 DRBM (double-stranded RNA-binding) domains.
  • Contains 1 WW domain.
genes like me logo Genes that share domains with MIR3618: view

No data available for Suggested Antigen Peptide Sequences for MIR3618 Gene

Function for MIR3618 Gene

Molecular function for MIR3618 Gene

UniProtKB/Swiss-Prot Function:
Component of the microprocessor complex that acts as a RNA- and heme-binding protein that is involved in the initial step of microRNA (miRNA) biogenesis. Component of the microprocessor complex that is required to process primary miRNA transcripts (pri-miRNAs) to release precursor miRNA (pre-miRNA) in the nucleus. Within the microprocessor complex, DGCR8 function as a molecular anchor necessary for the recognition of pri-miRNA at dsRNA-ssRNA junction and directs DROSHA to cleave 11 bp away form the junction to release hairpin-shaped pre-miRNAs that are subsequently cut by the cytoplasmic DICER to generate mature miRNAs (PubMed:26027739, PubMed:26748718). The heme-bound DGCR8 dimer binds pri-miRNAs as a cooperative trimer (of dimers) and is active in triggering pri-miRNA cleavage, whereas the heme-free DGCR8 monomer binds pri-miRNAs as a dimer and is much less active. Both double-stranded and single-stranded regions of a pri-miRNA are required for its binding (PubMed:15531877, PubMed:15574589, PubMed:15589161, PubMed:16751099, PubMed:16906129, PubMed:16963499, PubMed:17159994). Specifically recognizes and binds N6-methyladenosine (m6A)-containing pri-miRNAs, a modification required for pri-miRNAs processing (PubMed:25799998). Involved in the silencing of embryonic stem cell self-renewal (By similarity).

Gene Ontology (GO) - Molecular Function for MIR3618 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003725 double-stranded RNA binding IDA --
GO:0004525 ribonuclease III activity IDA --
GO:0005515 protein binding IPI --
GO:0020037 heme binding IDA --
GO:0042803 protein homodimerization activity IDA --
genes like me logo Genes that share ontologies with MIR3618: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR3618 Gene

Localization for MIR3618 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MIR3618 Gene

Nucleus. Nucleus, nucleolus. Note=Colocalizes with nucleolin and DROSHA in the nucleolus. Mostly detected in the nucleolus as electron-dense granular patches around the fibrillar center (FC) and granular component (GC). Also detected in the nucleoplasm as small foci adjacent to splicing speckles near the chromatin structure. Localized with DROSHA in GW bodies (GWBs), also known as P-bodies (PubMed:17159994).

Gene Ontology (GO) - Cellular Components for MIR3618 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005654 nucleoplasm TAS --
GO:0005730 nucleolus IEA --
GO:0005737 cytoplasm IDA --
GO:0015630 microtubule cytoskeleton IDA --
genes like me logo Genes that share ontologies with MIR3618: view

No data available for Subcellular locations from COMPARTMENTS for MIR3618 Gene

Pathways & Interactions for MIR3618 Gene

genes like me logo Genes that share pathways with MIR3618: view

Pathways by source for MIR3618 Gene

1 BioSystems pathway for MIR3618 Gene

Gene Ontology (GO) - Biological Process for MIR3618 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0031047 gene silencing by RNA TAS --
GO:0031053 primary miRNA processing IDA --
GO:0072091 regulation of stem cell proliferation IEA --
GO:0090501 RNA phosphodiester bond hydrolysis IEA --
GO:0090502 RNA phosphodiester bond hydrolysis, endonucleolytic IEA --
genes like me logo Genes that share ontologies with MIR3618: view

No data available for SIGNOR curated interactions for MIR3618 Gene

Transcripts for MIR3618 Gene

mRNA/cDNA for MIR3618 Gene

(12) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR3618 Gene

No ASD Table

Relevant External Links for MIR3618 Gene

GeneLoc Exon Structure for
MIR3618
ECgene alternative splicing isoforms for
MIR3618

Expression for MIR3618 Gene

mRNA expression in normal human tissues for MIR3618 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR3618 Gene:

MIR3618

mRNA Expression by UniProt/SwissProt for MIR3618 Gene:

Q8WYQ5-DGCR8_HUMAN
Tissue specificity: Ubiquitously expressed.
genes like me logo Genes that share expression patterns with MIR3618: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for MIR3618 Gene

Orthologs for MIR3618 Gene

This gene was present in the common ancestor of animals.

Orthologs for MIR3618 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-1306 35
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia cfa-mir-1306 35
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Dgcr8 35
  • 95 (a)
OneToOne
cow
(Bos Taurus)
Mammalia bta-mir-1306 35
  • 93 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia DGCR8 35
  • 92 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia DGCR8 35
  • 82 (a)
OneToOne
chicken
(Gallus gallus)
Aves gga-mir-1306 35
  • 84 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia aca-mir-5417 35
  • 82 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii dgcr8 35
  • 70 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta pasha 35
  • 36 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea pash-1 35
  • 22 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 41 (a)
OneToOne
Species where no ortholog for MIR3618 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for MIR3618 Gene

ENSEMBL:
Gene Tree for MIR3618 (if available)
TreeFam:
Gene Tree for MIR3618 (if available)

Paralogs for MIR3618 Gene

No data available for Paralogs for MIR3618 Gene

Variants for MIR3618 Gene

Sequence variations from dbSNP and Humsavar for MIR3618 Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type
rs111669527 -- 20,086,041(+) CGCCC(C/T)TTCCA downstream-variant-500B, upstream-variant-2KB, reference, synonymous-codon
rs114176820 -- 20,084,817(+) CTCTG(G/T)CCTGG intron-variant, upstream-variant-2KB
rs12159555 -- 20,085,800(+) GCTGT(C/G)TACAT nc-transcript-variant, upstream-variant-2KB, utr-variant-5-prime
rs138462648 -- 20,086,050(+) CAAGC(A/G)CTGCC downstream-variant-500B, upstream-variant-2KB, reference, synonymous-codon
rs138886652 -- 20,086,291(+) TCTCC(C/T)CTGAC downstream-variant-500B, reference, missense

Structural Variations from Database of Genomic Variants (DGV) for MIR3618 Gene

Variant ID Type Subtype PubMed ID
dgv4480n100 CNV gain 25217958
dgv726n67 CNV gain 20364138
dgv7983n54 CNV gain 21841781
esv2758825 CNV loss 17122850
esv3647284 CNV gain 21293372
esv3893434 CNV gain 25118596
nsv471183 CNV loss 18288195
nsv828938 CNV gain 20364138
nsv828939 CNV loss 20364138
nsv834133 CNV loss 17160897
nsv953027 CNV deletion 24416366

Relevant External Links for MIR3618 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR3618

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR3618 Gene

Disorders for MIR3618 Gene

Relevant External Links for MIR3618

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR3618

No disorders were found for MIR3618 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR3618 Gene

Publications for MIR3618 Gene

  1. Structure of human DROSHA. (PMID: 26748718) Kwon S.C. … Woo J.S. (Cell 2016) 4 64
  2. System-wide analysis of SUMOylation dynamics in response to replication stress reveals novel small ubiquitin-like modified target proteins and acceptor lysines relevant for genome stability. (PMID: 25755297) Xiao Z. … Vertegaal A.C. (Mol. Cell. Proteomics 2015) 4 64
  3. N6-methyladenosine marks primary microRNAs for processing. (PMID: 25799998) Alarcon C.R. … Tavazoie S.F. (Nature 2015) 4 64
  4. Functional Anatomy of the Human Microprocessor. (PMID: 26027739) Nguyen T.A. … Woo J.S. (Cell 2015) 4 64
  5. An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. (PMID: 24275569) Bian Y. … Zou H. (J. Proteomics 2014) 4 64

Products for MIR3618 Gene

Sources for MIR3618 Gene

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