Free for academic non-profit institutions. Other users need a Commercial license

Aliases for MIR3615 Gene

Subcategory (RNA class) for MIR3615 Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR3615 Gene

  • MicroRNA 3615 2 3
  • SLC9A3R1 4 5
  • Solute Carrier Family 9 Isoform A3 Regulatory Factor 1 4
  • Ezrin-Radixin-Moesin-Binding Phosphoprotein 50 4
  • Sodium-Hydrogen Exchanger Regulatory Factor 1 4
  • Regulatory Cofactor Of Na(+)/H(+) Exchanger 4
  • SLC9A3 Regulator 1 5
  • Hsa-Mir-3615 3
  • Mir-3615 3
  • NHERF-1 4
  • NHERF1 4
  • EBP50 4
  • NHERF 4

External Ids for MIR3615 Gene

Previous GeneCards Identifiers for MIR3615 Gene

  • GC17U901553
  • GC17P072747

Summaries for MIR3615 Gene

Entrez Gene Summary for MIR3615 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR3615 Gene

MIR3615 (MicroRNA 3615) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR3615 include Nephrolithiasis/Osteoporosis, Hypophosphatemic, 2. An important paralog of this gene is SLC9A3R2.

UniProtKB/Swiss-Prot for MIR3615 Gene

  • Scaffold protein that connects plasma membrane proteins with members of the ezrin/moesin/radixin family and thereby helps to link them to the actin cytoskeleton and to regulate their surface expression. Necessary for recycling of internalized ADRB2. Was first known to play a role in the regulation of the activity and subcellular location of SLC9A3. Necessary for cAMP-mediated phosphorylation and inhibition of SLC9A3. May enhance Wnt signaling. May participate in HTR4 targeting to microvilli (By similarity). Involved in the regulation of phosphate reabsorption in the renal proximal tubules. Involved in sperm capacitation. May participate in the regulation of the chloride and bicarbonate homeostasis in spermatozoa.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR3615 Gene

Genomics for MIR3615 Gene

Regulatory Elements for MIR3615 Gene


Promoters for MIR3615 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around MIR3615 on UCSC Golden Path with GeneCards custom track

Genomic Location for MIR3615 Gene

Chromosome:
17
Start:
74,748,613 bp from pter
End:
74,769,353 bp from pter
Size:
20,741 bases
Orientation:
Plus strand

Genomic View for MIR3615 Gene

Genes around MIR3615 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR3615 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR3615 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR3615 Gene

Proteins for MIR3615 Gene

  • Protein details for MIR3615 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O14745-NHRF1_HUMAN
    Recommended name:
    Na(+)/H(+) exchange regulatory cofactor NHE-RF1
    Protein Accession:
    O14745
    Secondary Accessions:
    • B3KY21
    • O43552
    • Q86WQ5

    Protein attributes for MIR3615 Gene

    Size:
    358 amino acids
    Molecular mass:
    38868 Da
    Quaternary structure:
    • Homodimer, and heterodimer with SLC9A3R2. Binds the N-termini of EZR, RDX and MSN. Binds the C-termini of PDGFRA, PDGFRB, ADRB2, NOS2 and CFTR. Binds ARHGAP17, EPI64, RACK1, OPRK1, GNAQ, CTNNB1 and PLCB3. Binds PDZK1 (By similarity). Interacts with CLCN3. Binds the C-terminus of PAG1. In resting T-cells, part of a PAG1-SLC9A3R1-MSN complex which is disrupted upon TCR activation. Forms a complex with CFTR and SLC4A7. Forms a complex with SLC4A7 and ATP6V1B1. Interacts with TRPC4 (via the PDZ-binding domain). Directly interacts with HTR4 (By similarity). Interacts (via the PDZ 1 domain) with PODXL (via the C-terminal PDZ-binding motif DTHL); interaction is not detected in glomerular epithelium cells. Interacts (via the PDZ 1 domain) with PODXL (via the C-terminal PDZ-binding motif DTHL); the interaction take place early in the secretory pathway and is necessary for its apical membrane sorting (By similarity). Interacts with SLC26A3 (By similarity). Interacts with MCC. Interacts with SLC34A1. Interacts (via the PDZ domains) with SLC26A6 isoform 4 and isoform 5.
    • Homodimer, and heterodimer with SLC9A3R2. Binds the N-termini of EZR, RDX and MSN. Binds the C-termini of PDGFRA, PDGFRB, ADRB2, NOS2 and CFTR. Binds ARHGAP17, EPI64, RACK1, OPRK1, GNAQ, CTNNB1 and PLCB3. Binds PDZK1 (By similarity). Interacts with CLCN3. Binds the C-terminus of PAG1. In resting T-cells, part of a PAG1-SLC9A3R1-MSN complex which is disrupted upon TCR activation. Forms a complex with CFTR and SLC4A7. Forms a complex with SLC4A7 and ATP6V1B1. Interacts with TRPC4 (via the PDZ-binding domain). Directly interacts with HTR4 (By similarity). Interacts (via the PDZ 1 domain) with PODXL (via the C-terminal PDZ-binding motif DTHL); interaction is not detected in glomerular epithelium cells. Interacts (via the PDZ 1 domain) with PODXL (via the C-terminal PDZ-binding motif DTHL); the interaction take place early in the secretory pathway and is necessary for its apical membrane sorting (By similarity). Interacts with SLC26A3 (By similarity). Interacts with MCC. Interacts with SLC34A1. Interacts (via the PDZ domains) with SLC26A6 isoform 4 and isoform 5.
    SequenceCaution:
    • Sequence=AAH49220.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for MIR3615 Gene

    Alternative splice isoforms for MIR3615 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MIR3615 Gene

Post-translational modifications for MIR3615 Gene

Other Protein References for MIR3615 Gene

No data available for DME Specific Peptides for MIR3615 Gene

Domains & Families for MIR3615 Gene

Gene Families for MIR3615 Gene

Protein Domains for MIR3615 Gene

Graphical View of Domain Structure for InterPro Entry

O14745

UniProtKB/Swiss-Prot:

NHRF1_HUMAN :
  • Contains 2 PDZ (DHR) domains.
Domain:
  • Contains 2 PDZ (DHR) domains.
genes like me logo Genes that share domains with MIR3615: view

No data available for Suggested Antigen Peptide Sequences for MIR3615 Gene

Function for MIR3615 Gene

Molecular function for MIR3615 Gene

UniProtKB/Swiss-Prot Function:
Scaffold protein that connects plasma membrane proteins with members of the ezrin/moesin/radixin family and thereby helps to link them to the actin cytoskeleton and to regulate their surface expression. Necessary for recycling of internalized ADRB2. Was first known to play a role in the regulation of the activity and subcellular location of SLC9A3. Necessary for cAMP-mediated phosphorylation and inhibition of SLC9A3. May enhance Wnt signaling. May participate in HTR4 targeting to microvilli (By similarity). Involved in the regulation of phosphate reabsorption in the renal proximal tubules. Involved in sperm capacitation. May participate in the regulation of the chloride and bicarbonate homeostasis in spermatozoa.
UniProtKB/Swiss-Prot Induction:
By estrogen.

Gene Ontology (GO) - Molecular Function for MIR3615 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005102 receptor binding IPI --
GO:0005515 protein binding IPI --
GO:0008013 beta-catenin binding IPI --
GO:0017081 chloride channel regulator activity IDA --
GO:0019902 phosphatase binding IPI --
genes like me logo Genes that share ontologies with MIR3615: view

Animal Model Products

miRNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR3615 Gene

Localization for MIR3615 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MIR3615 Gene

Cytoplasm. Apical cell membrane. Endomembrane system; Peripheral membrane protein. Cell projection, filopodium. Cell projection, ruffle. Cell projection, microvillus. Note=Translocates from the cytoplasm to the apical cell membrane in a PODXL-dependent manner. Colocalizes with CFTR at the midpiece of sperm tail (By similarity). Colocalizes with actin in microvilli-rich apical regions of the syncytiotrophoblast. Found in microvilli, ruffling membrane and filopodia of HeLa cells. Present in lipid rafts of T-cells. {ECO:0000250}.

Gene Ontology (GO) - Cellular Components for MIR3615 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA --
GO:0005813 centrosome IDA --
GO:0005886 plasma membrane IDA --
GO:0005902 microvillus IDA --
GO:0012505 endomembrane system IEA --
genes like me logo Genes that share ontologies with MIR3615: view

No data available for Subcellular locations from COMPARTMENTS for MIR3615 Gene

Pathways & Interactions for MIR3615 Gene

SuperPathways for MIR3615 Gene

No Data Available

Gene Ontology (GO) - Biological Process for MIR3615 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003096 renal sodium ion transport IEA --
GO:0006461 protein complex assembly TAS --
GO:0007191 adenylate cyclase-activating dopamine receptor signaling pathway IEA --
GO:0007605 sensory perception of sound IEA --
GO:0008285 negative regulation of cell proliferation IMP --
genes like me logo Genes that share ontologies with MIR3615: view

No data available for Pathways by source and SIGNOR curated interactions for MIR3615 Gene

Drugs & Compounds for MIR3615 Gene

No Compound Related Data Available

Transcripts for MIR3615 Gene

mRNA/cDNA for MIR3615 Gene

(6) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR3615 Gene

No ASD Table

Relevant External Links for MIR3615 Gene

GeneLoc Exon Structure for
MIR3615
ECgene alternative splicing isoforms for
MIR3615

Expression for MIR3615 Gene

mRNA expression in normal human tissues for MIR3615 Gene

mRNA differential expression in normal tissues according to GTEx for MIR3615 Gene

This gene is overexpressed in Testis (x22.2), Kidney - Cortex (x11.3), and Small Intestine - Terminal Ileum (x9.6).

NURSA nuclear receptor signaling pathways regulating expression of MIR3615 Gene:

MIR3615

mRNA Expression by UniProt/SwissProt for MIR3615 Gene:

O14745-NHRF1_HUMAN
Tissue specificity: Detected in liver, kidney, pancreas, prostate, spleen, small intestine and placenta, in particular in the syncytiotrophoblast.
genes like me logo Genes that share expression patterns with MIR3615: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for MIR3615 Gene

Orthologs for MIR3615 Gene

This gene was present in the common ancestor of animals.

Orthologs for MIR3615 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia SLC9A3R1 35
  • 86 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SLC9A3R1 35
  • 88 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SLC9A3R1 35
  • 78 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Slc9a3r1 35
  • 88 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SLC9A3R1 35
  • 72 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia SLC9A3R1 35
  • 99 (a)
OneToOne
chicken
(Gallus gallus)
Aves SLC9A3R1 35
  • 64 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SLC9A3R1 35
  • 78 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii slc9a3r1 35
  • 48 (a)
OneToMany
SLC9A3R1 (2 of 2) 35
  • 52 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta Sip1 35
  • 29 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8280 35
  • 44 (a)
OneToMany
Species where no ortholog for MIR3615 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MIR3615 Gene

ENSEMBL:
Gene Tree for MIR3615 (if available)
TreeFam:
Gene Tree for MIR3615 (if available)

Paralogs for MIR3615 Gene

Paralogs for MIR3615 Gene

genes like me logo Genes that share paralogs with MIR3615: view

Variants for MIR3615 Gene

Relevant External Links for MIR3615 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR3615

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations from dbSNP and Humsavar , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for MIR3615 Gene

Disorders for MIR3615 Gene

MalaCards: The human disease database

(1) MalaCards diseases for MIR3615 Gene - From: GeneCards

Disorder Aliases PubMed IDs
nephrolithiasis/osteoporosis, hypophosphatemic, 2
  • hypophosphatemic nephrolithiasis/osteoporosis 2
- elite association - COSMIC cancer census association via MalaCards

UniProtKB/Swiss-Prot

NHRF1_HUMAN
  • Nephrolithiasis/osteoporosis, hypophosphatemic, 2 (NPHLOP2) [MIM:612287]: A disease characterized by decreased renal phosphate absorption, renal phosphate wasting, hypophosphatemia, hyperphosphaturia, hypercalciuria, nephrolithiasis and osteoporosis. {ECO:0000269 PubMed:18784102, ECO:0000269 PubMed:22506049}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for MIR3615

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR3615
genes like me logo Genes that share disorders with MIR3615: view

No data available for Genatlas for MIR3615 Gene

Publications for MIR3615 Gene

  1. N-terminome analysis of the human mitochondrial proteome. (PMID: 25944712) Vaca Jacome A.S. … Carapito C. (Proteomics 2015) 4 65
  2. An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. (PMID: 24275569) Bian Y. … Zou H. (J. Proteomics 2014) 4 65
  3. Toward a comprehensive characterization of a human cancer cell phosphoproteome. (PMID: 23186163) Zhou H. … Mohammed S. (J. Proteome Res. 2013) 4 65
  4. Comparative large scale characterization of plant versus mammal proteins reveals similar and idiosyncratic N-I+-acetylation features. (PMID: 22223895) Bienvenut W.V. … Giglione C. (Mol. Cell Proteomics 2012) 4 65
  5. A new human NHERF1 mutation decreases renal phosphate transporter NPT2a expression by a PTH-independent mechanism. (PMID: 22506049) Courbebaisse M. … Prie D. (PLoS ONE 2012) 4 65

Products for MIR3615 Gene

Sources for MIR3615 Gene

Content