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Aliases for MIR3614 Gene

Subcategory (RNA class) for MIR3614 Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR3614 Gene

  • MicroRNA 3614 2 3
  • Ubiquitin/ISG15-Conjugating Enzyme TRIM25 4
  • Tripartite Motif-Containing Protein 25 4
  • Estrogen-Responsive Finger Protein 4
  • RING-Type E3 Ubiquitin Transferase 4
  • Tripartite Motif Containing 25 5
  • RING Finger Protein 147 4
  • Zinc Finger Protein 147 4
  • Hsa-Mir-3614 3
  • EC 6.3.2.n3 4
  • EC 2.3.2.27 4
  • Mir-3614 3
  • RNF147 4
  • ZNF147 4
  • TRIM25 5
  • EFP 4

External Ids for MIR3614 Gene

Previous GeneCards Identifiers for MIR3614 Gene

  • GC17U901561
  • GC17M054973

Summaries for MIR3614 Gene

Entrez Gene Summary for MIR3614 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR3614 Gene

MIR3614 (MicroRNA 3614) is an RNA Gene, and is affiliated with the miRNA class. An important paralog of this gene is TRIM47.

UniProtKB/Swiss-Prot for MIR3614 Gene

  • Functions as a ubiquitin E3 ligase and as an ISG15 E3 ligase. Involved in innate immune defense against viruses by mediating ubiquitination of DDX58. Mediates Lys-63-linked polyubiquitination of the DDX58 N-terminal CARD-like region which is crucial for triggering the cytosolic signal transduction that leads to the production of interferons in response to viral infection. Promotes ISGylation of 14-3-3 sigma (SFN), an adapter protein implicated in the regulation of a large spectrum signaling pathway. Mediates estrogen action in various target organs. Mediates the ubiquitination and subsequent proteasomal degradation of ZFHX3 (PubMed:22452784).

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR3614 Gene

Genomics for MIR3614 Gene

Regulatory Elements for MIR3614 Gene

Enhancers for MIR3614 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around MIR3614 on UCSC Golden Path with GeneCards custom track

Promoters for MIR3614 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around MIR3614 on UCSC Golden Path with GeneCards custom track

Genomic Location for MIR3614 Gene

Chromosome:
17
Start:
56,887,909 bp from pter
End:
56,914,038 bp from pter
Size:
26,130 bases
Orientation:
Minus strand

Genomic View for MIR3614 Gene

Genes around MIR3614 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR3614 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR3614 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR3614 Gene

ORGUL Member Location for MIR3614 Gene

ORGUL Member Location for MIR3614 gene

Proteins for MIR3614 Gene

  • Protein details for MIR3614 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q14258-TRI25_HUMAN
    Recommended name:
    E3 ubiquitin/ISG15 ligase TRIM25
    Protein Accession:
    Q14258

    Protein attributes for MIR3614 Gene

    Size:
    630 amino acids
    Molecular mass:
    70973 Da
    Quaternary structure:
    • Interacts (via SPRY domain) with DDX58 (via CARD domain). Interacts (via coiled coil) with influenza A virus NS1 protein; this interaction specifically inhibits TRIM25 multimerization and TRIM25-mediated DDX58 CARD ubiquitination, thereby suppressing DDX58 signal transduction. Interacts with ZFHX3.
    • Interacts (via SPRY domain) with DDX58 (via CARD domain). Interacts (via coiled coil) with influenza A virus NS1 protein; this interaction specifically inhibits TRIM25 multimerization and TRIM25-mediated DDX58 CARD ubiquitination, thereby suppressing DDX58 signal transduction. Interacts with ZFHX3.

    Three dimensional structures from OCA and Proteopedia for MIR3614 Gene

neXtProt entry for MIR3614 Gene

Post-translational modifications for MIR3614 Gene

  • Auto-ISGylated.
  • Ubiquitination at Lys 117, Lys 273, Lys 320, Lys 439, Lys 447, and Lys 567
  • Modification sites at PhosphoSitePlus

Other Protein References for MIR3614 Gene

No data available for DME Specific Peptides for MIR3614 Gene

Domains & Families for MIR3614 Gene

Gene Families for MIR3614 Gene

Graphical View of Domain Structure for InterPro Entry

Q14258

UniProtKB/Swiss-Prot:

TRI25_HUMAN :
  • The RING-type zinc finger is important for ISG15 E3 ligase activity and autoISGylation. AutoISGylation negatively regulates ISG15 E3 ligase activity.
  • Contains 1 RING-type zinc finger.
Domain:
  • The RING-type zinc finger is important for ISG15 E3 ligase activity and autoISGylation. AutoISGylation negatively regulates ISG15 E3 ligase activity.
  • The C-terminal B30.2/SPRY domain interacts with the first N-terminal CARD domain of DDX58.
  • Contains 1 B30.2/SPRY domain.
Similarity:
  • Contains 1 RING-type zinc finger.
genes like me logo Genes that share domains with MIR3614: view

No data available for Suggested Antigen Peptide Sequences for MIR3614 Gene

Function for MIR3614 Gene

Molecular function for MIR3614 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.
UniProtKB/Swiss-Prot CatalyticActivity:
ATP + [ISG15] + [protein]-lysine = AMP + diphosphate + [protein]-N-ISGyllysine.
UniProtKB/Swiss-Prot Function:
Functions as a ubiquitin E3 ligase and as an ISG15 E3 ligase. Involved in innate immune defense against viruses by mediating ubiquitination of DDX58. Mediates Lys-63-linked polyubiquitination of the DDX58 N-terminal CARD-like region which is crucial for triggering the cytosolic signal transduction that leads to the production of interferons in response to viral infection. Promotes ISGylation of 14-3-3 sigma (SFN), an adapter protein implicated in the regulation of a large spectrum signaling pathway. Mediates estrogen action in various target organs. Mediates the ubiquitination and subsequent proteasomal degradation of ZFHX3 (PubMed:22452784).
UniProtKB/Swiss-Prot Induction:
By interferons.

Enzyme Numbers (IUBMB) for MIR3614 Gene

Gene Ontology (GO) - Molecular Function for MIR3614 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004842 ubiquitin-protein transferase activity EXP --
GO:0005515 protein binding IPI --
GO:0008270 zinc ion binding IEA --
GO:0016881 acid-amino acid ligase activity IEA --
GO:0044822 poly(A) RNA binding IDA --
genes like me logo Genes that share ontologies with MIR3614: view

Animal Model Products

miRNA Products

Clone Products

Flow Cytometry Products

No data available for Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR3614 Gene

Localization for MIR3614 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MIR3614 Gene

Cytoplasm. Note=Colocalized with DDX58 at cytoplasmic perinuclear bodies.

Gene Ontology (GO) - Cellular Components for MIR3614 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm IDA --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with MIR3614: view

No data available for Subcellular locations from COMPARTMENTS for MIR3614 Gene

Pathways & Interactions for MIR3614 Gene

SuperPathways for MIR3614 Gene

No Data Available

UniProtKB/Swiss-Prot Q14258-TRI25_HUMAN

  • Pathway: Protein modification; protein ubiquitination.

Gene Ontology (GO) - Biological Process for MIR3614 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006513 protein monoubiquitination IMP --
GO:0016032 viral process IEA --
GO:0019985 translesion synthesis TAS --
GO:0032480 negative regulation of type I interferon production TAS --
GO:0033280 response to vitamin D IEA --
genes like me logo Genes that share ontologies with MIR3614: view

No data available for Pathways by source and SIGNOR curated interactions for MIR3614 Gene

Drugs & Compounds for MIR3614 Gene

No Compound Related Data Available

Transcripts for MIR3614 Gene

mRNA/cDNA for MIR3614 Gene

(10) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR3614 Gene

No ASD Table

Relevant External Links for MIR3614 Gene

GeneLoc Exon Structure for
MIR3614
ECgene alternative splicing isoforms for
MIR3614

Expression for MIR3614 Gene

mRNA expression in normal human tissues for MIR3614 Gene

mRNA differential expression in normal tissues according to GTEx for MIR3614 Gene

This gene is overexpressed in Whole Blood (x11.4).

NURSA nuclear receptor signaling pathways regulating expression of MIR3614 Gene:

MIR3614

mRNA Expression by UniProt/SwissProt for MIR3614 Gene:

Q14258-TRI25_HUMAN
Tissue specificity: Expressed in breast tumors (at protein level). Ubiquitous.
genes like me logo Genes that share expression patterns with MIR3614: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for MIR3614 Gene

Orthologs for MIR3614 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for MIR3614 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia TRIM25 35
  • 77 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TRIM25 35
  • 76 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TRIM25 35
  • 59 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Trim25 35
  • 73 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia TRIM25 35
  • 99 (a)
OneToOne
chicken
(Gallus gallus)
Aves TRIM25 35
  • 45 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TRIM25 35
  • 48 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii trim25 35
  • 32 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PSH1 37
Species where no ortholog for MIR3614 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MIR3614 Gene

ENSEMBL:
Gene Tree for MIR3614 (if available)
TreeFam:
Gene Tree for MIR3614 (if available)

Paralogs for MIR3614 Gene

Paralogs for MIR3614 Gene

Pseudogenes.org Pseudogenes for MIR3614 Gene

genes like me logo Genes that share paralogs with MIR3614: view

Variants for MIR3614 Gene

Structural Variations from Database of Genomic Variants (DGV) for MIR3614 Gene

Variant ID Type Subtype PubMed ID
esv32884 CNV loss 17666407

Relevant External Links for MIR3614 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR3614

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations from dbSNP and Humsavar and Variation tolerance for MIR3614 Gene

Disorders for MIR3614 Gene

Relevant External Links for MIR3614

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR3614

No disorders were found for MIR3614 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR3614 Gene

Publications for MIR3614 Gene

  1. An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. (PMID: 24275569) Bian Y. … Zou H. (J. Proteomics 2014) 4 65
  2. Toward a comprehensive characterization of a human cancer cell phosphoproteome. (PMID: 23186163) Zhou H. … Mohammed S. (J. Proteome Res. 2013) 4 65
  3. Oestrogen causes ATBF1 protein degradation through the oestrogen-responsive E3 ubiquitin ligase EFP. (PMID: 22452784) Dong X.Y. … Dong J.T. (Biochem. J. 2012) 4 65
  4. miRBase: integrating microRNA annotation and deep-sequencing data. (PMID: 21037258) Kozomara A. … Griffiths-Jones S. (Nucleic Acids Res. 2011) 3 65
  5. Identification of new microRNAs in paired normal and tumor breast tissue suggests a dual role for the ERBB2/Her2 gene. (PMID: 21199797) Persson H. … Rovira C. (Cancer Res. 2011) 3 65

Products for MIR3614 Gene

Sources for MIR3614 Gene

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