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Aliases for MIR3610 Gene

Subcategory (RNA class) for MIR3610 Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR3610 Gene

  • MicroRNA 3610 2 3
  • RAD21 4 5
  • RAD21 Cohesin Complex Component 5
  • Nuclear Matrix Protein 1 4
  • Hsa-Mir-3610 3
  • SCC1 Homolog 4
  • Mir-3610 3
  • KIAA0078 4
  • NXP-1 4
  • HHR21 4
  • HR21 4
  • NXP1 4

External Ids for MIR3610 Gene

Previous GeneCards Identifiers for MIR3610 Gene

  • GC08U901480
  • GC08M117888

Summaries for MIR3610 Gene

Entrez Gene Summary for MIR3610 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR3610 Gene

MIR3610 (MicroRNA 3610) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR3610 include Cornelia De Lange Syndrome 4 and Cornelia De Lange Syndrome. An important paralog of this gene is RAD21L1.

UniProtKB/Swiss-Prot for MIR3610 Gene

  • Cleavable component of the cohesin complex, involved in chromosome cohesion during cell cycle, in DNA repair, and in apoptosis. The cohesin complex is required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At metaphase-anaphase transition, this protein is cleaved by separase/ESPL1 and dissociates from chromatin, allowing sister chromatids to segregate. The cohesin complex may also play a role in spindle pole assembly during mitosis. Also plays a role in apoptosis, via its cleavage by caspase-3/CASP3 or caspase-7/CASP7 during early steps of apoptosis: the C-terminal 64 kDa cleavage product may act as a nuclear signal to initiate cytoplasmic events involved in the apoptotic pathway.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR3610 Gene

Genomics for MIR3610 Gene

Regulatory Elements for MIR3610 Gene


Promoters for MIR3610 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Location for MIR3610 Gene

Chromosome:
8
Start:
116,845,935 bp from pter
End:
116,874,866 bp from pter
Size:
28,932 bases
Orientation:
Minus strand

Genomic View for MIR3610 Gene

Genes around MIR3610 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR3610 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR3610 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR3610 Gene

ORGUL Member Location for MIR3610 Gene

ORGUL Member Location for MIR3610 gene

Proteins for MIR3610 Gene

  • Protein details for MIR3610 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O60216-RAD21_HUMAN
    Recommended name:
    Double-strand-break repair protein rad21 homolog
    Protein Accession:
    O60216
    Secondary Accessions:
    • A8K0E0
    • Q15001
    • Q99568

    Protein attributes for MIR3610 Gene

    Size:
    631 amino acids
    Molecular mass:
    71690 Da
    Quaternary structure:
    • Cohesin complexes are composed of the SMC1 (SMC1A or SMC1B) and SMC3 heterodimer attached via their hinge domain, RAD21 which link them, and one STAG protein (STAG1, STAG2 or STAG3), which interacts with RAD21. Found in a complex with SMC1A, SMC3, CDCA5, PDS5A/SCC-112 and PDS5B/APRIN. Interacts with PDS5B and WAPL; the interaction is direct.
    • Cohesin complexes are composed of the SMC1 (SMC1A or SMC1B) and SMC3 heterodimer attached via their hinge domain, RAD21 which link them, and one STAG protein (STAG1, STAG2 or STAG3), which interacts with RAD21. Found in a complex with SMC1A, SMC3, CDCA5, PDS5A/SCC-112 and PDS5B/APRIN. Interacts with PDS5B and WAPL; the interaction is direct.
    SequenceCaution:
    • Sequence=BAA07554.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for MIR3610 Gene

neXtProt entry for MIR3610 Gene

Post-translational modifications for MIR3610 Gene

  • Cleaved by separase/ESPL1 at the onset of anaphase. Cleaved by caspase-3 and caspase-7 at the beginning of apoptosis. The cleavage by ESPL1 and caspase-3 take place at different sites.
  • Phosphorylated; becomes hyperphosphorylated in M phase of cell cycle. The large dissociation of cohesin from chromosome arms during prophase may be partly due to its phosphorylation by PLK.
  • Ubiquitination at Lys 72, Lys 86, Lys 364, Lys 371, Lys 387, Lys 573, and Lys 605
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for MIR3610 Gene

Domains & Families for MIR3610 Gene

Gene Families for MIR3610 Gene

Protein Domains for MIR3610 Gene

Graphical View of Domain Structure for InterPro Entry

O60216

UniProtKB/Swiss-Prot:

RAD21_HUMAN :
  • The C-terminal part associates with the head of SMC1A, while the N-terminal part binds to the head of SMC3.
  • Belongs to the rad21 family.
Domain:
  • The C-terminal part associates with the head of SMC1A, while the N-terminal part binds to the head of SMC3.
Family:
  • Belongs to the rad21 family.
genes like me logo Genes that share domains with MIR3610: view

No data available for Suggested Antigen Peptide Sequences for MIR3610 Gene

Function for MIR3610 Gene

Molecular function for MIR3610 Gene

UniProtKB/Swiss-Prot Function:
Cleavable component of the cohesin complex, involved in chromosome cohesion during cell cycle, in DNA repair, and in apoptosis. The cohesin complex is required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At metaphase-anaphase transition, this protein is cleaved by separase/ESPL1 and dissociates from chromatin, allowing sister chromatids to segregate. The cohesin complex may also play a role in spindle pole assembly during mitosis. Also plays a role in apoptosis, via its cleavage by caspase-3/CASP3 or caspase-7/CASP7 during early steps of apoptosis: the C-terminal 64 kDa cleavage product may act as a nuclear signal to initiate cytoplasmic events involved in the apoptotic pathway.

Gene Ontology (GO) - Molecular Function for MIR3610 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding IEA --
GO:0005515 protein binding IEA --
genes like me logo Genes that share ontologies with MIR3610: view

Animal Model Products

miRNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR3610 Gene

Localization for MIR3610 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MIR3610 Gene

Nucleus. Chromosome. Chromosome, centromere. Note=Associates with chromatin. Before prophase it is scattered along chromosome arms. During prophase, most of cohesin complexes dissociate from chromatin probably because of phosphorylation by PLK, except at centromeres, where cohesin complexes remain. At anaphase, it is cleaved by separase/ESPL1, leading to the dissociation of the complex from chromosomes, allowing chromosome separation. Once cleaved by caspase-3, the C-terminal 64 kDa cleavage product translocates to the cytoplasm, where it may trigger apoptosis. {ECO:0000269 PubMed:11073952}.

Gene Ontology (GO) - Cellular Components for MIR3610 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000785 chromatin IEA --
GO:0000794 condensed nuclear chromosome IEA --
GO:0005654 nucleoplasm TAS --
GO:0005694 chromosome TAS --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with MIR3610: view

No data available for Subcellular locations from COMPARTMENTS for MIR3610 Gene

Pathways & Interactions for MIR3610 Gene

SuperPathways for MIR3610 Gene

No Data Available

Gene Ontology (GO) - Biological Process for MIR3610 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006302 double-strand break repair TAS --
GO:0006310 DNA recombination TAS --
GO:0006357 regulation of transcription from RNA polymerase II promoter IDA --
GO:0006915 apoptotic process IEA --
GO:0007062 sister chromatid cohesion TAS --
genes like me logo Genes that share ontologies with MIR3610: view

No data available for Pathways by source and SIGNOR curated interactions for MIR3610 Gene

Drugs & Compounds for MIR3610 Gene

No Compound Related Data Available

Transcripts for MIR3610 Gene

mRNA/cDNA for MIR3610 Gene

(11) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR3610 Gene

No ASD Table

Relevant External Links for MIR3610 Gene

GeneLoc Exon Structure for
MIR3610
ECgene alternative splicing isoforms for
MIR3610

Expression for MIR3610 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR3610 Gene:

MIR3610
No Expression Related Data Available

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for MIR3610 Gene

Orthologs for MIR3610 Gene

This gene was present in the common ancestor of animals.

Orthologs for MIR3610 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia RAD21 35
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RAD21 35
  • 99 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia RAD21 35
  • 94 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Rad21 35
  • 97 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RAD21 35
  • 87 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia RAD21 35
  • 100 (a)
OneToOne
chicken
(Gallus gallus)
Aves RAD21 35
  • 93 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RAD21 35
  • 92 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii rad21a 35
  • 75 (a)
OneToMany
rad21a 35
  • 75 (a)
OneToMany
rad21b 35
  • 79 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta vtd 35
  • 36 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea coh-1 35
  • 29 (a)
ManyToMany
scc-1 35
  • 31 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 55 (a)
OneToMany
Species where no ortholog for MIR3610 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for MIR3610 Gene

ENSEMBL:
Gene Tree for MIR3610 (if available)
TreeFam:
Gene Tree for MIR3610 (if available)

Paralogs for MIR3610 Gene

Paralogs for MIR3610 Gene

Pseudogenes.org Pseudogenes for MIR3610 Gene

genes like me logo Genes that share paralogs with MIR3610: view

Variants for MIR3610 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for MIR3610 Gene

RAD21_HUMAN-O60216
Some radiosensitive cancer patients seem to have Arg-481 instead of the conserved Gly-481. It may be that this mutation could contribute to radiosensitivity.

Structural Variations from Database of Genomic Variants (DGV) for MIR3610 Gene

Variant ID Type Subtype PubMed ID
nsv1144231 CNV deletion 24896259
nsv6359 CNV insertion 18451855
nsv831434 CNV gain 17160897

Relevant External Links for MIR3610 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR3610

No data available for Sequence variations from dbSNP and Humsavar and Variation tolerance for MIR3610 Gene

Disorders for MIR3610 Gene

MalaCards: The human disease database

(2) MalaCards diseases for MIR3610 Gene - From: OMIM and GeneCards

Disorder Aliases PubMed IDs
cornelia de lange syndrome 4
  • cdls4
cornelia de lange syndrome
  • brachmann de lange syndrome
- elite association - COSMIC cancer census association via MalaCards

UniProtKB/Swiss-Prot

RAD21_HUMAN
  • Cornelia de Lange syndrome 4 (CDLS4) [MIM:614701]: A form of Cornelia de Lange syndrome, a clinically heterogeneous developmental disorder associated with malformations affecting multiple systems. It is characterized by facial dysmorphisms, abnormal hands and feet, growth delay, cognitive retardation, hirsutism, gastroesophageal dysfunction and cardiac, ophthalmologic and genitourinary anomalies. {ECO:0000269 PubMed:22633399}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for MIR3610

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR3610
genes like me logo Genes that share disorders with MIR3610: view

No data available for Genatlas for MIR3610 Gene

Publications for MIR3610 Gene

  1. An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. (PMID: 24275569) Bian Y. … Zou H. (J. Proteomics 2014) 4 65
  2. Toward a comprehensive characterization of a human cancer cell phosphoproteome. (PMID: 23186163) Zhou H. … Mohammed S. (J. Proteome Res. 2013) 4 65
  3. RAD21 mutations cause a human cohesinopathy. (PMID: 22633399) Deardorff M.A. … Kaiser F.J. (Am. J. Hum. Genet. 2012) 4 65
  4. miRBase: integrating microRNA annotation and deep-sequencing data. (PMID: 21037258) Kozomara A. … Griffiths-Jones S. (Nucleic Acids Res. 2011) 3 65
  5. Initial characterization of the human central proteome. (PMID: 21269460) Burkard T.R. … Colinge J. (BMC Syst. Biol. 2011) 4 65

Products for MIR3610 Gene

Sources for MIR3610 Gene

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