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Aliases for MIR3606 Gene

Subcategory (RNA class) for MIR3606 Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR3606 Gene

  • MicroRNA 3606 2 3
  • COL3A1 4 5
  • Collagen Type III Alpha 1 Chain 5
  • Hsa-Mir-3606 3
  • Mir-3606 3

External Ids for MIR3606 Gene

Previous GeneCards Identifiers for MIR3606 Gene

  • GC02U902314
  • GC02P189862

Summaries for MIR3606 Gene

Entrez Gene Summary for MIR3606 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR3606 Gene

MIR3606 (MicroRNA 3606) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR3606 include Acrogeria, Gottron Type and Ehlers-Danlos Syndrome, Type Iv. An important paralog of this gene is COL1A1.

UniProtKB/Swiss-Prot for MIR3606 Gene

  • Collagen type III occurs in most soft connective tissues along with type I collagen. Involved in regulation of cortical development. Is the major ligand of ADGRG1 in the developing brain and binding to ADGRG1 inhibits neuronal migration and activates the RhoA pathway by coupling ADGRG1 to GNA13 and possibly GNA12.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR3606 Gene

Genomics for MIR3606 Gene

Regulatory Elements for MIR3606 Gene

Enhancers for MIR3606 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around MIR3606 on UCSC Golden Path with GeneCards custom track

Genomic Location for MIR3606 Gene

Chromosome:
2
Start:
188,974,320 bp from pter
End:
189,012,746 bp from pter
Size:
38,427 bases
Orientation:
Plus strand

Genomic View for MIR3606 Gene

Genes around MIR3606 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR3606 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR3606 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR3606 Gene

Proteins for MIR3606 Gene

  • Protein details for MIR3606 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P02461-CO3A1_HUMAN
    Recommended name:
    Collagen alpha-1(III) chain
    Protein Accession:
    P02461
    Secondary Accessions:
    • D2JYH5
    • D3DPH4
    • P78429
    • Q15112
    • Q16403
    • Q53S91
    • Q541P8
    • Q6LDB3
    • Q6LDJ2
    • Q6LDJ3
    • Q7KZ56
    • Q8N6U4
    • Q9UC88
    • Q9UC89
    • Q9UC90
    • Q9UC91
    • R4N3C5
    • V9GZI1

    Protein attributes for MIR3606 Gene

    Size:
    1466 amino acids
    Molecular mass:
    138564 Da
    Quaternary structure:
    • Trimers of identical alpha 1(III) chains. The chains are linked to each other by interchain disulfide bonds. Trimers are also cross-linked via hydroxylysines.
    • Trimers of identical alpha 1(III) chains. The chains are linked to each other by interchain disulfide bonds. Trimers are also cross-linked via hydroxylysines.

    Three dimensional structures from OCA and Proteopedia for MIR3606 Gene

    Alternative splice isoforms for MIR3606 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MIR3606 Gene

Post-translational modifications for MIR3606 Gene

  • O-linked glycan consists of a Glc-Gal disaccharide bound to the oxygen atom of a post-translationally added hydroxyl group.
  • Proline residues at the third position of the tripeptide repeating unit (G-X-Y) are hydroxylated in some or all of the chains.
  • Glycosylation at Lys 263 and Ser 1145
  • Modification sites at PhosphoSitePlus

Other Protein References for MIR3606 Gene

No data available for DME Specific Peptides for MIR3606 Gene

Domains & Families for MIR3606 Gene

Gene Families for MIR3606 Gene

Graphical View of Domain Structure for InterPro Entry

P02461

UniProtKB/Swiss-Prot:

CO3A1_HUMAN :
  • The C-terminal propeptide, also known as COLFI domain, have crucial roles in tissue growth and repair by controlling both the intracellular assembly of procollagen molecules and the extracellular assembly of collagen fibrils. It binds a calcium ion which is essential for its function.
  • Belongs to the fibrillar collagen family.
Domain:
  • The C-terminal propeptide, also known as COLFI domain, have crucial roles in tissue growth and repair by controlling both the intracellular assembly of procollagen molecules and the extracellular assembly of collagen fibrils. It binds a calcium ion which is essential for its function.
  • Contains 1 fibrillar collagen NC1 domain.
  • Contains 1 VWFC domain.
Family:
  • Belongs to the fibrillar collagen family.
genes like me logo Genes that share domains with MIR3606: view

No data available for Suggested Antigen Peptide Sequences for MIR3606 Gene

Function for MIR3606 Gene

Molecular function for MIR3606 Gene

UniProtKB/Swiss-Prot Function:
Collagen type III occurs in most soft connective tissues along with type I collagen. Involved in regulation of cortical development. Is the major ligand of ADGRG1 in the developing brain and binding to ADGRG1 inhibits neuronal migration and activates the RhoA pathway by coupling ADGRG1 to GNA13 and possibly GNA12.

Gene Ontology (GO) - Molecular Function for MIR3606 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005178 integrin binding NAS --
GO:0005201 extracellular matrix structural constituent IMP --
GO:0005515 protein binding IPI --
GO:0046332 SMAD binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with MIR3606: view

Animal Model Products

miRNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR3606 Gene

Localization for MIR3606 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MIR3606 Gene

Secreted, extracellular space, extracellular matrix.

Gene Ontology (GO) - Cellular Components for MIR3606 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005578 proteinaceous extracellular matrix IEA --
GO:0005581 collagen trimer IEA --
GO:0005586 collagen type III trimer NAS --
GO:0005615 extracellular space NAS --
genes like me logo Genes that share ontologies with MIR3606: view

No data available for Subcellular locations from COMPARTMENTS for MIR3606 Gene

Pathways & Interactions for MIR3606 Gene

SuperPathways for MIR3606 Gene

No Data Available

Gene Ontology (GO) - Biological Process for MIR3606 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001568 blood vessel development IEA --
GO:0007160 cell-matrix adhesion IDA --
GO:0007179 transforming growth factor beta receptor signaling pathway IDA --
GO:0007229 integrin-mediated signaling pathway IMP --
GO:0007507 heart development IMP --
genes like me logo Genes that share ontologies with MIR3606: view

No data available for Pathways by source and SIGNOR curated interactions for MIR3606 Gene

Drugs & Compounds for MIR3606 Gene

No Compound Related Data Available

Transcripts for MIR3606 Gene

mRNA/cDNA for MIR3606 Gene

(7) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR3606 Gene

No ASD Table

Relevant External Links for MIR3606 Gene

GeneLoc Exon Structure for
MIR3606
ECgene alternative splicing isoforms for
MIR3606

Expression for MIR3606 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR3606 Gene:

MIR3606
No Expression Related Data Available

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for MIR3606 Gene

Orthologs for MIR3606 Gene

This gene was present in the common ancestor of animals.

Orthologs for MIR3606 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia COL3A1 35
  • 91 (a)
OneToOne
dog
(Canis familiaris)
Mammalia COL3A1 35
  • 92 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia COL3A1 35
  • 81 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Col3a1 35
  • 91 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia COL3A1 35
  • 76 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia COL3A1 35
  • 100 (a)
OneToOne
chicken
(Gallus gallus)
Aves -- 35
  • 19 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia COL3A1 35
  • 73 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Cg25C 35
  • 27 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.7880 35
  • 49 (a)
OneToMany
Species where no ortholog for MIR3606 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MIR3606 Gene

ENSEMBL:
Gene Tree for MIR3606 (if available)
TreeFam:
Gene Tree for MIR3606 (if available)

Paralogs for MIR3606 Gene

genes like me logo Genes that share paralogs with MIR3606: view

Variants for MIR3606 Gene

Structural Variations from Database of Genomic Variants (DGV) for MIR3606 Gene

Variant ID Type Subtype PubMed ID
dgv7234n54 CNV loss 21841781

Relevant External Links for MIR3606 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR3606

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations from dbSNP and Humsavar and Variation tolerance for MIR3606 Gene

Disorders for MIR3606 Gene

MalaCards: The human disease database

(3) MalaCards diseases for MIR3606 Gene - From: GeneCards

Disorder Aliases PubMed IDs
acrogeria, gottron type
  • metageria
ehlers-danlos syndrome, type iv
  • ehlers-danlos syndrome, type iv, autosomal dominant
ehlers-danlos syndrome, type iii
  • ehlers-danlos syndrome, hypermobility type
- elite association - COSMIC cancer census association via MalaCards

UniProtKB/Swiss-Prot

CO3A1_HUMAN
  • Aortic aneurysm, familial abdominal (AAA) [MIM:100070]: A common multifactorial disorder characterized by permanent dilation of the abdominal aorta, usually due to degenerative changes in the aortic wall. Histologically, AAA is characterized by signs of chronic inflammation, destructive remodeling of the extracellular matrix, and depletion of vascular smooth muscle cells. {ECO:0000269 PubMed:2243125, ECO:0000269 PubMed:2349939, ECO:0000269 PubMed:8514866}. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.
  • Ehlers-Danlos syndrome 3 (EDS3) [MIM:130020]: A connective tissue disorder characterized by hyperextensible skin, atrophic cutaneous scars due to tissue fragility and joint hyperlaxity. It is a form of Ehlers-Danlos syndrome characterized by marked joint hyperextensibility without skeletal deformity. {ECO:0000269 PubMed:7833919}. Note=The disease is caused by mutations affecting the gene represented in this entry.
  • Ehlers-Danlos syndrome 4 (EDS4) [MIM:130050]: The most severe form of Ehlers-Danlos syndrome, a connective tissue disorder characterized by hyperextensible skin, atrophic cutaneous scars due to tissue fragility and joint hyperlaxity. Characterized by the joint and dermal manifestations as in other forms of the syndrome, characteristic facial features (acrogeria) in most patients, and by proneness to spontaneous rupture of bowel and large arteries. The vascular complications may affect all anatomical areas. {ECO:0000269 PubMed:10706896, ECO:0000269 PubMed:10923041, ECO:0000269 PubMed:11168790, ECO:0000269 PubMed:12694234, ECO:0000269 PubMed:12786757, ECO:0000269 PubMed:1352273, ECO:0000269 PubMed:1357232, ECO:0000269 PubMed:1370809, ECO:0000269 PubMed:1496983, ECO:0000269 PubMed:1895316, ECO:0000269 PubMed:2492273, ECO:0000269 PubMed:2808425, ECO:0000269 PubMed:7749417, ECO:0000269 PubMed:7912131, ECO:0000269 PubMed:8019562, ECO:0000269 PubMed:8098182, ECO:0000269 PubMed:8411057, ECO:0000269 PubMed:8664902, ECO:0000269 PubMed:8680408, ECO:0000269 PubMed:8884076, ECO:0000269 PubMed:8990011, ECO:0000269 PubMed:9036918, ECO:0000269 PubMed:9147870, ECO:0000269 PubMed:9452103, ECO:0000269 Ref.46, ECO:0000269 Ref.51}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for MIR3606

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR3606
genes like me logo Genes that share disorders with MIR3606: view

No data available for Genatlas for MIR3606 Gene

Publications for MIR3606 Gene

  1. An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. (PMID: 24275569) Bian Y. … Zou H. (J. Proteomics 2014) 4 65
  2. Resveratrol-induced changes of the human adipocyte secretion profile. (PMID: 22905912) Rosenow A. … Renes J. (J. Proteome Res. 2012) 4 65
  3. Structural basis of fibrillar collagen trimerization and related genetic disorders. (PMID: 23001006) Bourhis J.M. … Hulmes D.J. (Nat. Struct. Mol. Biol. 2012) 4 65
  4. miRBase: integrating microRNA annotation and deep-sequencing data. (PMID: 21037258) Kozomara A. … Griffiths-Jones S. (Nucleic Acids Res. 2011) 3 65
  5. Ultra-high throughput sequencing-based small RNA discovery and discrete statistical biomarker analysis in a collection of cervical tumours and matched controls. (PMID: 20459774) Witten D. … Lui W.O. (BMC Biol. 2010) 3 65

Products for MIR3606 Gene

Sources for MIR3606 Gene

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