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Aliases for MIR3605 Gene

Subcategory (RNA class) for MIR3605 Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR3605 Gene

  • MicroRNA 3605 2 3
  • PHC2 4 5
  • Early Development Regulatory Protein 2 4
  • Polyhomeotic Homolog 2 5
  • Hsa-Mir-3605 3
  • Mir-3605 3
  • HPH2 4
  • EDR2 4
  • PH2 4

External Ids for MIR3605 Gene

Previous GeneCards Identifiers for MIR3605 Gene

  • GC01U903130
  • GC01M033801
  • GC01M033804

Summaries for MIR3605 Gene

Entrez Gene Summary for MIR3605 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR3605 Gene

MIR3605 (MicroRNA 3605) is an RNA Gene, and is affiliated with the miRNA class. Among its related pathways are SUMOylation and Cellular Senescence. An important paralog of this gene is PHC3.

UniProtKB/Swiss-Prot for MIR3605 Gene

  • Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A Lys-119, rendering chromatin heritably changed in its expressibility.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR3605 Gene

Genomics for MIR3605 Gene

Regulatory Elements for MIR3605 Gene

Enhancers for MIR3605 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01F033458 1.5 FANTOM5 Ensembl ENCODE 11.9 -29.6 -29649 5.0 TBP TBL1XR1 WRNIP1 ZFP64 ZNF76 BMI1 EGR1 ZNF366 ETV6 KLF7 ENSG00000270115 MIR3605 PHC2 TMEM54 RNF19B GC01M033423 TLR12P
GH01F033381 1.1 Ensembl ENCODE 11.6 +47.5 47527 4.0 PKNOX1 ZNF175 MAX CEBPG TEAD3 ZBTB48 FOS MAFK TEAD1 L3MBTL2 PHC2 A3GALT2 MIR3605 TRIM62 GC01M033371 LOC101929464
GH01F033396 1.1 Ensembl ENCODE 11.3 +34.2 34152 1.0 HDGF HDAC1 ATF1 PKNOX1 CBX3 TBL1XR1 ZBTB40 ELK1 GATA2 CREM PHC2 A3GALT2 MIR3605 TRIM62 GC01P033393 GC01P033403
GH01F033393 1.1 Ensembl 11.2 +37.9 37852 0.4 RFX1 PHC2 A3GALT2 MIR3605 TRIM62 GC01P033393 GC01M033371
GH01F033386 1 Ensembl ENCODE 11.2 +41.9 41922 4.8 BHLHE40 MAFG REST ZNF316 RAD51 MAFF SMARCA4 POLR2A FOS MAFK PHC2 A3GALT2 MIR3605 TRIM62 GC01M033371 LOC101929464
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around MIR3605 on UCSC Golden Path with GeneCards custom track

Promoters for MIR3605 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001519047 452 2001 ZNF76 SIN3A ZNF48 RAD21 GLIS2 EGR1 ZNF366 FOS NFYC USF2
ENSR00001743595 1752 201 ZFP3

Genomic Location for MIR3605 Gene

Chromosome:
1
Start:
33,323,623 bp from pter
End:
33,431,052 bp from pter
Size:
107,430 bases
Orientation:
Minus strand

Genomic View for MIR3605 Gene

Genes around MIR3605 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR3605 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR3605 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR3605 Gene

Proteins for MIR3605 Gene

  • Protein details for MIR3605 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IXK0-PHC2_HUMAN
    Recommended name:
    Polyhomeotic-like protein 2
    Protein Accession:
    Q8IXK0
    Secondary Accessions:
    • A1L4Q1
    • A8KA40
    • D3DPR2
    • Q2TAL3
    • Q5T0C1
    • Q6NUJ6
    • Q6ZQR1
    • Q8N306
    • Q8TAG8
    • Q96BL4
    • Q9Y4Y7

    Protein attributes for MIR3605 Gene

    Size:
    858 amino acids
    Molecular mass:
    90713 Da
    Quaternary structure:
    • Component of a PRC1-like complex. Interacts with CBX4. Interacts with BMI1, PCGF2, PHC1 and RNF2. Interacts with CHTOP (By similarity). Interacts with the N-terminal region of the SP1 transcription factor and with MAPKAPK2.
    • Component of a PRC1-like complex. Interacts with CBX4. Interacts with BMI1, PCGF2, PHC1 and RNF2. Interacts with CHTOP (By similarity). Interacts with the N-terminal region of the SP1 transcription factor and with MAPKAPK2.
    Miscellaneous:
    • The hPRC-H complex purification reported by PubMed:12167701 probably presents a mixture of different PRC1-like complexes.
    SequenceCaution:
    • Sequence=AAH68573.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=AAH92492.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=CAI13956.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for MIR3605 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MIR3605 Gene

Post-translational modifications for MIR3605 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MIR3605 Gene

No data available for DME Specific Peptides for MIR3605 Gene

Domains & Families for MIR3605 Gene

Gene Families for MIR3605 Gene

Protein Domains for MIR3605 Gene

Graphical View of Domain Structure for InterPro Entry

Q8IXK0

UniProtKB/Swiss-Prot:

PHC2_HUMAN :
  • HD1 motif interacts with SAM domain of PHC1.
  • Contains 1 FCS-type zinc finger.
Domain:
  • HD1 motif interacts with SAM domain of PHC1.
  • Contains 1 SAM (sterile alpha motif) domain.
Similarity:
  • Contains 1 FCS-type zinc finger.
genes like me logo Genes that share domains with MIR3605: view

No data available for Suggested Antigen Peptide Sequences for MIR3605 Gene

Function for MIR3605 Gene

Molecular function for MIR3605 Gene

UniProtKB/Swiss-Prot Function:
Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A Lys-119, rendering chromatin heritably changed in its expressibility.

Gene Ontology (GO) - Molecular Function for MIR3605 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0005515 protein binding IPI --
GO:0008270 zinc ion binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with MIR3605: view

Animal Model Products

miRNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR3605 Gene

Localization for MIR3605 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MIR3605 Gene

Gene Ontology (GO) - Cellular Components for MIR3605 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm TAS --
GO:0031519 PcG protein complex IDA --
GO:0035102 PRC1 complex IDA --
genes like me logo Genes that share ontologies with MIR3605: view

No data available for Subcellular locations from COMPARTMENTS for MIR3605 Gene

Pathways & Interactions for MIR3605 Gene

genes like me logo Genes that share pathways with MIR3605: view

Gene Ontology (GO) - Biological Process for MIR3605 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007275 multicellular organism development IEA --
GO:0007283 spermatogenesis IEA --
GO:0016925 protein sumoylation TAS --
genes like me logo Genes that share ontologies with MIR3605: view

No data available for SIGNOR curated interactions for MIR3605 Gene

Transcripts for MIR3605 Gene

mRNA/cDNA for MIR3605 Gene

(13) Ensembl transcripts including schematic representations, and UCSC links where relevant :

miRNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR3605 Gene

No ASD Table

Relevant External Links for MIR3605 Gene

GeneLoc Exon Structure for
MIR3605
ECgene alternative splicing isoforms for
MIR3605

Expression for MIR3605 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MIR3605 Gene

mRNA differential expression in normal tissues according to GTEx for MIR3605 Gene

This gene is overexpressed in Whole Blood (x12.1).

NURSA nuclear receptor signaling pathways regulating expression of MIR3605 Gene:

MIR3605
genes like me logo Genes that share expression patterns with MIR3605: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for MIR3605 Gene

Orthologs for MIR3605 Gene

This gene was present in the common ancestor of animals.

Orthologs for MIR3605 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PHC2 35
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia PHC2 35
  • 92 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PHC2 35
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Phc2 35
  • 88 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia PHC2 35
  • 79 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PHC2 35
  • 65 (a)
OneToOne
chicken
(Gallus gallus)
Aves PHC2 35
  • 56 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PHC2 35
  • 71 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii phc2a 35
  • 49 (a)
OneToMany
phc2b 35
  • 47 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta ph-d 35
  • 13 (a)
ManyToMany
ph-p 35
  • 13 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 28 (a)
OneToMany
Species where no ortholog for MIR3605 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MIR3605 Gene

ENSEMBL:
Gene Tree for MIR3605 (if available)
TreeFam:
Gene Tree for MIR3605 (if available)

Paralogs for MIR3605 Gene

Paralogs for MIR3605 Gene

genes like me logo Genes that share paralogs with MIR3605: view

Variants for MIR3605 Gene

Sequence variations from dbSNP and Humsavar for MIR3605 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs112435318 -- 33,332,406(+) CCACC(G/T)AGAGG nc-transcript-variant, splice-acceptor-variant
rs112519810 -- 33,334,298(+) CTGCA(C/G/T)GAGAG intron-variant, upstream-variant-2KB
rs113525648 -- 33,332,490(+) TATAA(A/G)GTATC intron-variant, nc-transcript-variant
rs114477955 -- 33,332,964(+) TTACG(C/T)GTTTA intron-variant, upstream-variant-2KB
rs114578011 -- 33,334,433(+) CTCCC(C/T)TCAGT intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MIR3605 Gene

Variant ID Type Subtype PubMed ID
nsv516693 CNV loss 19592680
nsv522364 CNV loss 19592680
nsv545963 CNV loss 21841781

Relevant External Links for MIR3605 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR3605

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR3605 Gene

Disorders for MIR3605 Gene

Relevant External Links for MIR3605

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR3605

No disorders were found for MIR3605 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR3605 Gene

Publications for MIR3605 Gene

  1. Toward a comprehensive characterization of a human cancer cell phosphoproteome. (PMID: 23186163) Zhou H. … Mohammed S. (J. Proteome Res. 2013) 4 64
  2. miRBase: integrating microRNA annotation and deep-sequencing data. (PMID: 21037258) Kozomara A. … Griffiths-Jones S. (Nucleic Acids Res. 2011) 3 64
  3. Interaction proteomics analysis of polycomb proteins defines distinct PRC1 Complexes in mammalian cells. (PMID: 21282530) Vandamme J. … Angrand P.O. (Mol. Cell. Proteomics 2011) 4 64
  4. Discovery of novel microRNAs in female reproductive tract using next generation sequencing. (PMID: 20224791) Creighton C.J. … Gunaratne P.H. (PLoS ONE 2010) 3 64
  5. Ultra-high throughput sequencing-based small RNA discovery and discrete statistical biomarker analysis in a collection of cervical tumours and matched controls. (PMID: 20459774) Witten D. … Lui W.O. (BMC Biol. 2010) 3 64

Products for MIR3605 Gene

Sources for MIR3605 Gene

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