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Aliases for MIR3591 Gene

Subcategory (RNA class) for MIR3591 Gene

miRNA

Quality Score for this RNA gene is

8

Aliases for MIR3591 Gene

  • MicroRNA 3591 2 3 5
  • Hsa-Mir-3591 3

External Ids for MIR3591 Gene

Previous GeneCards Identifiers for MIR3591 Gene

  • GC18U900662
  • GC18M056121

Summaries for MIR3591 Gene

Entrez Gene Summary for MIR3591 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR3591 Gene

MIR3591 (MicroRNA 3591) is an RNA Gene, and is affiliated with the miRNA class. Among its related pathways are DNA Damage Response and Cell Differentiation - Index.

Additional gene information for MIR3591 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR3591 Gene

Genomics for MIR3591 Gene

Regulatory Elements for MIR3591 Gene

Enhancers for MIR3591 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH18H058524 1.8 FANTOM5 Ensembl ENCODE dbSUPER 10.3 -76.2 -76215 4 ELF3 TBP FOXA2 ARID4B SIN3A ZSCAN9 RAD21 SLC30A9 ETV6 RUNX3 MALT1 SNORA108 MIR122 MIR3591 ENSG00000199713 ENSG00000267257 NEDD4L ENSG00000274354
GH18H058360 1.7 FANTOM5 Ensembl ENCODE dbSUPER 10.5 +87.9 87946 4 FOXA2 TAF1 JUN ZSCAN4 FEZF1 RAD21 YY1 ZFHX2 FOS NFE2 MIR122 MIR3591 ENSG00000267504 MALT1 LOC105372143
GH18H058230 1.5 Ensembl ENCODE dbSUPER 9.5 +217.0 217048 8 PKNOX1 FOXA2 ZNF121 GLIS2 FOS JUNB TSHZ1 REST NFIL3 GLIS1 NEDD4L MIR122 MIR3591 LOC105372143 ENSG00000267504
GH18H058283 1.4 Ensembl ENCODE dbSUPER 9.8 +163.5 163491 7 PKNOX1 FOXA2 ZFP64 YY1 TCF12 RUNX3 JUNB PPARG NFIL3 SSRP1 HMGN1P30 MIR122 MIR3591 ENSG00000267504 LOC105372143
GH18H058401 1.2 Ensembl ENCODE 10.9 +47.8 47846 2 FOXA2 MLX YY1 PAF1 SP5 ZHX2 NFYC REST MIER2 PPARG MIR122 MIR3591 ENSG00000267504 ENSG00000267396 ENSG00000267675
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MIR3591 on UCSC Golden Path with GeneCards custom track

Genomic Location for MIR3591 Gene

Chromosome:
18
Start:
58,451,080 bp from pter
End:
58,451,152 bp from pter
Size:
73 bases
Orientation:
Minus strand

Genomic View for MIR3591 Gene

Genes around MIR3591 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR3591 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR3591 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR3591 Gene

ORGUL Member Location for MIR3591 Gene

ORGUL Member Location for MIR3591 gene

Proteins for MIR3591 Gene

Post-translational modifications for MIR3591 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR3591 Gene

Domains & Families for MIR3591 Gene

Gene Families for MIR3591 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR3591: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR3591 Gene

Function for MIR3591 Gene

Phenotypes From GWAS Catalog for MIR3591 Gene

Animal Model Products

CRISPR Products

miRNA Products

Clone Products

  • Applied Biological Materials Clones for MIR3591
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR3591 Gene

Localization for MIR3591 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR3591 Gene

Pathways & Interactions for MIR3591 Gene

genes like me logo Genes that share pathways with MIR3591: view

Pathways by source for MIR3591 Gene

Interacting Proteins for MIR3591 Gene

Gene Ontology (GO) - Biological Process for MIR3591 Gene

None

No data available for SIGNOR curated interactions for MIR3591 Gene

Drugs & Compounds for MIR3591 Gene

No Compound Related Data Available

Transcripts for MIR3591 Gene

mRNA/cDNA for MIR3591 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

CRISPR Products

miRNA Products

Clone Products

  • Applied Biological Materials Clones for MIR3591
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for MIR3591 Gene

No ASD Table

Relevant External Links for MIR3591 Gene

GeneLoc Exon Structure for
MIR3591
ECgene alternative splicing isoforms for
MIR3591

Expression for MIR3591 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MIR3591 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR3591 Gene:

MIR3591
genes like me logo Genes that share expression patterns with MIR3591: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR3591 Gene

Orthologs for MIR3591 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIR3591 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-122 34
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia bta-mir-122 34
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia cfa-mir-122 34
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mir122a 34
  • 97 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia mdo-mir-122 34
  • 93 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia oan-mir-122 34
  • 68 (a)
OneToOne
chicken
(Gallus gallus)
Aves gga-mir-122-1 34
  • 96 (a)
OneToMany
gga-mir-122-2 34
  • 95 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia aca-mir-122 34
  • 71 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii dre-mir-122 34
  • 84 (a)
OneToOne
Species where no ortholog for MIR3591 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MIR3591 Gene

ENSEMBL:
Gene Tree for MIR3591 (if available)
TreeFam:
Gene Tree for MIR3591 (if available)

Paralogs for MIR3591 Gene

No data available for Paralogs for MIR3591 Gene

Variants for MIR3591 Gene

Sequence variations from dbSNP and Humsavar for MIR3591 Gene

SNP ID Clin Chr 18 pos Sequence Context AA Info Type
rs1000314392 -- 58,451,596(+) TGAGG(C/G)TGTAG downstream-variant-500B, upstream-variant-2KB
rs1000425495 -- 58,451,828(+) CGCAA(G/T)CTTAT upstream-variant-2KB
rs1001645584 -- 58,452,286(+) ATTCA(A/G)CCATT upstream-variant-2KB
rs1001856597 -- 58,451,927(+) TTTCA(A/G)AAATT upstream-variant-2KB
rs1004044286 -- 58,451,786(+) AGAAG(A/G)CTAAG upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MIR3591 Gene

Variant ID Type Subtype PubMed ID
dgv3364n100 CNV gain 25217958

Relevant External Links for MIR3591 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR3591

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR3591 Gene

Disorders for MIR3591 Gene

Relevant External Links for MIR3591

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR3591

No disorders were found for MIR3591 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR3591 Gene

Publications for MIR3591 Gene

  1. Identification of new microRNAs in paired normal and tumor breast tissue suggests a dual role for the ERBB2/Her2 gene. (PMID: 21199797) Persson H … Rovira C (Cancer research 2011) 3 60
  2. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S … Enright AJ (Nucleic acids research 2006) 3 60

Products for MIR3591 Gene

Sources for MIR3591 Gene

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