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Aliases for MIR3591 Gene

Subcategory (RNA class) for MIR3591 Gene

miRNA

Quality Score for this RNA gene is

8

Aliases for MIR3591 Gene

  • MicroRNA 3591 2 3
  • MicroRNA 122 5
  • Hsa-Mir-3591 3
  • MIR122 5

External Ids for MIR3591 Gene

Previous GeneCards Identifiers for MIR3591 Gene

  • GC18U900662
  • GC18M056121

Summaries for MIR3591 Gene

Entrez Gene Summary for MIR3591 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR3591 Gene

MIR3591 (MicroRNA 3591) is an RNA Gene, and is affiliated with the miRNA class.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR3591 Gene

Genomics for MIR3591 Gene

Genomic Location for MIR3591 Gene

Chromosome:
18
Start:
58,451,080 bp from pter
End:
58,451,152 bp from pter
Size:
73 bases
Orientation:
Minus strand

Genomic View for MIR3591 Gene

Genes around MIR3591 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR3591 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR3591 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR3591 Gene

ORGUL Member Location for MIR3591 Gene

ORGUL Member Location for MIR3591 gene

No data available for Regulatory Elements for MIR3591 Gene

Proteins for MIR3591 Gene

Post-translational modifications for MIR3591 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR3591 Gene

Domains & Families for MIR3591 Gene

Gene Families for MIR3591 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR3591: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR3591 Gene

Function for MIR3591 Gene

Animal Model Products

miRNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR3591 Gene

Localization for MIR3591 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR3591 Gene

Pathways & Interactions for MIR3591 Gene

SuperPathways for MIR3591 Gene

No Data Available

Interacting Proteins for MIR3591 Gene

Gene Ontology (GO) - Biological Process for MIR3591 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for MIR3591 Gene

Drugs & Compounds for MIR3591 Gene

No Compound Related Data Available

Transcripts for MIR3591 Gene

mRNA/cDNA for MIR3591 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR3591 Gene

No ASD Table

Relevant External Links for MIR3591 Gene

GeneLoc Exon Structure for
MIR3591
ECgene alternative splicing isoforms for
MIR3591

Expression for MIR3591 Gene

mRNA expression in normal human tissues for MIR3591 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR3591 Gene:

MIR3591
genes like me logo Genes that share expression patterns with MIR3591: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for MIR3591 Gene

Orthologs for MIR3591 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIR3591 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia bta-mir-122 35
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia cfa-mir-122 35
  • 98 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia mdo-mir-122 35
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mir122a 35
  • 97 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia oan-mir-122 35
  • 68 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-122 35
  • 99 (a)
OneToOne
chicken
(Gallus gallus)
Aves gga-mir-122-1 35
  • 96 (a)
OneToMany
gga-mir-122-2 35
  • 95 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia aca-mir-122 35
  • 71 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii dre-mir-122 35
  • 84 (a)
OneToOne
Species where no ortholog for MIR3591 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MIR3591 Gene

ENSEMBL:
Gene Tree for MIR3591 (if available)
TreeFam:
Gene Tree for MIR3591 (if available)

Paralogs for MIR3591 Gene

No data available for Paralogs for MIR3591 Gene

Variants for MIR3591 Gene

Sequence variations from dbSNP and Humsavar for MIR3591 Gene

SNP ID Clin Chr 18 pos Sequence Context AA Info Type
rs1136296 -- 58,451,781(+) GACGC(A/T)GAAGG upstream-variant-2KB
rs11663046 -- 58,452,397(+) GATGG(C/G)CATTC upstream-variant-2KB
rs8087300 -- 58,452,471(+) CTTTG(C/T)GAAAT upstream-variant-2KB
rs35440331 -- 58,451,696(+) CAGAG(-/C)CCCCC upstream-variant-2KB
rs4940705 -- 58,452,923(+) CTTAC(A/G)TGGCA upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MIR3591 Gene

Variant ID Type Subtype PubMed ID
dgv3364n100 CNV gain 25217958

Relevant External Links for MIR3591 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR3591

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR3591 Gene

Disorders for MIR3591 Gene

Relevant External Links for MIR3591

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR3591

No disorders were found for MIR3591 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR3591 Gene

Publications for MIR3591 Gene

  1. Identification of new microRNAs in paired normal and tumor breast tissue suggests a dual role for the ERBB2/Her2 gene. (PMID: 21199797) Persson H. … Rovira C. (Cancer Res. 2011) 3 65
  2. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S. … Enright A.J. (Nucleic Acids Res. 2006) 3 65

Products for MIR3591 Gene

Sources for MIR3591 Gene

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