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Aliases for MIR3591 Gene

Subcategory (RNA class) for MIR3591 Gene

miRNA

Quality Score for this RNA gene is

8

Aliases for MIR3591 Gene

  • MicroRNA 3591 2 3 5
  • Hsa-Mir-3591 3

External Ids for MIR3591 Gene

Previous GeneCards Identifiers for MIR3591 Gene

  • GC18U900662
  • GC18M056121

Summaries for MIR3591 Gene

Entrez Gene Summary for MIR3591 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR3591 Gene

MIR3591 (MicroRNA 3591) is an RNA Gene, and is affiliated with the miRNA class. Among its related pathways are DNA damage response.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR3591 Gene

Genomics for MIR3591 Gene

Regulatory Elements for MIR3591 Gene

Enhancers for MIR3591 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH18F058524 1.6 FANTOM5 Ensembl ENCODE 10.3 -76.4 -76438 5.2 ELF3 TBP ARID4B ZNF48 ZSCAN9 RAD21 SLC30A9 GATA4 ZNF143 ETV6 MALT1 ENSG00000252284 MIR3591 MIR122 ENSG00000199713 ENSG00000267257 NEDD4L ENSG00000274354
GH18F058360 1.4 FANTOM5 Ensembl ENCODE 10.5 +87.9 87868 4.7 CTCF JUN FEZF1 RAD21 YY1 ZFHX2 HNF4G NFE2 FOS MAFK MIR122 MIR3591 ENSG00000267504 MALT1 LOC105372143
GH18F058401 1.2 Ensembl ENCODE 10.9 +47.8 47846 2.8 MLX ZNF48 PAF1 SP5 NFYC ZHX2 MIER2 PPARG KAT8 SSRP1 MIR122 MIR3591 ENSG00000267504 ENSG00000267396 ENSG00000267675
GH18F058520 1.2 FANTOM5 Ensembl ENCODE 10.3 -70.0 -70021 0.5 PKNOX1 MAZ JUNB ATF2 ZNF664 JUND GLIS2 ATF3 ZNF692 IKZF1 MALT1 MIR122 MIR3591 ENSG00000274354 ENSG00000267257
GH18F058415 1.1 Ensembl ENCODE 11.2 +34.2 34221 2.0 THRB ZNF48 DNMT3B RAD21 RARA YY1 CREM PAF1 PPARG NR2F2 MIR122 MIR3591 ENSG00000267675 GC18P058443
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MIR3591 on UCSC Golden Path with GeneCards custom track

Genomic Location for MIR3591 Gene

Chromosome:
18
Start:
58,451,080 bp from pter
End:
58,451,152 bp from pter
Size:
73 bases
Orientation:
Minus strand

Genomic View for MIR3591 Gene

Genes around MIR3591 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR3591 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR3591 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR3591 Gene

ORGUL Member Location for MIR3591 Gene

ORGUL Member Location for MIR3591 gene

Proteins for MIR3591 Gene

Post-translational modifications for MIR3591 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR3591 Gene

Domains & Families for MIR3591 Gene

Gene Families for MIR3591 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR3591: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR3591 Gene

Function for MIR3591 Gene

Animal Model Products

miRNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR3591 Gene

Localization for MIR3591 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR3591 Gene

Pathways & Interactions for MIR3591 Gene

SuperPathways for MIR3591 Gene

SuperPathway Contained pathways
1 DNA damage response
genes like me logo Genes that share pathways with MIR3591: view

Pathways by source for MIR3591 Gene

1 BioSystems pathway for MIR3591 Gene

Interacting Proteins for MIR3591 Gene

Gene Ontology (GO) - Biological Process for MIR3591 Gene

None

No data available for SIGNOR curated interactions for MIR3591 Gene

Transcripts for MIR3591 Gene

mRNA/cDNA for MIR3591 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR3591 Gene

No ASD Table

Relevant External Links for MIR3591 Gene

GeneLoc Exon Structure for
MIR3591
ECgene alternative splicing isoforms for
MIR3591

Expression for MIR3591 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MIR3591 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR3591 Gene:

MIR3591
genes like me logo Genes that share expression patterns with MIR3591: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for MIR3591 Gene

Orthologs for MIR3591 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIR3591 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-122 35
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia bta-mir-122 35
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia cfa-mir-122 35
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mir122a 35
  • 97 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia mdo-mir-122 35
  • 93 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia oan-mir-122 35
  • 68 (a)
OneToOne
chicken
(Gallus gallus)
Aves gga-mir-122-1 35
  • 96 (a)
OneToMany
gga-mir-122-2 35
  • 95 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia aca-mir-122 35
  • 71 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii dre-mir-122 35
  • 84 (a)
OneToOne
Species where no ortholog for MIR3591 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MIR3591 Gene

ENSEMBL:
Gene Tree for MIR3591 (if available)
TreeFam:
Gene Tree for MIR3591 (if available)

Paralogs for MIR3591 Gene

No data available for Paralogs for MIR3591 Gene

Variants for MIR3591 Gene

Sequence variations from dbSNP and Humsavar for MIR3591 Gene

SNP ID Clin Chr 18 pos Sequence Context AA Info Type
rs10514884 -- 58,451,920(-) GAAAC(A/G)TCAGT upstream-variant-2KB
rs111316406 -- 58,451,046(+) GGTGA(A/T)GTTAA downstream-variant-500B, upstream-variant-2KB
rs111436359 -- 58,451,011(+) TTCCC(C/T)TATTA downstream-variant-500B, upstream-variant-2KB
rs111673925 -- 58,451,565(+) GAGGT(G/T)GGAGG downstream-variant-500B, upstream-variant-2KB
rs111930048 -- 58,451,719(+) GGCAC(C/G)AGGTA upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MIR3591 Gene

Variant ID Type Subtype PubMed ID
dgv3364n100 CNV gain 25217958

Relevant External Links for MIR3591 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR3591

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR3591 Gene

Disorders for MIR3591 Gene

Relevant External Links for MIR3591

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR3591

No disorders were found for MIR3591 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR3591 Gene

Publications for MIR3591 Gene

  1. Identification of new microRNAs in paired normal and tumor breast tissue suggests a dual role for the ERBB2/Her2 gene. (PMID: 21199797) Persson H. … Rovira C. (Cancer Res. 2011) 3 64
  2. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S. … Enright A.J. (Nucleic Acids Res. 2006) 3 64

Products for MIR3591 Gene

Sources for MIR3591 Gene

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