Free for academic non-profit institutions. Other users need a Commercial license

Aliases for MIR34C Gene

Subcategory (RNA class) for MIR34C Gene

miRNA

Quality Score for this RNA gene is

13

Aliases for MIR34C Gene

  • MicroRNA 34c 2 3 5
  • Hsa-Mir-34c 3
  • MiRNA34C 3
  • Mir-34c 3
  • MIRN34C 3

External Ids for MIR34C Gene

ORGUL Members for MIR34C Gene

Previous HGNC Symbols for MIR34C Gene

  • MIRN34C

Previous GeneCards Identifiers for MIR34C Gene

  • GC11P110906
  • GC11P110909
  • GC11P111384
  • GC11P111514
  • GC11P111517
  • GC11P111520
  • GC11P111523

Summaries for MIR34C Gene

Entrez Gene Summary for MIR34C Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR34C Gene

MIR34C (MicroRNA 34c) is an RNA Gene, and is affiliated with the miRNA class. Among its related pathways are Focal Adhesion and Parkinsons Disease Pathway.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR34C Gene

Genomics for MIR34C Gene

Regulatory Elements for MIR34C Gene

Enhancers for MIR34C Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11F111357 1.6 FANTOM5 Ensembl ENCODE 9.2 -148.5 -148535 15.7 HDGF PKNOX1 MLX WRNIP1 ZFP64 ARID4B YBX1 FEZF1 DMAP1 ZNF2 COLCA2 COLCA1 LAYN BTG4 C11orf88 MIR34B MIR34C POU2AF1 MIR4491 RNU2-60P
GH11F111697 1.4 FANTOM5 Ensembl ENCODE 9.7 +185.3 185324 2.6 PKNOX1 ATF1 ARNT CREB3L1 CHAMP1 GATA2 SMARCA5 JUNB CEBPB ZEB2 PPP2R1B BTG4 C11orf88 MIR34B MIR34C SIK2 RN7SKP273 PIR48599
GH11F111445 1.2 Ensembl ENCODE 10 -66.9 -66940 1.4 HDGF ELF3 PKNOX1 WRNIP1 ARID4B ZBTB40 ZNF2 RAD21 EGR1 ZNF366 BTG4 C11orf88 MIR34B MIR34C LAYN ENSG00000254980 DIXDC1 LOC644277 POU2AF1
GH11F111413 1.2 Ensembl ENCODE 9.9 -96.7 -96741 6.6 HDGF ELF3 TBP PKNOX1 TBL1XR1 WRNIP1 ARID4B YBX1 BMI1 RAD21 COLCA1 RNU2-60P COLCA2 BTG4 C11orf88 MIR34B MIR34C LOC100132078 BCO2 GC11M111399
GH11F111776 1.2 Ensembl ENCODE 9.8 +264.4 264441 2.7 HDGF TBP PKNOX1 ATF1 ARID4B SIN3A DMAP1 THRB ZSCAN9 RAD21 PPP2R1B SIK2 LOC644277 POU2AF1 MIR34B MIR34C BTG4 C11orf88 ENSG00000254980 ENSG00000254990
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MIR34C on UCSC Golden Path with GeneCards custom track

Promoters for MIR34C Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000568859 -739 1001 CTCF POLR2A NR3C1 ZBTB7A ZBTB26 EZH2
ENSR00001772164 1361 401 CTCF RFX1 PRDM10 BMI1

Genomic Location for MIR34C Gene

Chromosome:
11
Start:
111,513,439 bp from pter
End:
111,513,515 bp from pter
Size:
77 bases
Orientation:
Plus strand

Genomic View for MIR34C Gene

Genes around MIR34C on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR34C Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR34C Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR34C Gene

Proteins for MIR34C Gene

Post-translational modifications for MIR34C Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR34C Gene

Domains & Families for MIR34C Gene

Gene Families for MIR34C Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR34C: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR34C Gene

Function for MIR34C Gene

Animal Model Products

miRNA for MIR34C Gene

miRTarBase miRNAs that target MIR34C

miRNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MIR34C Gene

Localization for MIR34C Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR34C Gene

Pathways & Interactions for MIR34C Gene

genes like me logo Genes that share pathways with MIR34C: view

Interacting Proteins for MIR34C Gene

Gene Ontology (GO) - Biological Process for MIR34C Gene

None

No data available for SIGNOR curated interactions for MIR34C Gene

Transcripts for MIR34C Gene

mRNA/cDNA for MIR34C Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR34C Gene

No ASD Table

Relevant External Links for MIR34C Gene

GeneLoc Exon Structure for
MIR34C
ECgene alternative splicing isoforms for
MIR34C

Expression for MIR34C Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MIR34C Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR34C Gene:

MIR34C
genes like me logo Genes that share expression patterns with MIR34C: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for MIR34C Gene

Orthologs for MIR34C Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIR34C Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia cfa-mir-34c 35
  • 100 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-34c 35
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia bta-mir-34c 35
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mir34c 35
  • 97 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia mdo-mir-34c 35
  • 89 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia oan-mir-34a 35
  • 77 (a)
OneToOne
chicken
(Gallus gallus)
Aves gga-mir-34c 35
  • 86 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea csa-mir-34 35
  • 32 (a)
OneToMany
Species where no ortholog for MIR34C was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MIR34C Gene

ENSEMBL:
Gene Tree for MIR34C (if available)
TreeFam:
Gene Tree for MIR34C (if available)

Paralogs for MIR34C Gene

No data available for Paralogs for MIR34C Gene

Variants for MIR34C Gene

Sequence variations from dbSNP and Humsavar for MIR34C Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs10789838 -- 111,512,390(+) TCCCC(C/T)CCCCC upstream-variant-2KB
rs112456112 -- 111,512,624(+) GAACC(C/T)GAGCG upstream-variant-2KB
rs113782040 -- 111,512,347(+) GAGGC(C/T)CTTCA nc-transcript-variant, upstream-variant-2KB, utr-variant-5-prime
rs114807289 -- 111,513,698(+) GTTTT(G/T)TTTTC downstream-variant-500B, upstream-variant-2KB
rs115364848 -- 111,511,789(+) CGTGC(A/G)TCAAG intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MIR34C Gene

Variant ID Type Subtype PubMed ID
nsv832268 CNV loss 17160897

Relevant External Links for MIR34C Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR34C

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR34C Gene

Disorders for MIR34C Gene

Relevant External Links for MIR34C

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR34C

No disorders were found for MIR34C Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR34C Gene

Publications for MIR34C Gene

  1. MiR-29c regulates the expression of miR-34c and miR-449a by targeting DNA methyltransferase 3a and 3b in nasopharyngeal carcinoma. (PMID: 26975503) Niu M. … Peng S. (BMC Cancer 2016) 3 64
  2. microRNA-34a and microRNA-34c promote the activation of human hepatic stellate cells by targeting peroxisome proliferator-activated receptor I^. (PMID: 25370690) Li X. … Wang J. (Mol Med Rep 2015) 3 64
  3. Association between rs4938723 functional polymorphism in the promoter region of miR-34b/c gene and cancer risk. (PMID: 25475831) Liu Q. … Shi G. (Clin Res Hepatol Gastroenterol 2015) 3 64
  4. Inhibition of miR-34b and miR-34c enhances I+-synuclein expression in Parkinson's disease. (PMID: 25541488) Kabaria S. … Junn E. (FEBS Lett. 2015) 3 64
  5. The regulation and function of miR-21-FOXO3a-miR-34b/c signaling in breast cancer. (PMID: 25647415) Liu X. … Zhu S. (Int J Mol Sci 2015) 3 64

Products for MIR34C Gene

Sources for MIR34C Gene

Content
Loading form....