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Aliases for MIR34C Gene

Subcategory (RNA class) for MIR34C Gene

miRNA

Quality Score for this RNA gene is

13

Aliases for MIR34C Gene

  • MicroRNA 34c 2 3 5
  • Hsa-Mir-34c 3
  • MiRNA34C 3
  • Mir-34c 3
  • MIRN34C 3

External Ids for MIR34C Gene

ORGUL Members for MIR34C Gene

Previous HGNC Symbols for MIR34C Gene

  • MIRN34C

Previous GeneCards Identifiers for MIR34C Gene

  • GC11P110906
  • GC11P110909
  • GC11P111384
  • GC11P111514
  • GC11P111517

Summaries for MIR34C Gene

Entrez Gene Summary for MIR34C Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR34C Gene

MIR34C (MicroRNA 34c) is an RNA Gene, and is affiliated with the miRNA class. Among its related pathways are MicroRNAs in cancer and miRNAs involved in DDR.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR34C Gene

Genomics for MIR34C Gene

Regulatory Elements for MIR34C Gene

Promoters for MIR34C Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around MIR34C on UCSC Golden Path with GeneCards custom track

Genomic Location for MIR34C Gene

Chromosome:
11
Start:
111,513,431 bp from pter
End:
111,513,538 bp from pter
Size:
108 bases
Orientation:
Plus strand

Genomic View for MIR34C Gene

Genes around MIR34C on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR34C Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR34C Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR34C Gene

Proteins for MIR34C Gene

Post-translational modifications for MIR34C Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR34C Gene

Domains & Families for MIR34C Gene

Gene Families for MIR34C Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR34C: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR34C Gene

Function for MIR34C Gene

miRNA for MIR34C Gene

miRTarBase miRNAs that target MIR34C

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MIR34C Gene

Localization for MIR34C Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR34C Gene

Pathways & Interactions for MIR34C Gene

genes like me logo Genes that share pathways with MIR34C: view

Pathways by source for MIR34C Gene

1 BioSystems pathway for MIR34C Gene
1 KEGG pathway for MIR34C Gene

Interacting Proteins for MIR34C Gene

Gene Ontology (GO) - Biological Process for MIR34C Gene

None

No data available for SIGNOR curated interactions for MIR34C Gene

Drugs & Compounds for MIR34C Gene

No Compound Related Data Available

Transcripts for MIR34C Gene

mRNA/cDNA for MIR34C Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR34C Gene

No ASD Table

Relevant External Links for MIR34C Gene

GeneLoc Exon Structure for
MIR34C
ECgene alternative splicing isoforms for
MIR34C

Expression for MIR34C Gene

mRNA expression in normal human tissues for MIR34C Gene

genes like me logo Genes that share expression patterns with MIR34C: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for MIR34C Gene

Orthologs for MIR34C Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIR34C Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia bta-mir-34c 36
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia cfa-mir-34c 36
  • 100 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia mdo-mir-34c 36
  • 89 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mir34c 36
  • 97 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia oan-mir-34a 36
  • 77 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-34c 36
  • 100 (a)
OneToOne
chicken
(Gallus gallus)
Aves gga-mir-34c 36
  • 86 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea csa-mir-34 36
  • 32 (a)
OneToMany
Species with no ortholog for MIR34C:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MIR34C Gene

ENSEMBL:
Gene Tree for MIR34C (if available)
TreeFam:
Gene Tree for MIR34C (if available)

Paralogs for MIR34C Gene

No data available for Paralogs for MIR34C Gene

Variants for MIR34C Gene

Structural Variations from Database of Genomic Variants (DGV) for MIR34C Gene

Variant ID Type Subtype PubMed ID
nsv832268 CNV Loss 17160897

Relevant External Links for MIR34C Gene

HapMap Linkage Disequilibrium report
MIR34C

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations from dbSNP and Humsavar and Variation tolerance for MIR34C Gene

Disorders for MIR34C Gene

Relevant External Links for MIR34C

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR34C

No disorders were found for MIR34C Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR34C Gene

Publications for MIR34C Gene

  1. Increased MicroRNA-34b and -34c Predominantly Expressed in Stromal Tissues Is Associated with Poor Prognosis in Human Colon Cancer. (PMID: 25894979) Hiyoshi Y. … Harris C.C. (PLoS ONE 2015) 3 67
  2. miR-34c regulates the permeability of blood-tumor barrier via MAZ-mediated expression changes of ZO-1, occludin, and claudin-5. (PMID: 25201524) Zhao L. … Xue Y. (J. Cell. Physiol. 2015) 3
  3. microRNA-34a and microRNA-34c promote the activation of human hepatic stellate cells by targeting peroxisome proliferator-activated receptor I^. (PMID: 25370690) Li X. … Wang J. (Mol Med Rep 2015) 3
  4. Inhibition of miR-34b and miR-34c enhances I+-synuclein expression in Parkinson's disease. (PMID: 25541488) Kabaria S. … Junn E. (FEBS Lett. 2015) 3
  5. MiR-34c suppresses tumor growth and metastasis in nasopharyngeal carcinoma by targeting MET. (PMID: 25611392) Li Y.Q. … Ma J. (Cell Death Dis 2015) 3

Products for MIR34C Gene

Sources for MIR34C Gene

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