|
|
microRNA 34b
(Previous symbol: MIRN34B)
| |
Aliases
for MIR34B gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
Subcategory (RNA class): miRNA
Quality score for this RNA gene is 13
| Aliases |
|---|
| MicroRNA 34b1 2 | | MIRN34B1 2 | | Hsa-Mir-34b1 | | MiRNA34B1 | | Mir-34b1 |
| External Ids: | HGNC: 316361 | Entrez Gene: 4070412 | Ensembl: ENSG000002078117 | OMIM: 6113745 |
Export aliases for MIR34B gene to outside databasesPrevious GC identifers: GC11P110905 GC11P110908
|---|
Summaries
for MIR34B gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for MIR34B:
microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of geneexpression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribedby RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be eitherprotein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce anapproximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicerribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporatedinto a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with themiRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeqrepresents the predicted microRNA stem-loop. (provided by RefSeq, Sep 2009)
|
Genomic Views
for MIR34B gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| Regulatory elements:
 Search SABiosciences Regulatory transcription factor binding sites for MIR34B
Other transcription factors
Search SABiosciences Chromatin IP Primers for MIR34B
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MIR34B |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 11q23.1 Ensembl cytogenetic band: 11q23.1 HGNC cytogenetic band: 11q23.1MIR34B Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 11 GeneLoc Exon Structure GeneLoc location for GC11P111383: view genomic region (via miRBase)
(about GC identifiers)
Start:
|
111,383,663 bp from pter |
End:
|
111,383,746 bp from pter |
Size:
|
84 bases |
Orientation:
|
plus strand |
|
Proteins
for MIR34B gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB: --
|
Protein
Domains /
Families
for MIR34B gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| -- |
Function
for MIR34B gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
miRNA
Products: | | miRTarBase genes targeted by MIR34B:
VEGFA(MIRT004519), CDK4(MIRT000764), MET(MIRT004825), SRSF2(MIRT004404), ZAP70(MIRT005761), MYC(MIRT004401), MET(MIRT000758), MYB(MIRT000747), BCL2(MIRT000065), CDK4(MIRT003450), CAV1(MIRT000753), CDK6(MIRT003579), MYC(MIRT005319), CREB1(MIRT000066), CDK6(MIRT000762), CCNE2(MIRT000767) |
| |  | Browse 3'-UTR reporter clones for miRNA target validation
Browse MicroRNA Expression Plasmids
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MIR34B | | | Search QIAGEN for miScript miRNA Assays for microRNAs that regulate MIR34B | |  | Browse SwitchGear 3'UTR luciferase reporter plasmids |
|
Pathways & Interactions
for MIR34B gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for MIR34B
|
Drugs & Compounds
for MIR34B gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for MIR34B
Search CenterWatch for drugs/clinical trials and news about MIR34B 
|
Transcripts
for MIR34B gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
1 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000385076(miRNA)
GeneLoc Exon Structure
|
Expression
for MIR34B gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| Expression evidence for MIR34B:none
MIR34B expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image SABiosciences Custom PCR Arrays for MIR34B
Primer
Products: | | Browse OriGene genome-wide validated SYBR primer pairs
Browse OriGene validated miRNA SYBR primer pairs
| | | Search SABiosciences RT2 qPCR
Primer Assays in human, mouse, rat MIR34B | | | Search QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MIR34B | | | Search QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MIR34B |
Orthologs
for MIR34B gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
--
ENSEMBL Gene Tree for MIR34B (if available)
TreeFam Gene Tree for MIR34B (if available) |
Paralogs
for MIR34B gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for MIR34B gene
- MIR34C2 MIR34A2
MIR34B for paralogs About GeneDecksing
|
Genomic Variants
for MIR34B gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for MIR34B
1 CNV: 86042
Human Gene Mutation Database (HGMD): MIR34B
| SABiosciences Cancer Mutation PCR Assays |
|
Disorders
/ Diseases
for MIR34B gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
MIR34B for disorders About GeneDecksing
OMIM gene information: 611374
OMIM disorders: --
10  diseases for MIR34B: About MalaCardspapillary thyroid carcinoma thyroid carcinoma thyroiditis gastric cancer
colorectal cancer osteosarcoma lung cancer carcinoma
melanoma neuronitis
Human Genome Epidemiology (HuGE) Navigator: MIR34B (1 document)
Export disorders for MIR34B gene to outside databases
|
Publications
for MIR34B gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for MIR34B gene, integrated from 9 sources (see all 23):
(articles sorted by number of sources associating them with MIR34B) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Frequent methylation and oncogenic role of microRNA-34 b/c in small-cell lung cancer. (PubMed id 22047961)1 Tanaka N....Miyoshi S. (2012)
- Effect of miR-34b overexpression on the radiosensitivi ty of non-small cell lung cancer cell lines. (PubMed id 22593438)1 Balca-Silva J....Silva H.C. (2012)
- Interactions of miR-34b/c and TP53 polymorphisms on th e risk of intracranial aneurysm. (PubMed id 22844323)1 Li L....Gao L. (2012)
- MicroRNA-34b functions as a potential tumor suppressor in endometrial serous adenocarcinoma. (PubMed id 22052540)1 Hiroki E....Yaegashi N. (2012)
- MiR-34b is associated with clinical outcome in triple- negative breast cancer patients. (PubMed id 22439831)1 Svoboda M....Vyzula R. (2012)
- MicroRNA signature distinguishes the degree of aggres siveness of papillary thyroid carcinoma. (PubMed id 21537871)1 Yip L....Nikiforova M.N. (2011)
- Epigenetic inactivation of the MIR34B/C in multiple m yeloma. (PubMed id 21976676)1 Wong K.Y....Chim C.S. (2011)
- Epigenetic regulation of miR-34b and miR-129 expressi on in gastric cancer. (PubMed id 21960261)1 Tsai K.W....Lin W.C. (2011)
- Epigenetically silenced miR-34b/c as a novel faecal-b ased screening marker for colorectal cancer. (PubMed id 21610744)1 Kalimutho M....Bernardini S. (2011)
- Epigenetic regulation of microRNA genes and the role of miR-34b in cell invasion and motility in human melanoma. (PubMed id 21949788)1 Mazar J....Perera R.J. (2011)
|
External Searches for MIR34B gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing MIR34B gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing MIR34B gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing MIR34B gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for MIR34B | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for MIR34B gene:
Search GeneIP for patents involving MIR34B
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for MIR34B gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 |
| | | | |
 |
 |
|  | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat MIR34B | | | Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MIR34B | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MIR34B | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MIR34B | | | Search QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MIR34B | | | Search QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MIR34B |
| |
 |  |  |  | |
| | | | Search Tocris compounds for MIR34B |
| |  |  |  |  | | | | |
 |
 |
 |
 | | | | |  |  |  | | | | Search ThermoFisher Antibodies for MIR34B |
| | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat MIR34B |
|
|
|
|
GeneCards Homepage -
Last full update: 19 Mar 2013 -
Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013
View Random Gene
|
Category
|
|
|
von Willebrand factor
|
| GIFtS Group |
|
Developed at the Crown Human Genome Center,
Department of Molecular Genetics,
the Weizmann Institute of Science
Copyright © 1996-2013
, Weizmann Institute of Science. All Rights Reserved.
hostname: 356977-web1.xennexinc.com
index build: 100 solr: 1.4
|
