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Aliases for MIR34B Gene

Subcategory (RNA class) for MIR34B Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR34B Gene

  • MicroRNA 34b 2 3
  • Hsa-Mir-34b 3
  • MiRNA34B 3
  • MIRN34B 3

External Ids for MIR34B Gene

ORGUL Members for MIR34B Gene

Previous Symbols for MIR34B Gene

  • MIRN34B

Summaries for MIR34B Gene

Entrez Gene Summary for MIR34B Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR34B Gene

MIR34B (MicroRNA 34b) is an RNA Gene, and belongs to the miRNA class. Diseases associated with MIR34B include malignant pleural mesothelioma. Among its related pathways are MicroRNAs in cancer and miRNAs involved in DDR.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR34B Gene

Genomics for MIR34B Gene

Genomic Location for MIR34B Gene

Start:
111,512,931 bp from pter
End:
111,513,040 bp from pter
Size:
110 bases
Orientation:
Plus strand

Genomic View for MIR34B Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MIR34B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR34B Gene

No data available for Regulatory Elements for MIR34B Gene

Proteins for MIR34B Gene

Post-translational modifications for MIR34B Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR34B Gene

Domains for MIR34B Gene

Gene Families for MIR34B Gene

HGNC:
  • MIR :ncRNAs / Micro RNAs

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR34B: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR34B Gene

Function for MIR34B Gene

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for MIR34B Gene

Localization for MIR34B Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR34B Gene

Pathways for MIR34B Gene

genes like me logo Genes that share pathways with MIR34B: view

Pathways by source for MIR34B Gene

1 BioSystems pathway for MIR34B Gene
1 KEGG pathway for MIR34B Gene

Interacting Proteins for MIR34B Gene

Gene Ontology (GO) - Biological Process for MIR34B Gene

None

Transcripts for MIR34B Gene

mRNA/cDNA for MIR34B Gene

(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR34B Gene

No ASD Table

Relevant External Links for MIR34B Gene

GeneLoc Exon Structure for
MIR34B
ECgene alternative splicing isoforms for
MIR34B

Expression for MIR34B Gene

mRNA expression in normal human tissues for MIR34B Gene

genes like me logo Genes that share expressions with MIR34B: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein expression and mRNA Expression by UniProt/SwissProt for MIR34B Gene

Orthologs for MIR34B Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIR34B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-34b 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia bta-mir-34b 36
  • 92 (a)
OneToOne
dog
(Canis familiaris)
Mammalia cfa-mir-34b 36
  • 94 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mir34b 36
  • 94 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia mdo-mir-34b 36
  • 90 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia oan-mir-34b 36
  • 86 (a)
OneToOne
chicken
(Gallus gallus)
Aves gga-mir-34b 36
  • 82 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia aca-mir-34c 36
  • 78 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii dre-mir-34b 36
  • 69 (a)
OneToMany
dre-mir-34c 36
  • 51 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea csa-mir-34 36
  • 36 (a)
OneToMany
Species with no ortholog for MIR34B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MIR34B Gene

ENSEMBL:
Gene Tree for MIR34B (if available)
TreeFam:
Gene Tree for MIR34B (if available)

Paralogs for MIR34B Gene

No data available for Paralogs for MIR34B Gene

Variants for MIR34B Gene

Structural Variations from Database of Genomic Variants (DGV) for MIR34B Gene

Variant ID Type Subtype PubMed ID
nsv832268 CNV Loss 17160897

Relevant External Links for MIR34B Gene

HapMap Linkage Disequilibrium report
MIR34B
Human Gene Mutation Database (HGMD)
MIR34B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations from dbSNP and Humsavar for MIR34B Gene

Disorders for MIR34B Gene

Relevant External Links for MIR34B

Human Genome Epidemiology (HuGE) Navigator
MIR34B
genes like me logo Genes that share disorders with MIR34B: view

No data available for UniProtKB/Swiss-Prot for MIR34B Gene

Publications for MIR34B Gene

  1. Embryonic stem cell-specific MicroRNAs. (PMID: 12919684) Houbaviy H.B. … Sharp P.A. (Dev. Cell 2003) 3
  2. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S. … Enright A.J. (Nucleic Acids Res. 2006) 3
  3. A microRNA component of the p53 tumour suppressor network. (PMID: 17554337) He L. … Hannon G.J. (Nature 2007) 3
  4. A mammalian microRNA expression atlas based on small RNA library sequencing. (PMID: 17604727) Landgraf P. … Tuschl T. (Cell 2007) 3
  5. Nutlin-3a activates p53 to both down-regulate inhibitor of growth 2 and up-regulate mir-34a, mir-34b, and mir-34c expression, and induce senescence. (PMID: 18451145) Kumamoto K. … Harris C.C. (Cancer Res. 2008) 3

Products for MIR34B Gene

Sources for MIR34B Gene

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