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Aliases for MIR34B Gene

Subcategory (RNA class) for MIR34B Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR34B Gene

  • MicroRNA 34b 2 3 5
  • Hsa-Mir-34b 3
  • MiRNA34B 3
  • Mir-34b 3
  • MIRN34B 3

External Ids for MIR34B Gene

ORGUL Members for MIR34B Gene

Previous HGNC Symbols for MIR34B Gene

  • MIRN34B

Previous GeneCards Identifiers for MIR34B Gene

  • GC11P110905
  • GC11P110908
  • GC11P111383
  • GC11P111513
  • GC11P111516
  • GC11P111519
  • GC11P111522
  • GC11P111525
  • GC11P111528

Summaries for MIR34B Gene

Entrez Gene Summary for MIR34B Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR34B Gene

MIR34B (MicroRNA 34b) is an RNA Gene, and is affiliated with the miRNA class. Among its related pathways are Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. and MicroRNAs in cancer.

Additional gene information for MIR34B Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR34B Gene

Genomics for MIR34B Gene

Regulatory Elements for MIR34B Gene

Enhancers for MIR34B Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11H111697 1.7 FANTOM5 Ensembl ENCODE dbSUPER 9.7 +185.8 185825 2 PKNOX1 ATF1 ARNT CHAMP1 TCF12 GATA2 SMARCA5 ZEB2 SMARCB1 ZNF592 PPP2R1B NKAPD1 BTG4 C11orf88 MIR34B MIR34C SIK2 RN7SKP273 PIR48599
GH11H111357 1.6 FANTOM5 ENCODE dbSUPER 9.2 -148.0 -148034 15 HDGF PKNOX1 FOXA2 MLX ZFP64 ARID4B DMAP1 YBX1 YY1 SLC30A9 COLCA2 COLCA1 LAYN BTG4 MIR34B MIR34C C11orf88 POU2AF1 MIR4491 RNU2-60P
GH11H111413 1.4 Ensembl ENCODE dbSUPER 10 -96.3 -96340 6 ELF3 HDGF PKNOX1 TBL1XR1 RB1 ARID4B BMI1 YBX1 BATF RAD21 COLCA1 RNU2-60P COLCA2 BTG4 C11orf88 MIR34B MIR34C LOC100132078 BCO2 GC11M111399
GH11H111776 1.4 Ensembl ENCODE dbSUPER 9.8 +264.9 264942 2 HDGF FOXA2 PKNOX1 ATF1 ARID4B DMAP1 YY1 ZNF143 ATF7 RUNX3 PPP2R1B SIK2 LOC644277 POU2AF1 BTG4 MIR34B MIR34C C11orf88 ENSG00000254980 ENSG00000254990
GH11H111375 1.4 Ensembl ENCODE dbSUPER 9.2 -134.5 -134452 5 HDGF PKNOX1 TBL1XR1 RB1 BMI1 BATF ZBTB40 ZNF143 ZNF207 ATF7 COLCA1 COLCA2 LOC644277 POU2AF1 C11orf88 BTG4 MIR34B MIR34C RNU2-60P MIR4491
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MIR34B on UCSC Golden Path with GeneCards custom track

Promoters for MIR34B Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000044857 -438 201 CTCF POLR2A NR3C1 EZH2

Genomic Location for MIR34B Gene

Chromosome:
11
Start:
111,512,938 bp from pter
End:
111,513,021 bp from pter
Size:
84 bases
Orientation:
Plus strand

Genomic View for MIR34B Gene

Genes around MIR34B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR34B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR34B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR34B Gene

Proteins for MIR34B Gene

Post-translational modifications for MIR34B Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR34B Gene

Domains & Families for MIR34B Gene

Gene Families for MIR34B Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR34B: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR34B Gene

Function for MIR34B Gene

Phenotypes From GWAS Catalog for MIR34B Gene

Animal Model Products

CRISPR Products

miRNA Products

Clone Products

  • Applied Biological Materials Clones for MIR34B
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR34B Gene

Localization for MIR34B Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR34B Gene

Pathways & Interactions for MIR34B Gene

genes like me logo Genes that share pathways with MIR34B: view

Pathways by source for MIR34B Gene

Interacting Proteins for MIR34B Gene

Gene Ontology (GO) - Biological Process for MIR34B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0051898 negative regulation of protein kinase B signaling ISS --
GO:1903244 positive regulation of cardiac muscle hypertrophy in response to stress ISS --
GO:1903671 negative regulation of sprouting angiogenesis ISS --
GO:1905205 positive regulation of connective tissue replacement ISS --
genes like me logo Genes that share ontologies with MIR34B: view

No data available for SIGNOR curated interactions for MIR34B Gene

Drugs & Compounds for MIR34B Gene

No Compound Related Data Available

Transcripts for MIR34B Gene

mRNA/cDNA for MIR34B Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

CRISPR Products

miRNA Products

Clone Products

  • Applied Biological Materials Clones for MIR34B
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for MIR34B Gene

No ASD Table

Relevant External Links for MIR34B Gene

GeneLoc Exon Structure for
MIR34B
ECgene alternative splicing isoforms for
MIR34B

Expression for MIR34B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MIR34B Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR34B Gene:

MIR34B
genes like me logo Genes that share expression patterns with MIR34B: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR34B Gene

Orthologs for MIR34B Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIR34B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-34b 34
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia cfa-mir-34b 34
  • 94 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mir34b 34
  • 94 (a)
OneToOne
cow
(Bos Taurus)
Mammalia bta-mir-34b 34
  • 92 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia mdo-mir-34b 34
  • 90 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia oan-mir-34b 34
  • 86 (a)
OneToOne
chicken
(Gallus gallus)
Aves gga-mir-34b 34
  • 82 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia aca-mir-34c 34
  • 78 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii dre-mir-34b 34
  • 69 (a)
OneToMany
dre-mir-34c 34
  • 51 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea csa-mir-34 34
  • 36 (a)
OneToMany
Species where no ortholog for MIR34B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MIR34B Gene

ENSEMBL:
Gene Tree for MIR34B (if available)
TreeFam:
Gene Tree for MIR34B (if available)

Paralogs for MIR34B Gene

No data available for Paralogs for MIR34B Gene

Variants for MIR34B Gene

Sequence variations from dbSNP and Humsavar for MIR34B Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs1000378890 -- 111,511,264(+) GGGTG(C/T)ACAGA intron-variant, upstream-variant-2KB
rs1000746492 -- 111,510,949(+) TAAAA(C/G)TGACT intron-variant, upstream-variant-2KB
rs1004837620 -- 111,510,962(+) CAATT(C/T)GGTAG intron-variant, upstream-variant-2KB
rs1004930989 -- 111,511,426(+) TGTTA(A/C)TTGTG intron-variant, upstream-variant-2KB
rs1006196846 -- 111,512,203(+) CAGGG(A/C)GGAAT nc-transcript-variant, upstream-variant-2KB, utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for MIR34B Gene

Variant ID Type Subtype PubMed ID
nsv832268 CNV loss 17160897

Relevant External Links for MIR34B Gene

Human Gene Mutation Database (HGMD)
MIR34B
SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR34B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR34B Gene

Disorders for MIR34B Gene

Relevant External Links for MIR34B

Human Genome Epidemiology (HuGE) Navigator
MIR34B
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR34B

No disorders were found for MIR34B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR34B Gene

Publications for MIR34B Gene

  1. Pri-miR-34b/c rs4938723 polymorphism increased the risk of prostate cancer. (PMID: 27983526) Hashemi M … Taheri M (Cancer biomarkers : section A of Disease markers 2017) 3 60
  2. A polymorphism in mir-34b/c as a potential biomarker for early onset of hereditary retinoblastoma. (PMID: 28106538) Carvalho IN … Vargas FR (Cancer biomarkers : section A of Disease markers 2017) 3 60
  3. Germline miRNA DNA variants and the risk of colorectal cancer by subtype. (PMID: 27636879) Lindor NM … Thibodeau SN (Genes, chromosomes & cancer 2017) 3 60
  4. Pri-miR-34b/c rs4938723 polymorphism is associated with the risk of childhood acute lymphoblastic leukemia. (PMID: 27886674) Hashemi M … Taheri M (Cancer genetics 2016) 3 60
  5. Interactions of Pri-miRNA-34b/c and TP53 Polymorphisms on the Risk of Osteoporosis. (PMID: 27227383) Jia F … Fu W (Genetic testing and molecular biomarkers 2016) 3 60

Products for MIR34B Gene

Sources for MIR34B Gene

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