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Aliases for MIR34B Gene

Subcategory (RNA class) for MIR34B Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR34B Gene

  • MicroRNA 34b 2 3 5
  • Hsa-Mir-34b 3
  • MiRNA34B 3
  • Mir-34b 3
  • MIRN34B 3

External Ids for MIR34B Gene

ORGUL Members for MIR34B Gene

Previous HGNC Symbols for MIR34B Gene

  • MIRN34B

Previous GeneCards Identifiers for MIR34B Gene

  • GC11P110905
  • GC11P110908
  • GC11P111383
  • GC11P111513
  • GC11P111516
  • GC11P111519
  • GC11P111522

Summaries for MIR34B Gene

Entrez Gene Summary for MIR34B Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR34B Gene

MIR34B (MicroRNA 34b) is an RNA Gene, and is affiliated with the miRNA class. Among its related pathways are Parkinsons Disease Pathway and MicroRNAs in cancer.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR34B Gene

Genomics for MIR34B Gene

Regulatory Elements for MIR34B Gene

Enhancers for MIR34B Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11F111357 1.6 FANTOM5 Ensembl ENCODE 9.2 -148.0 -148034 15.7 HDGF PKNOX1 MLX WRNIP1 ZFP64 ARID4B YBX1 FEZF1 DMAP1 ZNF2 COLCA2 COLCA1 LAYN BTG4 C11orf88 MIR34B MIR34C POU2AF1 MIR4491 RNU2-60P
GH11F111697 1.4 FANTOM5 Ensembl ENCODE 9.7 +185.8 185825 2.6 PKNOX1 ATF1 ARNT CREB3L1 CHAMP1 GATA2 SMARCA5 JUNB CEBPB ZEB2 PPP2R1B BTG4 C11orf88 MIR34B MIR34C SIK2 RN7SKP273 PIR48599
GH11F111445 1.2 Ensembl ENCODE 10 -66.4 -66439 1.4 HDGF ELF3 PKNOX1 WRNIP1 ARID4B ZBTB40 ZNF2 RAD21 EGR1 ZNF366 BTG4 C11orf88 MIR34B MIR34C LAYN ENSG00000254980 DIXDC1 LOC644277 POU2AF1
GH11F111413 1.2 Ensembl ENCODE 9.9 -96.2 -96240 6.6 HDGF ELF3 TBP PKNOX1 TBL1XR1 WRNIP1 ARID4B YBX1 BMI1 RAD21 COLCA1 RNU2-60P COLCA2 BTG4 C11orf88 MIR34B MIR34C LOC100132078 BCO2 GC11M111399
GH11F111776 1.2 Ensembl ENCODE 9.8 +264.9 264942 2.7 HDGF TBP PKNOX1 ATF1 ARID4B SIN3A DMAP1 THRB ZSCAN9 RAD21 PPP2R1B SIK2 LOC644277 POU2AF1 MIR34B MIR34C BTG4 C11orf88 ENSG00000254980 ENSG00000254990
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MIR34B on UCSC Golden Path with GeneCards custom track

Promoters for MIR34B Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000568859 -238 1001 CTCF POLR2A NR3C1 ZBTB7A ZBTB26 EZH2
ENSR00001772164 1862 401 CTCF RFX1 PRDM10 BMI1

Genomic Location for MIR34B Gene

Chromosome:
11
Start:
111,512,938 bp from pter
End:
111,513,021 bp from pter
Size:
84 bases
Orientation:
Plus strand

Genomic View for MIR34B Gene

Genes around MIR34B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR34B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR34B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR34B Gene

Proteins for MIR34B Gene

Post-translational modifications for MIR34B Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR34B Gene

Domains & Families for MIR34B Gene

Gene Families for MIR34B Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR34B: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR34B Gene

Function for MIR34B Gene

Animal Model Products

miRNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR34B Gene

Localization for MIR34B Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR34B Gene

Pathways & Interactions for MIR34B Gene

genes like me logo Genes that share pathways with MIR34B: view

Pathways by source for MIR34B Gene

Interacting Proteins for MIR34B Gene

Gene Ontology (GO) - Biological Process for MIR34B Gene

None

No data available for SIGNOR curated interactions for MIR34B Gene

Transcripts for MIR34B Gene

mRNA/cDNA for MIR34B Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR34B Gene

No ASD Table

Relevant External Links for MIR34B Gene

GeneLoc Exon Structure for
MIR34B
ECgene alternative splicing isoforms for
MIR34B

Expression for MIR34B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MIR34B Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR34B Gene:

MIR34B
genes like me logo Genes that share expression patterns with MIR34B: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for MIR34B Gene

Orthologs for MIR34B Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIR34B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-34b 35
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia cfa-mir-34b 35
  • 94 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mir34b 35
  • 94 (a)
OneToOne
cow
(Bos Taurus)
Mammalia bta-mir-34b 35
  • 92 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia mdo-mir-34b 35
  • 90 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia oan-mir-34b 35
  • 86 (a)
OneToOne
chicken
(Gallus gallus)
Aves gga-mir-34b 35
  • 82 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia aca-mir-34c 35
  • 78 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii dre-mir-34b 35
  • 69 (a)
OneToMany
dre-mir-34c 35
  • 51 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea csa-mir-34 35
  • 36 (a)
OneToMany
Species where no ortholog for MIR34B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MIR34B Gene

ENSEMBL:
Gene Tree for MIR34B (if available)
TreeFam:
Gene Tree for MIR34B (if available)

Paralogs for MIR34B Gene

No data available for Paralogs for MIR34B Gene

Variants for MIR34B Gene

Sequence variations from dbSNP and Humsavar for MIR34B Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs10789838 -- 111,512,390(+) TCCCC(C/T)CCCCC upstream-variant-2KB
rs112456112 -- 111,512,624(+) GAACC(C/T)GAGCG upstream-variant-2KB
rs113782040 -- 111,512,347(+) GAGGC(C/T)CTTCA nc-transcript-variant, upstream-variant-2KB, utr-variant-5-prime
rs115364848 -- 111,511,789(+) CGTGC(A/G)TCAAG intron-variant, upstream-variant-2KB
rs11606481 -- 111,513,064(+) TCGGG(C/T)AGCCC downstream-variant-500B, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MIR34B Gene

Variant ID Type Subtype PubMed ID
nsv832268 CNV loss 17160897

Relevant External Links for MIR34B Gene

Human Gene Mutation Database (HGMD)
MIR34B
SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR34B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR34B Gene

Disorders for MIR34B Gene

Relevant External Links for MIR34B

Human Genome Epidemiology (HuGE) Navigator
MIR34B
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR34B

No disorders were found for MIR34B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR34B Gene

Publications for MIR34B Gene

  1. Pri-miR-34b/c rs4938723 polymorphism is associated with a decreased risk of gastric cancer. (PMID: 25658980) Pan X.M. … Gao L.B. (Genet Test Mol Biomarkers 2015) 3 64
  2. Investigation of Gene Regulatory Networks Associated with Autism Spectrum Disorder Based on MiRNA Expression in China. (PMID: 26061495) Huang F. … Jiang H. (PLoS ONE 2015) 3 64
  3. Pri-Mir-34b/C and Tp-53 Polymorphisms are Associated With The Susceptibility of Papillary Thyroid Carcinoma: A Case-Control Study. (PMID: 26402809) Chen P. … Gao L. (Medicine (Baltimore) 2015) 3 64
  4. MiR-34b/c rs4938723 Polymorphism Significantly Decreases the Risk of Digestive Tract Cancer: Meta-analysis. (PMID: 26320502) Ji T.X. … Ma F.F. (Asian Pac. J. Cancer Prev. 2015) 3 64
  5. Deregulation of MiR-34b/Sox2 Predicts Prostate Cancer Progression. (PMID: 26107383) Forno I. … Bosari S. (PLoS ONE 2015) 3 64

Products for MIR34B Gene

Sources for MIR34B Gene

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