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Aliases for MIR34A Gene

Subcategory (RNA class) for MIR34A Gene

miRNA

Quality Score for this RNA gene is

9.2

Aliases for MIR34A Gene

  • MicroRNA 34a 2 3 5
  • Hsa-Mir-34a 3
  • MiRNA34A 3
  • Mir-34a 3
  • MIRN34A 3
  • Mir-34 3

External Ids for MIR34A Gene

Previous HGNC Symbols for MIR34A Gene

  • MIRN34A

Previous GeneCards Identifiers for MIR34A Gene

  • GC01M009134
  • GC01M009211

Summaries for MIR34A Gene

Entrez Gene Summary for MIR34A Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. This miRNA is a member of the highly conserved miR-34 family. This miRNA functions as a tumor suppressor and dysregulation or loss of the host gene from which this miRNA is processed is associated with cancer progression in numerous cell types. [provided by RefSeq, Sep 2015]

GeneCards Summary for MIR34A Gene

MIR34A (MicroRNA 34a) is an RNA Gene, and is affiliated with the miRNA class. Among its related pathways are mir34a and TGIF2 in osteoclastogenesis and MicroRNAs in cancer.

fRNAdb sequence ontologies for MIR34A Gene - the ORGUL cluster for this gene includes several descriptions:

  • miRNA: Small, ~22-nt, RNA molecule that is the endogenous transcript of a miRNA gene. Micro RNAs are produced from precursor molecules (SO:0000647) that can form local hairpin structures, which ordinarily are processed (via the Dicer pathway) such that a single miRNA molecule accumulates from one arm of a hairpin precursor molecule. Micro RNAs may trigger the cleavage of their target molecules or act as translational repressors.

  • nc_conserved_region: Non-coding region of sequence similarity by descent from a common ancestor.

View fRNAdb secondary structures for MIR34A

Additional gene information for MIR34A Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR34A Gene

Genomics for MIR34A Gene

Regulatory Elements for MIR34A Gene

Enhancers for MIR34A Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01H009237 1.8 FANTOM5 Ensembl ENCODE dbSUPER 11.1 -90.1 -90051 8.2 PKNOX1 FOXA2 ZFP64 ARID4B YY1 RUNX3 PAF1 SP5 REST PPARG H6PD GPR157 MIR34A PIR53045
GH01H009434 1.8 FANTOM5 Ensembl ENCODE dbSUPER 10.3 -287.9 -287906 10.9 PKNOX1 FOXA2 ATF1 MLX ARID4B DMAP1 YY1 ZNF121 SLC30A9 GATA2 GPR157 MIR34A SPSB1 LOC100506022 RNA5SP40
GH01H009369 1.7 VISTA Ensembl ENCODE dbSUPER 10.3 -221.8 -221847 8.1 CTCF ZFP64 ZMYM3 EBF1 ZNF507 ZFHX2 SCRT2 ZBTB20 RFX1 NRF1 MIR34A RBP7 ENSG00000284652 SPSB1
GH01H009231 1.5 FANTOM5 Ensembl ENCODE dbSUPER 11.4 -80.1 -80060 1.3 ZNF76 RELA ZNF316 IKZF1 SCRT2 ZSCAN5C RUNX3 EMSY MAFK IKZF2 H6PD MIR34A GPR157 GC01M009234 GC01P009203
GH01H009314 1.4 Ensembl ENCODE dbSUPER 10.2 -164.7 -164744 4.6 PTBP1 NFIB KLF17 BMI1 NFXL1 BATF EGR1 SCRT2 FOS RUNX3 MIR34A PIK3CD SPSB1 ENSG00000284652
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MIR34A on UCSC Golden Path with GeneCards custom track

Genomic Locations for MIR34A Gene

Genomic Locations for MIR34A Gene
chr1:9,151,668-9,151,777
(GRCh38/hg38)
Size:
110 bases
Orientation:
Minus strand
chr1:9,211,727-9,211,836
(GRCh37/hg19)

Genomic View for MIR34A Gene

Genes around MIR34A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR34A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR34A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR34A Gene

ORGUL Member Location for MIR34A Gene

ORGUL Member Location for MIR34A gene

Proteins for MIR34A Gene

Post-translational modifications for MIR34A Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR34A Gene

Domains & Families for MIR34A Gene

Gene Families for MIR34A Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR34A: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR34A Gene

Function for MIR34A Gene

Phenotypes From GWAS Catalog for MIR34A Gene

Animal Model Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR34A Gene

Localization for MIR34A Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR34A Gene

Pathways & Interactions for MIR34A Gene

genes like me logo Genes that share pathways with MIR34A: view

Pathways by source for MIR34A Gene

1 BioSystems pathway for MIR34A Gene
1 KEGG pathway for MIR34A Gene

Interacting Proteins for MIR34A Gene

Gene Ontology (GO) - Biological Process for MIR34A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0010942 positive regulation of cell death IMP 22651868
GO:0030336 negative regulation of cell migration IMP 22651868
GO:0035195 gene silencing by miRNA IGI 23047694
GO:0051152 positive regulation of smooth muscle cell differentiation IDA 25526086
GO:0051898 negative regulation of protein kinase B signaling ISS --
genes like me logo Genes that share ontologies with MIR34A: view

No data available for SIGNOR curated interactions for MIR34A Gene

Drugs & Compounds for MIR34A Gene

No Compound Related Data Available

Transcripts for MIR34A Gene

fRNAdb Secondary structures for MIR34A Gene

  • FR109864
  • FR136403

mRNA/cDNA for MIR34A Gene

(1) Additional mRNA sequences :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for MIR34A Gene

MicroRNA 34a:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR34A Gene

No ASD Table

Relevant External Links for MIR34A Gene

GeneLoc Exon Structure for
MIR34A
ECgene alternative splicing isoforms for
MIR34A

Expression for MIR34A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MIR34A Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR34A Gene:

MIR34A

SOURCE GeneReport for Unigene cluster for MIR34A Gene:

Hs.730325
genes like me logo Genes that share expression patterns with MIR34A: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR34A Gene

Orthologs for MIR34A Gene

Evolution for MIR34A Gene

ENSEMBL:
Gene Tree for MIR34A (if available)
TreeFam:
Gene Tree for MIR34A (if available)

No data available for Orthologs for MIR34A Gene

Paralogs for MIR34A Gene

No data available for Paralogs for MIR34A Gene

Variants for MIR34A Gene

Sequence variations from dbSNP and Humsavar for MIR34A Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1002048210 -- 9,151,863(+) GGGAG(A/G)AAAGA intron-variant, upstream-variant-2KB
rs1004891985 -- 9,153,022(+) GTTAT(A/G)GGCAT intron-variant, upstream-variant-2KB
rs1005463528 -- 9,153,336(+) CGTTG(A/G)AGTTG intron-variant, upstream-variant-2KB
rs1005585465 -- 9,152,710(+) AGGCC(C/T)ACCCA intron-variant, upstream-variant-2KB
rs1006188293 -- 9,151,992(+) ACATG(C/T)GTGCC intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MIR34A Gene

Variant ID Type Subtype PubMed ID
nsv832092 CNV loss 17160897
nsv831981 CNV loss 17160897
esv2422210 CNV duplication 17116639

Relevant External Links for MIR34A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR34A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR34A Gene

Disorders for MIR34A Gene

Relevant External Links for MIR34A

Human Genome Epidemiology (HuGE) Navigator
MIR34A
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR34A

No disorders were found for MIR34A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR34A Gene

Publications for MIR34A Gene

  1. miR-34a repression of SIRT1 regulates apoptosis. (PMID: 18755897) Yamakuchi M … Lowenstein CJ (Proceedings of the National Academy of Sciences of the United States of America 2008) 3 22 60
  2. Vertebrate microRNA genes. (PMID: 12624257) Lim LP … Bartel DP (Science (New York, N.Y.) 2003) 1 3 60
  3. MicroRNA-21 versus microRNA-34: Lung cancer promoting and inhibitory microRNAs analysed in silico and in vitro and their clinical impact. (PMID: 28705115) Kunz M … Dandekar T (Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 2017) 3 60
  4. miR-34a and miR-9 are overexpressed and SIRT genes are downregulated in peripheral blood mononuclear cells of aging humans. (PMID: 28699360) Owczarz M … Puzianowska-Kuznicka M (Experimental biology and medicine (Maywood, N.J.) 2017) 3 60
  5. MiR-34a/sirtuin-1/foxo3a is involved in genistein protecting against ox-LDL-induced oxidative damage in HUVECs. (PMID: 28688900) Zhang H … Zhao J (Toxicology letters 2017) 3 60

Products for MIR34A Gene

Sources for MIR34A Gene

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