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Aliases for MIR34A Gene

Subcategory (RNA class) for MIR34A Gene

miRNA

Quality Score for this RNA gene is

9.2

Aliases for MIR34A Gene

  • MicroRNA 34a 2 3 5
  • Hsa-Mir-34a 3
  • MiRNA34A 3
  • Mir-34a 3
  • MIRN34A 3
  • Mir-34 3

External Ids for MIR34A Gene

Previous HGNC Symbols for MIR34A Gene

  • MIRN34A

Previous GeneCards Identifiers for MIR34A Gene

  • GC01M009134
  • GC01M009211

Summaries for MIR34A Gene

Entrez Gene Summary for MIR34A Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. This miRNA is a member of the highly conserved miR-34 family. This miRNA functions as a tumor suppressor and dysregulation or loss of the host gene from which this miRNA is processed is associated with cancer progression in numerous cell types. [provided by RefSeq, Sep 2015]

GeneCards Summary for MIR34A Gene

MIR34A (MicroRNA 34a) is an RNA Gene, and is affiliated with the miRNA class. Among its related pathways are mir34a and TGIF2 in osteoclastogenesis and MicroRNAs in cancer.

fRNAdb sequence ontologies for MIR34A Gene - the ORGUL cluster for this gene includes several descriptions:

  • miRNA: Small, ~22-nt, RNA molecule that is the endogenous transcript of a miRNA gene. Micro RNAs are produced from precursor molecules (SO:0000647) that can form local hairpin structures, which ordinarily are processed (via the Dicer pathway) such that a single miRNA molecule accumulates from one arm of a hairpin precursor molecule. Micro RNAs may trigger the cleavage of their target molecules or act as translational repressors.

  • nc_conserved_region: Non-coding region of sequence similarity by descent from a common ancestor.

View fRNAdb secondary structures for MIR34A

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR34A Gene

Genomics for MIR34A Gene

Regulatory Elements for MIR34A Gene

Enhancers for MIR34A Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01G009237 1.9 FANTOM5 Ensembl ENCODE dbSUPER 11.1 -90.1 -90051 8.2 FOXA2 PKNOX1 CREB3L1 ZFP64 ARID4B SIN3A FEZF1 YY1 FOS PAF1 H6PD GPR157 MIR34A PIR53045
GH01G009369 2 VISTA Ensembl ENCODE dbSUPER 10.3 -221.8 -221847 8.1 HDGF FOXA2 ZFP64 ARID4B DMAP1 ZNF48 YY1 GATA2 FOS SP5 MIR34A RBP7 LOC100506022 SPSB1
GH01G009434 1.9 FANTOM5 Ensembl ENCODE dbSUPER 10.3 -287.9 -287906 10.9 HNRNPUL1 PKNOX1 FOXA2 MLX CREB3L1 ARID4B DMAP1 ZNF2 YY1 SLC30A9 GPR157 MIR34A SPSB1 RNA5SP40 GC01P009482
GH01G009231 1.7 FANTOM5 Ensembl ENCODE dbSUPER 11.4 -80.1 -80060 1.3 NFIB ZNF76 ARID4B SIN3A ZNF335 GLIS2 SCRT2 ZSCAN5C IKZF2 EGR2 H6PD MIR34A GPR157 GC01M009234 GC01P009203
GH01G009121 1.3 ENCODE dbSUPER 11.8 +29.5 29450 0.9 PKNOX1 ARID4B SIN3A DMAP1 ZNF48 ZNF2 YY1 ZNF121 GLIS2 ZNF143 MIR34A RNU6-304P GPR157 SLC2A5 PIR42185
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MIR34A on UCSC Golden Path with GeneCards custom track

Genomic Location for MIR34A Gene

Chromosome:
1
Start:
9,151,668 bp from pter
End:
9,151,777 bp from pter
Size:
110 bases
Orientation:
Minus strand

Genomic View for MIR34A Gene

Genes around MIR34A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR34A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR34A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR34A Gene

ORGUL Member Location for MIR34A Gene

ORGUL Member Location for MIR34A gene

Proteins for MIR34A Gene

Post-translational modifications for MIR34A Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR34A Gene

Domains & Families for MIR34A Gene

Gene Families for MIR34A Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR34A: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR34A Gene

Function for MIR34A Gene

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR34A Gene

Localization for MIR34A Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR34A Gene

Pathways & Interactions for MIR34A Gene

genes like me logo Genes that share pathways with MIR34A: view

Pathways by source for MIR34A Gene

1 BioSystems pathway for MIR34A Gene
1 KEGG pathway for MIR34A Gene

Interacting Proteins for MIR34A Gene

Gene Ontology (GO) - Biological Process for MIR34A Gene

None

No data available for SIGNOR curated interactions for MIR34A Gene

Transcripts for MIR34A Gene

fRNAdb Secondary structures for MIR34A Gene

  • FR109864
  • FR136403

mRNA/cDNA for MIR34A Gene

(1) Additional mRNA sequences :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for MIR34A Gene

MicroRNA 34a:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MIR34A Gene

No ASD Table

Relevant External Links for MIR34A Gene

GeneLoc Exon Structure for
MIR34A
ECgene alternative splicing isoforms for
MIR34A

Expression for MIR34A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MIR34A Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR34A Gene:

MIR34A

SOURCE GeneReport for Unigene cluster for MIR34A Gene:

Hs.730325
genes like me logo Genes that share expression patterns with MIR34A: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR34A Gene

Orthologs for MIR34A Gene

Evolution for MIR34A Gene

ENSEMBL:
Gene Tree for MIR34A (if available)
TreeFam:
Gene Tree for MIR34A (if available)

No data available for Orthologs for MIR34A Gene

Paralogs for MIR34A Gene

No data available for Paralogs for MIR34A Gene

Variants for MIR34A Gene

Sequence variations from dbSNP and Humsavar for MIR34A Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1002048210 -- 9,151,863(+) GGGAG(A/G)AAAGA intron-variant, upstream-variant-2KB
rs1004891985 -- 9,153,022(+) GTTAT(A/G)GGCAT intron-variant, upstream-variant-2KB
rs1005463528 -- 9,153,336(+) CGTTG(A/G)AGTTG intron-variant, upstream-variant-2KB
rs1005585465 -- 9,152,710(+) AGGCC(C/T)ACCCA intron-variant, upstream-variant-2KB
rs1006188293 -- 9,151,992(+) ACATG(C/T)GTGCC intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MIR34A Gene

Variant ID Type Subtype PubMed ID
esv2422210 CNV duplication 17116639
nsv831981 CNV loss 17160897
nsv832092 CNV loss 17160897

Relevant External Links for MIR34A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR34A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR34A Gene

Disorders for MIR34A Gene

Relevant External Links for MIR34A

Human Genome Epidemiology (HuGE) Navigator
MIR34A
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR34A

No disorders were found for MIR34A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR34A Gene

Publications for MIR34A Gene

  1. miR-34a repression of SIRT1 regulates apoptosis. (PMID: 18755897) Yamakuchi M. … Lowenstein C.J. (Proc. Natl. Acad. Sci. U.S.A. 2008) 3 22 64
  2. Vertebrate microRNA genes. (PMID: 12624257) Lim L.P. … Bartel D.P. (Science 2003) 1 3 64
  3. MiR-34a modulates ErbB2 in breast cancer. (PMID: 27813227) Wang Y. … Lai L. (Cell Biol. Int. 2017) 3 64
  4. Decreased levels of miR-34a and miR-217 act as predictor biomarkers of aggressive progression and poor prognosis in hepatocellular carcinoma. (PMID: 27879964) Tian Y.W. … Xue H.Z. (Minerva Med. 2017) 3 64
  5. EZH2 coupled with HOTAIR to silence MicroRNA-34a by the induction of heterochromatin formation in human pancreatic ductal adenocarcinoma. (PMID: 27594424) Li C.H. … Chen Y. (Int. J. Cancer 2017) 3 64

Products for MIR34A Gene

Sources for MIR34A Gene

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