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Aliases for MIR34A Gene

Subcategory (RNA class) for MIR34A Gene


Quality Score for this RNA gene is


Aliases for MIR34A Gene

  • MicroRNA 34a 2 3
  • MIRN34A 3 6
  • OmimId=611172 2
  • Hsa-Mir-34a 3
  • MiRNA34A 3
  • Mir-34 3

External Ids for MIR34A Gene

Previous HGNC Symbols for MIR34A Gene

  • prevNames=

Previous GeneCards Identifiers for MIR34A Gene

  • GC01M009134
  • GC01M009211

Summaries for MIR34A Gene

Entrez Gene Summary for MIR34A Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR34A Gene

MIR34A (MicroRNA 34a) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR34A include placenta accreta and soft tissue sarcoma. Among its related pathways are MicroRNAs in cancer.

fRNAdb sequence ontologies for MIR34A Gene - the ORGUL cluster for this gene includes several descriptions:

  • miRNA: Small, ~22-nt, RNA molecule that is the endogenous transcript of a miRNA gene. Micro RNAs are produced from precursor molecules (SO:0000647) that can form local hairpin structures, which ordinarily are processed (via the Dicer pathway) such that a single miRNA molecule accumulates from one arm of a hairpin precursor molecule. Micro RNAs may trigger the cleavage of their target molecules or act as translational repressors.

  • nc_conserved_region: Non-coding region of sequence similarity by descent from a common ancestor.

View fRNAdb secondary structures for MIR34A

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR34A Gene

Genomics for MIR34A Gene

Genomic Location for MIR34A Gene

9,151,668 bp from pter
9,151,777 bp from pter
110 bases
Minus strand

Genomic View for MIR34A Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MIR34A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR34A Gene

ORGUL Member Location for MIR34A Gene

ORGUL Member Location for MIR34A gene

No data available for Regulatory Elements for MIR34A Gene

Proteins for MIR34A Gene

Post-translational modifications for MIR34A Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR34A Gene

Domains for MIR34A Gene

Gene Families for MIR34A Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR34A: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR34A Gene

Function for MIR34A Gene

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for MIR34A Gene

Localization for MIR34A Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR34A Gene

Pathways for MIR34A Gene

SuperPathways for MIR34A Gene

Superpath Contained pathways
1 MicroRNAs in cancer
genes like me logo Genes that share pathways with MIR34A: view

Pathways by source for MIR34A Gene

1 KEGG pathway for MIR34A Gene

Interacting Proteins for MIR34A Gene

Gene Ontology (GO) - Biological Process for MIR34A Gene


Transcripts for MIR34A Gene

fRNAdb Secondary structures for MIR34A Gene

  • FR109864
  • FR136403

mRNA/cDNA for MIR34A Gene

(1) Additional mRNA sequences :
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for MIR34A Gene

MicroRNA 34a:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MIR34A Gene

No ASD Table

Relevant External Links for MIR34A Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MIR34A Gene

mRNA expression in normal human tissues for MIR34A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

SOURCE GeneReport for Unigene cluster for MIR34A Gene Hs.730325

genes like me logo Genes that share expressions with MIR34A: view

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Expression partners for MIR34A Gene

Orthologs for MIR34A Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIR34A Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia bta-mir-34a 36
  • 72 (a)
(Canis familiaris)
Mammalia cfa-mir-34a 36
  • 85 (a)
(Monodelphis domestica)
Mammalia mdo-mir-34a 36
  • 90 (a)
(Mus musculus)
Mammalia Mir34a 36
  • 75 (a)
(Pan troglodytes)
Mammalia ptr-mir-34a 36
  • 100 (a)
(Gallus gallus)
Aves gga-mir-34a 36
  • 77 (a)
(Anolis carolinensis)
Reptilia aca-mir-34b 36
  • 76 (a)
(Danio rerio)
Actinopterygii dre-mir-34a 36
  • 72 (a)
sea squirt
(Ciona savignyi)
Ascidiacea csa-mir-34 36
  • 31 (a)
Species with no ortholog for MIR34A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MIR34A Gene

Gene Tree for MIR34A (if available)
Gene Tree for MIR34A (if available)

Paralogs for MIR34A Gene

No data available for Paralogs for MIR34A Gene

Variants for MIR34A Gene

Sequence variations from dbSNP and Humsavar for MIR34A Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs2666433 -- 9,153,118(-) AACAG(C/T)CCTTC upstream-variant-2KB
rs6577554 -- 9,152,213(+) CTGGT(C/T)AACAT upstream-variant-2KB
rs6577555 -- 9,152,228(+) AGACC(A/C)CCACC upstream-variant-2KB
rs9729651 -- 9,153,687(+) gaggc(A/G)gaggt upstream-variant-2KB
rs12128240 -- 9,151,244(+) GGAGC(C/T)GGTGG downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for MIR34A Gene

Variant ID Type Subtype PubMed ID
nsv831981 CNV Loss 17160897
esv2422210 CNV Duplication 17116639
nsv871145 CNV Loss 21882294
nsv832092 CNV Loss 17160897

Relevant External Links for MIR34A Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MIR34A Gene

Disorders for MIR34A Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for MIR34A Gene in MalaCards »

(3) Diseases for MIR34A Gene

Relevant External Links for MIR34A

Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with MIR34A: view

No data available for OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for MIR34A Gene

Publications for MIR34A Gene

  1. miR-34a repression of SIRT1 regulates apoptosis. (PMID: 18755897) Yamakuchi M. … Lowenstein C.J. (Proc. Natl. Acad. Sci. U.S.A. 2008) 3 23
  2. Numerous microRNPs in neuronal cells containing novel microRNAs. (PMID: 12554860) Dostie J. … Dreyfuss G. (RNA 2003) 3
  3. Vertebrate microRNA genes. (PMID: 12624257) Lim L.P. … Bartel D.P. (Science 2003) 3
  4. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S. … Enright A.J. (Nucleic Acids Res. 2006) 3
  5. MicroRNA-34a functions as a potential tumor suppressor by inducing apoptosis in neuroblastoma cells. (PMID: 17297439) Welch C. … Stallings R.L. (Oncogene 2007) 3

Products for MIR34A Gene

Sources for MIR34A Gene

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