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Aliases for MIR34A Gene

Subcategory (RNA class) for MIR34A Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR34A Gene

  • MicroRNA 34a 2 3 5
  • Hsa-Mir-34a 3
  • MiRNA34A 3
  • Mir-34a 3
  • MIRN34A 3
  • Mir-34 3

External Ids for MIR34A Gene

Previous HGNC Symbols for MIR34A Gene

  • MIRN34A

Previous GeneCards Identifiers for MIR34A Gene

  • GC01M009134
  • GC01M009211

Summaries for MIR34A Gene

Entrez Gene Summary for MIR34A Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. This miRNA is a member of the highly conserved miR-34 family. This miRNA functions as a tumor suppressor and dysregulation or loss of the host gene from which this miRNA is processed is associated with cancer progression in numerous cell types. [provided by RefSeq, Sep 2015]

GeneCards Summary for MIR34A Gene

MIR34A (MicroRNA 34a) is an RNA Gene, and is affiliated with the miRNA class. Among its related pathways are MicroRNAs in cancer.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR34A Gene

Genomics for MIR34A Gene

Regulatory Elements for MIR34A Gene

Enhancers for MIR34A Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01F008869 1.3 FANTOM5 ENCODE 28 +321.2 321193 11.8 CREB3L1 DMAP1 YY1 SLC30A9 ZNF263 SP3 NFYC TBX21 MEF2D SSRP1 LOC102724552 MIR34A ENO1 H6PD PIK3CD-AS2 ENO1-IT1 MIR6728
GH01F008812 0.2 ENCODE 19.1 +380.9 380877 6.6 CREB3L1 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 SP3 NFYC TBX21 LOC102724552 MIR34A PIK3CD-AS2 H6PD ENO1 RERE ENSG00000228423
GH01F009942 0.4 ENCODE 18.6 -746.2 -746214 2.4 CREB3L1 MLX ZFP64 DMAP1 SLC30A9 ZNF143 ZNF548 ZNF263 SP3 NFYC LINC01759 LZIC MIR34A SPSB1 H6PD PIK3CD-AS2 NMNAT1 RBP7 ENSG00000228150
GH01F009121 1 Ensembl ENCODE 11.7 +74.9 74883 1.8 HDGF PKNOX1 ARID4B SIN3A DMAP1 ZNF2 ZNF48 YY1 ZNF121 GLIS2 MIR34A RNU6-304P GPR157 SLC2A5 PIR42185
GH01F009119 1.5 FANTOM5 Ensembl ENCODE 11.6 +76.7 76683 1.4 PKNOX1 ATF1 TBL1XR1 WRNIP1 KLF17 ZBTB40 RARA ZNF366 FOS CREM MIR34A RNU6-304P PIR42185 SLC2A5
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around MIR34A on UCSC Golden Path with GeneCards custom track

Genomic Location for MIR34A Gene

Chromosome:
1
Start:
9,148,011 bp from pter
End:
9,196,983 bp from pter
Size:
48,973 bases
Orientation:
Minus strand

Genomic View for MIR34A Gene

Genes around MIR34A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR34A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR34A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR34A Gene

Proteins for MIR34A Gene

Post-translational modifications for MIR34A Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR34A Gene

Domains & Families for MIR34A Gene

Gene Families for MIR34A Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR34A: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR34A Gene

Function for MIR34A Gene

Animal Model Products

miRNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR34A Gene

Localization for MIR34A Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR34A Gene

Pathways & Interactions for MIR34A Gene

SuperPathways for MIR34A Gene

SuperPathway Contained pathways
1 MicroRNAs in cancer
genes like me logo Genes that share pathways with MIR34A: view

Pathways by source for MIR34A Gene

1 KEGG pathway for MIR34A Gene

Interacting Proteins for MIR34A Gene

Gene Ontology (GO) - Biological Process for MIR34A Gene

None

No data available for SIGNOR curated interactions for MIR34A Gene

Transcripts for MIR34A Gene

mRNA/cDNA for MIR34A Gene

(1) Additional mRNA sequences :
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for MIR34A Gene

MicroRNA 34a:
Representative Sequences:

miRNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR34A Gene

No ASD Table

Relevant External Links for MIR34A Gene

GeneLoc Exon Structure for
MIR34A
ECgene alternative splicing isoforms for
MIR34A

Expression for MIR34A Gene

mRNA expression in normal human tissues for MIR34A Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR34A Gene:

MIR34A

SOURCE GeneReport for Unigene cluster for MIR34A Gene:

Hs.730325
genes like me logo Genes that share expression patterns with MIR34A: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for MIR34A Gene

Orthologs for MIR34A Gene

Evolution for MIR34A Gene

ENSEMBL:
Gene Tree for MIR34A (if available)
TreeFam:
Gene Tree for MIR34A (if available)

No data available for Orthologs for MIR34A Gene

Paralogs for MIR34A Gene

No data available for Paralogs for MIR34A Gene

Variants for MIR34A Gene

Sequence variations from dbSNP and Humsavar for MIR34A Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs111688317 -- 9,151,222(+) TCCAC(G/T)TTCAT nc-transcript-variant, downstream-variant-500B
rs112545895 -- 9,151,599(+) CGTGG(C/T)GCAGA nc-transcript-variant, downstream-variant-500B
rs113688112 -- 9,151,174(+) AGCGC(A/G)TACGC nc-transcript-variant, downstream-variant-500B
rs114525429 -- 9,152,997(+) CGCCT(C/T)GGCCT intron-variant, upstream-variant-2KB
rs116400975 -- 9,153,189(+) GGTAA(A/G)GTAGT intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MIR34A Gene

Variant ID Type Subtype PubMed ID
esv2422210 CNV duplication 17116639
nsv831981 CNV loss 17160897
nsv832092 CNV loss 17160897

Relevant External Links for MIR34A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR34A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR34A Gene

Disorders for MIR34A Gene

Relevant External Links for MIR34A

Human Genome Epidemiology (HuGE) Navigator
MIR34A
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR34A

No disorders were found for MIR34A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR34A Gene

Publications for MIR34A Gene

  1. miR-34a repression of SIRT1 regulates apoptosis. (PMID: 18755897) Yamakuchi M. … Lowenstein C.J. (Proc. Natl. Acad. Sci. U.S.A. 2008) 3 22 64
  2. miRNA-21 and miRNA-34a Are Potential Minimally Invasive Biomarkers for the Diagnosis of Pancreatic Ductal Adenocarcinoma. (PMID: 26262588) Alemar B. … Ashton-Prolla P. (Pancreas 2016) 3 64
  3. Methylation-induced silencing of miR-34a enhances chemoresistance by directly upregulating ATG4B-induced autophagy through AMPK/mTOR pathway in prostate cancer. (PMID: 26499184) Liao H. … Chen Y. (Oncol. Rep. 2016) 3 64
  4. MicroRNA-34a induces a senescence-like change via the down-regulation of SIRT1 and up-regulation of p53 protein in human esophageal squamous cancer cells with a wild-type p53 gene background. (PMID: 26523671) Ye Z. … Huang P. (Cancer Lett. 2016) 3 64
  5. MicroRNA-34a and its target genes: Key factors in cancer multidrug resistance. (PMID: 26648462) Ghandadi M. … Sahebkar A. (Curr. Pharm. Des. 2016) 3 64

Products for MIR34A Gene

Sources for MIR34A Gene

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