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Aliases for MIR34A Gene

Subcategory (RNA class) for MIR34A Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR34A Gene

  • MicroRNA 34a 2 3 5
  • Hsa-Mir-34a 3
  • MiRNA34A 3
  • Mir-34a 3
  • MIRN34A 3
  • Mir-34 3

External Ids for MIR34A Gene

Previous HGNC Symbols for MIR34A Gene

  • MIRN34A

Previous GeneCards Identifiers for MIR34A Gene

  • GC01M009134
  • GC01M009211

Summaries for MIR34A Gene

Entrez Gene Summary for MIR34A Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. This miRNA is a member of the highly conserved miR-34 family. This miRNA functions as a tumor suppressor and dysregulation or loss of the host gene from which this miRNA is processed is associated with cancer progression in numerous cell types. [provided by RefSeq, Sep 2015]

GeneCards Summary for MIR34A Gene

MIR34A (MicroRNA 34a) is an RNA Gene, and is affiliated with the miRNA class. Among its related pathways are MicroRNAs in cancer.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR34A Gene

Genomics for MIR34A Gene

Regulatory Elements for MIR34A Gene

Enhancers for MIR34A Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around MIR34A on UCSC Golden Path with GeneCards custom track

Promoters for MIR34A Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Location for MIR34A Gene

Chromosome:
1
Start:
9,148,011 bp from pter
End:
9,196,983 bp from pter
Size:
48,973 bases
Orientation:
Minus strand

Genomic View for MIR34A Gene

Genes around MIR34A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR34A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR34A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR34A Gene

ORGUL Member Location for MIR34A Gene

ORGUL Member Location for MIR34A gene

Proteins for MIR34A Gene

Post-translational modifications for MIR34A Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR34A Gene

Domains & Families for MIR34A Gene

Gene Families for MIR34A Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR34A: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR34A Gene

Function for MIR34A Gene

Animal Model Products

miRNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR34A Gene

Localization for MIR34A Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR34A Gene

Pathways & Interactions for MIR34A Gene

SuperPathways for MIR34A Gene

Superpath Contained pathways
1 MicroRNAs in cancer
genes like me logo Genes that share pathways with MIR34A: view

Pathways by source for MIR34A Gene

1 KEGG pathway for MIR34A Gene

Interacting Proteins for MIR34A Gene

Gene Ontology (GO) - Biological Process for MIR34A Gene

None

No data available for SIGNOR curated interactions for MIR34A Gene

Drugs & Compounds for MIR34A Gene

No Compound Related Data Available

Transcripts for MIR34A Gene

mRNA/cDNA for MIR34A Gene

(1) Additional mRNA sequences :
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for MIR34A Gene

MicroRNA 34a:
Representative Sequences:

miRNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR34A Gene

No ASD Table

Relevant External Links for MIR34A Gene

GeneLoc Exon Structure for
MIR34A
ECgene alternative splicing isoforms for
MIR34A

Expression for MIR34A Gene

mRNA expression in normal human tissues for MIR34A Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR34A Gene:

MIR34A

SOURCE GeneReport for Unigene cluster for MIR34A Gene:

Hs.730325
genes like me logo Genes that share expression patterns with MIR34A: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for MIR34A Gene

Orthologs for MIR34A Gene

Evolution for MIR34A Gene

ENSEMBL:
Gene Tree for MIR34A (if available)
TreeFam:
Gene Tree for MIR34A (if available)

No data available for Orthologs for MIR34A Gene

Paralogs for MIR34A Gene

No data available for Paralogs for MIR34A Gene

Variants for MIR34A Gene

Sequence variations from dbSNP and Humsavar for MIR34A Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs2666433 -- 9,153,118(-) AACAG(C/T)CCTTC upstream-variant-2KB
rs6577554 -- 9,152,213(+) CTGGT(C/T)AACAT upstream-variant-2KB
rs6577555 -- 9,152,228(+) AGACC(A/C)CCACC upstream-variant-2KB
rs9729651 -- 9,153,687(+) gaggc(A/G)gaggt upstream-variant-2KB
rs12128240 -- 9,151,244(+) GGAGC(C/T)GGTGG downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for MIR34A Gene

Variant ID Type Subtype PubMed ID
esv2422210 CNV duplication 17116639
nsv831981 CNV loss 17160897
nsv832092 CNV loss 17160897

Relevant External Links for MIR34A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR34A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR34A Gene

Disorders for MIR34A Gene

Relevant External Links for MIR34A

Human Genome Epidemiology (HuGE) Navigator
MIR34A
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR34A

No disorders were found for MIR34A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR34A Gene

Publications for MIR34A Gene

  1. miR-34a repression of SIRT1 regulates apoptosis. (PMID: 18755897) Yamakuchi M. … Lowenstein C.J. (Proc. Natl. Acad. Sci. U.S.A. 2008) 3 22 65
  2. MicroRNA-34a induces a senescence-like change via the down-regulation of SIRT1 and up-regulation of p53 protein in human esophageal squamous cancer cells with a wild-type p53 gene background. (PMID: 26523671) Ye Z. … Huang P. (Cancer Lett. 2016) 3 65
  3. Carbonic Anhydrase 9 mRNA/microRNA34a Interplay in Hypoxic Human Mammospheres. (PMID: 26553365) De Carolis S. … BonafAc M. (J. Cell. Physiol. 2016) 3 65
  4. Negative feedback regulation of AXL by miR-34a modulates apoptosis in lung cancer cells. (PMID: 26667302) Cho C.Y. … Chuang S.E. (RNA 2016) 3 65
  5. MicroRNA-34a Negatively Regulates Efferocytosis by Tissue Macrophages in Part via SIRT1. (PMID: 26718338) McCubbrey A.L. … Curtis J.L. (J. Immunol. 2016) 3 65

Products for MIR34A Gene

Sources for MIR34A Gene

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