Free for academic non-profit institutions. Other users need a Commercial license

Aliases for MIR346 Gene

Subcategory (RNA class) for MIR346 Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR346 Gene

  • MicroRNA 346 2 3 5
  • Hsa-Mir-346 3
  • MiRNA346 3
  • MiR-346 3
  • MIRN346 3

External Ids for MIR346 Gene

Previous HGNC Symbols for MIR346 Gene

  • MIRN346

Previous GeneCards Identifiers for MIR346 Gene

  • GC10M088016

Summaries for MIR346 Gene

Entrez Gene Summary for MIR346 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR346 Gene

MIR346 (MicroRNA 346) is an RNA Gene, and is affiliated with the miRNA class.

fRNAdb sequence ontologies for MIR346 Gene

  • pre_miRNA: The 60-70 nucleotide region remain after Drosha processing of the primary transcript, that folds back upon itself to form a hairpin sructure.

View fRNAdb secondary structures for MIR346

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR346 Gene

Genomics for MIR346 Gene

Regulatory Elements for MIR346 Gene

Enhancers for MIR346 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH10F086224 1.1 FANTOM5 Ensembl ENCODE 11.7 +39.5 39471 1.2 ZNF316 IKZF1 MAFG KLF17 NFE2 EMSY MAFK SPI1 MIR346 GC10P086201
GH10F086354 1.1 Ensembl ENCODE 10.8 -91.0 -90953 2.1 ELF3 CTCF SAP130 MAX ARID4B ZNF644 RAD21 YY1 POLR2A SMC3 GRID1 MIR346
GH10F086376 1.1 Ensembl ENCODE 10.6 -112.4 -112436 0.9 ZNF48 BRCA1 RAD21 SCRT2 ZNF143 ZNF207 RCOR1 THAP11 ZNF263 ZNF654 MIR346 GC10M086380 GRID1
GH10F086585 1.2 Ensembl ENCODE 9.3 -320.7 -320709 0.7 ELF3 ARID4B RAD21 GLIS2 ZNF143 KLF7 DEK MIXL1 THAP11 ZNF263 WAPL LOC105378405 RNU6-780P MIR346 OPN4 GC10P086567 RPL7AP8
GH10F086233 0.7 Ensembl ENCODE 12.5 +30.4 30388 1.6 TEAD4 REST MIR346 GC10P086201
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MIR346 on UCSC Golden Path with GeneCards custom track

Genomic Location for MIR346 Gene

Chromosome:
10
Start:
86,264,694 bp from pter
End:
86,264,788 bp from pter
Size:
95 bases
Orientation:
Minus strand

Genomic View for MIR346 Gene

Genes around MIR346 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR346 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR346 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR346 Gene

ORGUL Member Location for MIR346 Gene

ORGUL Member Location for MIR346 gene

Proteins for MIR346 Gene

Post-translational modifications for MIR346 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR346 Gene

Domains & Families for MIR346 Gene

Gene Families for MIR346 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR346: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR346 Gene

Function for MIR346 Gene

Animal Model Products

miRNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR346 Gene

Localization for MIR346 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR346 Gene

Pathways & Interactions for MIR346 Gene

SuperPathways for MIR346 Gene

No Data Available

Interacting Proteins for MIR346 Gene

Gene Ontology (GO) - Biological Process for MIR346 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for MIR346 Gene

Transcripts for MIR346 Gene

fRNAdb Secondary structures for MIR346 Gene

  • hsa-mir-346_MI0000826_Homo_sapiens_miR-346_stem-loop_hairpin

mRNA/cDNA for MIR346 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR346 Gene

No ASD Table

Relevant External Links for MIR346 Gene

GeneLoc Exon Structure for
MIR346
ECgene alternative splicing isoforms for
MIR346

Expression for MIR346 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MIR346 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR346 Gene:

MIR346
genes like me logo Genes that share expression patterns with MIR346: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for MIR346 Gene

Orthologs for MIR346 Gene

This gene was present in the common ancestor of mammals.

Orthologs for MIR346 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-346 35
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia bta-mir-346 35
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia cfa-mir-346 35
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mir346 35
  • 90 (a)
OneToOne
Species where no ortholog for MIR346 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MIR346 Gene

ENSEMBL:
Gene Tree for MIR346 (if available)
TreeFam:
Gene Tree for MIR346 (if available)

Paralogs for MIR346 Gene

No data available for Paralogs for MIR346 Gene

Variants for MIR346 Gene

Sequence variations from dbSNP and Humsavar for MIR346 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
rs10887569 -- 86,264,796(+) CCACA(C/T)GCTCG intron-variant, upstream-variant-2KB
rs111910992 -- 86,266,411(+) CTGAC(C/G)CCCAA intron-variant, upstream-variant-2KB
rs11201958 -- 86,264,522(+) GGAGC(C/T)CATTC intron-variant, downstream-variant-500B
rs113264645 -- 86,266,228(+) CACCT(A/G)TGACC intron-variant, upstream-variant-2KB
rs115649375 -- 86,266,416(+) CCCCA(A/G)ATACA intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MIR346 Gene

Variant ID Type Subtype PubMed ID
esv3579031 CNV loss 25503493
nsv1051761 CNV loss 25217958
nsv1052427 CNV gain 25217958
nsv1141879 OTHER inversion 24896259
nsv520914 CNV loss 19592680
nsv551773 CNV loss 21841781
nsv831936 CNV loss 17160897
nsv831938 CNV gain 17160897

Relevant External Links for MIR346 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR346

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR346 Gene

Disorders for MIR346 Gene

Relevant External Links for MIR346

Human Genome Epidemiology (HuGE) Navigator
MIR346
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR346

No disorders were found for MIR346 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR346 Gene

Publications for MIR346 Gene

  1. New human and mouse microRNA genes found by homology search. (PMID: 15634332) Weber M.J. (FEBS J. 2005) 1 3 64
  2. Identification of many microRNAs that copurify with polyribosomes in mammalian neurons. (PMID: 14691248) Kim J. … Ruvkun G. (Proc. Natl. Acad. Sci. U.S.A. 2004) 1 3 64
  3. MiR-346 regulates CD4a8_CXCR5a8_ T cells in the pathogenesis of Graves' disease. (PMID: 25666935) Chen J. … Wang S. (Endocrine 2015) 3 64
  4. miR-346 and miR-138 competitively regulate hTERT in GRSF1- and AGO2-dependent manners, respectively. (PMID: 26507454) Song G. … Tang H. (Sci Rep 2015) 3 64
  5. miR-346 Up-regulates Argonaute 2 (AGO2) Protein Expression to Augment the Activity of Other MicroRNAs (miRNAs) and Contributes to Cervical Cancer Cell Malignancy. (PMID: 26518874) Guo J. … Tang H. (J. Biol. Chem. 2015) 3 64

Products for MIR346 Gene

Sources for MIR346 Gene

Content
Loading form....