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Aliases for MIR345 Gene

Subcategory (RNA class) for MIR345 Gene


Quality Score for this RNA gene is


Aliases for MIR345 Gene

  • MicroRNA 345 2 3 5
  • Hsa-Mir-345 3
  • Mir-345 3
  • MIRN345 3

External Ids for MIR345 Gene

ORGUL Members for MIR345 Gene

Previous HGNC Symbols for MIR345 Gene

  • MIRN345

Previous GeneCards Identifiers for MIR345 Gene

  • GC14P099845
  • GC14P100944
  • GC14P100993
  • GC14P101004
  • GC14P101012
  • GC14P101021
  • GC14P101032
  • GC14P101046
  • GC14P101076
  • GC14P101113
  • GC14P101162
  • GC14P101224

Summaries for MIR345 Gene

Entrez Gene Summary for MIR345 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR345 Gene

MIR345 (MicroRNA 345) is an RNA Gene, and is affiliated with the miRNA class. Among its related pathways are MicroRNAs in cancer.

Additional gene information for MIR345 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR345 Gene

Genomics for MIR345 Gene

Regulatory Elements for MIR345 Gene

Enhancers for MIR345 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH14H100278 0.9 ENCODE dbSUPER 12.2 -28.8 -28770 0.9 SOX5 SOX13 CTCF PKNOX1 TEAD1 HMG20A PPARG RAD21 NR2F6 KDM1A MIR345 SLC25A29 WDR25 WARS SLC25A47 MIR342 MIR6764 GC14P100279
GH14H100336 0.6 dbSUPER 12 +29.1 29134 1.4 ZNF687 JUNB EBF1 DPF2 ZNF24 BATF IKZF2 ZNF592 WARS MIR345 SLC25A29 WDR25 ENSG00000258666 PIR52719
GH14H100273 0.5 dbSUPER 12.1 -32.5 -32451 3.9 GATA3 BATF SP7 SLC25A29 MIR345 YY1 WARS WDR25 SLC25A47 MIR342 DEGS2 GC14P100275 ENSG00000258904
GH14H100266 0.5 dbSUPER 11 -40.3 -40318 2.9 ZNF600 HNF4A PRDM4 PRDM1 SLC25A29 YY1 MIR345 SLC25A47 WARS WDR25 DEGS2 MIR342 ENSG00000258904 GC14P100275
GH14H100281 0.2 ENCODE 12.2 -26.2 -26163 0.9 SLC25A29 MIR345 WDR25 WARS SLC25A47 MIR342 GC14P100279 PIR46113
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MIR345 on UCSC Golden Path with GeneCards custom track

Promoters for MIR345 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000073112 -1659 2401 SIN3A ZBTB7B GLIS2 ELK1 ZNF143 SP3 SP5 NFYC GLIS1 HNF4A

Genomic Locations for MIR345 Gene

Genomic Locations for MIR345 Gene
98 bases
Plus strand

Genomic View for MIR345 Gene

Genes around MIR345 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR345 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR345 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR345 Gene

Proteins for MIR345 Gene

Post-translational modifications for MIR345 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR345 Gene

Domains & Families for MIR345 Gene

Gene Families for MIR345 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR345: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR345 Gene

Function for MIR345 Gene

Gene Ontology (GO) - Molecular Function for MIR345 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:1903231 mRNA binding involved in posttranscriptional gene silencing IDA 20190813
genes like me logo Genes that share ontologies with MIR345: view

Animal Model Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR345 Gene

Localization for MIR345 Gene

Gene Ontology (GO) - Cellular Components for MIR345 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IDA 26646931
genes like me logo Genes that share ontologies with MIR345: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for MIR345 Gene

Pathways & Interactions for MIR345 Gene

SuperPathways for MIR345 Gene

SuperPathway Contained pathways
1 MicroRNAs in cancer
genes like me logo Genes that share pathways with MIR345: view

Pathways by source for MIR345 Gene

1 KEGG pathway for MIR345 Gene

Interacting Proteins for MIR345 Gene

Gene Ontology (GO) - Biological Process for MIR345 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0035278 miRNA mediated inhibition of translation IDA 20190813
genes like me logo Genes that share ontologies with MIR345: view

No data available for SIGNOR curated interactions for MIR345 Gene

Drugs & Compounds for MIR345 Gene

No Compound Related Data Available

Transcripts for MIR345 Gene

mRNA/cDNA for MIR345 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR345 Gene

No ASD Table

Relevant External Links for MIR345 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MIR345 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MIR345 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR345 Gene:

genes like me logo Genes that share expression patterns with MIR345: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR345 Gene

Orthologs for MIR345 Gene

This gene was present in the common ancestor of mammals.

Orthologs for MIR345 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ptr-mir-345 34
  • 100 (a)
(Bos Taurus)
Mammalia bta-mir-345 34
  • 96 (a)
(Canis familiaris)
Mammalia cfa-mir-345 34
  • 93 (a)
-- 34
  • 72 (a)
(Mus musculus)
Mammalia Mir345 34
  • 79 (a)
Species where no ortholog for MIR345 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MIR345 Gene

Gene Tree for MIR345 (if available)
Gene Tree for MIR345 (if available)

Paralogs for MIR345 Gene

No data available for Paralogs for MIR345 Gene

Variants for MIR345 Gene

Sequence variations from dbSNP and Humsavar for MIR345 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
rs1000333206 -- 100,307,471(+) CGTCC(C/T)ATTCG upstream-variant-2KB
rs1000781767 -- 100,306,742(+) GGACT(A/C)CCCCA upstream-variant-2KB
rs1002953285 -- 100,306,546(+) TGGGC(G/T)GGCAC upstream-variant-2KB, utr-variant-5-prime
rs1003249132 -- 100,306,364(+) GGAGC(C/T)CGGGC nc-transcript-variant, upstream-variant-2KB, utr-variant-5-prime
rs1006419093 -- 100,306,328(+) GGTGC(A/C/T)GGGGC nc-transcript-variant, upstream-variant-2KB, utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for MIR345 Gene

Variant ID Type Subtype PubMed ID
nsv832875 CNV loss 17160897
esv3635502 CNV gain 21293372

Relevant External Links for MIR345 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR345 Gene

Disorders for MIR345 Gene

Relevant External Links for MIR345

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for MIR345 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR345 Gene

Publications for MIR345 Gene

  1. Association of MicroRNAs and YRNAs With Platelet Function. (PMID: 26646931) Kaudewitz D … Mayr M (Circulation research 2016) 3 60
  2. MicroRNA-345 induces apoptosis in pancreatic cancer cells through potentiation of caspase-dependent and -independent pathways. (PMID: 26247574) Srivastava SK … Singh AP (British journal of cancer 2015) 3 60
  3. miR-345 in metastatic colorectal cancer: a non-invasive biomarker for clinical outcome in non-KRAS mutant patients treated with 3rd line cetuximab and irinotecan. (PMID: 24940606) Schou JV … Johansen JS (PloS one 2014) 3 60
  4. Hepatitis C virus core protein down-regulates p21(Waf1/Cip1) and inhibits curcumin-induced apoptosis through microRNA-345 targeting in human hepatoma cells. (PMID: 23577194) Shiu TY … Hsieh TY (PloS one 2013) 3 60
  5. miRBase: integrating microRNA annotation and deep-sequencing data. (PMID: 21037258) Kozomara A … Griffiths-Jones S (Nucleic acids research 2011) 3 60

Products for MIR345 Gene

Sources for MIR345 Gene

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