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Aliases for MIR345 Gene

Subcategory (RNA class) for MIR345 Gene


Quality Score for this RNA gene is


Aliases for MIR345 Gene

  • MicroRNA 345 2 3 5
  • Hsa-Mir-345 3
  • Mir-345 3
  • MIRN345 3

External Ids for MIR345 Gene

ORGUL Members for MIR345 Gene

Previous HGNC Symbols for MIR345 Gene

  • MIRN345

Previous GeneCards Identifiers for MIR345 Gene

  • GC14P099845
  • GC14P100944
  • GC14P100993
  • GC14P101004
  • GC14P101012
  • GC14P101021
  • GC14P101032
  • GC14P101046
  • GC14P101076
  • GC14P101113
  • GC14P101162
  • GC14P101224

Summaries for MIR345 Gene

Entrez Gene Summary for MIR345 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR345 Gene

MIR345 (MicroRNA 345) is an RNA Gene, and is affiliated with the miRNA class. Among its related pathways are MicroRNAs in cancer.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR345 Gene

Genomics for MIR345 Gene

Regulatory Elements for MIR345 Gene

Enhancers for MIR345 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH14F100278 0.9 Ensembl ENCODE 12.1 -28.8 -28770 0.9 SOX13 CTCF SOX5 PKNOX1 TEAD1 HMG20A PPARG ATF2 SMC3 NFE2 MIR345 SLC25A29 WARS WDR25 SLC25A47 MIR342 GC14P100275 GC14P100279
GH14F100281 0.4 ENCODE 12.1 -26.2 -26163 0.9 POLR2A SLC25A29 MIR345 WDR25 WARS SLC25A47 MIR342 GC14P100279 PIR46113
GH14F100311 0.9 Ensembl ENCODE 0.8 +4.5 4542 2.8 TAL1 ZNF223 ZIC2 ARID1B ZNF121 POLR2A NCOR1 PBX2 IKZF1 ID3 SLC25A29 MIR345 RN7SL523P
GH14F100308 0.7 ENCODE 0.8 +0.4 430 0.2 CTCF ZNF687 PKNOX1 L3MBTL2 MAX SIN3A MNT DPF2 RAD21 ZNF592 MIR345 RN7SL523P
GH14F100317 1.1 Ensembl ENCODE 0.4 +10.4 10442 1.4 BCOR CTCF TFAP4 ZFP64 ZMYM3 ZNF48 RAD21 ZFHX2 ZNF143 SMC3 SLC25A29 RN7SL523P MIR345
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MIR345 on UCSC Golden Path with GeneCards custom track

Promoters for MIR345 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000423758 -1559 3001 HDGF PKNOX1 ARNT CREB3L1 SIN3A ZNF766 ZNF143 KLF13 SP3 SP5

Genomic Location for MIR345 Gene

100,307,859 bp from pter
100,307,956 bp from pter
98 bases
Plus strand

Genomic View for MIR345 Gene

Genes around MIR345 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR345 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR345 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR345 Gene

Proteins for MIR345 Gene

Post-translational modifications for MIR345 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR345 Gene

Domains & Families for MIR345 Gene

Gene Families for MIR345 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR345: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR345 Gene

Function for MIR345 Gene

Animal Model Products

miRNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR345 Gene

Localization for MIR345 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR345 Gene

Pathways & Interactions for MIR345 Gene

SuperPathways for MIR345 Gene

SuperPathway Contained pathways
1 MicroRNAs in cancer
genes like me logo Genes that share pathways with MIR345: view

Pathways by source for MIR345 Gene

1 KEGG pathway for MIR345 Gene

Interacting Proteins for MIR345 Gene

Gene Ontology (GO) - Biological Process for MIR345 Gene


No data available for SIGNOR curated interactions for MIR345 Gene

Transcripts for MIR345 Gene

mRNA/cDNA for MIR345 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR345 Gene

No ASD Table

Relevant External Links for MIR345 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MIR345 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MIR345 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR345 Gene:

genes like me logo Genes that share expression patterns with MIR345: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for MIR345 Gene

Orthologs for MIR345 Gene

This gene was present in the common ancestor of mammals.

Orthologs for MIR345 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ptr-mir-345 35
  • 100 (a)
(Bos Taurus)
Mammalia bta-mir-345 35
  • 96 (a)
(Canis familiaris)
Mammalia cfa-mir-345 35
  • 93 (a)
-- 35
  • 72 (a)
(Mus musculus)
Mammalia Mir345 35
  • 79 (a)
Species where no ortholog for MIR345 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MIR345 Gene

Gene Tree for MIR345 (if available)
Gene Tree for MIR345 (if available)

Paralogs for MIR345 Gene

No data available for Paralogs for MIR345 Gene

Variants for MIR345 Gene

Sequence variations from dbSNP and Humsavar for MIR345 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
rs112562948 -- 100,307,364(+) CCAGG(A/G)TATCC upstream-variant-2KB
rs11557209 -- 100,306,335(+) GGGCT(C/G)GGCCT nc-transcript-variant, upstream-variant-2KB, utr-variant-5-prime
rs12590502 -- 100,307,358(+) GGGTC(A/C)CCAGG upstream-variant-2KB
rs12894237 -- 100,307,337(+) AGTCG(A/G)AGGGT upstream-variant-2KB
rs140341141 -- 100,308,215(+) CAAAT(C/T)CCTGC downstream-variant-500B, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MIR345 Gene

Variant ID Type Subtype PubMed ID
esv3635502 CNV gain 21293372
nsv832875 CNV loss 17160897

Relevant External Links for MIR345 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR345 Gene

Disorders for MIR345 Gene

Relevant External Links for MIR345

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for MIR345 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR345 Gene

Publications for MIR345 Gene

  1. MicroRNA-345 induces apoptosis in pancreatic cancer cells through potentiation of caspase-dependent and -independent pathways. (PMID: 26247574) Srivastava S.K. … Singh A.P. (Br. J. Cancer 2015) 3 64
  2. miR-345 in metastatic colorectal cancer: a non-invasive biomarker for clinical outcome in non-KRAS mutant patients treated with 3rd line cetuximab and irinotecan. (PMID: 24940606) Schou J.V. … Johansen J.S. (PLoS ONE 2014) 3 64
  3. Hepatitis C virus core protein down-regulates p21(Waf1/Cip1) and inhibits curcumin-induced apoptosis through microRNA-345 targeting in human hepatoma cells. (PMID: 23577194) Shiu T.Y. … Hsieh T.Y. (PLoS ONE 2013) 3 64
  4. miRBase: integrating microRNA annotation and deep-sequencing data. (PMID: 21037258) Kozomara A. … Griffiths-Jones S. (Nucleic Acids Res. 2011) 3 64
  5. MicroRNA 345, a methylation-sensitive microRNA is involved in cell proliferation and invasion in human colorectal cancer. (PMID: 21665895) Tang J.T. … Fang J.Y. (Carcinogenesis 2011) 3 64

Products for MIR345 Gene

Sources for MIR345 Gene

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