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Aliases for MIR340 Gene

Subcategory (RNA class) for MIR340 Gene

miRNA

Quality Score for this RNA gene is

8

Aliases for MIR340 Gene

  • MicroRNA 340 2 3 5
  • Hsa-Mir-340 3
  • Mir-340 3
  • MIRN340 3

External Ids for MIR340 Gene

Previous HGNC Symbols for MIR340 Gene

  • MIRN340

Previous GeneCards Identifiers for MIR340 Gene

  • GC05M179377
  • GC05M179442

Summaries for MIR340 Gene

Entrez Gene Summary for MIR340 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR340 Gene

MIR340 (MicroRNA 340) is an RNA Gene, and is affiliated with the miRNA class.

fRNAdb sequence ontologies for MIR340 Gene - the ORGUL cluster for this gene includes several descriptions:

  • miRNA: Small, ~22-nt, RNA molecule that is the endogenous transcript of a miRNA gene. Micro RNAs are produced from precursor molecules (SO:0000647) that can form local hairpin structures, which ordinarily are processed (via the Dicer pathway) such that a single miRNA molecule accumulates from one arm of a hairpin precursor molecule. Micro RNAs may trigger the cleavage of their target molecules or act as translational repressors.

  • pre_miRNA: The 60-70 nucleotide region remain after Drosha processing of the primary transcript, that folds back upon itself to form a hairpin sructure.

View fRNAdb secondary structures for MIR340

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR340 Gene

Genomics for MIR340 Gene

Genomic Location for MIR340 Gene

Chromosome:
5
Start:
180,015,292 bp from pter
End:
180,015,402 bp from pter
Size:
111 bases
Orientation:
Minus strand

Genomic View for MIR340 Gene

Genes around MIR340 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR340 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR340 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR340 Gene

ORGUL Member Location for MIR340 Gene

ORGUL Member Location for MIR340 gene

No data available for Regulatory Elements for MIR340 Gene

Proteins for MIR340 Gene

Post-translational modifications for MIR340 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR340 Gene

Domains & Families for MIR340 Gene

Gene Families for MIR340 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR340: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR340 Gene

Function for MIR340 Gene

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR340 Gene

Localization for MIR340 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR340 Gene

Pathways & Interactions for MIR340 Gene

SuperPathways for MIR340 Gene

No Data Available

Interacting Proteins for MIR340 Gene

Gene Ontology (GO) - Biological Process for MIR340 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for MIR340 Gene

Drugs & Compounds for MIR340 Gene

No Compound Related Data Available

Transcripts for MIR340 Gene

fRNAdb Secondary structures for MIR340 Gene

  • hsa-miR-340-5p_MIMAT0004692_Homo_sapiens_miR-340-5p_mature

mRNA/cDNA for MIR340 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR340 Gene

No ASD Table

Relevant External Links for MIR340 Gene

GeneLoc Exon Structure for
MIR340
ECgene alternative splicing isoforms for
MIR340

Expression for MIR340 Gene

mRNA expression in normal human tissues for MIR340 Gene

genes like me logo Genes that share expression patterns with MIR340: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for MIR340 Gene

Orthologs for MIR340 Gene

This gene was present in the common ancestor of mammals.

Orthologs for MIR340 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia bta-mir-340 36
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia cfa-mir-340 36
  • 91 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia mdo-mir-340 36
  • 59 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mir340 36
  • 95 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-340 36
  • 100 (a)
OneToOne
Species with no ortholog for MIR340:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MIR340 Gene

ENSEMBL:
Gene Tree for MIR340 (if available)
TreeFam:
Gene Tree for MIR340 (if available)

Paralogs for MIR340 Gene

No data available for Paralogs for MIR340 Gene

Variants for MIR340 Gene

Structural Variations from Database of Genomic Variants (DGV) for MIR340 Gene

Variant ID Type Subtype PubMed ID
nsv830561 CNV Loss 17160897
esv2731313 CNV Deletion 23290073
esv2731314 CNV Deletion 23290073

Relevant External Links for MIR340 Gene

HapMap Linkage Disequilibrium report
MIR340

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations from dbSNP and Humsavar and Variation tolerance for MIR340 Gene

Disorders for MIR340 Gene

Relevant External Links for MIR340

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR340

No disorders were found for MIR340 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR340 Gene

Publications for MIR340 Gene

  1. miR340 suppresses the stem-like cell function of glioma-initiating cells by targeting tissue plasminogen activator. (PMID: 25627976) Yamashita D. … Ohnishi T. (Cancer Res. 2015) 3 67
  2. New human and mouse microRNA genes found by homology search. (PMID: 15634332) Weber M.J. (FEBS J. 2005) 1 3
  3. Identification of many microRNAs that copurify with polyribosomes in mammalian neurons. (PMID: 14691248) Kim J. … Ruvkun G. (Proc. Natl. Acad. Sci. U.S.A. 2004) 1 3
  4. miR-340 inhibits tumor cell proliferation and induces apoptosis by targeting multiple negative regulators of p27 in non-small cell lung cancer. (PMID: 25151966) Fernandez S. … Verde P. (Oncogene 2015) 3
  5. MicroRNA-340-mediated degradation of microphthalmia-associated transcription factor (MITF) mRNA is inhibited by coding region determinant-binding protein (CRD-BP). (PMID: 25414259) Goswami S. … Spiegelman V.S. (J. Biol. Chem. 2015) 3

Products for MIR340 Gene

Sources for MIR340 Gene

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