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Aliases for MIR33B Gene

Subcategory (RNA class) for MIR33B Gene

miRNA

Quality Score for this RNA gene is

9

Aliases for MIR33B Gene

  • MicroRNA 33b 2 3 5
  • Hsa-Mir-33b 3
  • Mir-33b 3
  • MIRN33B 3

External Ids for MIR33B Gene

Previous HGNC Symbols for MIR33B Gene

  • MIRN33B

Previous GeneCards Identifiers for MIR33B Gene

  • GC17M017659
  • GC17M017717

Summaries for MIR33B Gene

Entrez Gene Summary for MIR33B Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR33B Gene

MIR33B (MicroRNA 33b) is an RNA Gene, and is affiliated with the miRNA class. Among its related pathways are Nuclear Receptors in Lipid Metabolism and Toxicity and Statin Pathway.

fRNAdb sequence ontologies for MIR33B Gene - the ORGUL cluster for this gene includes several descriptions:

  • miRNA: Small, ~22-nt, RNA molecule that is the endogenous transcript of a miRNA gene. Micro RNAs are produced from precursor molecules (SO:0000647) that can form local hairpin structures, which ordinarily are processed (via the Dicer pathway) such that a single miRNA molecule accumulates from one arm of a hairpin precursor molecule. Micro RNAs may trigger the cleavage of their target molecules or act as translational repressors.

  • pre_miRNA: The 60-70 nucleotide region remain after Drosha processing of the primary transcript, that folds back upon itself to form a hairpin sructure.

View fRNAdb secondary structures for MIR33B

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR33B Gene

Genomics for MIR33B Gene

Regulatory Elements for MIR33B Gene

Enhancers for MIR33B Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH17G017847 1.9 FANTOM5 Ensembl ENCODE dbSUPER 12.6 -35.7 -35729 3.6 HDGF PKNOX1 ARNT ARID4B SIN3A DMAP1 ZBTB7B YY1 ZNF766 ZNF143 ZNF286B USP32P2 SMCR5 TOM1L2 ENSG00000273018 LOC100419436 MIR33B LLGL1 ENSG00000264885 RAI1
GH17G017689 2 FANTOM5 Ensembl ENCODE dbSUPER 11.2 +118.5 118541 12.1 HDGF PKNOX1 FOXA2 WRNIP1 ZFP64 ARID4B SIN3A FEZF1 DMAP1 YBX1 ZNF286B ENSG00000264885 LOC100419436 UPF3AP1 SREBF1 FOXO3B FAM106A USP32P2 ENSG00000273018 DRG2
GH17G017708 1.9 FANTOM5 Ensembl ENCODE dbSUPER 10.7 +102.0 101972 6.7 HDGF PKNOX1 FOXA2 MLX ARID4B SIN3A DMAP1 ZBTB7B SLC30A9 ZNF143 RAI1 SREBF1 MIR33B MYO15A TOM1L2 TOP3A PEMT KRT17P4 PIR55057 RAI1-AS1
GH17G017875 1.5 Ensembl ENCODE dbSUPER 12.2 -63.5 -63510 3.6 PKNOX1 SIN3A FEZF1 ZNF2 YY1 GLIS2 GATA2 ZNF263 SP3 REST TOM1L2 SREBF1 MIR33B RAI1 PIR35691 GC17M017867 PIR37368
GH17G017859 1.4 Ensembl ENCODE dbSUPER 12.2 -46.7 -46653 1.7 ZSCAN4 ARID4B KLF17 SIN3A ZNF48 ZSCAN9 RAD21 YY1 ZNF143 ZNF391 ENSG00000197815 TOM1L2 SREBF1 MIR33B RAI1 GC17P017858 PIR35691 GC17M017867
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MIR33B on UCSC Golden Path with GeneCards custom track

Genomic Location for MIR33B Gene

Chromosome:
17
Start:
17,813,836 bp from pter
End:
17,813,931 bp from pter
Size:
96 bases
Orientation:
Minus strand

Genomic View for MIR33B Gene

Genes around MIR33B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR33B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR33B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR33B Gene

ORGUL Member Location for MIR33B Gene

ORGUL Member Location for MIR33B gene

Proteins for MIR33B Gene

Post-translational modifications for MIR33B Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR33B Gene

Domains & Families for MIR33B Gene

Gene Families for MIR33B Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR33B: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR33B Gene

Function for MIR33B Gene

Animal Model Products

miRNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR33B Gene

Localization for MIR33B Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR33B Gene

Drugs & Compounds for MIR33B Gene

No Compound Related Data Available

Transcripts for MIR33B Gene

fRNAdb Secondary structures for MIR33B Gene

  • hsa-miR-33b-5p_MIMAT0003301_Homo_sapiens_miR-33b-5p_mature
  • FR011874
  • hsa-mir-33b_MI0003646_Homo_sapiens_miR-33b_stem-loop_hairpin

mRNA/cDNA for MIR33B Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

miRNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR33B Gene

No ASD Table

Relevant External Links for MIR33B Gene

GeneLoc Exon Structure for
MIR33B
ECgene alternative splicing isoforms for
MIR33B

Expression for MIR33B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MIR33B Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR33B Gene:

MIR33B
genes like me logo Genes that share expression patterns with MIR33B: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR33B Gene

Orthologs for MIR33B Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIR33B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-33b 35
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia bta-mir-33b 35
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia cfa-mir-33b 35
  • 89 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia oan-mir-33a 35
  • 64 (a)
OneToOne
chicken
(Gallus gallus)
Aves -- 35
  • 65 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia aca-mir-33-2 35
  • 65 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 56 (a)
OneToMany
Species where no ortholog for MIR33B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MIR33B Gene

ENSEMBL:
Gene Tree for MIR33B (if available)
TreeFam:
Gene Tree for MIR33B (if available)

Paralogs for MIR33B Gene

No data available for Paralogs for MIR33B Gene

Variants for MIR33B Gene

Sequence variations from dbSNP and Humsavar for MIR33B Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs1000978803 -- 17,814,565(+) GGGAT(A/G)AGGAA intron-variant, upstream-variant-2KB
rs1001475002 -- 17,813,803(+) CCAGG(A/G)CTCCA intron-variant, downstream-variant-500B, upstream-variant-2KB
rs1002484609 -- 17,815,139(+) GGGCT(C/G)TCTCC intron-variant, upstream-variant-2KB
rs1004143021 -- 17,814,163(+) TGCAG(-/C)CCCCT intron-variant, upstream-variant-2KB
rs1004549247 -- 17,814,056(+) TGAGG(A/C)CAGAT intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MIR33B Gene

Variant ID Type Subtype PubMed ID
nsv155 OTHER inversion 15895083
nsv499114 OTHER inversion 21111241
nsv522668 CNV loss 19592680
nsv833385 CNV loss 17160897
nsv953838 CNV deletion 24416366

Relevant External Links for MIR33B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR33B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR33B Gene

Disorders for MIR33B Gene

Relevant External Links for MIR33B

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR33B

No disorders were found for MIR33B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR33B Gene

Publications for MIR33B Gene

  1. The colorectal microRNAome. (PMID: 16505370) Cummins J.M. … Velculescu V.E. (Proc. Natl. Acad. Sci. U.S.A. 2006) 1 3 64
  2. miR33a/miR33b* and miR122 as Possible Contributors to Hepatic Lipid Metabolism in Obese Women with Nonalcoholic Fatty Liver Disease. (PMID: 27669236) Auguet T. … Richart C. (Int J Mol Sci 2016) 3 64
  3. DNA Methylation mediated down-regulating of MicroRNA-33b and its role in gastric cancer. (PMID: 26729612) Yin H. … Yu J. (Sci Rep 2016) 3 64
  4. SREBP-1c/MicroRNA 33b Genomic Loci Control Adipocyte Differentiation. (PMID: 26830228) Price N.L. … FernA!ndez-Hernando C. (Mol. Cell. Biol. 2016) 3 64
  5. Clinical Significance of Determining Plasma MicroRNA33b in Type 2 Diabetic Patients with Dyslipidemia. (PMID: 27301461) Kimura Y. … Daimon M. (J. Atheroscler. Thromb. 2016) 3 64

Products for MIR33B Gene

Sources for MIR33B Gene

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