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Aliases for MIR33B Gene

Subcategory (RNA class) for MIR33B Gene

miRNA

Quality Score for this RNA gene is

9

Aliases for MIR33B Gene

  • MicroRNA 33b 2 3 5
  • Hsa-Mir-33b 3
  • Mir-33b 3
  • MIRN33B 3

External Ids for MIR33B Gene

Previous HGNC Symbols for MIR33B Gene

  • MIRN33B

Previous GeneCards Identifiers for MIR33B Gene

  • GC17M017659
  • GC17M017717

Summaries for MIR33B Gene

Entrez Gene Summary for MIR33B Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR33B Gene

MIR33B (MicroRNA 33b) is an RNA Gene, and is affiliated with the miRNA class. Among its related pathways are SREBF and miR33 in cholesterol and lipid homeostasis and Regulation of cholesterol biosynthesis by SREBP (SREBF).

fRNAdb sequence ontologies for MIR33B Gene - the ORGUL cluster for this gene includes several descriptions:

  • miRNA: Small, ~22-nt, RNA molecule that is the endogenous transcript of a miRNA gene. Micro RNAs are produced from precursor molecules (SO:0000647) that can form local hairpin structures, which ordinarily are processed (via the Dicer pathway) such that a single miRNA molecule accumulates from one arm of a hairpin precursor molecule. Micro RNAs may trigger the cleavage of their target molecules or act as translational repressors.

  • pre_miRNA: The 60-70 nucleotide region remain after Drosha processing of the primary transcript, that folds back upon itself to form a hairpin sructure.

View fRNAdb secondary structures for MIR33B

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR33B Gene

Genomics for MIR33B Gene

Regulatory Elements for MIR33B Gene

Enhancers for MIR33B Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around MIR33B on UCSC Golden Path with GeneCards custom track

Genomic Location for MIR33B Gene

Chromosome:
17
Start:
17,813,836 bp from pter
End:
17,813,931 bp from pter
Size:
96 bases
Orientation:
Minus strand

Genomic View for MIR33B Gene

Genes around MIR33B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR33B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR33B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR33B Gene

ORGUL Member Location for MIR33B Gene

ORGUL Member Location for MIR33B gene

Proteins for MIR33B Gene

Post-translational modifications for MIR33B Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR33B Gene

Domains & Families for MIR33B Gene

Gene Families for MIR33B Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR33B: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR33B Gene

Function for MIR33B Gene

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR33B Gene

Localization for MIR33B Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR33B Gene

Pathways & Interactions for MIR33B Gene

genes like me logo Genes that share pathways with MIR33B: view

Interacting Proteins for MIR33B Gene

Gene Ontology (GO) - Biological Process for MIR33B Gene

None

No data available for SIGNOR curated interactions for MIR33B Gene

Drugs & Compounds for MIR33B Gene

No Compound Related Data Available

Transcripts for MIR33B Gene

fRNAdb Secondary structures for MIR33B Gene

  • hsa-miR-33b-5p_MIMAT0003301_Homo_sapiens_miR-33b-5p_mature
  • FR011874
  • hsa-mir-33b_MI0003646_Homo_sapiens_miR-33b_stem-loop_hairpin

mRNA/cDNA for MIR33B Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR33B Gene

No ASD Table

Relevant External Links for MIR33B Gene

GeneLoc Exon Structure for
MIR33B
ECgene alternative splicing isoforms for
MIR33B

Expression for MIR33B Gene

mRNA expression in normal human tissues for MIR33B Gene

genes like me logo Genes that share expression patterns with MIR33B: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for MIR33B Gene

Orthologs for MIR33B Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIR33B Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia bta-mir-33b 36
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia cfa-mir-33b 36
  • 89 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia oan-mir-33a 36
  • 64 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-33b 36
  • 100 (a)
OneToOne
chicken
(Gallus gallus)
Aves -- 36
  • 65 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia aca-mir-33-2 36
  • 65 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 56 (a)
OneToMany
Species with no ortholog for MIR33B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MIR33B Gene

ENSEMBL:
Gene Tree for MIR33B (if available)
TreeFam:
Gene Tree for MIR33B (if available)

Paralogs for MIR33B Gene

No data available for Paralogs for MIR33B Gene

Variants for MIR33B Gene

Structural Variations from Database of Genomic Variants (DGV) for MIR33B Gene

Variant ID Type Subtype PubMed ID
nsv155 OTHER Inversion 15895083
nsv499114 OTHER Inversion 21111241
nsv907748 CNV Loss 21882294
dgv3072n71 CNV Loss 21882294
nsv833385 CNV Loss 17160897
dgv3073n71 CNV Loss 21882294
nsv522668 CNV Loss 19592680
dgv3074n71 CNV Loss 21882294
dgv3075n71 CNV Loss 21882294
dgv3076n71 CNV Loss 21882294
nsv907766 CNV Loss 21882294
nsv907767 CNV Loss 21882294
nsv907768 CNV Loss 21882294

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations from dbSNP and Humsavar , Variation tolerance and Relevant External Links for MIR33B Gene

Disorders for MIR33B Gene

Relevant External Links for MIR33B

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR33B

No disorders were found for MIR33B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR33B Gene

Publications for MIR33B Gene

  1. MicroRNAs and High-Density Lipoprotein Cholesterol Metabolism. (PMID: 26084456) Ono K. … Kimura T. (Int Heart J 2015) 3 67
  2. The colorectal microRNAome. (PMID: 16505370) Cummins J.M. … Velculescu V.E. (Proc. Natl. Acad. Sci. U.S.A. 2006) 1 3
  3. Identification of microRNAs 758 and 33b as potential modulators of ABCA1 expression in human atherosclerotic plaques. (PMID: 25445880) Mandolini C. … Cipollone F. (Nutr Metab Cardiovasc Dis 2015) 3
  4. MicroRNA-33b, upregulated by EF24, a curcumin analog, suppresses the epithelial-to-mesenchymal transition (EMT) and migratory potential of melanoma cells by targeting HMGA2. (PMID: 25725129) Zhang P. … Song E. (Toxicol. Lett. 2015) 3
  5. Methyl protodioscin increases ABCA1 expression and cholesterol efflux while inhibiting gene expressions for synthesis of cholesterol and triglycerides by suppressing SREBP transcription and microRNA 33a/b levels. (PMID: 25733328) Ma W. … Lin G. (Atherosclerosis 2015) 3

Products for MIR33B Gene

Sources for MIR33B Gene

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