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Aliases for MIR33A Gene

Subcategory (RNA class) for MIR33A Gene

undefined

Quality Score for this RNA gene is

3

Aliases for MIR33A Gene

  • MicroRNA 33a 2 3 5
  • MicroRNA 33 2 3
  • Hsa-Mir-33a 3
  • Hsa-Mir-33 3
  • MiRNA33A 3
  • Mir-33a 3
  • MIRN33A 3
  • MiR-33 3
  • MIRN33 3
  • MIR33 3

External Ids for MIR33A Gene

ORGUL Members for MIR33A Gene

Previous HGNC Symbols for MIR33A Gene

  • MIRN33
  • MIRN33A

Previous GeneCards Identifiers for MIR33A Gene

  • GC22P040628
  • GC22P042296

Summaries for MIR33A Gene

Entrez Gene Summary for MIR33A Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR33A Gene

MIR33A (MicroRNA 33a) is an RNA Gene, and is affiliated with the undefined RNA class. Among its related pathways are Nuclear receptors in lipid metabolism and toxicity and Statin Pathway.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR33A Gene

Genomics for MIR33A Gene

Genomic Location for MIR33A Gene

Chromosome:
22
Start:
41,900,944 bp from pter
End:
41,901,012 bp from pter
Size:
69 bases
Orientation:
Plus strand

Genomic View for MIR33A Gene

Genes around MIR33A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR33A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR33A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR33A Gene

No data available for Regulatory Elements for MIR33A Gene

Proteins for MIR33A Gene

Post-translational modifications for MIR33A Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR33A Gene

Domains & Families for MIR33A Gene

Gene Families for MIR33A Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR33A: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR33A Gene

Function for MIR33A Gene

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR33A Gene

Localization for MIR33A Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR33A Gene

Pathways & Interactions for MIR33A Gene

genes like me logo Genes that share pathways with MIR33A: view

Interacting Proteins for MIR33A Gene

Gene Ontology (GO) - Biological Process for MIR33A Gene

None

No data available for SIGNOR curated interactions for MIR33A Gene

Drugs & Compounds for MIR33A Gene

No Compound Related Data Available

Transcripts for MIR33A Gene

mRNA/cDNA for MIR33A Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR33A Gene

No ASD Table

Relevant External Links for MIR33A Gene

GeneLoc Exon Structure for
MIR33A
ECgene alternative splicing isoforms for
MIR33A

Expression for MIR33A Gene

mRNA expression in normal human tissues for MIR33A Gene

genes like me logo Genes that share expression patterns with MIR33A: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for MIR33A Gene

Orthologs for MIR33A Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIR33A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-33a 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia bta-mir-33a 36
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia cfa-mir-33a 36
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mir33 36
  • 91 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia mdo-mir-33 36
  • 74 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia oan-mir-33b 36
  • 65 (a)
OneToOne
chicken
(Gallus gallus)
Aves gga-mir-33 36
  • 83 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia aca-mir-33-1 36
  • 64 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 51 (a)
OneToMany
Species with no ortholog for MIR33A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MIR33A Gene

ENSEMBL:
Gene Tree for MIR33A (if available)
TreeFam:
Gene Tree for MIR33A (if available)

Paralogs for MIR33A Gene

No data available for Paralogs for MIR33A Gene

Variants for MIR33A Gene

Structural Variations from Database of Genomic Variants (DGV) for MIR33A Gene

Variant ID Type Subtype PubMed ID
nsv508736 CNV Insertion 20534489
dgv4979n71 CNV Loss 21882294

Relevant External Links for MIR33A Gene

HapMap Linkage Disequilibrium report
MIR33A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations from dbSNP and Humsavar and Variation tolerance for MIR33A Gene

Disorders for MIR33A Gene

Relevant External Links for MIR33A

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR33A

No disorders were found for MIR33A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR33A Gene

Publications for MIR33A Gene

  1. MicroRNAs and High-Density Lipoprotein Cholesterol Metabolism. (PMID: 26084456) Ono K. … Kimura T. (Int Heart J 2015) 3 67
  2. Asymptomatic individuals with high HDL-C levels overexpress ABCA1 and ABCG1 and present miR-33a dysregulation in peripheral blood mononuclear cells. (PMID: 26051418) Scherrer D.Z. … de Faria E.C. (Gene 2015) 3
  3. Macrophage Mitochondrial Energy Status Regulates Cholesterol Efflux and Is Enhanced by Anti-miR33 in Atherosclerosis. (PMID: 26002865) Karunakaran D. … Rayner K.J. (Circ. Res. 2015) 3
  4. Profibrotic effect of miR-33a with Akt activation in hepatic stellate cells. (PMID: 24100264) Li Z.J. … Han X.P. (Cell. Signal. 2014) 3
  5. Elevated miR-33a and miR-224 in steatotic chronic hepatitis C liver biopsies. (PMID: 25386083) Lendvai G. … Kiss A. (World J. Gastroenterol. 2014) 3

Products for MIR33A Gene

Sources for MIR33A Gene

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