Free for academic non-profit institutions. Other users need a Commercial license

Aliases for MIR339 Gene

Subcategory (RNA class) for MIR339 Gene

miRNA

Quality Score for this RNA gene is

8

Aliases for MIR339 Gene

  • MicroRNA 339 2 3 5
  • Hsa-Mir-339 3
  • Mir-339 3
  • MIRN339 3

External Ids for MIR339 Gene

Previous HGNC Symbols for MIR339 Gene

  • MIRN339

Previous GeneCards Identifiers for MIR339 Gene

  • GC07M001030
  • GC07M001062

Summaries for MIR339 Gene

Entrez Gene Summary for MIR339 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR339 Gene

MIR339 (MicroRNA 339) is an RNA Gene, and is affiliated with the miRNA class.

fRNAdb sequence ontologies for MIR339 Gene - the ORGUL cluster for this gene includes several descriptions:

  • miRNA: Small, ~22-nt, RNA molecule that is the endogenous transcript of a miRNA gene. Micro RNAs are produced from precursor molecules (SO:0000647) that can form local hairpin structures, which ordinarily are processed (via the Dicer pathway) such that a single miRNA molecule accumulates from one arm of a hairpin precursor molecule. Micro RNAs may trigger the cleavage of their target molecules or act as translational repressors.

  • pre_miRNA: The 60-70 nucleotide region remain after Drosha processing of the primary transcript, that folds back upon itself to form a hairpin sructure.

View fRNAdb secondary structures for MIR339

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR339 Gene

Genomics for MIR339 Gene

Regulatory Elements for MIR339 Gene

Enhancers for MIR339 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH07F000971 1.4 FANTOM5 ENCODE 13 +46.8 46783 8.8 HDGF PKNOX1 CREB3L1 ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 CYP2W1 LOC105375120 GPR146 MIR339 ADAP1 ENSG00000225146 C7orf50 MAFK COX19 LOC101927021
GH07F000981 1.3 Ensembl ENCODE 12.3 +37.5 37452 7.7 HDGF PKNOX1 ARNT MLX CREB3L1 ARID4B SIN3A DMAP1 YBX1 YY1 CYP2W1 LOC105375120 GPR146 MIR339 ADAP1 COX19 ENSG00000225146 C7orf50 LOC101927021 GC07M001007
GH07F001175 1.3 Ensembl ENCODE 11 -153.4 -153419 1.7 CREB3L1 ARID4B SIN3A DMAP1 ZNF48 ZNF2 ZNF121 GLIS2 ELK1 ZNF143 LOC101927021 C7orf50 GPR146 ENSG00000225146 ADAP1 MIR339 GC07P001163 GC07P001203
GH07F001100 1.2 FANTOM5 ENCODE 11.3 -78.1 -78102 2.2 ELF3 ZNF48 ZSCAN9 RAD21 RARA YY1 CREM THAP11 KAT8 TGIF2 LOC101927021 ZFAND2A LOC105375120 GPER1 C7orf50 MIR339 GPR146 ENSG00000225146 ADAP1 TMEM184A
GH07F001102 1.1 Ensembl ENCODE 11.6 -81.1 -81093 2.9 TBP SIN3A RAD21 ZNF121 EGR1 ETV6 CREM CBFB JUNB TBX21 LOC101927021 LOC105375120 GPER1 C7orf50 MIR339 GPR146 ZFAND2A ENSG00000225146 ADAP1 PIR59593
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MIR339 on UCSC Golden Path with GeneCards custom track

Genomic Location for MIR339 Gene

Chromosome:
7
Start:
1,022,933 bp from pter
End:
1,023,026 bp from pter
Size:
94 bases
Orientation:
Minus strand

Genomic View for MIR339 Gene

Genes around MIR339 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR339 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR339 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR339 Gene

ORGUL Member Location for MIR339 Gene

ORGUL Member Location for MIR339 gene

Proteins for MIR339 Gene

Post-translational modifications for MIR339 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR339 Gene

Domains & Families for MIR339 Gene

Gene Families for MIR339 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR339: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR339 Gene

Function for MIR339 Gene

Animal Model Products

miRNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR339 Gene

Localization for MIR339 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR339 Gene

Pathways & Interactions for MIR339 Gene

SuperPathways for MIR339 Gene

No Data Available

Interacting Proteins for MIR339 Gene

Gene Ontology (GO) - Biological Process for MIR339 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for MIR339 Gene

Transcripts for MIR339 Gene

fRNAdb Secondary structures for MIR339 Gene

  • FR054928
  • hsa-mir-339_MI0000815_Homo_sapiens_miR-339_stem-loop_hairpin

mRNA/cDNA for MIR339 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR339 Gene

No ASD Table

Relevant External Links for MIR339 Gene

GeneLoc Exon Structure for
MIR339
ECgene alternative splicing isoforms for
MIR339

Expression for MIR339 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MIR339 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR339 Gene:

MIR339
genes like me logo Genes that share expression patterns with MIR339: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for MIR339 Gene

Orthologs for MIR339 Gene

This gene was present in the common ancestor of mammals.

Orthologs for MIR339 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-339 35
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia -- 35
  • 82 (a)
OneToOne
cow
(Bos Taurus)
Mammalia bta-mir-339a 35
  • 81 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mir339 35
  • 80 (a)
OneToOne
Species where no ortholog for MIR339 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MIR339 Gene

ENSEMBL:
Gene Tree for MIR339 (if available)
TreeFam:
Gene Tree for MIR339 (if available)

Paralogs for MIR339 Gene

No data available for Paralogs for MIR339 Gene

Variants for MIR339 Gene

Sequence variations from dbSNP and Humsavar for MIR339 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs1057558 -- 1,022,730(+) CAAAT(C/T)CTTTA intron-variant, downstream-variant-500B
rs1057559 -- 1,022,812(+) GCTCT(C/G)CCCCT intron-variant, downstream-variant-500B
rs1057561 -- 1,022,892(+) AAGCG(C/T)GGCGA intron-variant, downstream-variant-500B
rs112079349 -- 1,022,799(+) TGGAA(C/G)ATCCC intron-variant, downstream-variant-500B
rs113023471 -- 1,023,294(+) GGGAG(C/T)GCCCA intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MIR339 Gene

Variant ID Type Subtype PubMed ID
nsv1161477 CNV deletion 26073780
nsv464245 CNV gain 19166990
nsv605699 CNV loss 21841781
nsv605700 CNV gain 21841781
nsv605705 CNV loss 21841781
nsv605720 CNV loss 21841781
nsv950784 CNV deletion 24416366

Relevant External Links for MIR339 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR339

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR339 Gene

Disorders for MIR339 Gene

Relevant External Links for MIR339

Human Genome Epidemiology (HuGE) Navigator
MIR339
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR339

No disorders were found for MIR339 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR339 Gene

Publications for MIR339 Gene

  1. New human and mouse microRNA genes found by homology search. (PMID: 15634332) Weber M.J. (FEBS J. 2005) 1 3 64
  2. Identification of many microRNAs that copurify with polyribosomes in mammalian neurons. (PMID: 14691248) Kim J. … Ruvkun G. (Proc. Natl. Acad. Sci. U.S.A. 2004) 1 3 64
  3. Altered expression profiles of microRNAs during TPA-induced differentiation of HL-60 cells. (PMID: 15325244) Kasashima K. … Kozu T. (Biochem. Biophys. Res. Commun. 2004) 1 3 64
  4. Effects of miR-339-5p on invasion and prognosis of hepatocellular carcinoma. (PMID: 26186881) Wang Y.L. … Wang L. (Clin Res Hepatol Gastroenterol 2016) 3 64
  5. miR-339-5p regulates the p53 tumor-suppressor pathway by targeting MDM2. (PMID: 24882579) Jansson M.D. … Lund A.H. (Oncogene 2015) 3 64

Products for MIR339 Gene

Sources for MIR339 Gene

Content
Loading form....