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Aliases for MIR335 Gene

Subcategory (RNA class) for MIR335 Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR335 Gene

  • MicroRNA 335 2 3 5
  • Hsa-Mir-335 3
  • MiRNA335 3
  • Mir-335 3
  • MIRN335 3

External Ids for MIR335 Gene

ORGUL Members for MIR335 Gene

Previous HGNC Symbols for MIR335 Gene

  • MIRN335

Previous GeneCards Identifiers for MIR335 Gene

  • GC07P129924
  • GC07P130135

Summaries for MIR335 Gene

Entrez Gene Summary for MIR335 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR335 Gene

MIR335 (MicroRNA 335) is an RNA Gene, and is affiliated with the miRNA class. Among its related pathways are MicroRNAs in cancer.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR335 Gene

Genomics for MIR335 Gene

Regulatory Elements for MIR335 Gene

Enhancers for MIR335 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH07F130271 1.2 Ensembl ENCODE 10.4 -219.1 -219145 10.8 CBX3 PKNOX1 ATF1 ZBTB40 RAD21 ZNF121 SCRT2 HSF1 RCOR1 SMARCA5 MEST CPA5 CPA1 MIR335 CDC26P1 KLHDC10 GC07M130268 CPA4
GH07F130443 0.7 ENCODE 10.7 -51.2 -51189 1.9 HDAC1 CTCF PKNOX1 CEBPG RAD21 CHAMP1 MCM7 CEBPA PBX2 ZBTB33 MEST CPA1 MIR335 CPA4 CPA2 COPG2 CEP41 ENSG00000259920
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MIR335 on UCSC Golden Path with GeneCards custom track

Genomic Location for MIR335 Gene

Chromosome:
7
Start:
130,496,111 bp from pter
End:
130,496,204 bp from pter
Size:
94 bases
Orientation:
Plus strand

Genomic View for MIR335 Gene

Genes around MIR335 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR335 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR335 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR335 Gene

Proteins for MIR335 Gene

Post-translational modifications for MIR335 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR335 Gene

Domains & Families for MIR335 Gene

Gene Families for MIR335 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR335: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR335 Gene

Function for MIR335 Gene

Animal Model Products

miRNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR335 Gene

Localization for MIR335 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR335 Gene

Pathways & Interactions for MIR335 Gene

SuperPathways for MIR335 Gene

SuperPathway Contained pathways
1 MicroRNAs in cancer
genes like me logo Genes that share pathways with MIR335: view

Pathways by source for MIR335 Gene

1 KEGG pathway for MIR335 Gene

Interacting Proteins for MIR335 Gene

Gene Ontology (GO) - Biological Process for MIR335 Gene

None

No data available for SIGNOR curated interactions for MIR335 Gene

Transcripts for MIR335 Gene

mRNA/cDNA for MIR335 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR335 Gene

No ASD Table

Relevant External Links for MIR335 Gene

GeneLoc Exon Structure for
MIR335
ECgene alternative splicing isoforms for
MIR335

Expression for MIR335 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR335 Gene:

MIR335
No Expression Related Data Available

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for MIR335 Gene

Orthologs for MIR335 Gene

This gene was present in the common ancestor of mammals.

Orthologs for MIR335 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-335 35
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia cfa-mir-335 35
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia bta-mir-335 35
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mir335 35
  • 87 (a)
OneToOne
Species where no ortholog for MIR335 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MIR335 Gene

ENSEMBL:
Gene Tree for MIR335 (if available)
TreeFam:
Gene Tree for MIR335 (if available)

Paralogs for MIR335 Gene

No data available for Paralogs for MIR335 Gene

Variants for MIR335 Gene

Sequence variations from dbSNP and Humsavar for MIR335 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs138096878 -- 130,496,320(+) CCTTA(C/G)ATTTT intron-variant, downstream-variant-500B
rs141004270 -- 130,494,522(+) TTTTT(A/C)CAAAG intron-variant, upstream-variant-2KB
rs142807984 -- 130,495,283(+) ATCTC(C/T)CACCC intron-variant, upstream-variant-2KB
rs143143525 -- 130,495,923(+) ATACC(-/ATTATATAA)ATTAT intron-variant, upstream-variant-2KB
rs143663567 -- 130,494,201(+) CGAAC(A/G)GGTAG intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MIR335 Gene

Variant ID Type Subtype PubMed ID
nsv831130 CNV loss 17160897
nsv831131 CNV loss 17160897

Relevant External Links for MIR335 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR335

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR335 Gene

Disorders for MIR335 Gene

Relevant External Links for MIR335

Human Genome Epidemiology (HuGE) Navigator
MIR335
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR335

No disorders were found for MIR335 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR335 Gene

Publications for MIR335 Gene

  1. MiR-335 functions as a tumor suppressor and regulates survivin expression in osteosarcoma. (PMID: 27097943) Liu Z.F. … Zhao J. (Eur Rev Med Pharmacol Sci 2016) 3 64
  2. Overexpression of miR-335 confers cell proliferation and tumour growth to colorectal carcinoma cells. (PMID: 26708214) Lu Y. … Li X. (Mol. Cell. Biochem. 2016) 3 64
  3. A crucial epithelial to mesenchymal transition regulator, Sox4/Ezh2 axis is closely related to the clinical outcome in pancreatic cancer patients. (PMID: 26648239) Hasegawa S. … Ishii H. (Int. J. Oncol. 2016) 3 64
  4. MicroRNA-335 represents an independent prognostic marker in cervical cancer. (PMID: 25712373) Wang C. … Jiang T. (Tumour Biol. 2015) 3 64
  5. MiR-335 acts as a potential tumor suppressor miRNA via downregulating ROCK1 expression in hepatocellular carcinoma. (PMID: 25804796) Liu H. … Long X. (Tumour Biol. 2015) 3 64

Products for MIR335 Gene

Sources for MIR335 Gene

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