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Aliases for MIR331 Gene

Subcategory (RNA class) for MIR331 Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR331 Gene

  • MicroRNA 331 2 3 5
  • Hsa-Mir-331 3
  • Mir-331 3
  • MIRN331 3

External Ids for MIR331 Gene

ORGUL Members for MIR331 Gene

Previous HGNC Symbols for MIR331 Gene

  • MIRN331

Previous GeneCards Identifiers for MIR331 Gene

  • GC12P094227
  • GC12P095702

Summaries for MIR331 Gene

Entrez Gene Summary for MIR331 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR331 Gene

MIR331 (MicroRNA 331) is an RNA Gene, and is affiliated with the miRNA class. Among its related pathways are MicroRNAs in cancer.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR331 Gene

Genomics for MIR331 Gene

Regulatory Elements for MIR331 Gene

Enhancers for MIR331 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH12F095334 1.1 Ensembl ENCODE 11.1 +26.2 26181 0.4 CTCF ZNF654 SAP130 ZNF384 RAD21 JUND SMC3 TCF7 FOS SMAD4 MIR331 GC12P095319 GC12M095381 PIR53930
GH12F095335 1.2 Ensembl ENCODE 11.1 +27.8 27794 2.0 ELF3 PKNOX1 ARID4B SIN3A RAD21 ZNF121 ZNF143 MIXL1 THAP11 REST MIR331 FGD6 GC12P095319 PIR53930 GC12M095381
GH12F095337 0.6 ENCODE 11.1 +29.0 28980 0.1 MIR331 GC12P095319 PIR53930 GC12M095381
GH12F095333 0.5 FANTOM5 11.1 +25.1 25100 0.1 MIR331 GC12P095319 GC12M095381 PIR53930
GH12F095286 0.4 FANTOM5 10.5 -21.4 -21364 0.4 MIR331 FGD6 CBX3P5 GC12P095291
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around MIR331 on UCSC Golden Path with GeneCards custom track

Genomic Location for MIR331 Gene

Chromosome:
12
Start:
95,308,420 bp from pter
End:
95,308,513 bp from pter
Size:
94 bases
Orientation:
Plus strand

Genomic View for MIR331 Gene

Genes around MIR331 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR331 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR331 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR331 Gene

Proteins for MIR331 Gene

Post-translational modifications for MIR331 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR331 Gene

Domains & Families for MIR331 Gene

Gene Families for MIR331 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR331: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR331 Gene

Function for MIR331 Gene

Animal Model Products

miRNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR331 Gene

Localization for MIR331 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR331 Gene

Pathways & Interactions for MIR331 Gene

SuperPathways for MIR331 Gene

SuperPathway Contained pathways
1 MicroRNAs in cancer
genes like me logo Genes that share pathways with MIR331: view

Pathways by source for MIR331 Gene

1 KEGG pathway for MIR331 Gene

Interacting Proteins for MIR331 Gene

Gene Ontology (GO) - Biological Process for MIR331 Gene

None

No data available for SIGNOR curated interactions for MIR331 Gene

Transcripts for MIR331 Gene

mRNA/cDNA for MIR331 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

miRNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR331 Gene

No ASD Table

Relevant External Links for MIR331 Gene

GeneLoc Exon Structure for
MIR331
ECgene alternative splicing isoforms for
MIR331

Expression for MIR331 Gene

mRNA expression in normal human tissues for MIR331 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR331 Gene:

MIR331
genes like me logo Genes that share expression patterns with MIR331: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for MIR331 Gene

Orthologs for MIR331 Gene

This gene was present in the common ancestor of mammals.

Orthologs for MIR331 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-331 35
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia bta-mir-331 35
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia cfa-mir-331 35
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mir331 35
  • 95 (a)
OneToOne
Species where no ortholog for MIR331 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MIR331 Gene

ENSEMBL:
Gene Tree for MIR331 (if available)
TreeFam:
Gene Tree for MIR331 (if available)

Paralogs for MIR331 Gene

No data available for Paralogs for MIR331 Gene

Variants for MIR331 Gene

Sequence variations from dbSNP and Humsavar for MIR331 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs11107972 -- 95,307,016(+) AACCA(A/G)AAAGA upstream-variant-2KB
rs11107973 -- 95,308,609(+) TGGTA(C/T)GTGTG downstream-variant-500B, upstream-variant-2KB
rs111546589 -- 95,306,674(+) ACCCC(A/G)TCTCT upstream-variant-2KB
rs112310009 -- 95,308,093(+) CTAAA(G/T)CATGT upstream-variant-2KB
rs113105533 -- 95,308,296(+) ACAAC(A/G)TACAG upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MIR331 Gene

Variant ID Type Subtype PubMed ID
nsv7234 OTHER inversion 18451855

Relevant External Links for MIR331 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR331

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR331 Gene

Disorders for MIR331 Gene

Relevant External Links for MIR331

Human Genome Epidemiology (HuGE) Navigator
MIR331
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR331

No disorders were found for MIR331 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR331 Gene

Publications for MIR331 Gene

  1. MiR-331-3p inhibits proliferation and promotes apoptosis by targeting HER2 through the PI3K/Akt and ERK1/2 pathways in colorectal cancer. (PMID: 26718987) Zhao D. … Zheng X. (Oncol. Rep. 2016) 3 64
  2. Hsa-miR-331-3p inhibits VHL expression by directly targeting its mRNA 3'-UTR in HCC cell lines. (PMID: 25750939) Cao Y. … Tang H. (Acta Biochim. Pol. 2015) 3 64
  3. Serum miR-182 and miR-331-3p as diagnostic and prognostic markers in patients with hepatocellular carcinoma. (PMID: 25903466) Chen L. … Wang F. (Tumour Biol. 2015) 3 64
  4. Upregulated in Hepatitis B virus-associated hepatocellular carcinoma cells, miR-331-3p promotes proliferation of hepatocellular carcinoma cells by targeting ING5. (PMID: 26497554) Cao Y. … Tang H. (Oncotarget 2015) 3 64
  5. Lnc RNA HOTAIR functions as a competing endogenous RNA to regulate HER2 expression by sponging miR-331-3p in gastric cancer. (PMID: 24775712) Liu X.H. … Wang Z.X. (Mol. Cancer 2014) 3 64

Products for MIR331 Gene

Sources for MIR331 Gene

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