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Aliases for MIR330 Gene

Subcategory (RNA class) for MIR330 Gene

miRNA

Quality Score for this RNA gene is

8.2

Aliases for MIR330 Gene

  • MicroRNA 330 2 3 5
  • Hsa-Mir-330 3
  • Mir-330 3
  • MIRN330 3

External Ids for MIR330 Gene

Previous HGNC Symbols for MIR330 Gene

  • MIRN330

Previous GeneCards Identifiers for MIR330 Gene

  • GC19M050836
  • GC19M046142
  • GC19M045642
  • GC19M045607

Summaries for MIR330 Gene

Entrez Gene Summary for MIR330 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR330 Gene

MIR330 (MicroRNA 330) is an RNA Gene, and is affiliated with the miRNA class. Among its related pathways are MicroRNAs in cancer.

fRNAdb sequence ontologies for MIR330 Gene - the ORGUL cluster for this gene includes several descriptions:

  • nc_conserved_region: Non-coding region of sequence similarity by descent from a common ancestor.

  • miRNA: Small, ~22-nt, RNA molecule that is the endogenous transcript of a miRNA gene. Micro RNAs are produced from precursor molecules (SO:0000647) that can form local hairpin structures, which ordinarily are processed (via the Dicer pathway) such that a single miRNA molecule accumulates from one arm of a hairpin precursor molecule. Micro RNAs may trigger the cleavage of their target molecules or act as translational repressors.

  • pre_miRNA: The 60-70 nucleotide region remain after Drosha processing of the primary transcript, that folds back upon itself to form a hairpin sructure.

View fRNAdb secondary structures for MIR330

Additional gene information for MIR330 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR330 Gene

Genomics for MIR330 Gene

GeneHancer (GH) Regulatory Elements for MIR330 Gene

Promoters and enhancers for MIR330 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19I045637 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 550.8 -1.9 -1892 6.2 HDGF PKNOX1 FOXA2 SMAD1 ARID4B SIN3A FEZF1 ZNF2 ZBTB7B IRF4 EML2-AS1 EML2 GC19M045643 MIR330 CCDC61 ENSG00000268810 IRF2BP1 ENSG00000267114 SYMPK CLASRP
GH19I045401 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 10.5 +234.5 234515 6.2 CLOCK FEZF1 YY1 ZNF213 E2F8 ZNF143 SP3 MEF2D GLIS1 RCOR2 CD3EAP PPP1R13L CCDC61 ZNF180 CLASRP FBXO46 ENSG00000269148 IRF2BP1 ERCC1 ENSG00000268810
GH19I045690 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 10.9 -53.4 -53385 3.2 HDGF FOXA2 PKNOX1 SMAD1 ARID4B SIN3A DMAP1 ZNF2 YY1 POLR2B QPCTL SNRPD2 CCDC61 ENSG00000268810 SYMPK FBXO46 CLASRP ENSG00000269148 ENSG00000267114 IRF2BP1
GH19I045477 Promoter/Enhancer 2.1 FANTOM5 Ensembl ENCODE dbSUPER 10.1 +160.8 160787 2.4 HDGF PKNOX1 CLOCK SMAD1 ARNT ARID4B SIN3A ZNF2 ZBTB7B IRF4 ERCC1 PIR58452 TRU-TCA1-1 ZNF180 CCDC61 CD3EAP IRF2BP1 CLASRP PPP1R37 ENSG00000268810
GH19I045575 Enhancer 1.4 Ensembl ENCODE dbSUPER 11.8 +61.8 61826 3.8 PKNOX1 CLOCK FOXA2 ARID4B SIN3A DMAP1 ZNF48 SLC30A9 ZNF121 E2F8 ENSG00000268810 OPA3 GPR4 DM1-AS CCDC61 MIR330 EML2 CLASRP ENSG00000259605 GC19P045560
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around MIR330 on UCSC Golden Path with GeneCards custom track

Genomic Locations for MIR330 Gene

Genomic Locations for MIR330 Gene
chr19:45,638,994-45,639,087
(GRCh38/hg38)
Size:
94 bases
Orientation:
Minus strand
chr19:46,142,252-46,142,345
(GRCh37/hg19)

Genomic View for MIR330 Gene

Genes around MIR330 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR330 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR330 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR330 Gene

ORGUL Member Location for MIR330 Gene

ORGUL Member Location for MIR330 gene

Proteins for MIR330 Gene

Post-translational modifications for MIR330 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR330 Gene

Domains & Families for MIR330 Gene

Gene Families for MIR330 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR330: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR330 Gene

Function for MIR330 Gene

Phenotypes From GWAS Catalog for MIR330 Gene

Animal Model Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR330 Gene

Localization for MIR330 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR330 Gene

Pathways & Interactions for MIR330 Gene

SuperPathways for MIR330 Gene

SuperPathway Contained pathways
1 MicroRNAs in cancer
genes like me logo Genes that share pathways with MIR330: view

Pathways by source for MIR330 Gene

1 KEGG pathway for MIR330 Gene

Interacting Proteins for MIR330 Gene

Gene Ontology (GO) - Biological Process for MIR330 Gene

None

No data available for SIGNOR curated interactions for MIR330 Gene

Drugs & Compounds for MIR330 Gene

No Compound Related Data Available

Transcripts for MIR330 Gene

fRNAdb Secondary structures for MIR330 Gene

  • FR394581
  • hsa-mir-330_MI0000803_Homo_sapiens_miR-330_stem-loop_hairpin

mRNA/cDNA for MIR330 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR330 Gene

No ASD Table

Relevant External Links for MIR330 Gene

GeneLoc Exon Structure for
MIR330
ECgene alternative splicing isoforms for
MIR330

Expression for MIR330 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MIR330 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR330 Gene:

MIR330
genes like me logo Genes that share expression patterns with MIR330: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR330 Gene

Orthologs for MIR330 Gene

Evolution for MIR330 Gene

ENSEMBL:
Gene Tree for MIR330 (if available)
TreeFam:
Gene Tree for MIR330 (if available)

No data available for Orthologs for MIR330 Gene

Paralogs for MIR330 Gene

No data available for Paralogs for MIR330 Gene

Variants for MIR330 Gene

Sequence variations from dbSNP and Humsavar for MIR330 Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs1001139067 -- 45,640,129(-) T/A upstream_transcript_variant
rs1001211057 -- 45,639,879(-) A/G upstream_transcript_variant
rs1002217059 -- 45,641,068(-) T/G upstream_transcript_variant
rs1002809443 -- 45,638,902(-) GGG/GG downstream_transcript_variant
rs1002927640 -- 45,639,845(-) T/G upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for MIR330 Gene

Variant ID Type Subtype PubMed ID
nsv833848 CNV loss 17160897

Additional Variant Information for MIR330 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR330

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR330 Gene

Disorders for MIR330 Gene

Additional Disease Information for MIR330

No disorders were found for MIR330 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR330 Gene

Publications for MIR330 Gene

  1. New human and mouse microRNA genes found by homology search. (PMID: 15634332) Weber MJ (The FEBS journal 2005) 1 3 58
  2. Identification of many microRNAs that copurify with polyribosomes in mammalian neurons. (PMID: 14691248) Kim J … Ruvkun G (Proceedings of the National Academy of Sciences of the United States of America 2004) 1 3 58
  3. Targeting of CCBE1 by miR-330-3p in human breast cancer promotes metastasis. (PMID: 28419078) Mesci A … Liu SK (British journal of cancer 2017) 3 58
  4. Roles of microRNA-330 and Its Target Gene ING4 in the Development of Aggressive Phenotype in Hepatocellular Carcinoma Cells. (PMID: 28050784) Hu X … Sun C (Digestive diseases and sciences 2017) 3 58
  5. MicroRNA-330-5p negatively regulates ITGA5 expression in human colorectal cancer. (PMID: 27633518) Yoo HI … Yoon SK (Oncology reports 2016) 3 58

Products for MIR330 Gene

Sources for MIR330 Gene

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