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Aliases for MIR330 Gene

Subcategory (RNA class) for MIR330 Gene

miRNA

Quality Score for this RNA gene is

8.2

Aliases for MIR330 Gene

  • MicroRNA 330 2 3 5
  • Hsa-Mir-330 3
  • Mir-330 3
  • MIRN330 3

External Ids for MIR330 Gene

Previous HGNC Symbols for MIR330 Gene

  • MIRN330

Previous GeneCards Identifiers for MIR330 Gene

  • GC19M050836
  • GC19M046142

Summaries for MIR330 Gene

Entrez Gene Summary for MIR330 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR330 Gene

MIR330 (MicroRNA 330) is an RNA Gene, and is affiliated with the miRNA class. Among its related pathways are MicroRNAs in cancer and miRNAs involved in DDR.

fRNAdb sequence ontologies for MIR330 Gene - the ORGUL cluster for this gene includes several descriptions:

  • nc_conserved_region: Non-coding region of sequence similarity by descent from a common ancestor.

  • miRNA: Small, ~22-nt, RNA molecule that is the endogenous transcript of a miRNA gene. Micro RNAs are produced from precursor molecules (SO:0000647) that can form local hairpin structures, which ordinarily are processed (via the Dicer pathway) such that a single miRNA molecule accumulates from one arm of a hairpin precursor molecule. Micro RNAs may trigger the cleavage of their target molecules or act as translational repressors.

  • pre_miRNA: The 60-70 nucleotide region remain after Drosha processing of the primary transcript, that folds back upon itself to form a hairpin sructure.

View fRNAdb secondary structures for MIR330

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR330 Gene

Genomics for MIR330 Gene

Regulatory Elements for MIR330 Gene

Promoters for MIR330 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around MIR330 on UCSC Golden Path with GeneCards custom track

Genomic Location for MIR330 Gene

Chromosome:
19
Start:
45,638,994 bp from pter
End:
45,639,087 bp from pter
Size:
94 bases
Orientation:
Minus strand

Genomic View for MIR330 Gene

Genes around MIR330 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR330 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR330 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR330 Gene

ORGUL Member Location for MIR330 Gene

ORGUL Member Location for MIR330 gene

Proteins for MIR330 Gene

Post-translational modifications for MIR330 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR330 Gene

Domains & Families for MIR330 Gene

Gene Families for MIR330 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR330: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR330 Gene

Function for MIR330 Gene

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR330 Gene

Localization for MIR330 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR330 Gene

Pathways & Interactions for MIR330 Gene

genes like me logo Genes that share pathways with MIR330: view

Pathways by source for MIR330 Gene

1 BioSystems pathway for MIR330 Gene
1 KEGG pathway for MIR330 Gene

Interacting Proteins for MIR330 Gene

Gene Ontology (GO) - Biological Process for MIR330 Gene

None

No data available for SIGNOR curated interactions for MIR330 Gene

Drugs & Compounds for MIR330 Gene

No Compound Related Data Available

Transcripts for MIR330 Gene

fRNAdb Secondary structures for MIR330 Gene

  • FR394581
  • hsa-mir-330_MI0000803_Homo_sapiens_miR-330_stem-loop_hairpin

mRNA/cDNA for MIR330 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR330 Gene

No ASD Table

Relevant External Links for MIR330 Gene

GeneLoc Exon Structure for
MIR330
ECgene alternative splicing isoforms for
MIR330

Expression for MIR330 Gene

mRNA expression in normal human tissues for MIR330 Gene

genes like me logo Genes that share expression patterns with MIR330: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for MIR330 Gene

Orthologs for MIR330 Gene

This gene was present in the common ancestor of mammals.

Orthologs for MIR330 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia bta-mir-330 36
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia cfa-mir-330 36
  • 92 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mir330 36
  • 89 (a)
OneToOne
Species with no ortholog for MIR330:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MIR330 Gene

ENSEMBL:
Gene Tree for MIR330 (if available)
TreeFam:
Gene Tree for MIR330 (if available)

Paralogs for MIR330 Gene

No data available for Paralogs for MIR330 Gene

Variants for MIR330 Gene

Structural Variations from Database of Genomic Variants (DGV) for MIR330 Gene

Variant ID Type Subtype PubMed ID
nsv833848 CNV Loss 17160897
nsv912159 CNV Loss 21882294

Relevant External Links for MIR330 Gene

HapMap Linkage Disequilibrium report
MIR330

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations from dbSNP and Humsavar and Variation tolerance for MIR330 Gene

Disorders for MIR330 Gene

Relevant External Links for MIR330

Human Genome Epidemiology (HuGE) Navigator
MIR330
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR330

No disorders were found for MIR330 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR330 Gene

Publications for MIR330 Gene

  1. New human and mouse microRNA genes found by homology search. (PMID: 15634332) Weber M.J. (FEBS J. 2005) 1 3
  2. Identification of many microRNAs that copurify with polyribosomes in mammalian neurons. (PMID: 14691248) Kim J. … Ruvkun G. (Proc. Natl. Acad. Sci. U.S.A. 2004) 1 3
  3. The effects of a MAP2K5 microRNA target site SNP on risk for anxiety and depressive disorders. (PMID: 24436253) Jensen K.P. … Gelernter J. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2014) 3
  4. MiR-330-mediated regulation of SH3GL2 expression enhances malignant behaviors of glioblastoma stem cells by activating ERK and PI3K/AKT signaling pathways. (PMID: 24736727) Yao Y. … Liu Y. (PLoS ONE 2014) 3
  5. miR-330-5p targets tyrosinase and induces depigmentation. (PMID: 24862846) Rambow F. … Larue L. (J. Invest. Dermatol. 2014) 3

Products for MIR330 Gene

Sources for MIR330 Gene

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