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Aliases for MIR330 Gene

Subcategory (RNA class) for MIR330 Gene

miRNA

Quality Score for this RNA gene is

8.2

Aliases for MIR330 Gene

  • MicroRNA 330 2 3 5
  • Hsa-Mir-330 3
  • Mir-330 3
  • MIRN330 3

External Ids for MIR330 Gene

Previous HGNC Symbols for MIR330 Gene

  • MIRN330

Previous GeneCards Identifiers for MIR330 Gene

  • GC19M050836
  • GC19M046142
  • GC19M045642
  • GC19M045607

Summaries for MIR330 Gene

Entrez Gene Summary for MIR330 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR330 Gene

MIR330 (MicroRNA 330) is an RNA Gene, and is affiliated with the miRNA class. Among its related pathways are MicroRNAs in cancer.

fRNAdb sequence ontologies for MIR330 Gene - the ORGUL cluster for this gene includes several descriptions:

  • nc_conserved_region: Non-coding region of sequence similarity by descent from a common ancestor.

  • miRNA: Small, ~22-nt, RNA molecule that is the endogenous transcript of a miRNA gene. Micro RNAs are produced from precursor molecules (SO:0000647) that can form local hairpin structures, which ordinarily are processed (via the Dicer pathway) such that a single miRNA molecule accumulates from one arm of a hairpin precursor molecule. Micro RNAs may trigger the cleavage of their target molecules or act as translational repressors.

  • pre_miRNA: The 60-70 nucleotide region remain after Drosha processing of the primary transcript, that folds back upon itself to form a hairpin sructure.

View fRNAdb secondary structures for MIR330

Additional gene information for MIR330 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR330 Gene

Genomics for MIR330 Gene

Regulatory Elements for MIR330 Gene

Enhancers for MIR330 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19H045401 1.7 FANTOM5 ENCODE dbSUPER 10.5 +234.5 234515 6 FEZF1 YY1 ZNF143 SP3 MEF2D GLIS1 RCOR2 NBN NR2C1 KDM1A ZNF180 CCDC61 CLASRP FBXO46 ENSG00000269148 CD3EAP IRF2BP1 ERCC1 RPS16P9 ENSG00000267614
GH19H045575 1.5 Ensembl ENCODE dbSUPER 11.8 +61.8 61826 3 PKNOX1 FOXA2 ARID4B SIN3A DMAP1 ZNF121 SLC30A9 ZNF143 FOS ATF7 ENSG00000268810 GPR4 OPA3 DM1-AS CCDC61 MIR330 EML2 CLASRP ENSG00000259605 GC19P045560
GH19H045477 1.7 FANTOM5 ENCODE dbSUPER 10.1 +160.8 160788 2 HDGF PKNOX1 ARNT ARID4B SIN3A ZNF2 ZBTB7B YY1 ZNF766 ZNF207 ZNF180 CCDC61 CLASRP CD3EAP FBXO46 ENSG00000269148 IRF2BP1 PPP1R37 ENSG00000268810 PPM1N
GH19H045567 1.4 Ensembl ENCODE dbSUPER 11.4 +69.9 69897 2 PKNOX1 RB1 INSM2 KLF17 SIN3A FEZF1 ZBTB40 RAD21 ZEB1 YY1 CCDC61 SYMPK OPA3 CLASRP BLOC1S3 VASP ENSG00000269148 FBXO46 RTN2 PPM1N
GH19H045472 1.2 Ensembl ENCODE dbSUPER 10.8 +164.6 164563 4 ZNF384 CHD7 ZFHX2 POLR2A EGR1 EGR2 SMAD5 MTA2 HLF NR4A1 CD3EAP PPP1R13L RTN2 VASP ERCC2 EML2 MIR330 ERCC1 PPM1N OPA3
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MIR330 on UCSC Golden Path with GeneCards custom track

Promoters for MIR330 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000110241 -213 1001 HDAC1 HDGF RB1 NFRKB SIN3A NFXL1 ZNF2 YY1 GLIS2 ZNF143

Genomic Location for MIR330 Gene

Chromosome:
19
Start:
45,638,994 bp from pter
End:
45,639,087 bp from pter
Size:
94 bases
Orientation:
Minus strand

Genomic View for MIR330 Gene

Genes around MIR330 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR330 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR330 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR330 Gene

ORGUL Member Location for MIR330 Gene

ORGUL Member Location for MIR330 gene

Proteins for MIR330 Gene

Post-translational modifications for MIR330 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR330 Gene

Domains & Families for MIR330 Gene

Gene Families for MIR330 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR330: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR330 Gene

Function for MIR330 Gene

Phenotypes From GWAS Catalog for MIR330 Gene

Animal Model Products

CRISPR Products

miRNA Products

Clone Products

  • Applied Biological Materials Clones for MIR330
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR330 Gene

Localization for MIR330 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR330 Gene

Pathways & Interactions for MIR330 Gene

SuperPathways for MIR330 Gene

SuperPathway Contained pathways
1 MicroRNAs in cancer
genes like me logo Genes that share pathways with MIR330: view

Pathways by source for MIR330 Gene

1 KEGG pathway for MIR330 Gene

Interacting Proteins for MIR330 Gene

Gene Ontology (GO) - Biological Process for MIR330 Gene

None

No data available for SIGNOR curated interactions for MIR330 Gene

Drugs & Compounds for MIR330 Gene

No Compound Related Data Available

Transcripts for MIR330 Gene

fRNAdb Secondary structures for MIR330 Gene

  • FR394581
  • hsa-mir-330_MI0000803_Homo_sapiens_miR-330_stem-loop_hairpin

mRNA/cDNA for MIR330 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

CRISPR Products

miRNA Products

Clone Products

  • Applied Biological Materials Clones for MIR330
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for MIR330 Gene

No ASD Table

Relevant External Links for MIR330 Gene

GeneLoc Exon Structure for
MIR330
ECgene alternative splicing isoforms for
MIR330

Expression for MIR330 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MIR330 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR330 Gene:

MIR330
genes like me logo Genes that share expression patterns with MIR330: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR330 Gene

Orthologs for MIR330 Gene

Evolution for MIR330 Gene

ENSEMBL:
Gene Tree for MIR330 (if available)
TreeFam:
Gene Tree for MIR330 (if available)

No data available for Orthologs for MIR330 Gene

Paralogs for MIR330 Gene

No data available for Paralogs for MIR330 Gene

Variants for MIR330 Gene

Sequence variations from dbSNP and Humsavar for MIR330 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs1001139067 -- 45,640,129(+) TGAAA(A/T)GTGCA intron-variant, upstream-variant-2KB
rs1001211057 -- 45,639,879(+) ATCCC(A/G)GCTAC intron-variant, upstream-variant-2KB
rs1002217059 -- 45,641,068(+) GCACC(G/T)CTTGG intron-variant, upstream-variant-2KB
rs1002809443 -- 45,638,902(+) AAAAA(-/G)GGTCT intron-variant, downstream-variant-500B
rs1002927640 -- 45,639,845(+) AAAAC(G/T)TAGCC intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MIR330 Gene

Variant ID Type Subtype PubMed ID
nsv833848 CNV loss 17160897

Relevant External Links for MIR330 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR330

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR330 Gene

Disorders for MIR330 Gene

Relevant External Links for MIR330

Human Genome Epidemiology (HuGE) Navigator
MIR330
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR330

No disorders were found for MIR330 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR330 Gene

Publications for MIR330 Gene

  1. New human and mouse microRNA genes found by homology search. (PMID: 15634332) Weber MJ (The FEBS journal 2005) 1 3 60
  2. Identification of many microRNAs that copurify with polyribosomes in mammalian neurons. (PMID: 14691248) Kim J … Ruvkun G (Proceedings of the National Academy of Sciences of the United States of America 2004) 1 3 60
  3. Targeting of CCBE1 by miR-330-3p in human breast cancer promotes metastasis. (PMID: 28419078) Mesci A … Liu SK (British journal of cancer 2017) 3 60
  4. Roles of microRNA-330 and Its Target Gene ING4 in the Development of Aggressive Phenotype in Hepatocellular Carcinoma Cells. (PMID: 28050784) Hu X … Sun C (Digestive diseases and sciences 2017) 3 60
  5. Negative regulation of TIM-3 expression in AML cell line (HL-60) using miR-330-5p. (PMID: 27341144) Fooladinezhad H … Doosti A (British journal of biomedical science 2016) 3 60

Products for MIR330 Gene

Sources for MIR330 Gene

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