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Aliases for MIR330 Gene

Subcategory (RNA class) for MIR330 Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR330 Gene

  • MicroRNA 330 2 3
  • EML2 4 5
  • Echinoderm Microtubule Associated Protein Like 2 5
  • Hsa-Mir-330 3
  • HuEMAP-2 4
  • Mir-330 3
  • MIRN330 3
  • EMAP-2 4
  • EMAPL2 4
  • EMAP2 4

External Ids for MIR330 Gene

Previous HGNC Symbols for MIR330 Gene

  • MIRN330

Previous GeneCards Identifiers for MIR330 Gene

  • GC19M050836
  • GC19M046142
  • GC19M045642

Summaries for MIR330 Gene

Entrez Gene Summary for MIR330 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR330 Gene

MIR330 (MicroRNA 330) is an RNA Gene, and is affiliated with the miRNA class. Among its related pathways are MicroRNAs in cancer. An important paralog of this gene is EML1.

UniProtKB/Swiss-Prot for MIR330 Gene

  • Tubulin binding protein that inhibits microtubule nucleation and growth, resulting in shorter microtubules.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR330 Gene

Genomics for MIR330 Gene

Regulatory Elements for MIR330 Gene

Enhancers for MIR330 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19F045575 1.2 Ensembl ENCODE 11.8 +68.4 68368 3.8 PKNOX1 ARID4B SIN3A DMAP1 ZNF48 ZNF121 SLC30A9 ZNF766 ZNF143 FOS OPA3 GPR4 IRF2BP1 ENSG00000268810 EML2 MIR330 QPCTL LOC105372418 GC19P045560
GH19F045567 1.1 Ensembl ENCODE 11.4 +76.4 76439 2.4 PKNOX1 INSM2 KLF17 SIN3A FEZF1 ZNF48 ZBTB40 RAD21 ZEB1 ZNF121 OPA3 VASP RTN2 PPM1N EML2 MIR330 MIR642A ERCC1 CD3EAP PPP1R13L
GH19F045690 0.6 ENCODE 11 -46.8 -46844 3.2 HDGF PKNOX1 CREB3L1 WRNIP1 ARID4B SIN3A DMAP1 ZNF2 YY1 CBX5 ENSG00000267395 DMWD ENSG00000268810 SNRPD2 CCDC61 QPCTL SIX5 FBXO46 BHMG1 EML2
GH19F045477 0.9 FANTOM5 ENCODE 11 +167.3 167330 2.4 PKNOX1 ARNT CREB3L1 WRNIP1 ARID4B SIN3A ZNF2 YY1 ZNF143 ZNF207 ZNF180 IRF2BP1 CD3EAP FBXO46 CCDC61 ENSG00000269148 PPP1R37 PPM1N ENSG00000268810 VASP
GH19F045476 0.6 ENCODE 11 +169.7 169732 0.2 NR2F1 ZNF384 ZBTB8A ZKSCAN1 CD3EAP PPP1R13L RTN2 VASP ERCC2 EML2 MIR330 GC19P045474 TRU-TCA1-1 PIR58452
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around MIR330 on UCSC Golden Path with GeneCards custom track

Promoters for MIR330 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000217034 -371 1201 ATF1 PKNOX1 ARNT CREB3L1 WRNIP1 SIN3A ZNF2 ZNF207 KLF7 FOS

Genomic Location for MIR330 Gene

Chromosome:
19
Start:
45,606,994 bp from pter
End:
45,645,629 bp from pter
Size:
38,636 bases
Orientation:
Minus strand

Genomic View for MIR330 Gene

Genes around MIR330 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR330 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR330 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR330 Gene

Proteins for MIR330 Gene

  • Protein details for MIR330 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O95834-EMAL2_HUMAN
    Recommended name:
    Echinoderm microtubule-associated protein-like 2
    Protein Accession:
    O95834
    Secondary Accessions:
    • B7Z3I2
    • B7Z3Q9
    • K7ERL7
    • Q59EN8
    • Q8N5A2
    • Q9UG50

    Protein attributes for MIR330 Gene

    Size:
    649 amino acids
    Molecular mass:
    70679 Da
    Quaternary structure:
    • Interacts with GRID2 and may also interact with GRID1 (By similarity). Binds unpolymerized tubulins via its WD repeat region.
    • Interacts with GRID2 and may also interact with GRID1 (By similarity). Binds unpolymerized tubulins via its WD repeat region.

    Three dimensional structures from OCA and Proteopedia for MIR330 Gene

    Alternative splice isoforms for MIR330 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MIR330 Gene

Post-translational modifications for MIR330 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for MIR330 Gene

Domains & Families for MIR330 Gene

Gene Families for MIR330 Gene

Graphical View of Domain Structure for InterPro Entry

O95834

UniProtKB/Swiss-Prot:

EMAL2_HUMAN :
  • Contains a tandem atypical propeller in EMLs (TAPE) domain. The N-terminal beta-propeller is formed by canonical WD repeats; in contrast, the second beta-propeller contains one blade that is formed by discontinuous parts of the polypeptide chain (By similarity).
  • Belongs to the WD repeat EMAP family.
  • Contains 11 WD repeats.
Domain:
  • Contains a tandem atypical propeller in EMLs (TAPE) domain. The N-terminal beta-propeller is formed by canonical WD repeats; in contrast, the second beta-propeller contains one blade that is formed by discontinuous parts of the polypeptide chain (By similarity).
Family:
  • Belongs to the WD repeat EMAP family.
Similarity:
  • Contains 11 WD repeats.
genes like me logo Genes that share domains with MIR330: view

No data available for Suggested Antigen Peptide Sequences for MIR330 Gene

Function for MIR330 Gene

Molecular function for MIR330 Gene

UniProtKB/Swiss-Prot Function:
Tubulin binding protein that inhibits microtubule nucleation and growth, resulting in shorter microtubules.

Gene Ontology (GO) - Molecular Function for MIR330 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008017 microtubule binding IEA --
GO:0008022 protein C-terminus binding IEA --
GO:0015631 tubulin binding IDA --
genes like me logo Genes that share ontologies with MIR330: view

Animal Model Products

miRNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR330 Gene

Localization for MIR330 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MIR330 Gene

Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, spindle. Note=Colocalizes with the microtubule cytoskeleton. Colocalizes with the mitotic spindle.

Gene Ontology (GO) - Cellular Components for MIR330 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005819 spindle IEA --
GO:0005856 cytoskeleton IEA --
GO:0005874 microtubule IEA --
GO:0005875 microtubule associated complex TAS --
genes like me logo Genes that share ontologies with MIR330: view

No data available for Subcellular locations from COMPARTMENTS for MIR330 Gene

Pathways & Interactions for MIR330 Gene

SuperPathways for MIR330 Gene

SuperPathway Contained pathways
1 MicroRNAs in cancer
genes like me logo Genes that share pathways with MIR330: view

Pathways by source for MIR330 Gene

1 KEGG pathway for MIR330 Gene

Gene Ontology (GO) - Biological Process for MIR330 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007601 visual perception TAS --
GO:0007605 sensory perception of sound TAS --
GO:0010968 regulation of microtubule nucleation IEA --
GO:0031115 negative regulation of microtubule polymerization IEA --
genes like me logo Genes that share ontologies with MIR330: view

No data available for SIGNOR curated interactions for MIR330 Gene

Transcripts for MIR330 Gene

mRNA/cDNA for MIR330 Gene

(32) Ensembl transcripts including schematic representations, and UCSC links where relevant :

miRNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR330 Gene

No ASD Table

Relevant External Links for MIR330 Gene

GeneLoc Exon Structure for
MIR330
ECgene alternative splicing isoforms for
MIR330

Expression for MIR330 Gene

mRNA expression in normal human tissues for MIR330 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR330 Gene:

MIR330

mRNA Expression by UniProt/SwissProt for MIR330 Gene:

O95834-EMAL2_HUMAN
Tissue specificity: Ubiquitous.
genes like me logo Genes that share expression patterns with MIR330: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for MIR330 Gene

Orthologs for MIR330 Gene

This gene was present in the common ancestor of animals.

Orthologs for MIR330 Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia EML2 35
  • 97 (a)
OneToOne
cow
(Bos Taurus)
Mammalia EML2 35
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Eml2 35
  • 92 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia EML2 35
  • 84 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia EML2 35
  • 80 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia EML2 35
  • 77 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii eml2 35
  • 66 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta DCX-EMAP 35
  • 25 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea elp-1 35
  • 24 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10048 35
  • 50 (a)
OneToMany
Species where no ortholog for MIR330 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for MIR330 Gene

ENSEMBL:
Gene Tree for MIR330 (if available)
TreeFam:
Gene Tree for MIR330 (if available)

Paralogs for MIR330 Gene

Paralogs for MIR330 Gene

genes like me logo Genes that share paralogs with MIR330: view

Variants for MIR330 Gene

Sequence variations from dbSNP and Humsavar for MIR330 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs10421136 -- 45,640,119(+) TGAGC(A/C)GAGTT intron-variant, upstream-variant-2KB
rs112932562 -- 45,639,995(+) TCTCA(-/AAAT)AAATA intron-variant, upstream-variant-2KB
rs113010467 -- 45,640,811(+) TCCGC(C/G)TCCCA intron-variant, upstream-variant-2KB
rs113926831 -- 45,640,402(+) TCTCT(C/T)TTTTT intron-variant, upstream-variant-2KB
rs114670763 -- 45,640,260(+) GTCGA(C/T)CAAAC intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MIR330 Gene

Variant ID Type Subtype PubMed ID
nsv833848 CNV loss 17160897

Relevant External Links for MIR330 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR330

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR330 Gene

Disorders for MIR330 Gene

Relevant External Links for MIR330

Human Genome Epidemiology (HuGE) Navigator
MIR330
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR330

No disorders were found for MIR330 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR330 Gene

Publications for MIR330 Gene

  1. miR-330-3p controls cell proliferation by targeting early growth response 2 in non-small-cell lung cancer. (PMID: 25935837) Liu X. … Yu B. (Acta Biochim. Biophys. Sin. (Shanghai) 2015) 3 64
  2. Micro-RNAs miR-29a and miR-330-5p function as tumor suppressors by targeting the MUC1 mucin in pancreatic cancer cells. (PMID: 26036346) TrAchoux S. … Van Seuningen I. (Biochim. Biophys. Acta 2015) 3 64
  3. MicroRNA-330-5p as a Putative Modulator of Neoadjuvant Chemoradiotherapy Sensitivity in Oesophageal Adenocarcinoma. (PMID: 26221725) Bibby B.A. … Maher S.G. (PLoS ONE 2015) 3 64
  4. The effects of a MAP2K5 microRNA target site SNP on risk for anxiety and depressive disorders. (PMID: 24436253) Jensen K.P. … Gelernter J. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2014) 3 64
  5. MiR-330-mediated regulation of SH3GL2 expression enhances malignant behaviors of glioblastoma stem cells by activating ERK and PI3K/AKT signaling pathways. (PMID: 24736727) Yao Y. … Liu Y. (PLoS ONE 2014) 3 64

Products for MIR330 Gene

Sources for MIR330 Gene

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