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Aliases for MIR328 Gene

Subcategory (RNA class) for MIR328 Gene

miRNA

Quality Score for this RNA gene is

8

Aliases for MIR328 Gene

  • MicroRNA 328 2 3 5
  • Hsa-Mir-328 3
  • Mir-328 3
  • MIRN328 3

External Ids for MIR328 Gene

Previous HGNC Symbols for MIR328 Gene

  • MIRN328

Previous GeneCards Identifiers for MIR328 Gene

  • GC16U900913
  • GC16M065795
  • GC16M067237

Summaries for MIR328 Gene

Entrez Gene Summary for MIR328 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR328 Gene

MIR328 (MicroRNA 328) is an RNA Gene, and is affiliated with the miRNA class.

fRNAdb sequence ontologies for MIR328 Gene

  • pre_miRNA: The 60-70 nucleotide region remain after Drosha processing of the primary transcript, that folds back upon itself to form a hairpin sructure.

View fRNAdb secondary structures for MIR328

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR328 Gene

Genomics for MIR328 Gene

Regulatory Elements for MIR328 Gene

Enhancers for MIR328 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH16G066977 1.5 Ensembl ENCODE dbSUPER 10.6 +224.6 224595 0.4 HDGF WRNIP1 ARID4B SIN3A ZNF2 ZNF48 SLC30A9 GLIS2 ZNF143 DEK CES2 ELMO3 CBFB B3GNT9 TRADD FBXL8 HSF4 C16orf70 RRAD CDH16
GH16G066960 1.2 Ensembl ENCODE 11.2 +241.3 241275 1.0 HDGF PKNOX1 ARNT SIN3A ARID4B ZNF2 ZNF48 ZNF143 DEK MIER2 FBXL8 TRADD HSF4 CES2 RRAD CDH16 FAM96B B3GNT9 CBFB MIR328
GH16G067235 1 ENCODE dbSUPER 12 -34.2 -34172 1.7 HDGF PKNOX1 AGO1 ZFP64 ZIC2 ZNF664 ZNF316 ZNF366 POLR2A NFE2 ATP6V0D1 MIR328 ELMO3 LRRC36 HSD11B2 ACD PARD6A SLC9A5 TMEM208
GH16G067052 0.9 Ensembl ENCODE 10.5 +148.7 148727 2.2 HDAC1 HDGF YBX1 MNT ZBTB40 ATF2 ZNF121 PRDM6 GATA3 ZNF316 ELMO3 CBFB C16orf70 MIR328 ATP6V0D1 ENSG00000260465 GC16P067102
GH16G067346 0.7 ENCODE 10.1 -144.1 -144118 0.2 JUN CEBPB EP300 RFX5 FOXA1 GATA3 GATA2 STAT3 CREB1 FOS RNU1-123P TPPP3 ZDHHC1 PLEKHG4 HSD11B2 MIR328 ELMO3 LRRC36
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MIR328 on UCSC Golden Path with GeneCards custom track

Genomic Location for MIR328 Gene

Chromosome:
16
Start:
67,202,321 bp from pter
End:
67,202,395 bp from pter
Size:
75 bases
Orientation:
Minus strand

Genomic View for MIR328 Gene

Genes around MIR328 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR328 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR328 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR328 Gene

ORGUL Member Location for MIR328 Gene

ORGUL Member Location for MIR328 gene

Proteins for MIR328 Gene

Post-translational modifications for MIR328 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR328 Gene

Domains & Families for MIR328 Gene

Gene Families for MIR328 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR328: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR328 Gene

Function for MIR328 Gene

Animal Model Products

miRNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR328 Gene

Localization for MIR328 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR328 Gene

Pathways & Interactions for MIR328 Gene

SuperPathways for MIR328 Gene

No Data Available

Interacting Proteins for MIR328 Gene

Gene Ontology (GO) - Biological Process for MIR328 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for MIR328 Gene

Drugs & Compounds for MIR328 Gene

No Compound Related Data Available

Transcripts for MIR328 Gene

fRNAdb Secondary structures for MIR328 Gene

  • hsa-miR-328-5p_MIMAT0026486_Homo_sapiens_miR-328-5p_mature
  • hsa-miR-328-3p_MIMAT0000752_Homo_sapiens_miR-328-3p_mature

mRNA/cDNA for MIR328 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

miRNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR328 Gene

No ASD Table

Relevant External Links for MIR328 Gene

GeneLoc Exon Structure for
MIR328
ECgene alternative splicing isoforms for
MIR328

Expression for MIR328 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MIR328 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR328 Gene:

MIR328
genes like me logo Genes that share expression patterns with MIR328: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR328 Gene

Orthologs for MIR328 Gene

This gene was present in the common ancestor of mammals.

Orthologs for MIR328 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-328 35
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia cfa-mir-328 35
  • 89 (a)
OneToOne
cow
(Bos Taurus)
Mammalia bta-mir-328 35
  • 75 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mir328 35
  • 71 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 64 (a)
OneToOne
Species where no ortholog for MIR328 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MIR328 Gene

ENSEMBL:
Gene Tree for MIR328 (if available)
TreeFam:
Gene Tree for MIR328 (if available)

Paralogs for MIR328 Gene

No data available for Paralogs for MIR328 Gene

Variants for MIR328 Gene

Sequence variations from dbSNP and Humsavar for MIR328 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs1000558856 -- 67,202,807(+) GGGAT(A/G)GATCC intron-variant, upstream-variant-2KB
rs1000784133 -- 67,203,538(+) CGTGG(C/G)GAGGA upstream-variant-2KB, reference, synonymous-codon
rs1001052752 -- 67,202,622(+) GCGGC(C/T)CCAGG intron-variant, upstream-variant-2KB
rs1001515701 -- 67,203,274(+) CGCCC(G/T)GGGCC intron-variant, upstream-variant-2KB
rs1001820445 -- 67,204,050(+) ACAGT(A/G)ACAGT downstream-variant-500B, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MIR328 Gene

Variant ID Type Subtype PubMed ID
nsv1160429 CNV deletion 26073780
nsv457513 CNV loss 19166990
nsv471092 CNV gain 18288195
nsv522852 CNV gain 19592680
nsv524363 CNV loss 19592680
nsv524492 CNV loss 19592680
nsv572905 CNV loss 21841781
nsv827707 CNV loss 20364138
nsv952044 CNV deletion 24416366

Relevant External Links for MIR328 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR328

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR328 Gene

Disorders for MIR328 Gene

Relevant External Links for MIR328

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR328

No disorders were found for MIR328 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR328 Gene

Publications for MIR328 Gene

  1. New human and mouse microRNA genes found by homology search. (PMID: 15634332) Weber M.J. (FEBS J. 2005) 1 3 64
  2. Identification of many microRNAs that copurify with polyribosomes in mammalian neurons. (PMID: 14691248) Kim J. … Ruvkun G. (Proc. Natl. Acad. Sci. U.S.A. 2004) 1 3 64
  3. MiR-328 suppresses the survival of esophageal cancer cells by targeting PLCE1. (PMID: 26773497) Han N. … Zheng P. (Biochem. Biophys. Res. Commun. 2016) 3 64
  4. Expression of microRNA-328 Functions as a Biomarker for Recurrence of Early Gastric Cancer (EGC) After Endoscopic Submucosal Dissection (ESD) by Modulating CD44. (PMID: 27923017) Xue H.G. … Tian Z.B. (Med. Sci. Monit. 2016) 3 64
  5. [Downregulation of miR-18a or miR-328 inhibits the invasion and migration of lung adenocarcinoma A549 cells]. (PMID: 27412935) DU C. … Wang Y. (Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi 2016) 3 64

Products for MIR328 Gene

Sources for MIR328 Gene

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