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Aliases for MIR326 Gene

Subcategory (RNA class) for MIR326 Gene

miRNA

Quality Score for this RNA gene is

8

Aliases for MIR326 Gene

  • MicroRNA 326 2 3 5
  • Hsa-Mir-326 3
  • Mir-326 3
  • MIRN326 3

External Ids for MIR326 Gene

Previous HGNC Symbols for MIR326 Gene

  • MIRN326

Previous GeneCards Identifiers for MIR326 Gene

  • GC11M074725
  • GC11M075046

Summaries for MIR326 Gene

Entrez Gene Summary for MIR326 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR326 Gene

MIR326 (MicroRNA 326) is an RNA Gene, and is affiliated with the miRNA class. Among its related pathways are MicroRNAs in cancer and Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins..

fRNAdb sequence ontologies for MIR326 Gene - the ORGUL cluster for this gene includes several descriptions:

  • miRNA: Small, ~22-nt, RNA molecule that is the endogenous transcript of a miRNA gene. Micro RNAs are produced from precursor molecules (SO:0000647) that can form local hairpin structures, which ordinarily are processed (via the Dicer pathway) such that a single miRNA molecule accumulates from one arm of a hairpin precursor molecule. Micro RNAs may trigger the cleavage of their target molecules or act as translational repressors.

  • pre_miRNA: The 60-70 nucleotide region remain after Drosha processing of the primary transcript, that folds back upon itself to form a hairpin sructure.

View fRNAdb secondary structures for MIR326

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR326 Gene

Genomics for MIR326 Gene

Regulatory Elements for MIR326 Gene

Enhancers for MIR326 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11G075273 1.9 FANTOM5 Ensembl ENCODE dbSUPER 11.5 +58.8 58780 5.3 HDGF AGO1 ARID4B SIN3A DMAP1 YY1 ZNF121 ZNF263 SP3 SP5 ARRB1 MIR326 DGAT2 ENSG00000254963 GC11M075326
GH11G075311 1.5 Ensembl ENCODE dbSUPER 12.1 +22.1 22135 3.6 ATF1 ZNF2 ZNF766 GATA2 ZNF143 FOS DEK ZNF263 REST ZNF579 ARRB1 MIR326 ENSG00000254429 SNORD15B GDPD5 GC11M075326 ENSG00000254963
GH11G075365 1.3 Ensembl ENCODE dbSUPER 12 -31.5 -31532 2.2 RAD21 TCF12 FOS RCOR1 USF2 CEBPB GATAD2B ZEB2 ZNF217 MBD2 MIR326 RPS3 SNORD15B ARRB1
GH11G075385 1.3 Ensembl ENCODE 11.8 -52.1 -52091 3.8 HDGF PKNOX1 ARNT SIN3A YY1 ZNF143 FOS JUNB REST ZNF592 ARRB1 POLD3 RNF169 MIR326 KLHL35 GDPD5 RN7SL239P LOC105369391 RPS3
GH11G075379 1.3 Ensembl ENCODE dbSUPER 11.8 -45.5 -45527 1.6 ELF3 PKNOX1 ATF1 CBX3 RB1 SAP130 TEAD4 ARID4B SIN3A HBP1 ARRB1 MIR326 SNORD15B KLHL35 GDPD5 LOC105369391 RPS3
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MIR326 on UCSC Golden Path with GeneCards custom track

Genomic Location for MIR326 Gene

Chromosome:
11
Start:
75,335,092 bp from pter
End:
75,335,186 bp from pter
Size:
95 bases
Orientation:
Minus strand

Genomic View for MIR326 Gene

Genes around MIR326 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR326 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR326 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR326 Gene

ORGUL Member Location for MIR326 Gene

ORGUL Member Location for MIR326 gene

Proteins for MIR326 Gene

Post-translational modifications for MIR326 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR326 Gene

Domains & Families for MIR326 Gene

Gene Families for MIR326 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR326: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR326 Gene

Function for MIR326 Gene

Animal Model Products

miRNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR326 Gene

Localization for MIR326 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR326 Gene

Pathways & Interactions for MIR326 Gene

genes like me logo Genes that share pathways with MIR326: view

Pathways by source for MIR326 Gene

1 BioSystems pathway for MIR326 Gene
1 KEGG pathway for MIR326 Gene

Interacting Proteins for MIR326 Gene

Gene Ontology (GO) - Biological Process for MIR326 Gene

None

No data available for SIGNOR curated interactions for MIR326 Gene

Drugs & Compounds for MIR326 Gene

No Compound Related Data Available

Transcripts for MIR326 Gene

fRNAdb Secondary structures for MIR326 Gene

  • hsa-miR-326_MIMAT0000756_Homo_sapiens_miR-326_mature
  • hsa-mir-326_MI0000808_Homo_sapiens_miR-326_stem-loop_hairpin

mRNA/cDNA for MIR326 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

miRNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR326 Gene

No ASD Table

Relevant External Links for MIR326 Gene

GeneLoc Exon Structure for
MIR326
ECgene alternative splicing isoforms for
MIR326

Expression for MIR326 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MIR326 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR326 Gene:

MIR326
genes like me logo Genes that share expression patterns with MIR326: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR326 Gene

Orthologs for MIR326 Gene

This gene was present in the common ancestor of mammals.

Orthologs for MIR326 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-326 35
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia bta-mir-326 35
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia cfa-mir-326 35
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mir326 35
  • 94 (a)
OneToOne
Species where no ortholog for MIR326 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MIR326 Gene

ENSEMBL:
Gene Tree for MIR326 (if available)
TreeFam:
Gene Tree for MIR326 (if available)

Paralogs for MIR326 Gene

No data available for Paralogs for MIR326 Gene

Variants for MIR326 Gene

Sequence variations from dbSNP and Humsavar for MIR326 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs1002479854 -- 75,334,666(+) AGATT(C/G)AAGTC intron-variant, downstream-variant-500B
rs1003378944 -- 75,335,708(+) GGAGC(C/T)TTCCA intron-variant, upstream-variant-2KB
rs1004246602 -- 75,334,593(+) CCAGG(C/G)AGTTT intron-variant, downstream-variant-500B
rs1005253613 -- 75,336,020(+) CAGTG(A/T)CTGGG intron-variant, upstream-variant-2KB
rs1006371059 -- 75,337,065(+) TGCGT(G/T)AAGGG intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MIR326 Gene

Variant ID Type Subtype PubMed ID
dgv1225n100 CNV gain 25217958
nsv522447 CNV loss 19592680
nsv832211 CNV loss 17160897

Relevant External Links for MIR326 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR326

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR326 Gene

Disorders for MIR326 Gene

Relevant External Links for MIR326

Human Genome Epidemiology (HuGE) Navigator
MIR326
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR326

No disorders were found for MIR326 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR326 Gene

Publications for MIR326 Gene

  1. New human and mouse microRNA genes found by homology search. (PMID: 15634332) Weber M.J. (FEBS J. 2005) 1 3 64
  2. Identification of many microRNAs that copurify with polyribosomes in mammalian neurons. (PMID: 14691248) Kim J. … Ruvkun G. (Proc. Natl. Acad. Sci. U.S.A. 2004) 1 3 64
  3. MiR-326 is a diagnostic biomarker and regulates cell survival and apoptosis by targeting Bcl-2 in osteosarcoma. (PMID: 27723574) Cao L. … Wang P.Q. (Biomed. Pharmacother. 2016) 3 64
  4. miR-326 reverses chemoresistance in human lung adenocarcinoma cells by targeting specificity protein 1. (PMID: 27460077) Li J. … Yu W. (Tumour Biol. 2016) 3 64
  5. Hsa-miR-326 targets CCND1 and inhibits non-small cell lung cancer development. (PMID: 26840018) Sun C. … Li D. (Oncotarget 2016) 3 64

Products for MIR326 Gene

Sources for MIR326 Gene

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