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Aliases for MIR326 Gene

Subcategory (RNA class) for MIR326 Gene

miRNA

Quality Score for this RNA gene is

8

Aliases for MIR326 Gene

  • MicroRNA 326 2 3
  • MIRN326 3 6
  • Hsa-Mir-326 3

External Ids for MIR326 Gene

Previous Symbols for MIR326 Gene

  • MIRN326

Summaries for MIR326 Gene

Entrez Gene Summary for MIR326 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR326 Gene

MIR326 (MicroRNA 326) is an RNA Gene, and belongs to the miRNA class. Among its related pathways are MicroRNAs in cancer.

fRNAdb sequence ontologies for MIR326 Gene - the ORGUL cluster for this gene includes several descriptions:

  • miRNA: Small, ~22-nt, RNA molecule that is the endogenous transcript of a miRNA gene. Micro RNAs are produced from precursor molecules (SO:0000647) that can form local hairpin structures, which ordinarily are processed (via the Dicer pathway) such that a single miRNA molecule accumulates from one arm of a hairpin precursor molecule. Micro RNAs may trigger the cleavage of their target molecules or act as translational repressors.

  • pre_miRNA: The 60-70 nucleotide region remain after Drosha processing of the primary transcript, that folds back upon itself to form a hairpin sructure.

View fRNAdb secondary structures for MIR326

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR326 Gene

Genomics for MIR326 Gene

Genomic Location for MIR326 Gene

Start:
75,335,092 bp from pter
End:
75,335,186 bp from pter
Size:
95 bases
Orientation:
Minus strand

Genomic View for MIR326 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MIR326 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR326 Gene

ORGUL Member Location for MIR326 Gene

ORGUL Member Location for MIR326 gene

No data available for Regulatory Elements for MIR326 Gene

Proteins for MIR326 Gene

Post-translational modifications for MIR326 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR326 Gene

Domains for MIR326 Gene

Gene Families for MIR326 Gene

HGNC:
  • MIR :ncRNAs / Micro RNAs

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR326: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR326 Gene

Function for MIR326 Gene

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for MIR326 Gene

Localization for MIR326 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR326 Gene

Pathways for MIR326 Gene

SuperPathways for MIR326 Gene

Superpath Contained pathways
1 MicroRNAs in cancer
genes like me logo Genes that share pathways with MIR326: view

Pathways by source for MIR326 Gene

1 KEGG pathway for MIR326 Gene

Interacting Proteins for MIR326 Gene

Gene Ontology (GO) - Biological Process for MIR326 Gene

None

Transcripts for MIR326 Gene

fRNAdb Secondary structures for MIR326 Gene

  • hsa-miR-326_MIMAT0000756_Homo_sapiens_miR-326_mature
  • hsa-mir-326_MI0000808_Homo_sapiens_miR-326_stem-loop_hairpin

mRNA/cDNA for MIR326 Gene

(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR326 Gene

No ASD Table

Relevant External Links for MIR326 Gene

GeneLoc Exon Structure for
MIR326
ECgene alternative splicing isoforms for
MIR326

Expression for MIR326 Gene

mRNA expression in normal human tissues for MIR326 Gene

genes like me logo Genes that share expressions with MIR326: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein expression and mRNA Expression by UniProt/SwissProt for MIR326 Gene

Orthologs for MIR326 Gene

This gene was present in the common ancestor of mammals.

Orthologs for MIR326 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-326 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia bta-mir-326 36
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia cfa-mir-326 36
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mir326 36
  • 94 (a)
OneToOne
Species with no ortholog for MIR326:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MIR326 Gene

ENSEMBL:
Gene Tree for MIR326 (if available)
TreeFam:
Gene Tree for MIR326 (if available)

Paralogs for MIR326 Gene

No data available for Paralogs for MIR326 Gene

Variants for MIR326 Gene

Structural Variations from Database of Genomic Variants (DGV) for MIR326 Gene

Variant ID Type Subtype PubMed ID
nsv832211 CNV Loss 17160897
nsv522447 CNV Loss 19592680

Relevant External Links for MIR326 Gene

HapMap Linkage Disequilibrium report
MIR326

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations from dbSNP and Humsavar for MIR326 Gene

Disorders for MIR326 Gene

Relevant External Links for MIR326

Human Genome Epidemiology (HuGE) Navigator
MIR326
genes like me logo Genes that share disorders with MIR326: view

No data available for UniProtKB/Swiss-Prot for MIR326 Gene

Publications for MIR326 Gene

  1. Identification of many microRNAs that copurify with polyribosomes in mammalian neurons. (PMID: 14691248) Kim J. … Ruvkun G. (Proc. Natl. Acad. Sci. U.S.A. 2004) 3
  2. New human and mouse microRNA genes found by homology search. (PMID: 15634332) Weber M.J. (FEBS J. 2005) 3
  3. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S. … Enright A.J. (Nucleic Acids Res. 2006) 3
  4. A mammalian microRNA expression atlas based on small RNA library sequencing. (PMID: 17604727) Landgraf P. … Tuschl T. (Cell 2007) 3
  5. MicroRNA miR-326 regulates TH-17 differentiation and is associated with the pathogenesis of multiple sclerosis. (PMID: 19838199) Du C. … Pei G. (Nat. Immunol. 2009) 3

Products for MIR326 Gene

  • QIAGEN qRT-PCR Assays for microRNAs that regulate MIR326
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for MIR326
    • Block miRNA regulation of MIR326 using miScript Target Protectors

    Sources for MIR326 Gene

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